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Karen Abbott

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiochemistry & Molecular Biology, College of Medicine
DivisionBiochemistry & Molecular Faculty
AddressB405 Biomedical Research I
4104 Outpatient Circle
Mail Slot # 516
Little Rock AR 72205
Phone501-686-7575
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    Other Positions
    TitleAssistant Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPhysiology and Biophysics, College of Medicine


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Allam H, Johnson BP, Zhang M, Lu Z, Cannon MJ, Abbott KL. The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer. J Biol Chem. 2017 Aug 23. PMID: 28842505.
      View in: PubMed
    2. Guo H, Abbott KL. Functional impact of tumor-specific N-linked glycan changes in breast and ovarian cancers. Adv Cancer Res. 2015; 126:281-303. PMID: 25727151.
      View in: PubMed
    3. Allam H, Aoki K, Benigno BB, McDonald JF, Mackintosh SG, Tiemeyer M, Abbott KL. Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions. J Proteome Res. 2015 Jan 02; 14(1):434-46. PMID: 25437919; PMCID: PMC4286206.
    4. Dolezal S, Hester S, Kirby PS, Nairn A, Pierce M, Abbott KL. Elevated levels of glycosylphosphatidylinositol (GPI) anchored proteins in plasma from human cancers detected by C. septicum alpha toxin. Cancer Biomark. 2014 Jan 01; 14(1):55-62. PMID: 24643042; PMCID: PMC4157464.
    5. Guido RS, Macer JA, Abbott K, Falls JL, Tilley IB, Chudnoff SG. Radiofrequency volumetric thermal ablation of fibroids: a prospective, clinical analysis of two years' outcome from the Halt trial. Health Qual Life Outcomes. 2013 Aug 13; 11:139. PMID: 23941588; PMCID: PMC3751251.
    6. Zhao P, Nairn AV, Hester S, Moremen KW, O'Regan RM, Oprea G, Wells L, Pierce M, Abbott KL. Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma. J Biol Chem. 2012 Jul 20; 287(30):25230-40. PMID: 22654114; PMCID: PMC3408190.
    7. Dangaj D, Abbott KL, Mookerjee A, Zhao A, Kirby PS, Sandaltzopoulos R, Powell DJ, Lamazière A, Siegel DL, Wolf C, Scholler N. Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody. PLoS One. 2011; 6(12):e28386. PMID: 22163010; PMCID: PMC3232216.
    8. Abbott KL, Lim JM, Wells L, Benigno BB, McDonald JF, Pierce M. Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis. Proteomics. 2010 Feb; 10(3):470-81. PMID: 19953551; PMCID: PMC4932840.
    9. Abbott KL, Pierce JM. Lectin-based glycoproteomic techniques for the enrichment and identification of potential biomarkers. Methods Enzymol. 2010; 480:461-76. PMID: 20816222.
      View in: PubMed
    10. Abbott KL. Glycomic analysis of ovarian cancer: past, present, and future. Cancer Biomark. 2010-2011; 8(4-5):273-80. PMID: 22045358.
      View in: PubMed
    11. Yang A, Abbott KL, Desjardins A, Di Lello P, Omichinski JG, Legault P. NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase. Biochemistry. 2009 Mar 10; 48(9):1964-74. PMID: 19215094.
      View in: PubMed
    12. Abbott KL, Matthews RT, Pierce M. Receptor tyrosine phosphatase beta (RPTPbeta) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding. J Biol Chem. 2008 Nov 28; 283(48):33026-35. PMID: 18838383; PMCID: PMC2586282.
    13. Abbott KL, Nairn AV, Hall EM, Horton MB, McDonald JF, Moremen KW, Dinulescu DM, Pierce M. Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer. Proteomics. 2008 Aug; 8(16):3210-20. PMID: 18690643; PMCID: PMC3970323.
    14. Abbott KL, Aoki K, Lim JM, Porterfield M, Johnson R, O'Regan RM, Wells L, Tiemeyer M, Pierce M. Targeted glycoproteomic identification of biomarkers for human breast carcinoma. J Proteome Res. 2008 Apr; 7(4):1470-80. PMID: 18271524; PMCID: PMC4932838.
    15. Abbott KL, Troupe K, Lee I, Pierce M. Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb. Exp Cell Res. 2006 Sep 10; 312(15):2837-50. PMID: 16857188.
      View in: PubMed
    16. Lee I, Guo HB, Kamar M, Abbott K, Troupe K, Lee JK, Alvarez-Manilla G, Pierce M. N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen. J Neurochem. 2006 May; 97(4):947-56. PMID: 16606368.
      View in: PubMed
    17. Abbott KL, Renfrow MB, Chalmers MJ, Nguyen BD, Marshall AG, Legault P, Omichinski JG. Enhanced binding of RNAP II CTD phosphatase FCP1 to RAP74 following CK2 phosphorylation. Biochemistry. 2005 Mar 01; 44(8):2732-45. PMID: 15723518.
      View in: PubMed
    18. Abbott KL, Archambault J, Xiao H, Nguyen BD, Roeder RG, Greenblatt J, Omichinski JG, Legault P. Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1. Biochemistry. 2005 Mar 01; 44(8):2716-31. PMID: 15723517.
      View in: PubMed
    19. Nguyen BD, Abbott KL, Potempa K, Kobor MS, Archambault J, Greenblatt J, Legault P, Omichinski JG. NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5688-93. PMID: 12732728; PMCID: PMC156262.
    20. Murphy TJ, Pavlath GK, Wang X, Boss V, Abbott KL, Robida AM, Nichols J, Xu K, Ellington ML, Loss JR. Retroviral vectors applied to gene regulation studies. Methods Enzymol. 2002; 345:539-51. PMID: 11665637.
      View in: PubMed
    21. Varma VA, Cerjan CM, Abbott KL, Hunter SB. Non-isotopic in situ hybridization method for mitochondria in oncocytes. J Histochem Cytochem. 1994; 42(2):273-6.
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