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Ya-Wei Qiang

TitleAssistant Research Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Hem-Onc
Address914 Cancer Institute
4104 Outpatient Circle
Mail Slot # 776
Little Rock AR 72205
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    Collapse Research 
    Collapse research activities and funding
    2010 MMRF microenvironment Award     (Ya-Wei Qiang)Feb 1, 2011 - Sep 30, 2013
    Identification of molecular targets in myeloma microenvironment
    Role: Principal Investigator

    24-06     (QIANG, YA-WEI)Oct 1, 2006 - Mar 31, 2009
    Multiple Myeloma Research Foundation
    Defining role of Wnt signaling in multiple myeloma: therapeutic implications
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Qiang YW, Ye S, Huang Y, Chen Y, Van Rhee F, Epstein J, Walker BA, Morgan GJ, Davies FE. MAFb protein confers intrinsic resistance to proteasome inhibitors in multiple myeloma. BMC Cancer. 2018 Jul 06; 18(1):724. PMID: 29980194.
      View in: PubMed
    2. Yang Y, Lei H, Qiang YW, Wang B. Ixazomib enhances parathyroid hormone-induced ß-catenin/T-cell factor signaling by dissociating ß-catenin from the parathyroid hormone receptor. Mol Biol Cell. 2017 Jul 01; 28(13):1792-1803. PMID: 28495797.
      View in: PubMed
    3. Qiang YW, Ye S, Chen Y, Buros AF, Edmonson R, van Rhee F, Barlogie B, Epstein J, Morgan GJ, Davies FE. MAF protein mediates innate resistance to proteasome inhibition therapy in multiple myeloma. Blood. 2016 12 22; 128(25):2919-2930. PMID: 27793878.
      View in: PubMed
    4. Walker BA, Wardell CP, Murison A, Boyle EM, Begum DB, Dahir NM, Proszek PZ, Melchor L, Pawlyn C, Kaiser MF, Johnson DC, Qiang YW, Jones JR, Cairns DA, Gregory WM, Owen RG, Cook G, Drayson MT, Jackson GH, Davies FE, Morgan GJ. APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma. Nat Commun. 2015 Apr 23; 6:6997. PMID: 25904160.
      View in: PubMed
    5. Hu B, Chen Y, Usmani SZ, Ye S, Qiang W, Papanikolaou X, Heuck CJ, Yaccoby S, Williams BO, Van Rhee F, Barlogie B, Epstein J, Qiang YW. Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma. PLoS One. 2013; 8(9):e74191. PMID: 24066119.
      View in: PubMed
    6. Shaughnessy JD Jr, Qiang YW, Yaccoby S. Overexpression of Wnt Ligands and treatment of lytic bone disease. 2013.
    7. Hu B, Chen Y, Usmani S, Ye S, Qiang W, Papanikolaou X, Heuk C, Yaccoby S, Williams BO, Van Rhee F, Barlogie B, Epstein J, Qiang YW. Characterization of the Molecular Mechanisms of the Bone-Anabolic Activity of Carfilzomib in Multiple Myeloma. PLOS ONE. 2013; 8(9):e74191.
    8. Qiang YW, Heuck CJ, Shaughnessy JD, Barlogie B, Epstein J. Proteasome inhibitors and bone disease. Semin Hematol. 2012 Jul; 49(3):243-8. PMID: 22726547.
      View in: PubMed
    9. Shaughnessy JD Jr., Barlogie B, Qiang YW. Methods of Controlling bone loss by inhibiting DKK1. 2012.
    10. Qiang YW, Chen Y, Brown N, Ho B, Epstein J, Barlogie B, Shaughnessy JD. Characerization of Wnt/beta-catenin Signaling in Osteoclast in Multiple Myeloma. Br J Haemotol. 2010; 148(5):726-38.
    11. Qiang YW, Chen Y, Brown N, Hu B, Epstein J, Barlogie B, Shaughnessy JD. Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma. Br J Haematol. 2010 Mar; 148(5):726-38. PMID: 19961481.
      View in: PubMed
    12. Qiang YW, Hu B, Chen Y, Zhong Y, Shi B, Barlogie B, Shaughnessy JD. Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling. Blood. 2009 Apr 30; 113(18):4319-30. PMID: 19196662.
      View in: PubMed
    13. Qiang YW. Multiple Myeloma: Symptoms, Diagnosis and Treatment. Wnt Signaling Pathways in Multiple Myeloma. 2009.
    14. Pinzone JJ, Hall BM, Thudi NK, Vonau M, Qiang YW, Rosol TJ, Shaughnessy JD. The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood. 2009 Jan 15; 113(3):517-25. PMID: 18687985.
      View in: PubMed
    15. Qiang YW, Shaughnessy JD, Yaccoby S. Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth. Blood. 2008 Jul 15; 112(2):374-82. PMID: 18344425.
      View in: PubMed
    16. Qiang YW, Chen Y, Stephens O, Brown N, Chen B, Epstein J, Barlogie B, Shaughnessy JD. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood. 2008 Jul 01; 112(1):196-207. PMID: 18305214.
      View in: PubMed
    17. Shaughnessy JD Jr, Barlogie B, Qiang YW. Molecular Determinants of myeloma bone disease and uses there of. 2008.
    18. Qiang YW, Barlogie B, Rudikoff S, Shaughnessy JD. Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone. 2008 Apr; 42(4):669-80. PMID: 18294945.
      View in: PubMed
    19. Qiang YW, Walsh K, Yao L, Kedei N, Blumberg PM, Rubin JS, Shaughnessy J, Rudikoff S. Wnts induce migration and invasion of myeloma plasma cells. Blood. 2005 Sep 01; 106(5):1786-93. PMID: 15886323.
      View in: PubMed
    20. Qiang YW, Rudikoff S. Wnt signaling in B and T lymphocytes. Front Biosci. 2004 Jan 01; 9:1000-10. PMID: 14766426.
      View in: PubMed
    21. Ya-Wei Qiang, Stuart Rudikoff, Qiang YW. Insulin-like growth factor I promotes multiple myeloma cell migration and invasion. CCR Frontiers in Science. 2004; (3):4-5.
    22. Qiang YW, Yao L, Tosato G, Rudikoff S. Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells. Blood. 2004 Jan 01; 103(1):301-8. PMID: 14504085.
      View in: PubMed
    23. Qiang YW, Endo Y, Rubin JS, Rudikoff S. Wnt signaling in B-cell neoplasia. Oncogene. 2003 Mar 13; 22(10):1536-45. PMID: 12629517.
      View in: PubMed
    24. Qiang YW, Kopantzev E, Rudikoff S. Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk. Blood. 2002 Jun 01; 99(11):4138-46. PMID: 12010818.
      View in: PubMed
    25. Qiang YW, Kitagawa M, Higashi M, Ishii G, Morimoto C, Harigaya K. Activation of mitogen-activated protein kinase through alpha5/beta1 integrin is required for cell cycle progression of B progenitor cell line, Reh, on human marrow stromal cells. Exp Hematol. 2000; 28(10):1147 - 1157.
    26. Ya-Wei Qiang, Bing-yin Shi, Genichiro Ishii, Atsuo Mikata, Kenichi Harigaya. Detection of bcl-2 gene major breakpoint region rearrangement in human B-cell lymphomas. Journal of Xian Medical University. 2000; (12 (1)):5-11.
    27. Ya-Wei Qiang, Motoo Kitagawa, Higashi Morihiro, Genicchiro Ishii, Kenichi Harigaya. Contact to human marrow stromal cells induces the proliferation of Pro-B cells via signaling of integrin a5/b1 and c-kit receptor. Japanese Journal of Cancer Research. 1999; (90 (Supplement)):1888.
    28. Ya-Wei Qiang, Motoo Kitagawa, Higashi Morihiro, Genicchiro Ishii, Chikao Morimoto, Kenichi Harigaya. Phosphorylation and activation p44/42 of mitogen-activated protein kinase ?are required for the cell cycle progression through alpha5beta1 integrin. Blood. 1999; ((Supplement)):3923.
    29. Genichiro Ishii, Seji Okata, Ya-Wei Qiang, Akira Yokota, Sukeyuki Nakamura, Masahiko Hatano, Takeshi Tokuhisa, Kenichi Harigaya. Deregulated IL-11 expression promotes B lymphopoiesis in transgenic mice. Blood. 1998; (92 (Supplement 1)):378a (1558).
    30. Genichiro Ishii, Kenichi Harigaya, Seji Okata, Ya-Wei Qiang, Masahiko Hatano, Takeshi Tokuhisa, Atsuo Mikata. Functional of IL-11 in hematopoiesis in transgenic mice. Japanese Journal of Pathology. 1998; (87):318.
    31. Genichiro Ishii, Kenichi Harigaya, Ya-Wei Qiang, Hidefumi Ezawa, Sukeyuki Nagamura, Atsuo Mikata. Study on Interleukin-11 gene expression in human lymphoid malignancy. Japases Journal of Pathalogy. 1997; (86):321.
    32. Kenichi Harigaya, Genichiro Ishii, Ya-Wei Qiang, Atsuo Mikata. Adhesion molecules of follicle center lymphoma during tumor progression. The Journal of Japanese Society of Reticuloendothelia System. 1997; (36 (5)):290-291.
    33. Genichiro Ishii, Kenichi Harigaya, Sukeyuki Nagamura, Ya-Wei Qiang, Hidefumi Ezawa, Atsuo Mikata. Interleukin-11 gene expression in human hematopoietic and stromal cell lines. The Journal of Japanese Societ of Reticuloendothelia System. 1996; (36 (2)):51.
    34. Ya-Wei Qiang, Wen-Bin Shao, Qi-Liang Wong, Tian-Lang Wan, Zhen Liu. Study on mangnesium, chromium, nickel, cadmium, copper and zinc in Serum and manganese, copper and zinc in blood in acute myelocytic leukemia. Journal of Shanxi Leukemia. 1994; (3):142-144.
    35. Shaan-Xi Liu, Wen-Bin Shao, Xin Liu, Ya-Wei Qiang, Mei Zhang. Study of allogenic bone marrow transplantation in patients with acute promyelocytic leukemia. The Journal of Xi’An Medical University. 1993; (14 (1)):60-62.
    36. Ya-Wei Qiang, Wen-Bin Shao, Qi-Liang Wong, Tian-Lang Wan, Zhen Liu. Study of magnesium, chromium, nickel, cadmium, copper and zinc in multiple myeloma. Chinese Journal of Hematology. 1993; (14):481-482.
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