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Curt Hagedorn

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Gastroenterology
Address3S 08 Shorey
324 UAMS Campus Dr.
Mail Slot # 567
Little Rock AR 72205
Phone501-686-5126
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentGenetics, College of Medicine


    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Chief, Medicine Service
    Central Arkansas Veterans Healthcare System


    Collapse Research Funds 
    Collapse research activities
    R21CA176130     (HAGEDORN, CURT H.)Apr 1, 2013 - Mar 31, 2015
    NIH/NCI
    Molecular Phenotype of Polyps in Serrated Polyposis Syndrome
    Role: Principal Investigator

    R21CA148068     (HAGEDORN, CURT H.)Sep 1, 2011 - Feb 28, 2014
    NIH/NCI
    Sentinel Pol II RNAs for Measuring RNA Integrity in Biospecimens
    Role: Principal Investigator

    S10RR016903     (HAGEDORN, CURT H)May 1, 2002 - Apr 30, 2003
    NIH/NCRR
    Emory Medicine Laser Capture Microdissection Facility
    Role: Principal Investigator

    R41AI044568     (HAGEDORN, CURT H)Sep 30, 1999 - Sep 29, 2000
    NIH/NIAID
    HEPATITIS C VIRUS NS5B POLYMERASE INHIBITORS
    Role: Principal Investigator

    R41CA077818     (HAGEDORN, CURT H)Sep 30, 1998 - Sep 29, 1999
    NIH/NCI
    NEW TREATMENT STRATEGIES FOR HEPATITIS C
    Role: Principal Investigator

    U01AI041424     (HAGEDORN, CURT H)Sep 30, 1996 - Sep 29, 1999
    NIH/NIAID
    HEPATITIS C--MODELS FOR REPLICATION
    Role: Principal Investigator

    R01CA063640     (HAGEDORN, CURT H)Jul 1, 1995 - Jul 31, 2010
    NIH/NCI
    Breast Cancer Biology of Translational De-repression
    Role: Principal Investigator

    R55CA063640     (HAGEDORN, CURT H)Sep 30, 1994 - Jun 30, 1995
    NIH/NCI
    DISRUPTION OF CELL CYCLE GENES IN BREAST CANCER
    Role: Principal Investigator

    R01GM040219     (HAGEDORN, CURT H)Apr 1, 1989 - Jun 30, 1992
    NIH/NIGMS
    COVALENT MODIFICATIONS OF EIF-4F/TRANSLATIONAL CONTROL
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Liu JJ, Rosson TB, Xie JJ, Harris ZP, McBride RG, Siegel E, Hagedorn C. Personalized Inflammatory Bowel Disease Care Reduced Hospitalizations. Dig Dis Sci. 2019 07; 64(7):1809-1814. PMID: 30746632.
      View in: PubMed
    2. Rahmatallah Y, Khaidakov M, Lai KK, Goyne HE, Lamps LW, Hagedorn CH, Glazko G. Platform-independent gene expression signature differentiates sessile serrated adenomas/polyps and hyperplastic polyps of the colon. BMC Med Genomics. 2017 12 28; 10(1):81. PMID: 29284484.
      View in: PubMed
    3. Aydin Y, Chedid M, Chava S, Danielle Williams D, Liu S, Hagedorn CH, Sumitran-Holgersson S, Reiss K, Moroz K, Lu H, Balart LA, Dash S. Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture. Sci Rep. 2017 08 23; 7(1):9223. PMID: 28835697.
      View in: PubMed
    4. Jarret A, McFarland AP, Horner SM, Kell A, Schwerk J, Hong M, Badil S, Joslyn RC, Baker DP, Carrington M, Hagedorn CH, Gale M, Savan R. Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. Nat Med. 2016 12; 22(12):1475-1481. PMID: 27841874.
      View in: PubMed
    5. Khaidakov M, Lai KK, Roudachevski D, Sargsyan J, Goyne HE, Pai RK, Lamps LW, Hagedorn CH. Gastric Proteins MUC5AC and TFF1 as Potential Diagnostic Markers of Colonic Sessile Serrated Adenomas/Polyps. Am J Clin Pathol. 2016 Nov 01; 146(5):530-537. PMID: 28430953.
      View in: PubMed
    6. Hong M, Schwerk J, Lim C, Kell A, Jarret A, Pangallo J, Loo YM, Liu S, Hagedorn CH, Gale M, Savan R. Interferon lambda 4 expression is suppressed by the host during viral infection. J Exp Med. 2016 11 14; 213(12):2539-2552. PMID: 27799623.
      View in: PubMed
    7. Kanth P, Bronner MP, Boucher KM, Burt RW, Neklason DW, Hagedorn CH, Delker DA. Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype. Cancer Prev Res (Phila). 2016 06; 9(6):456-65. PMID: 27026680.
      View in: PubMed
    8. Zhang Y, Liu C, Barbier O, Smalling R, Tsuchiya H, Lee S, Delker D, Zou A, Hagedorn CH, Wang L. Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function. Sci Rep. 2016 Feb 03; 6:20559. PMID: 26838806.
      View in: PubMed
    9. Liu S, Chen R, Hagedorn CH. Tannic Acid Inhibits Hepatitis C Virus Entry into Huh7.5 Cells. PLoS One. 2015; 10(7):e0131358. PMID: 26186636.
      View in: PubMed
    10. Meyer K, Kwon YC, Liu S, Hagedorn CH, Ray RB, Ray R. Interferon-a inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection. Sci Rep. 2015 Mar 11; 5:9012. PMID: 25757571.
      View in: PubMed
    11. Pothineni NV, Delongchamp R, Vallurupalli S, Ding Z, Dai Y, Hagedorn CH, Mehta JL. Impact of hepatitis C seropositivity on the risk of coronary heart disease events. Am J Cardiol. 2014 Dec 15; 114(12):1841-5. PMID: 25438910.
      View in: PubMed
    12. Delker DA, McGettigan BM, Kanth P, Pop S, Neklason DW, Bronner MP, Burt RW, Hagedorn CH. RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers. PLoS One. 2014; 9(2):e88367. PMID: 24533081.
      View in: PubMed
    13. McFarland AP, Horner SM, Jarret A, Joslyn RC, Bindewald E, Shapiro BA, Delker DA, Hagedorn CH, Carrington M, Gale M, Savan R. The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. Nat Immunol. 2014 Jan; 15(1):72-9. PMID: 24241692.
      View in: PubMed
    14. Liu S, Chen R, Hagedorn CH. Direct visualization of hepatitis C virus-infected Huh7.5 cells with a high titre of infectious chimeric JFH1-EGFP reporter virus in three-dimensional Matrigel cell cultures. J Gen Virol. 2014 Feb; 95(Pt 2):423-33. PMID: 24243732.
      View in: PubMed
    15. Chandra PK, Bao L, Song K, Aboulnasr FM, Baker DP, Shores N, Wimley WC, Liu S, Hagedorn CH, Fuchs SY, Wu T, Balart LA, Dash S. HCV infection selectively impairs type I but not type III IFN signaling. Am J Pathol. 2014 Jan; 184(1):214-29. PMID: 24215913.
      View in: PubMed
    16. Smalling RL, Delker DA, Zhang Y, Nieto N, McGuiness MS, Liu S, Friedman SL, Hagedorn CH, Wang L. Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease. Am J Physiol Gastrointest Liver Physiol. 2013 Sep 01; 305(5):G364-74. PMID: 23812039.
      View in: PubMed
    17. Negash AA, Ramos HJ, Crochet N, Lau DT, Doehle B, Papic N, Delker DA, Jo J, Bertoletti A, Hagedorn CH, Gale M. IL-1ß production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathog. 2013; 9(4):e1003330. PMID: 23633957.
      View in: PubMed
    18. Liu S, Xiao L, Nelson C, Hagedorn CH, Hagedorn C. A cell culture adapted HCV JFH1 variant that increases viral titers and permits the production of high titer infectious chimeric reporter viruses. PLoS One. 2012; 7(9):e44965. PMID: 23028707.
      View in: PubMed
    19. Papic N, Maxwell CI, Delker DA, Liu S, Heale BS, Hagedorn CH. RNA-sequencing analysis of 5' capped RNAs identifies many new differentially expressed genes in acute hepatitis C virus infection. Viruses. 2012 04; 4(4):581-612. PMID: 22590687.
      View in: PubMed
    20. Roy A, Wang C, Li C, Lu L, Torbenson M, Hagedorn CH, Schwarz KB. Phenotypic and genotypic differences between a child with vertically acquired severe hepatitis C liver disease and his mother. J Pediatr Gastroenterol Nutr. 2012 Apr; 54(4):567-9. PMID: 21716134.
      View in: PubMed
    21. Folkers ME, Delker DA, Maxwell CI, Nelson CA, Schwartz JJ, Nix DA, Hagedorn CH. ENCODE tiling array analysis identifies differentially expressed annotated and novel 5' capped RNAs in hepatitis C infected liver. PLoS One. 2011 Feb 16; 6(2):e14697. PMID: 21359205.
      View in: PubMed
    22. Liu S, Nelson CA, Xiao L, Lu L, Seth PP, Davis DR, Hagedorn CH. Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase. Antiviral Res. 2011 Jan; 89(1):54-63. PMID: 21075143.
      View in: PubMed
    23. Zhang Y, Hagedorn CH, Wang L. Role of nuclear receptor SHP in metabolism and cancer. Biochim Biophys Acta. 2011 Aug; 1812(8):893-908. PMID: 20970497.
      View in: PubMed
    24. Harrus D, Ahmed-El-Sayed N, Simister PC, Miller S, Triconnet M, Hagedorn CH, Mahias K, Rey FA, Astier-Gin T, Bressanelli S. Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis. J Biol Chem. 2010 Oct 22; 285(43):32906-18. PMID: 20729191.
      View in: PubMed
    25. Gowda M, Nunes CC, Sailsbery J, Xue M, Chen F, Nelson CA, Brown DE, Oh Y, Meng S, Mitchell T, Hagedorn CH, Dean RA. Genome-wide characterization of methylguanosine-capped and polyadenylated small RNAs in the rice blast fungus Magnaporthe oryzae. Nucleic Acids Res. 2010 Nov; 38(21):7558-69. PMID: 20660015.
      View in: PubMed
    26. Oler AJ, Alla RK, Roberts DN, Wong A, Hollenhorst PC, Chandler KJ, Cassiday PA, Nelson CA, Hagedorn CH, Graves BJ, Cairns BR. Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors. Nat Struct Mol Biol. 2010 May; 17(5):620-8. PMID: 20418882.
      View in: PubMed
    27. Xia X, Lu L, Tee KK, Zhao W, Wu J, Yu J, Li X, Lin Y, Mukhtar MM, Hagedorn CH, Takebe Y. The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co-infected with HIV-1 in Yunnan, China. J Med Virol. 2008 Jul; 80(7):1142-52. PMID: 18461611.
      View in: PubMed
    28. Meyskens FL, McLaren CE, Pelot D, Fujikawa-Brooks S, Carpenter PM, Hawk E, Kelloff G, Lawson MJ, Kidao J, McCracken J, Albers CG, Ahnen DJ, Turgeon DK, Goldschmid S, Lance P, Hagedorn CH, Gillen DL, Gerner EW. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev Res (Phila). 2008 Jun; 1(1):32-8. PMID: 18841250.
      View in: PubMed
    29. Lu L, Murphy D, Li C, Liu S, Xia X, Pham PH, Jin Y, Hagedorn CH, Abe K. Complete genomes of three subtype 6t isolates and analysis of many novel hepatitis C virus variants within genotype 6. J Gen Virol. 2008 Feb; 89(Pt 2):444-52. PMID: 18198375.
      View in: PubMed
    30. Bajak EZ, Hagedorn CH. Efficient 5' cap-dependent RNA purification : use in identifying and studying subsets of RNA. Methods Mol Biol. 2008; 419:147-60. PMID: 18369981.
      View in: PubMed
    31. Lu L, Li C, Fu Y, Gao F, Pybus OG, Abe K, Okamoto H, Hagedorn CH, Murphy D. Complete genomes of hepatitis C virus (HCV) subtypes 6c, 6l, 6o, 6p and 6q: completion of a full panel of genomes for HCV genotype 6. J Gen Virol. 2007 May; 88(Pt 5):1519-25. PMID: 17412981.
      View in: PubMed
    32. Lu L, Li C, Fu Y, Thaikruea L, Thongswat S, Maneekarn N, Apichartpiyakul C, Hotta H, Okamoto H, Netski D, Pybus OG, Murphy D, Hagedorn CH, Nelson KE. Complete genomes for hepatitis C virus subtypes 6f, 6i, 6j and 6m: viral genetic diversity among Thai blood donors and infected spouses. J Gen Virol. 2007 May; 88(Pt 5):1505-18. PMID: 17412980.
      View in: PubMed
    33. Puli SR, Singh S, Hagedorn CH, Reddy J, Olyaee M. Diagnostic accuracy of EUS for vascular invasion in pancreatic and periampullary cancers: a meta-analysis and systematic review. Gastrointest Endosc. 2007 May; 65(6):788-97. PMID: 17350008.
      View in: PubMed
    34. Goldson TM, Vielhauer G, Staub E, Miller S, Shim H, Hagedorn CH. Eukaryotic initiation factor 4E variants alter the morphology, proliferation, and colony-formation properties of MDA-MB-435 cancer cells. Mol Carcinog. 2007 Jan; 46(1):71-84. PMID: 17091471.
      View in: PubMed
    35. Li C, Fu Y, Lu L, Ji W, Yu J, Hagedorn CH, Zhang L. Complete genomic sequences for hepatitis C virus subtypes 6e and 6g isolated from Chinese patients with injection drug use and HIV-1 co-infection. J Med Virol. 2006 Aug; 78(8):1061-9. PMID: 16789024.
      View in: PubMed
    36. Loo YM, Owen DM, Li K, Erickson AK, Johnson CL, Fish PM, Carney DS, Wang T, Ishida H, Yoneyama M, Fujita T, Saito T, Lee WM, Hagedorn CH, Lau DT, Weinman SA, Lemon SM, Gale M. Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):6001-6. PMID: 16585524.
      View in: PubMed
    37. Lu L, Nakano T, Li C, Fu Y, Miller S, Kuiken C, Robertson BH, Hagedorn CH. Hepatitis C virus complete genome sequences identified from China representing subtypes 6k and 6n and a novel, as yet unassigned subtype within genotype 6. J Gen Virol. 2006 Mar; 87(Pt 3):629-34. PMID: 16476984.
      View in: PubMed
    38. Lu L, Li C, Hagedorn CH. Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis. Rev Med Virol. 2006 Jan-Feb; 16(1):5-36. PMID: 16175650.
      View in: PubMed
    39. Lu L, Nakano T, Smallwood GA, Heffron TG, Robertson BH, Hagedorn CH. A refined long RT-PCR technique to amplify complete viral RNA genome sequences from clinical samples: application to a novel hepatitis C virus variant of genotype 6. J Virol Methods. 2005 Jun; 126(1-2):139-48. PMID: 15847930.
      View in: PubMed
    40. Weber M, Hagedorn CH, Harrison DG, Searles CD. Laminar shear stress and 3' polyadenylation of eNOS mRNA. Circ Res. 2005 Jun 10; 96(11):1161-8. PMID: 15905462.
      View in: PubMed
    41. Lu L, Nakano T, He Y, Fu Y, Hagedorn CH, Robertson BH. Hepatitis C virus genotype distribution in China: predominance of closely related subtype 1b isolates and existence of new genotype 6 variants. J Med Virol. 2005 Apr; 75(4):538-49. PMID: 15714489.
      View in: PubMed
    42. Schnabl B, Choi YH, Hagedorn CH, Bataller R. DNA microarrays and data mining to study hepatic fibrosis. Methods Mol Med. 2005; 117:359-69. PMID: 16118462.
      View in: PubMed
    43. Cai X, Hagedorn CH, Cullen BR. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA. 2004 Dec; 10(12):1957-66. PMID: 15525708.
      View in: PubMed
    44. Lou H, Choi YH, LaVoy JE, Major ME, Hagedorn CH. Analysis of mutant NS5B proteins encoded by isolates from chimpanzees chronically infected following clonal HCV RNA inoculation. Virology. 2003 Dec 05; 317(1):65-72. PMID: 14675625.
      View in: PubMed
    45. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner DA. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest. 2003 Nov; 112(9):1383-94. PMID: 14597764.
      View in: PubMed
    46. Choi YH, Hagedorn CH. Purifying mRNAs with a high-affinity eIF4E mutant identifies the short 3' poly(A) end phenotype. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7033-8. PMID: 12777618.
      View in: PubMed
    47. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH, Brenner D. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology. 2003 Mar; 37(3):653-64. PMID: 12601363.
      View in: PubMed
    48. Duncan RF, Peterson H, Hagedorn CH, Sevanian A. Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells. Biochem J. 2003 Jan 15; 369(Pt 2):213-25. PMID: 12215171.
      View in: PubMed
    49. Cai Q, Bruno CJ, Hagedorn CH, Desbiens NA. Temporal trends over ten years in formal inpatient gastroenterology consultations at an inner city hospital. J Clin Gastroenterol. 2003 Jan; 36(1):34-8. PMID: 12488705.
      View in: PubMed
    50. Spivak-Kroizman T, Friedland DE, De Staercke C, Gernert KM, Goss DJ, Hagedorn CH. Mutations in the S4-H2 loop of eIF4E which increase the affinity for m7GTP. FEBS Lett. 2002 Apr 10; 516(1-3):9-14. PMID: 11959093.
      View in: PubMed
    51. Schnabl B, Choi YH, Olsen JC, Hagedorn CH, Brenner DA. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Lab Invest. 2002 Mar; 82(3):323-33. PMID: 11896211.
      View in: PubMed
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