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Valentina Todorova

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Hem-Onc
Address2/251 Cancer Institute
4300 W. 7th
Mail Slot # 508
Little Rock AR 72205
Phone501-686-8376
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    Other Positions
    TitleAssistant Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentSurgery, College of Medicine


    Collapse Research Funds 
    Collapse research activities
    U24CA215109     (PRIOR, FRED WILLIAM)Sep 22, 2017 - Jul 31, 2022
    NIH/NCI
    TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine
    Role: Co-Investigator

    P30AG028718     (WEI, JEANNE Y)Sep 1, 2011 - Aug 31, 2016
    NIH/NIA
    Arkansas Claude Pepper Older Americans Independence Center at UAMS
    Role: Co-Investigator

    BCTR78206     (TODOROVA, VALENTINA)May 1, 2006 - Apr 30, 2009
    Susan G. Komen for the Cure
    Dietary Glutamine and Protection Against Doxorubicin and Cyclophoshamide Toxicity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Hsu PC, Kadlubar SA, Siegel ER, Rogers LJ, Todorova VK, Su LJ, Makhoul I. Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer. PLoS One. 2020; 15(4):e0230248. PMID: 32298288.
      View in: PubMed
    2. Todorova VK, Siegel ER, Kaufmann Y, Kumarapeli A, Owen A, Wei JY, Makhoul I, Klimberg VS. Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model. Transl Oncol. 2020 Feb; 13(2):471-480. PMID: 31918212.
      View in: PubMed
    3. Odynets T, Briskin Y, Todorova V. Effects of Different Exercise Interventions on Quality of Life in Breast Cancer Patients: A Randomized Controlled Trial. Integr Cancer Ther. 2019 Jan-Dec; 18:1534735419880598. PMID: 31625419.
      View in: PubMed
    4. Jamshidi-Parsian A, Griffin RJ, Kore RA, Todorova VK, Makhoul I. Tumor-endothelial cell interaction in an experimental model of human hepatocellular carcinoma. Exp Cell Res. 2018 11 01; 372(1):16-24. PMID: 30205087.
      View in: PubMed
    5. Yu LR, Cao Z, Makhoul I, Daniels JR, Klimberg S, Wei JY, Bai JP, Li J, Lathrop JT, Beger RD, Todorova VK. Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients. Exp Biol Med (Maywood). 2018 02; 243(3):248-255. PMID: 29224368.
      View in: PubMed
    6. Todorova VK, Makhoul I, Dhakal I, Wei J, Stone A, Carter W, Owen A, Klimberg VS. Polymorphic Variations Associated With Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients. Oncol Res. 2017 Sep 21; 25(8):1223-1229. PMID: 28256194.
      View in: PubMed
    7. Todorova VK, Makhoul I, Wei J, Klimberg VS. Circulating miRNA Profiles of Doxorubicin-induced Cardiotoxicity in Breast Cancer Patients. Ann Clin Lab Sci. 2017 Mar; 47(2):115-119. PMID: 28442511.
      View in: PubMed
    8. Makhoul I, Todorova VK, Siegel ER, Erickson SW, Dhakal I, Raj VR, Lee JY, Orloff MS, Griffin RJ, Henry-Tillman RS, Klimberg S, Hutchins LF, Kadlubar SA. Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients. PLoS One. 2017; 12(1):e0168550. PMID: 28045923.
      View in: PubMed
    9. Todorova VK, Makhoul I, Siegel ER, Wei J, Stone A, Carter W, Beggs ML, Owen A, Klimberg VS. Biomarkers for Presymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients. PLoS One. 2016; 11(8):e0160224. PMID: 27490685.
      View in: PubMed
    10. Rubio I, Suva LJ, Todorova V, Bhattacharyya S, Kaufmann Y, Maners A, Smith M, Klimberg VS. Oral glutamine reduces radiation morbidity in breast conservation surgery. JPEN J Parenter Enteral Nutr. 2013 Sep; 37(5):623-30. PMID: 23389298.
      View in: PubMed
    11. Rubio I, Bhattacharyya S, Suva L, Todorova V, Kaufmann Y, Maners A, Smith M, Klimberg VS. Effect of Glutamine on Radiation Morbidity in Breast Conservation Surgery. Journal of Parenteral and Enteral Nutrition (JPEN). 2013; Epub ahead of print.
    12. Todorova VK, Beggs ML, Delongchamp RR, Dhakal I, Makhoul I, Wei JY, Klimberg VS. Transcriptome profiling of peripheral blood cells identifies potential biomarkers for doxorubicin cardiotoxicity in a rat model. PLoS One. 2012; 7(11):e48398. PMID: 23209553.
      View in: PubMed
    13. Todorova VK, Kaufmann Y, Klimberg VS. Increased efficacy and reduced cardiotoxicity of metronomic treatment with cyclophosphamide in rat breast cancer. Anticancer Res. 2011 Jan; 31(1):215-20. PMID: 21273601.
      View in: PubMed
    14. Todorova VK, Kaufmann Y, Luo S, Klimberg VS. Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother Pharmacol. 2011 Feb; 67(2):285-91. PMID: 20383709.
      View in: PubMed
    15. Todorova V, Kaufmann Y, Hennings L, Klimberg S. Protective effects of glutamine against acute doxorubicin cardiotoxicity in tumor-bearing rats. Journal of Nutrition. 2010; 140(1):44-48.
    16. Todorova VK, Klimberg VS, Hennings L, Kieber-Emmons T, Pashov A. Immunomodulatory effects of radiofrequency ablation in a breast cancer model. Immunol Invest. 2010; 39(1):74-92. PMID: 20064086.
      View in: PubMed
    17. Todorova VK, Klimberg VS, Hennings LJ, Kieber-Emmons T, Pashov A. Radiofrequency ablation of experimental breast tumors stimulated natural killer cells and reduced regulatory T cells. Immunological Investigations. 2010; 39(1):74-92.
    18. Todorova V, Kaufmann Y, Klimberg S. Oral glutamine and doxorubicin cardiotoxicity. 2009.
    19. Todorova VK, Kaufmann Y, Hennings LJ, Klimberg VS. Glutamine regulation of doxorubicin accumulation in hearts versus tumors in experimental rats. Cancer Chemother Pharmacol. 2010 Jul; 66(2):315-23. PMID: 19898822.
      View in: PubMed
    20. Todorova VK, Kaufmann Y, Hennings L, Klimberg VS. Oral glutamine protects against acute doxorubicin-induced cardiotoxicity of tumor-bearing rats. J Nutr. 2010 Jan; 140(1):44-8. PMID: 19889810.
      View in: PubMed
    21. Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R, Klimberg VS. Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione. Nutrition. 2009 Jul-Aug; 25(7-8):812-7. PMID: 19251394.
      View in: PubMed
    22. Todorova V, Kaufmann Y, Klimberg S. Effect of glutamine on doxorubicin-induced cardiotoxicity: an echocardiographic assessment. 2008.
    23. Knox D, Todorova V, Moore J, Xia Y, Kennedy MW. Molecular cloning of a serine protease from the parasitic nematode Trichinella spiralis. 2008.
    24. Margulies AG, Siegel E, Makhoul I, Thompson M, Henry-Tillman RS, Youssef E, Todorova VK, Thomas M, Korourian S, Hutchins LF, Westbrook KC, Klimberg VS. NeoSLN may predict primary tumor response to neoadjuvant chemotherapy in locally advanced breast cancer. 2008.
    25. Kaufmann Y, Todorova VK, Luo S, Klimberg VS. Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model. Nutr Cancer. 2008; 60(4):518-25. PMID: 18584486.
      View in: PubMed
    26. Todorova V, Kaufman Y, Klimberg S. Cardioprotective effects of oral dietary glutamine in tumor-bearing rats treated with doxorubicin. 2007.
    27. Todorova VK, Kaufmann Y, Luo S, Klimberg VS. Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine. Nutr Cancer. 2006; 54(2):263-73. PMID: 16898871.
      View in: PubMed
    28. Todorova VK, Harms SA, Kaufmann Y, Luo S, Luo KQ, Babb K, Klimberg VS. Effect of dietary glutamine on tumor glutathione levels and apoptosis-related proteins in DMBA-induced breast cancer of rats. Breast Cancer Res Treat. 2004 Dec; 88(3):247-56. PMID: 15609127.
      View in: PubMed
    29. Todorova VK, Harms SA, Luo S, Kaufmann Y, Babb KB, Klimberg VS. Oral glutamine (AES-14) supplementation inhibits PI-3k/Akt signaling in experimental breast cancer. JPEN J Parenter Enteral Nutr. 2003 Nov-Dec; 27(6):404-10. PMID: 14621121.
      View in: PubMed
    30. Todorova VK, Elbein AD, Kyosseva SV. Increased expression of c-Jun transcription factor in cerebellar vermis of patients with schizophrenia. Neuropsychopharmacology. 2003 Aug; 28(8):1506-14. PMID: 12799614.
      View in: PubMed
    31. Johnson AT, Kaufmann YC, Luo S, Todorova V, Klimberg VS. Effect of glutamine on glutathione, IGF-I, and TGF-beta 1. J Surg Res. 2003 May 15; 111(2):222-8. PMID: 12850466.
      View in: PubMed
    32. Todorova V. Secreted antigens of Toxocara canis. Comptes Rendus de l’Academie Bulgare des Sciences. 2000; 52:32-38.
    33. Todorova V, Bojkov S, Noeva K. Demonstration of Trichinella antigen, IgG, IgM and C3 in kidneys of rats with experimental trichinellosis. Comptes Rendus de l’Academie Bulgare des Sciences. 1991; 44(11):107-109 .
    34. Todorova V, Dimitrov T, Noeva K. Studies on immune complex-associated antigens in rats infected with Trichinella spiralis. Comptes Rendus del’Academie Bulgare de Sciences. 1991; 44(11):103-106.
    35. Todorova V, Noeva K. Circulating immune complexes in the course of experimental trichinellosis. Helminthologia (Bratislava). 1991; 28:56-63.
    36. Todorova V, Stratev S. [The complications of the polycystic kidney requiring surgical treatment]. Khirurgiia (Sofiia). 1991; 44(1):41 - 45.
    37. Todorova V, Krustev L, Petkov N. Immune complexes and antigammaglobulin factors in trichinellosis. Histological changes in the kidneys of rats experimentally infected with Trichinella spiralis. Khelminthologiya (Sofia). 1988; 25:35-42.
    38. Noeva K, Todorova V, Komandarev S, Mihov L. Isolation and characterization of immune complexes in experimental Trichinella spiralis invasion. Khelminthologiya (Sofia). 1985; 19:55-59.
    39. Todorova V, Komandarev S. To the problem of stage-specific immunity in trichinellosis. Khelminthologiya (Sofia). 1984; 17:58-63.
    40. Noeva K, Komandarev S, Todorova V. Immunochemical characterics of the antigammaglobulin factors in the sera of rats infected with Trichinella spiralis. Khelminthologiya (Sofia). 1983; 15:42-47 .
    41. Todorova V, Luo S, Kaufmann Y, Babb K, Harms S, Klimberg S. Oral glutamine supplementation inhibits PI-3K/Akt signaling pathway inexperimental breast cancer.
    42. Harms S, Todorova V, Luo S, Kaufmann Y, Babb KB, Klimberg S. Glutamine and breast cancer prevention: effect on insulin-like growth factor-binding proteins.
    43. Todorova V, Beggs M, Dhakal I, Hennings L, Makhoul I, Klimbergs S. Peripheral Blood Transcriptomics and Doxorubicin Cardiotoxicity.
    44. Todorova V, Harms S, Kaufmann Y, Luo S, Babb KB, Klimberg S. Dietary glutamine up-regulates p53, p21 and PTEN in rats with DMBA-induced breast cancer.
    45. Todorova V, Harms S, Luo S, Kaufmann Y, Babb KB, Klimberg S. Glutamine supplementation reduces glutathione levels and stimulates apoptosis in DMBA-induced mammary tumors. 37th Annual Meeting of the Association for Academic Surgery.
    46. Kaufmann Y, Luo S, Harms S, Todorova V, Babb KB, Hawk R, Kim LT, Klimberg S. Effect of Glutamine on Glutathione Recycling in Breast Cancer.
    47. Todorova V, Kaufman Y, Klimberg S. Glutamine reduces the cardiotoxicity of doxorubicin. Clinical Nutrition Week 2010 in Las Vegas, Nevada.
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