Valentina Todorova
Title | Assistant Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Internal Med, College of Medicine |
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Division | Internal Med Hem-Onc |
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Address | 2/251 Cancer Institute 4300 W. 7th Mail Slot # 508 Little Rock AR 72205
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Phone | 501-686-8376 |
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vCard | Download vCard |
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Title | Assistant Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Geriatrics, College of Medicine |
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Title | Assistant Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Surgery, College of Medicine |
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Research ABCRP FY19 (EOFF, ROBERT L)Feb 1, 2019 - Jun 30, 2021 UAMS Executive Breast Committee No FP attached Role: Principal Investigator |
| U24CA215109 (PRIOR, FRED WILLIAM)Sep 22, 2017 - Jul 31, 2022 NIH TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine Role: Co-Investigator |
| ABCRP FY16 (EOFF, ROBERT L)Sep 1, 2015 - Aug 31, 2017 UAMS Executive Breast Committee Advancing Breast Cancer Treatment through Suppression of Chemo-Resistance Role: Principal Investigator |
| P20GM109005 (BOERMA, MARJAN)Jun 24, 2015 - May 31, 2025 NIH Center for Studies of Host Response to Cancer Therapy Role: Co-Investigator |
| P30AG028718 (WEI, JEANNE Y)Sep 1, 2011 - Aug 31, 2018 NIH Arkansas Claude Pepper Older Americans Independence Center at UAMS Role: Co-Investigator |
| BCTR78206 (TODOROVA, VALENTINA K)May 1, 2006 - Apr 30, 2009 Susan G. Komen for the Cure Dietary glutamine and protection against doxorubicin and cyclophosphamide toxicity Role: Principal Investigator |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Todorova VK, Azhar G, Stone A, Malapati SJ, Che Y, Zhang W, Makhoul I, Wei JY. Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer. Int J Mol Sci. 2024 Sep 09; 25(17). PMID: 39273682.
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Todorova VK, Bauer MA, Azhar G, Wei JY. RNA sequencing of formalin fixed paraffin-embedded heart tissue provides transcriptomic information about chemotherapy-induced cardiotoxicity. Pathol Res Pract. 2024 May; 257:155309. PMID: 38678848.
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Todorova VK, Byrum SD, Mackintosh SG, Jamshidi-Parsian A, Gies AJ, Washam CL, Jenkins SV, Spiva T, Bowman E, Reyna NS, Griffin RJ, Makhoul I. Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells. Int J Mol Sci. 2023 Aug 23; 24(17). PMID: 37685904.
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Todorova VK, Byrum SD, Gies AJ, Haynie C, Smith H, Reyna NS, Makhoul I. Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer. Curr Oncol. 2022 01 28; 29(2):613-630. PMID: 35200555.
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Bauer MA, Todorova VK, Stone A, Carter W, Plotkin MD, Hsu PC, Wei JY, Su JL, Makhoul I. Genome-Wide DNA Methylation Signatures Predict the Early Asymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer. Cancers (Basel). 2021 12 15; 13(24). PMID: 34944912.
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Todorova VK, Wei JY, Makhoul I. Subclinical doxorubicin-induced cardiotoxicity update: role of neutrophils and endothelium. Am J Cancer Res. 2021; 11(9):4070-4091. PMID: 34659877.
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Todorova VK, Hsu PC, Wei JY, Lopez-Candales A, Chen JZ, Su LJ, Makhoul I. Biomarkers of inflammation, hypercoagulability and endothelial injury predict early asymptomatic doxorubicin-induced cardiotoxicity in breast cancer patients. Am J Cancer Res. 2020; 10(9):2933-2945. PMID: 33042627.
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Hsu PC, Kadlubar SA, Siegel ER, Rogers LJ, Todorova VK, Su LJ, Makhoul I. Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer. PLoS One. 2020; 15(4):e0230248. PMID: 32298288.
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Todorova VK, Siegel ER, Kaufmann Y, Kumarapeli A, Owen A, Wei JY, Makhoul I, Klimberg VS. Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model. Transl Oncol. 2020 Feb; 13(2):471-480. PMID: 31918212.
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Odynets T, Briskin Y, Todorova V. Effects of Different Exercise Interventions on Quality of Life in Breast Cancer Patients: A Randomized Controlled Trial. Integr Cancer Ther. 2019 Jan-Dec; 18:1534735419880598. PMID: 31625419.
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Jamshidi-Parsian A, Griffin RJ, Kore RA, Todorova VK, Makhoul I. Tumor-endothelial cell interaction in an experimental model of human hepatocellular carcinoma. Exp Cell Res. 2018 11 01; 372(1):16-24. PMID: 30205087.
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Yu LR, Cao Z, Makhoul I, Daniels JR, Klimberg S, Wei JY, Bai JP, Li J, Lathrop JT, Beger RD, Todorova VK. Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients. Exp Biol Med (Maywood). 2018 02; 243(3):248-255. PMID: 29224368.
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Todorova VK, Makhoul I, Dhakal I, Wei J, Stone A, Carter W, Owen A, Klimberg VS. Polymorphic Variations Associated With Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients. Oncol Res. 2017 Sep 21; 25(8):1223-1229. PMID: 28256194.
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Todorova VK, Makhoul I, Wei J, Klimberg VS. Circulating miRNA Profiles of Doxorubicin-induced Cardiotoxicity in Breast Cancer Patients. Ann Clin Lab Sci. 2017 Mar; 47(2):115-119. PMID: 28442511.
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Makhoul I, Todorova VK, Siegel ER, Erickson SW, Dhakal I, Raj VR, Lee JY, Orloff MS, Griffin RJ, Henry-Tillman RS, Klimberg S, Hutchins LF, Kadlubar SA. Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients. PLoS One. 2017; 12(1):e0168550. PMID: 28045923.
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Todorova VK, Makhoul I, Siegel ER, Wei J, Stone A, Carter W, Beggs ML, Owen A, Klimberg VS. Biomarkers for Presymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients. PLoS One. 2016; 11(8):e0160224. PMID: 27490685.
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Rubio I, Suva LJ, Todorova V, Bhattacharyya S, Kaufmann Y, Maners A, Smith M, Klimberg VS. Oral glutamine reduces radiation morbidity in breast conservation surgery. JPEN J Parenter Enteral Nutr. 2013 Sep; 37(5):623-30. PMID: 23389298.
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Rubio I, Bhattacharyya S, Suva L, Todorova V, Kaufmann Y, Maners A, Smith M, Klimberg VS. Effect of Glutamine on Radiation Morbidity in Breast Conservation Surgery. Journal of Parenteral and Enteral Nutrition (JPEN). 2013; Epub ahead of print.
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Todorova VK, Beggs ML, Delongchamp RR, Dhakal I, Makhoul I, Wei JY, Klimberg VS. Transcriptome profiling of peripheral blood cells identifies potential biomarkers for doxorubicin cardiotoxicity in a rat model. PLoS One. 2012; 7(11):e48398. PMID: 23209553.
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Todorova VK, Kaufmann Y, Klimberg VS. Increased efficacy and reduced cardiotoxicity of metronomic treatment with cyclophosphamide in rat breast cancer. Anticancer Res. 2011 Jan; 31(1):215-20. PMID: 21273601.
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Todorova VK, Kaufmann Y, Luo S, Klimberg VS. Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother Pharmacol. 2011 Feb; 67(2):285-91. PMID: 20383709.
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Todorova V, Kaufmann Y, Hennings L, Klimberg S. Protective effects of glutamine against acute doxorubicin cardiotoxicity in tumor-bearing rats. Journal of Nutrition. 2010; 140(1):44-48.
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Todorova VK, Klimberg VS, Hennings L, Kieber-Emmons T, Pashov A. Immunomodulatory effects of radiofrequency ablation in a breast cancer model. Immunol Invest. 2010; 39(1):74-92. PMID: 20064086.
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Todorova VK, Klimberg VS, Hennings LJ, Kieber-Emmons T, Pashov A. Radiofrequency ablation of experimental breast tumors stimulated natural killer cells and reduced regulatory T cells. Immunological Investigations. 2010; 39(1):74-92.
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Todorova V, Kaufmann Y, Klimberg S. Oral glutamine and doxorubicin cardiotoxicity. 2009.
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Todorova VK, Kaufmann Y, Hennings LJ, Klimberg VS. Glutamine regulation of doxorubicin accumulation in hearts versus tumors in experimental rats. Cancer Chemother Pharmacol. 2010 Jul; 66(2):315-23. PMID: 19898822.
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Todorova VK, Kaufmann Y, Hennings L, Klimberg VS. Oral glutamine protects against acute doxorubicin-induced cardiotoxicity of tumor-bearing rats. J Nutr. 2010 Jan; 140(1):44-8. PMID: 19889810.
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Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R, Klimberg VS. Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione. Nutrition. 2009 Jul-Aug; 25(7-8):812-7. PMID: 19251394.
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Todorova V, Kaufmann Y, Klimberg S. Effect of glutamine on doxorubicin-induced cardiotoxicity: an echocardiographic assessment. 2008.
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Knox D, Todorova V, Moore J, Xia Y, Kennedy MW. Molecular cloning of a serine protease from the parasitic nematode Trichinella spiralis. 2008.
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Margulies AG, Siegel E, Makhoul I, Thompson M, Henry-Tillman RS, Youssef E, Todorova VK, Thomas M, Korourian S, Hutchins LF, Westbrook KC, Klimberg VS. NeoSLN may predict primary tumor response to neoadjuvant chemotherapy in locally advanced breast cancer. 2008.
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Kaufmann Y, Todorova VK, Luo S, Klimberg VS. Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model. Nutr Cancer. 2008; 60(4):518-25. PMID: 18584486.
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Todorova V, Kaufman Y, Klimberg S. Cardioprotective effects of oral dietary glutamine in tumor-bearing rats treated with doxorubicin. 2007.
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Todorova VK, Kaufmann Y, Luo S, Klimberg VS. Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine. Nutr Cancer. 2006; 54(2):263-73. PMID: 16898871.
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Todorova VK, Harms SA, Kaufmann Y, Luo S, Luo KQ, Babb K, Klimberg VS. Effect of dietary glutamine on tumor glutathione levels and apoptosis-related proteins in DMBA-induced breast cancer of rats. Breast Cancer Res Treat. 2004 Dec; 88(3):247-56. PMID: 15609127.
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Todorova VK, Harms SA, Luo S, Kaufmann Y, Babb KB, Klimberg VS. Oral glutamine (AES-14) supplementation inhibits PI-3k/Akt signaling in experimental breast cancer. JPEN J Parenter Enteral Nutr. 2003 Nov-Dec; 27(6):404-10. PMID: 14621121.
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Todorova VK, Elbein AD, Kyosseva SV. Increased expression of c-Jun transcription factor in cerebellar vermis of patients with schizophrenia. Neuropsychopharmacology. 2003 Aug; 28(8):1506-14. PMID: 12799614.
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Johnson AT, Kaufmann YC, Luo S, Todorova V, Klimberg VS. Effect of glutamine on glutathione, IGF-I, and TGF-beta 1. J Surg Res. 2003 May 15; 111(2):222-8. PMID: 12850466.
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Todorova V. Secreted antigens of Toxocara canis. Comptes Rendus de l’Academie Bulgare des Sciences. 2000; 52:32-38.
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Todorova V, Bojkov S, Noeva K. Demonstration of Trichinella antigen, IgG, IgM and C3 in kidneys of rats with experimental trichinellosis. Comptes Rendus de l’Academie Bulgare des Sciences. 1991; 44(11):107-109 .
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Todorova V, Dimitrov T, Noeva K. Studies on immune complex-associated antigens in rats infected with Trichinella spiralis. Comptes Rendus del’Academie Bulgare de Sciences. 1991; 44(11):103-106.
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Todorova V, Noeva K. Circulating immune complexes in the course of experimental trichinellosis. Helminthologia (Bratislava). 1991; 28:56-63.
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Todorova V, Stratev S. [The complications of the polycystic kidney requiring surgical treatment]. Khirurgiia (Sofiia). 1991; 44(1):41 - 45.
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Todorova V, Krustev L, Petkov N. Immune complexes and antigammaglobulin factors in trichinellosis. Histological changes in the kidneys of rats experimentally infected with Trichinella spiralis. Khelminthologiya (Sofia). 1988; 25:35-42.
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Noeva K, Todorova V, Komandarev S, Mihov L. Isolation and characterization of immune complexes in experimental Trichinella spiralis invasion. Khelminthologiya (Sofia). 1985; 19:55-59.
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Todorova V, Komandarev S. To the problem of stage-specific immunity in trichinellosis. Khelminthologiya (Sofia). 1984; 17:58-63.
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Noeva K, Komandarev S, Todorova V. Immunochemical characterics of the antigammaglobulin factors in the sera of rats infected with Trichinella spiralis. Khelminthologiya (Sofia). 1983; 15:42-47 .
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Todorova V, Luo S, Kaufmann Y, Babb K, Harms S, Klimberg S. Oral glutamine supplementation inhibits PI-3K/Akt signaling pathway inexperimental breast cancer.
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Harms S, Todorova V, Luo S, Kaufmann Y, Babb KB, Klimberg S. Glutamine and breast cancer prevention: effect on insulin-like growth factor-binding proteins.
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Todorova V, Beggs M, Dhakal I, Hennings L, Makhoul I, Klimbergs S. Peripheral Blood Transcriptomics and Doxorubicin Cardiotoxicity.
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Todorova V, Harms S, Kaufmann Y, Luo S, Babb KB, Klimberg S. Dietary glutamine up-regulates p53, p21 and PTEN in rats with DMBA-induced breast cancer.
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Todorova V, Harms S, Luo S, Kaufmann Y, Babb KB, Klimberg S. Glutamine supplementation reduces glutathione levels and stimulates apoptosis in DMBA-induced mammary tumors. 37th Annual Meeting of the Association for Academic Surgery.
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Kaufmann Y, Luo S, Harms S, Todorova V, Babb KB, Hawk R, Kim LT, Klimberg S. Effect of Glutamine on Glutathione Recycling in Breast Cancer.
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Todorova V, Kaufman Y, Klimberg S. Glutamine reduces the cardiotoxicity of doxorubicin. Clinical Nutrition Week 2010 in Las Vegas, Nevada.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1991 | 4 | 2000 | 1 | 2003 | 3 | 2004 | 1 | 2006 | 1 | 2007 | 1 | 2008 | 4 | 2009 | 4 | 2010 | 4 | 2011 | 1 | 2012 | 1 | 2013 | 2 | 2016 | 1 | 2017 | 4 | 2018 | 1 | 2019 | 1 | 2020 | 3 | 2021 | 2 | 2022 | 1 | 2023 | 1 | 2024 | 2 |
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