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Frank Simmen

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPhysiology & Cell Biology, College of Medicine
Address260-2 Biomedical Research I
200 South Cedar
Mail Slot # 505
Little Rock AR 72202
Phone501-686-8128
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    Collapse Overview 
    Collapse overview
    Our laboratory is interested in the physiological drivers of colon cancers. Current work in the laboratory includes: 1) elucidating the roles of Krüppel-like factor 9 (KLF9) and Malic Enzyme 1 (ME1) in intestinal biology and cancer suppression; and 2) understanding how the hormonal milieu (focus on insulin) regulates colon tumor cell growth. Projects use a combination of in vitro and in vivo approaches, mouse models, pilot clinical trials, and are translational.


    Collapse Research 
    Collapse research activities and funding
    DEAP 2016     (SIMMEN, FRANK A)Nov 17, 2015 - Mar 31, 2017

    Dietart Factors and the Adipose-Regulated Mammary Epithelial Niche
    Role: Principal Investigator
    DEAP2016     (SIMMEN, FRANK A)Nov 17, 2015 - Mar 31, 2017

    Dietart Factors and the Adipose-Regulated Mammary Epithelial Niche
    Role: Principal Investigator
    R01CA136493     (SIMMEN, FRANK ALBERT)Dec 15, 2009 - May 31, 2016
    NIH
    Dietary Factors in Colon Cancer Prevention
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Simmen FA, Pabona JMP, Al-Dwairi A, Alhallak I, Montales MTE, Simmen RCM. Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice. Int J Mol Sci. 2023 Apr 01; 24(7). PMID: 37047583.
      View in: PubMed
    2. Brown AR, Alhallak I, Simmen RCM, Melnyk SB, Heard-Lipsmeyer ME, Montales MTE, Habenicht D, Van TT, Simmen FA. Kr?ppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet. Cancers (Basel). 2022 Mar 29; 14(7). PMID: 35406507.
      View in: PubMed
    3. Heard-Lipsmeyer ME, Alhallak I, Simmen FA, Melnyk SB, Simmen RCM. Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice. Front Physiol. 2021; 12:702674. PMID: 34712146.
      View in: PubMed
    4. Alhallak I, Wolter KG, Castro Munoz A, Simmen FA, Ward RJ, Petty SA, Li LX, Simmen RCM. Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10. J Mol Endocrinol. 2021 09 09; 67(4):173-188. PMID: 34382943.
      View in: PubMed
    5. Simmen FA, Alhallak I, Simmen RCM. Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism. J Mol Endocrinol. 2020 11; 65(4):R77-R90. PMID: 33064660.
      View in: PubMed
    6. Blossom SJ, Melnyk SB, Simmen FA. Complex epigenetic patterns in cerebellum generated after developmental exposure to trichloroethylene and/or high fat diet in autoimmune-prone mice. Environ Sci Process Impacts. 2020 Mar 01; 22(3):583-594. PMID: 31894794.
      View in: PubMed
    7. Pabona JMP, Burnett AF, Brown DM, Quick CM, Simmen FA, Montales MTE, Liu SJ, Rose T, Alhallak I, Siegel ER, Simmen RC. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reprod Sci. 2020 01; 27(1):267-277. PMID: 32046384.
      View in: PubMed
    8. Fernandes LM, Al-Dwairi A, Simmen RCM, Marji M, Brown DM, Jewell SW, Simmen FA. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 09 24; 8(1):14268. PMID: 30250042.
      View in: PubMed
    9. Blossom SJ, Fernandes L, Bai S, Khare S, Gokulan K, Yuan Y, Dewall M, Simmen FA, Gilbert KM. Opposing Actions of Developmental Trichloroethylene and High-Fat Diet Coexposure on Markers of Lipogenesis and Inflammation in Autoimmune-Prone Mice. Toxicol Sci. 2018 07 01; 164(1):313-327. PMID: 29669109.
      View in: PubMed
    10. Brown DM, Lee HC, Liu S, Quick CM, Fernandes LM, Simmen FA, Tsai SJ, Simmen RCM. Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis. J Endocr Soc. 2018 Jul 01; 2(7):765-778. PMID: 30151432.
      View in: PubMed
    11. Yu S, Wu X, Ferguson M, Simmen RC, Cleves MA, Simmen FA, Fang N. Diets Containing Shiitake Mushroom Reduce Serum Lipids and Serum Lipophilic Antioxidant Capacity in Rats. J Nutr. 2016 Dec; 146(12):2491-2496. PMID: 27798348.
      View in: PubMed
    12. Montales MT, Melnyk SB, Liu SJ, Simmen FA, Liu YL, Simmen RC. Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice. Endocr Relat Cancer. 2016 09; 23(9):677-90. PMID: 27402613.
      View in: PubMed
    13. Heard ME, Melnyk SB, Simmen FA, Yang Y, Pabona JM, Simmen RC. High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status. Endocrinology. 2016 07; 157(7):2870-82. PMID: 27175969.
      View in: PubMed
    14. Montales MT, Simmen RC, Ferreira ES, Neves VA, Simmen FA. Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. Genes Nutr. 2015 Nov; 10(6):49. PMID: 26506839.
      View in: PubMed
    15. Brown AR, Simmen RC, Raj VR, Van TT, MacLeod SL, Simmen FA. Kr?ppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling. Carcinogenesis. 2015 Sep; 36(9):946-55. PMID: 26210742.
      View in: PubMed
    16. Heard ME, Velarde MC, Giudice LC, Simmen FA, Simmen RC. Kr?ppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis. Biol Reprod. 2015 Jun; 92(6):140. PMID: 25904015.
      View in: PubMed
    17. Pabona JM, Zhang D, Ginsburg DS, Simmen FA, Simmen RC. Prolonged pregnancy in women is associated with attenuated myometrial expression of progesterone receptor co-regulator Kr?ppel-like Factor 9. J Clin Endocrinol Metab. 2015 Jan; 100(1):166-74. PMID: 25313913.
      View in: PubMed
    18. Al-Dwairi A, Brown AR, Pabona JM, Van TH, Hamdan H, Mercado CP, Quick CM, Wight PA, Simmen RC, Simmen FA. Enhanced gastrointestinal expression of cytosolic malic enzyme (ME1) induces intestinal and liver lipogenic gene expression and intestinal cell proliferation in mice. PLoS One. 2014; 9(11):e113058. PMID: 25402228.
      View in: PubMed
    19. Montales MT, Melnyk SB, Simmen FA, Simmen RC. Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes. Carcinogenesis. 2014 Sep; 35(9):2102-12. PMID: 24832086.
      View in: PubMed
    20. Heard ME, Simmons CD, Simmen FA, Simmen RC. Kr?ppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis. Endocrinology. 2014 Apr; 155(4):1532-46. PMID: 24476135.
      View in: PubMed
    21. Brown AR, Simmen RC, Simmen FA. The role of thyroid hormone signaling in the prevention of digestive system cancers. Int J Mol Sci. 2013 Aug 06; 14(8):16240-57. PMID: 23924944.
      View in: PubMed
    22. Heard, M.E., Simmen, R.C.M. Aberrant activation of stem cell-associated regulatory pathways and pro-inflammatory cytokine expression with absence of endometrial Krüppel-like factor 9 (KLF9) in a mouse model of endometriosis. Annual mtg. of the Endocrine Society. 2013.
    23. Al-Dwairi, A., Van, T.T., Simmen, R.C.M. Enhanced expression of cytosolic malic enzyme (ME1) in murine small intestine leads to inductions of lipogenic and lipid-partitioning genes and crypt cell proliferation. 95th annual mtg. of the Endocrine Society. 2013.
    24. Varughese, K.I., Saha, R., Thakkar, S. Computer-aided drug design for inhibitors of human cytosolic malic enzyme. SE Regional IDeA Meeting. 2013.
    25. Simmen, R.C.M.,, Rahal, O.M, Montales, M.T, Pabona, J.M.P, Heard, M.E., Al-Dwairi, A., Brown, A.R. Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer. Cancer Chemoprevention and Treatment by Diet Therapy. 2013; 121-140.
    26. Brown, A.R, Van, T.T, Simmen, R.C.M. The potential tumor-suppressive role of Krüppel-like factor 9 in colorectal cancer. American Association for Cancer Research Annual Meetng. 2013.
    27. Heard ME, Pabona JM, Clayberger C, Krensky AM, Simmen FA, Simmen RC. The reproductive phenotype of mice null for transcription factor Kr?ppel-like factor 13 suggests compensatory function of family member Kr?ppel-like factor 9 in the peri-implantation uterus. Biol Reprod. 2012 Nov; 87(5):115. PMID: 22993382.
      View in: PubMed
    28. Rahal OM, Pabona JM, Kelly T, Huang Y, Hennings LJ, Prior RL, Al-Dwairi A, Simmen FA, Simmen RC. Suppression of Wnt1-induced mammary tumor growth and lower serum insulin in offspring exposed to maternal blueberry diet suggest early dietary influence on developmental programming. Carcinogenesis. 2013 Feb; 34(2):464-74. PMID: 23144318.
      View in: PubMed
    29. Al-Dwairi A, Pabona JM, Simmen RC, Simmen FA. Cytosolic malic enzyme 1 (ME1) mediates high fat diet-induced adiposity, endocrine profile, and gastrointestinal tract proliferation-associated biomarkers in male mice. PLoS One. 2012; 7(10):e46716. PMID: 23056418.
      View in: PubMed
    30. Hakkak R, Al-Dwairi A, Fuchs GJ, Korourian S, Simmen FA. Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female Zucker rats bearing DMBA-initiated mammary tumors. Genes Nutr. 2012 Oct; 7(4):549-58. PMID: 22528625.
      View in: PubMed
    31. Pabona JM, Simmen FA, Nikiforov MA, Zhuang D, Shankar K, Velarde MC, Zelenko Z, Giudice LC, Simmen RC. Kr?ppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2012 Mar; 97(3):E376-92. PMID: 22259059.
      View in: PubMed
    32. Simmen, R.C.M., Pabona, J.M.P., Heard, M.E. Krüppel-like factor signaling and actions in endocrine resistance: implications for uterine dysfunctions and hormone-responsive cancers. 2012 FASEB Science Research Conference. 2012.
    33. Simmen F. Heard, M.E., Pabona, J.M.P., Clayberger, C., Krensky, A.M., Simmen, F.A. and Simmen, R.C.M. The reproductive phenotype of mice null for transcription factor Krüppel-like factor 13 suggests compensatory function of family member Küppel-like factor 9 in the peri-implantation uterus. Biol. Reprod. 2012; 87:1-11. .
    34. Simmen F. Hakkak, R., Al-Dwairi, A., Fuchs, G.J., Korourian, S. and Simmen, F.A. Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female Zucker rats bearing DMBA-initiated mammary tumors. Genes & Nutrition. 2012; 7:549-558. .
    35. Simmen FA, Simmen RC. The maternal womb: a novel target for cancer prevention in the era of the obesity pandemic? Eur J Cancer Prev. 2011 Nov; 20(6):539-48. PMID: 21701386.
      View in: PubMed
    36. Simmons CD, Pabona JM, Heard ME, Friedman TM, Spataro MT, Godley AL, Simmen FA, Burnett AF, Simmen RC. Kr?ppel-like factor 9 loss-of-expression in human endometrial carcinoma links altered expression of growth-regulatory genes with aberrant proliferative response to estrogen. Biol Reprod. 2011 Aug; 85(2):378-85. PMID: 21543766.
      View in: PubMed
    37. Pabona JM, Zeng Z, Simmen FA, Simmen RC. Functional differentiation of uterine stromal cells involves cross-regulation between bone morphogenetic protein 2 and Kruppel-like factor (KLF) family members KLF9 and KLF13. Endocrinology. 2010 Jul; 151(7):3396-406. PMID: 20410205.
      View in: PubMed
    38. Simmons CD, Pabona JM, Zeng Z, Velarde MC, Gaddy D, Simmen FA, Simmen RC. Response of adult mouse uterus to early disruption of estrogen receptor-alpha signaling is influenced by Kr?ppel-like factor 9. J Endocrinol. 2010 May; 205(2):147-57. PMID: 20164373.
      View in: PubMed
    39. Simmen FA, Mercado CP, Zavacki AM, Huang-SA, Greenway AD, Kang P, Bowman MT, Prior RL. Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rate. J Nutr Biochem. 2010.
    40. Simmons CD, Pabona JMP, Zeng Z, Velarde MC, Gaddy D, Simmen FA, Simmen RCM. Response of adult mouse uterus to early disruption of estrogen receptor-alpha signaling is influenced by Kruppel-like factor 9. J Endrocrinol. 2010; 205:147-157.
    41. Simmen RCM, Pabona JMP, Velarde MC, Simmons C, Rahal O, Simmen FA. The emerging role of Kruppel-like factors in endocrine-responsive cancers of female reproductive tissues. J. Endocrinol. 2010; 204:223-231.
    42. Simmen FA, Mercado CP, Zavacki AM, Huang SA, Greenway AD, Kang P, Bowman MT, Prior RL. Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat. J Nutr Biochem. 2010 Nov; 21(11):1106-13. PMID: 19962299.
      View in: PubMed
    43. Simmen RC, Pabona JM, Velarde MC, Simmons C, Rahal O, Simmen FA. The emerging role of Kr?ppel-like factors in endocrine-responsive cancers of female reproductive tissues. J Endocrinol. 2010 Mar; 204(3):223-31. PMID: 19833720.
      View in: PubMed
    44. Simmen FA, Frank JA, Wu X, Xiao R, Hennings LJ, Prior RL. Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon. BMC Gastroenterol. 2009 Sep 16; 9:67. PMID: 19758446.
      View in: PubMed
    45. Simmen FA, Frank JA, Wu X, Xiao R, Hennings LJ, Prior RL. Lack of efficacy of blueberry in nutritional prevention of azoxymethane-inititated cancers of rat small intestine and colon. BMC Gastroenterology. 2009; 9:67.
    46. Pabona JM, Simmen FA, Simmen RCM. Bone morphogenetic protein 2 (BMP2) and Kruppel-like Factor 9 (KLF9) cross-regulation in uterine stromal cells promotes timing of uterine endometrial receptivity. Biol Reprod. 2009.
    47. Simmen FA, Mercado CP, Kang P, Greenway AD. Dietary proteins alter hepatic and intestine lipid content and gene expression in Sprague-Dawley rats. FASEB J. 2009.
    48. Pabona JMP, Velarde MC, Zeng Z, Simmen FA, Simmen RCM. Nuclear receptor co-regulator Kruppel-like factor 9 and prohibitin 2 expression in oestrogen-induced epithelial cell proliferation in the mouse uterus. J. Endocrinol. 2009; 200(1):63-73.
    49. Pabona JM, Velarde MC, Zeng Z, Simmen FA, Simmen RC. Nuclear receptor co-regulator Kr?ppel-like factor 9 and prohibitin 2 expression in estrogen-induced epithelial cell proliferation in the mouse uterus. J Endocrinol. 2009 Jan; 200(1):63-73. PMID: 18835980.
      View in: PubMed
    50. Simmen FA, Su Y, Xiao R, Zeng Z, Simmen RC. The Kr?ppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression. Reprod Biol Endocrinol. 2008 Sep 10; 6:41. PMID: 18783612.
      View in: PubMed
    51. Zeng Z, Velarde MC, Simmen FA, Simmen RC. Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Kr?ppel-like factor 9. Biol Reprod. 2008 Jun; 78(6):1029-37. PMID: 18305227.
      View in: PubMed
    52. Xiao R, Su Y, Simmen RC, Simmen FA. Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G868-76. PMID: 18239060.
      View in: PubMed
    53. Zeng Z, Simmen FA, Simmen RCM. Nuclear receptor co-regulator Kruppel-like Factor 9 in human endometrial stromal cell differentiation. Experimental Biology. 2008.
    54. Zeng Z, Verlarde MC, Simmen FA, Simmen RCM. Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Kruppel-like factor 9. Biol. Reprod. 2008; 78:1029-1037.
    55. Simmen FA, Greenway AD, Bowman MT, Su Y, Kang P. Dietary proteins alter tissue-specific gene expression and adiposity in male Sprague-Dawley rats. Experimental Biology. 2008.
    56. Simmen FA, Su Y, Xiao R, Zeng Z, Simmen RCM. The Kruppel-like Factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests that carcinogenic potential of dys-regulated KLF9 expression. Reprod Biol & Endocrinol. 2008; 6(41).
    57. Simmen FA, Xiao R, Wu X, Prior RL. Blueberry consumption inhibits gastrointestinal tumorigenesis in AOM-treated rats. Experimental Biology. 2008.
    58. Simmons C, Zeng Z, Pabona JM, Velarde MC, Simmen FA, Simmen RCM. Kruppel-like factor 9 and regulation of endometrial estrogen receptor-a signaling. 2008; 2-438.
    59. Su Y, Shankar K, Simmen FA, Simmen RCM. Regulation of adipocyte lipid homeostasis by genistein alters mammary epithelial cell differentiation: a paracrine mechanism for mammary tumor protection. 2008; A5082.
    60. Xiao R, Hennings LJ, Badger TM, Simmen FA. Fetal programming of colon cancer in adult rats: correlations with altered neonatal growth trajectory, circulating IGF-I and IGF binding proteins, and testosterone. J Endocrinol. 2007 Oct; 195(1):79-87. PMID: 17911399.
      View in: PubMed
    61. Velarde MC, Zeng Z, McQuown JR, Simmen FA, Simmen RC. Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells. Mol Endocrinol. 2007 Dec; 21(12):2988-3001. PMID: 17717078.
      View in: PubMed
    62. He L, Marecki JC, Serrero G, Simmen FA, Ronis MJ, Badger TM. Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. Mol Endocrinol. 2007 Oct; 21(10):2541-50. PMID: 17622585.
      View in: PubMed
    63. Simmen FA, Xiao R, Velarde MC, Nicholson RD, Bowman MT, Fujii-Kuriyama Y, Oh SP, Simmen RC. Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1757-69. PMID: 17379758.
      View in: PubMed
    64. Su Y, Simmen FA, Xiao R, Simmen RC. Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors. Physiol Genomics. 2007 Jun 19; 30(1):8-16. PMID: 17341692.
      View in: PubMed
    65. Velarde M, Simmen FA, Simmen RCM. Kruppel-like factor 9 regulates cell proliferation and compartmental expression of estrogen and progesterone receptors in the mouse uterine endometrium. 40th Annual Meeting of the Society for the Study of Reproduction. 2007; 182-183.
    66. He L, Simmen FA, Ronis MJ, Badger TM. Chronic alcohol consumption induces Trb3 and disrupts insulin signaling through increased ER stress. 2007; A398.
    67. Simmen RCM, Velarde M, Zeng Z, Simmen FA, De Evsikova C. Altered gestational length in mice null for the Kruppel-like factor 9 gene or heterozygous for the leptic receptor mutation: useful models for parturition defects?. 40th Annual Meeting of the Society for the Study of Reproduction. 2007; 231-232.
    68. Su Y, Simmen FA, Xiao R, Simmen RCM. Prepubertal changes in lipid homeostasis gene expression in mammary glands of rats exposed to dietary soy. 89th Annual Meeting of the Endocrine Society. 2007; P1-250.
    69. Xiao R, Simmen FA. Colonic Fatty Acid Synthase is down-regulated in Sprague-Dawley rats fed soy protein isolate. 2007; A1103-A1103.
    70. Velarde MC, Zeng Z, Simmen FA, Simmen RCM. Parturition-related defects in mice lacking the Kruppel-like factor 9 gene. 2007.
    71. Shankar K, Hidestrand M, Liu X, Xiao R, Skinner CM, Simmen FA, Badger TM, Ronis MJ. Physiologic and genomic analyses of nutrition-ethanol interactions during gestation: Implications for fetal ethanol toxicity. Exp Biol Med (Maywood). 2006 Sep; 231(8):1379-97. PMID: 16946407.
      View in: PubMed
    72. Velarde MC, Iruthayanathan M, Eason RR, Zhang D, Simmen FA, Simmen RC. Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Kruppel-like factor 9/basic transcription element binding protein-1. Endocrinology. 2006; 147(4):1969 - 1978.
    73. Simmen FA, Simmen RC. Orchestrating the menstrual cycle: discerning the music from the noise. Endocrinology. 2006 Mar; 147(3):1094-6. PMID: 16481481.
      View in: PubMed
    74. He L, Simmen FA, Mehendale HM, Ronis MJ, Badger TM. Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation. J Biol Chem. 2006 Apr 21; 281(16):11126-34. PMID: 16452480.
      View in: PubMed
    75. Eason RR, Till SR, Frank JA, Badger TM, Korourian S, Simmen FA, Simmen RC. Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesis. Nutr Cancer. 2006; 55(2):171-7. PMID: 17044772.
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    76. Kwak I, Song S, Blum JL, Simmen RC, Simmen FA. Enhancer- and silencer-like sequences that mediate insulin-like growth factor-binding protein-2 gene expression in uterine cells of pregnancy. DNA Cell Biol. 2006 Jan; 25(1):6-18. PMID: 16405396.
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    77. He L, Simmen FA, Mehendale HM, Ronis MJ, Badger TM. Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. 88th Annual Meeting of the Endocrine Society. 2006; 449.
    78. Velarde MC, Geng Y, Simmen FA, Simmen RCM. Induction of progesterone receptor isoform expression by Kruppel-like factor 9/basic transcription element binding protein 1 in the myometrium is associated with labor onset in mice. 2006; 290-291.
    79. Xiao R, Frank JA, Skinner CM, Simmen FA. Diets containing soy protein isolate (SPI) or genistein (GEN) fed to female rats during pregnancy do not suppress azoxymethane (AOM)-induced intestinal cancers in the male progeny. FASEB J., Vol 20(4). 2006; A567-568.
    80. Ronis MJJ, Gilchrist JM, Nagarajan S, Simmen FA, Simmen RCM, Badger TM. Developmental exposure to soy protein isolate: potential health effects. Special conference on Food Components for Health Promotion at EB 2006 - Early Exposure to food components and long-term health. 2006.
    81. Simmen FA, Xiao R, Till SR, Hennings L, Badger TM, Simmen RCM. Inhibitory effects of soy protein isolate on intestinal carcinogenesis in azoxymethane (AOM)-treated Sprague-Dawley rats are subsite-specific and linked to insulin/IGF action. Fifth AACR International Conference "Frontiers in Cancer Prevention Research". 2006; 117, A160.
    82. Shankar K, Xiaoli L, Skinner CM, Simmen FA, Badger TM, Ronis MJJ. Nutritional status is a determinant of ethanol-induced hepatic gene expression during gestation. 2006; A2401.
    83. Velarde MC, Geng Y, Simmen FA, Simmen RCM. Proliferative response of uterine endometrium to estrogen involved Basic Transcription Element Binding Protein-1. 2006.
    84. Badger TM, He L, Simmen FA, Ronis MJJ. Chronic feeding of alcohol-containing diets via total enteral nutrition induces Alcohol Dehydrogenase (ADH) and insulin resistance. 2006; A2403.
    85. Badger TM, He L, Simmen FA, Ronis MJJ. Alcohol-induced insulin resistance in liver: potential roles in regulation of ADH expression, ethanol clearance and alcoholic liver disease. ISBRA World Congress on Alcohol Research. 2006; A112, 49A.
    86. Simmen FA, Xiao R, Velarde MC, Nicholson RD, Fujii-Kuriyama Y, Oh SP, Simmen RCM. Signaling between intestinal smooth muscle and crypt-villus epithelium is dysregulated in mice lacking the transcription factor, Kruppel-like factor 9 (Klf9). 2006.
    87. Geng Y, Till SR, Frank JA, Ferguson M, Badger TM, Simmen RCM, Simmen FA. Diets containing soy protein isolate or the soy isoflavone genistein suppress p53-mediated activation of the colon DNA damage response pathway in azoxymethane (AOM)-treated rats. 2006; A564-A564.
    88. Su Y, Xiao R, Geng Y, Skinner CM, Simmen FA, Simmen RCM. Identification of gene networks underlying mammary tumor protection by dietary exposure to soy and genistein. 2006; A560-A561.
    89. He L, Simmen FA, Ronis MJJ. Ethanol induces and insulin inhibits Alcohol Dehydrogenase Class 1 in FGC-4 cells: both appear to work through SREBP-1. 2006; A1368.
    90. Velarde MC, Iruthayanathan M, Eason RR, Zhang D, Simmen FA, Simmen RC. Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Kr?ppel-like factor 9/basic transcription element binding protein-1. Endocrinology. 2006 Apr; 147(4):1969-78. PMID: 16384861.
      View in: PubMed
    91. Xiao R, Carter JA, Linz AL, Ferguson M, Badger TM, Simmen FA. Dietary whey protein lowers serum C-peptide concentration and duodenal SREBP-1c mRNA abundance, and reduces occurrence of duodenal tumors and colon aberrant crypt foci in azoxymethane-treated male rats. J Nutr Biochem. 2006 Sep; 17(9):626-34. PMID: 16504496.
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    92. Eason RR, Till SR, Velarde MC, Geng Y, Chatman L, Gu L, Badger TM, Simmen FA, Simmen RC. Uterine phenotype of young adult rats exposed to dietary soy or genistein during development. J Nutr Biochem. 2005 Oct; 16(10):625-32. PMID: 16081271.
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    93. Velarde MC, Geng Y, Eason RR, Simmen FA, Simmen RC. Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice. Biol Reprod. 2005 Sep; 73(3):472-81. PMID: 15917344.
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    94. Badger TM, Ronis MJ, Simmen RC, Simmen FA. Soy protein isolate and protection against cancer. J Am Coll Nutr. 2005 Apr; 24(2):146S-149S. PMID: 15798082.
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    95. Xiao R, Ferguson M, Badger TM, Simmen FA. Dietary prevention of azoxymethane (AOM)-induced intestinal cancers by whey protein hydrolysate (WPH): are aberrant crypt foci (ACF) suitable intermediate endpoint biomarkers for tumor occurrence?. Annual Meeting of the American Assn. for Cancer Res., 46. 2005; 1223.
    96. Xiao R, Badger TM, Simmen FA. Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis. Mol Cancer. 2005 Jan 11; 4(1):1. PMID: 15644144.
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    97. Velarde MC, Parisek SI, Eason RR, Simmen FA, Simmen RC. The secretory leukocyte protease inhibitor gene is a target of epidermal growth factor receptor action in endometrial epithelial cells. J Endocrinol. 2005 Jan; 184(1):141-51. PMID: 15642791.
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    98. Carter JA, Xiao R, Badger TM, Simmen FA. Dietary whey protein hydrolysate (WPH) suppresses circulating insulin and C-peptide levels and inhibits colon tumorigenesis. 2005; A77-A78.
    99. Badger TM, He L, Simmen FA, Ronis MJJ. Ethanol induces rat hepatic alcohol dehydrogenase (ADH) class I by interfering with post-translational regulation of sterol regulatory element-binding protein-1 (SREBP-1). 2005; 392.
    100. Xiao R, Ferguson M, Badger TM, Simmen FA. Dietary prevention of azoxymethane (AOM)-induced intestinal cancers by whey protein hydrolysate (WPH): are aberrant crypt foci (ACF) suitable intermediate endpoint biomarkers for tumor occurrence?. 2005.
    101. He L, Ronis MJJ, Simmen FA, Badger TM. Ethanol has biphasic effects on expression of sterol regulatory element-binding protein-1 (SREBP-1) in rat FGC-4 hepatoma cells with inhibition at high doses resulting in induction of ADH class I. 2005; 392.
    102. Velarde MC, Eason RR, Xiao R, Simmen FA, Simmen RCM. Identification of Secretory Leukocyte Protease Inhibitor (SLPI) as a downstream target of Basic Transcription Element Binding Protein 1 (BTEB1) in uterine endometrial adenocarcinoma. 2005.
    103. Shankar K, Hidestrand M, Yarberry B, Xiao R, Simmen FA, Badger TM, Ronis MJJ. Microarray-based analysis of nutrition-ethanol interactions during gestation. 2005; 57.
    104. Ronis MJJ, Gilchrist JM, Nagarajan S, Simmen FA, Simmen RCM, Badger TM. Developmental exposure to soy protein isolate: potential health effects associated with feeding soy-based infant formulas. Society of Toxicology of Canada Meeting. 2005.
    105. Velarde MC, Geng Y, Eason RR, Simmen FA, Simmen RCM. The Sp/kruppel-like family (KLF) member, Basic Transcription Element Binding Protein-1 (BTEB1) is important for developmental synchrony of embryo and uterine endometrium. 38th Annual Meeting of the Society for the Study of Reproduction. 2005; 81.
    106. Linz AL, Xiao R, Parker JG, Simpson PM, Badger TM, Simmen FA. Feeding of soy protein isolate to rats during pregnancy and lactation suppresses formation of aberrant crypt foci in their progeny's colons: interaction of diet with fetal alcohol exposure. J Carcinog. 2004 Oct 15; 3(1):14. PMID: 15488141.
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    107. Linz AL, Xiao R, Parker JG, Simpson PM, Badger TM, Simmen FA. Feeding of soy protein isolate to rats during pregnancy and lactation suppresses formation of aberrant crypt foci in their progeny's colons: interaction of diet with fetal alcohol exposure. J Carcinog. 2004; 3(1):14 - .
    108. Gaucher EA, Graddy LG, Li T, Simmen RC, Simmen FA, Schreiber DR, Liberles DA, Janis CM, Benner SA. The planetary biology of cytochrome P450 aromatases. BMC Biol. 2004 Aug 17; 2:19. PMID: 15315709.
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    109. He L, Simmen FA, Ronis MJ, Badger TM. Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liver. J Biol Chem. 2004 Jul 02; 279(27):28113-21. PMID: 15123720.
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    110. Simmen RC, Eason RR, McQuown JR, Linz AL, Kang TJ, Chatman L, Till SR, Fujii-Kuriyama Y, Simmen FA, Oh SP. Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene. J Biol Chem. 2004 Jul 09; 279(28):29286-94. PMID: 15117941.
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    111. Kowalski AA, Vale-Cruz DS, Simmen FA, Simmen RC. Uterine androgen receptors: roles in estrogen-mediated gene expressionand DNA synthesis. Biol Reprod. 2004 May; 70(5):1349-57. PMID: 14711790.
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    112. Linz AL, Xiao R, Ferguson M, Badger TM, Simmen FA. Developmental feeding of soy protein isolate to male rats inhibits formation of colonic aberrant crypt foci: major response differences to azoxymethane (AOM) in Sprague-Dawley rats from two colonies. 2004; A127-A127.
    113. Xiao R, Linz AL, Ferguson M, Badger TM, Simmen FA. Soy and whey proteins alter colonic gene expression during tumorigenesis. 86th Annual Meeting of the Endocrine Society. 2004; 199-200.
    114. Linz AL, Xiao R, Ferguson M, Badger TM, Simmen FA. Nutritional exposure to whey protein hydrolysate (WPH), a rich source of bio-active peptides and hormones, inhibits formation of colonic aberrant crypt foci (ACF) and modulates specific gene expression. 86th Annual Meeting of the Endocrine Society. 2004; 372.
    115. Shankar K, Hidestrand M, Yarberry B, Xiao R, Simmen FA, Badger TM, Ronis MJJ. Microarray-based analysis of nutrition-ethanol interactions in the maternal rat liver during gestation. Annual Meeting of the South Central Chapter of the Society for Toxicology. 2004.
    116. Simmen FA, Kwak I, Blum JL, Simmen RCM. IGF and Nutrition in Health and Disease. Nutrition and the IGF System in Reproduction. 2004.
    117. Eason RR, Linz AL, Chatman L, Kang TJ, Till SR, Fujii-Kuriyama Y, Simmen FA, Oh SP, Simmen RCM. Sub-fertility in female mice lacking the Kruppel-like factor 9/basic transcription element binding protein-1 gene is correlated with decreased expression of implantation-associated genes and partial loss of progesterone responsiveness. 86th Annual Meeting of the Endocrine Society. 2004; 338.
    118. Zhang XL, Zhang D, Michel FJ, Blum JL, Simmen FA, Simmen RC. Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells. J Biol Chem. 2003 Jun 13; 278(24):21474-82. PMID: 12672823.
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    119. Sanders Y, Badger TM, Simmen FA. Lifetime feeding of whey protein-based diet suppresses hepatic GST-pi mRNA expression in female rats. 2003; A1162-A1162.
    120. Simmen RCM, McQuown JR, Kang T, Fujii-Kuriyama Y, Simmen FA, Oh SP. Functional role of the Kruppel-like transcription factor BTEB1 during pregnancy: studies with the BTEB1 knock-out mouse. 36th Annual Meeting of the Society for the Study of Reproduction. 2003; 356.
    121. Simmen RCM, Eason RR, Zhang D, Zhang X-L, Simmen FA. Over-expression of the Sp/KLF transcription factor BTEB1 alters cell cycle parameters in MCF-7 breast tumor cells. 94th Annual Meeting of the American Association for Cancer Research., Vol. 44. 2003; 539.
    122. Macpherson ML, Simmen RC, Simmen FA, Hernandez J, Sheerin BR, Varner DD, Loomis P, Cadario ME, Miller CD, Brinsko SP, Rigby S, Blanchard TL. Insulin-like growth factor-I and insulin-like growth factor binding protein-2 and -5 in equine seminal plasma: association with sperm characteristics and fertility. Biol Reprod. 2002 Aug; 67(2):648-54. PMID: 12135910.
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    123. Simmen RC, Simmen FA. Progesterone receptors and Sp/Kruppel-like family members in the uterine endometrium. Front Biosci. 2002; 7:d1556 - d1565.
    124. Zhang D, Simmen RC, Michel FJ, Zhao G, Vale-Cruz D, Simmen FA. Secretory leukocyte protease inhibitor mediates proliferation of human endometrial epithelial cells by positive and negative regulation of growth-associated genes. J Biol Chem. 2002 Aug 16; 277(33):29999-30009. PMID: 12023969.
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    125. Kowalski AA, Graddy LG, Vale-Cruz DS, Choi I, Katzenellenbogen BS, Simmen FA, Simmen RC. Molecular cloning of porcine estrogen receptor-beta complementary DNAs and developmental expression in periimplantation embryos. Biol Reprod. 2002 Mar; 66(3):760-9. PMID: 11870084.
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    126. Simmen RC, Zhang XL, Michel FJ, Min SH, Zhao G, Simmen FA. Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Kruppel-like factor BTEB1. DNA Cell Biol. 2002; 21(2):115 - 128.
    127. Hausman GJ, Richardson RL, Simmen FA. Secretion of insulin-like growth factor (IGF)-I and -II and IGF binding proteins (IGFBPs) in fetal stromal-vascular (S-V) cell cultures obtained before and after the onset of adipogenesis in vivo. Growth Dev Aging. 2002; 66(1):11-26. PMID: 12212627.
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    128. Zhang D, Zhang XL, Michel FJ, Blum JL, Simmen FA, Simmen RC. Direct interaction of the Kr?ppel-like family (KLF) member, BTEB1, and PR mediates progesterone-responsive gene expression in endometrial epithelial cells. Endocrinology. 2002 Jan; 143(1):62-73. PMID: 11751593.
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    129. Zhang D, Zhang XL, Michel FJ, Blum JL, Simmen FA, Simmen RC. Direct interaction of the Kruppel-like family (KLF) member, BTEB1, and PR mediates progesterone-responsive gene expression in endometrial epithelial cells. Endocrinology. 2002; 143(1):62 - 73.
    130. Min SH, Simmen RC, Alhonen L, Halmekyto M, Porter CW, Janne J, Simmen FA. Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT). J Biol Chem. 2002 Feb 01; 277(5):3647-57. PMID: 11709547.
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    131. Rodriguez-Sallaberry C, Simmen FA, Simmen RC. Polyamine- and insulin-like growth factor-I-mediated proliferation of porcine uterine endometrial cells: a potential role for spermidine/spermine N(1)-acetyltransferase during peri-implantation. Biol Reprod. 2001 Aug; 65(2):587-94. PMID: 11466230.
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    132. Lee CY, Kwak I, Chung CS, Choi WS, Simmen RC, Simmen FA. Molecular cloning of the porcine acid-labile subunit (ALS) of the insulin-like growth factor-binding protein complex and detection of ALS gene expression in hepatic and non-hepatic tissues. J Mol Endocrinol. 2001 Apr; 26(2):135-44. PMID: 11241165.
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    133. Vale-Cruz DS, Kowalski AA, Simmen FA, Simmen RCM. Expression of Androgen Receptors in the peri-attachment porcine uterus. 2001.
    134. Kowalski AA, Vale-Cruz D, Zhang D, Jaeger LA, Michel FJ, Simmen FA, Simmen RCM. Estrogen receptor (ER)-beta and estrogen (E)-regulated transcripts in porcine trophoblastic cells. 2001; 280.
    135. Vale-Cruz DS, Kowalski AA, Simmen FA, Simmen RCM. Expression of androgen receptors in the peri-attachment porcine uterus. 2001; 283-284.
    136. Zhang D, Simmen RCM, Simmen FA. Mitogenic activity: a novel function for Secretory Leukocyte Protease Inhibitor (SLPI) in uterine endometrial epithelial cells. 2001.
    137. Kao YC, Higashiyama T, Sun X, Okubo T, Yarborough C, Choi I, Osawa Y, Simmen FA, Chen S. Catalytic differences between porcine blastocyst and placental aromatase isozymes. Eur J Biochem. 2000 Oct; 267(20):6134-9. PMID: 11012665.
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    138. Wandji SA, Gadsby JE, Simmen FA, Barber JA, Hammond JM. Porcine ovarian cells express messenger ribonucleic acids for the acid-labile subunit and insulin-like growth factor binding protein-3 during follicular and luteal phases of the estrous cycle. Endocrinology. 2000 Jul; 141(7):2638-47. PMID: 10875269.
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    139. Modric T, Kowalski AA, Green ML, Simmen RC, Simmen FA. Pregnancy-dependent expression of leukaemia inhibitory factor (LIF), LIF receptor-beta and interleukin-6 (IL-6) messenger ribonucleic acids in the porcine female reproductive tract. Placenta. 2000 May; 21(4):345-53. PMID: 10833369.
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    140. Graddy LG, Kowalski AA, Simmen FA, Davis SL, Baumgartner WW, Simmen RC. Multiple isoforms of porcine aromatase are encoded by three distinct genes. J Steroid Biochem Mol Biol. 2000 May; 73(1-2):49-57. PMID: 10822024.
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    141. Hausman GJ, Richardson RL, Simmen FA. Expression of insulin-like growth factor binding proteins (IGFBPs) before and during the hormone sensitive period of adipose tissue development in the fetal pig. Growth Dev Aging. 2000 Spring-Summer; 64(1-2):51-67. PMID: 10969885.
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    142. Simmen RC, Zhang XL, Zhang D, Wang Y, Michel FJ, Simmen FA. Expression and regulatory function of the transcription factor Sp1 in the uterine endometrium at early pregnancy: implications for epithelial phenotype. Mol Cell Endocrinol. 2000 Jan 25; 159(1-2):159-70. PMID: 10687861.
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    143. Macpherson M, Simmen RCM, Simmen FA, Hernandez J, Sheerin B, Varner D, Miller C, Loomis P, Brinsko S, Rigby S, Blanchard T. Insulin-like growth factor I and associated binding proteins in equine seminal plasma. 2000.
    144. Rodriguez-Sallaberry C, Michel FJ, Zhao G, Simmen FA, Simmen RCM. Polyamine regulation of porcine endometrial cell proliferation during peri-implantation. 2000; 261.
    145. Zhang D, Zhang X-L, Simmen FA, Simmen RCM. Progesterone (P) alters functional interactions between its receptor and Sp-related transcription factors: mechanism for P control of endometrial gene expression?. 2000; 228.
    146. Kowalski AA, Graddy LG, Choi I, Katzenellenbogen BS, Simmen FA, Simmen RCM. Expression of estrogen receptor (ER)-alpha and beta and progesterone receptor (PR) by porcine embryos suggests potential autocrine functions in development. 2000; 106.
    147. Huisden CM, Simmen RCM, Simmen FA. Expression of estrogen biosynthetic enzyme and steroid receptor genes in porcine fetal brain. 2000; 52.
    148. Min S-H, Simmen RCM, Porter CW, Janne J, Simmen FA. Over-expression of spermidine/spermine N1 acetyltransferase (SSAT) alters genome expression profiles in the reproductive organs of female mice. 2000; 117.
    149. Badinga L, Song S, Simmen RC, Clarke JB, Clemmons DR, Simmen FA. Complex mediation of uterine endometrial epithelial cell growth by insulin-like growth factor-II (IGF-II) and IGF-binding protein-2. J Mol Endocrinol. 1999 Dec; 23(3):277-85. PMID: 10601973.
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    150. Simmen RC, Chung TE, Imataka H, Michel FJ, Badinga L, Simmen FA. Trans-activation functions of the Sp-related nuclear factor, basic transcription element-binding protein, and progesterone receptor in endometrial epithelial cells. Endocrinology. 1999 Jun; 140(6):2517-25. PMID: 10342837.
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    151. Severgnini S, Lowenthal DT, Millard WJ, Simmen FA, Pollock BH, Borst SE. Altered IGF-I and IGFBPs in senescent male and female rats. J Gerontol A Biol Sci Med Sci. 1999 Mar; 54(3):B111-5. PMID: 10191834.
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    152. Rodriguez-Sallaberry C, Kwak I, Michel FJ, Simmen FA, Simmen RCM. Insulin-like growth factor-I regulation of porcine endometrial spermidine/spermine N1-acetyltransferase (SSAT) gene expression at peri-implantation. 1999; 210.
    153. Graddy LG, Liberles DA, Benner SA, Kowalski AA, Schreiber D, Simmen FA, Simmen RCM. The molecular evolution of aromatase: a potential novel function in the pig. 1999; 23.
    154. Kwak I, Simmen RCM, Simmen FA. Functional roles of uterine estrogen receptors (ER): activation of IGF-I and inhibition of IGFBP-2 gene transcription by ER-alpha, but not ER-beta, in human endometrial adenocarcinoma cells (Hee1-A). 1999; 495.
    155. Kwak I, Hammond JM, Simmen FA. Two novel exons of the porcine insulin-like growth factor-I (IGF-I) gene are alternatively spliced in endometrium and ovary. 1999; 409.
    156. Lee CY, Kwak I, Simmen RCM, Simmen FA. Molecular cloning of the porcine acid-labile subunit (ALS) of the 150-kilodalton IGF-binding protein complex. 1999; 411.
    157. Rodriguez-Sallaberry, CJ, Kwak I, Michel FJ, Simmen FA, Green ML, Simmen RCM. Differential expression of spermidine/spermine N1-acetyltransferase (SSAT) during early pregnancy in pigs. 1999; 22.
    158. Richardson RL, Hausman GJ, Simmen FA. Adipogenesis in early fetal pig stromalvascular cells: insulin-like growth factor-2 (IGF) and IGF binding protein (BP) 2 and 4. 1999; A257.
    159. Green ML, Chung TE, Reed KL, Modric T, Badinga L, Yang J, Simmen FA, Simmen RC. Paracrine inducers of uterine endometrial spermidine/spermine N1-acetyltransferase gene expression during early pregnancy in the pig. Biol Reprod. 1998 Nov; 59(5):1251-8. PMID: 9780334.
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    160. Badinga L, Song S, Simmen RC, Simmen FA. A distal regulatory region of the insulin-like growth factor binding protein-2 (IGFBP-2) gene interacts with the basic helix-loop-helix transcription factor, AP-4. Endocrine. 1998 Jun; 8(3):281-9. PMID: 9741833.
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    161. Lee CY, Green ML, Simmen RC, Simmen FA. Proteolysis of insulin-like growth factor-binding proteins (IGFBPs) within the pig uterine lumen associated with peri-implantation conceptus development. J Reprod Fertil. 1998 Mar; 112(2):369-77. PMID: 9640276.
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    162. Simmen FA, Badinga L, Green ML, Kwak I, Song S, Simmen RC. The porcine insulin-like growth factor system: at the interface of nutrition, growth and reproduction. J Nutr. 1998 02; 128(2 Suppl):315S-320S. PMID: 9478014.
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    163. Badinga L, Simmen RCM, Simmen FA. Insulin-like growth factor-II (IGF-II) and insulin-like growth factor-binding protein-2 (IGFBP-2) stimulate uterine epithelial cell proliferation through distinct signaling pathways. 1998; 310-311.
    164. Simmen FA, Kowalski A, Graddy L, Baumgartner W, Neece D, Sunden SLF, Simmen RCM. Isolation and characterization of novel BAC clones containing member(s) of the porcine aromatase gene family. 1998; 95.
    165. Lee CY, Green ML, Simmen RCM, Simmen FA. Insulin-like growth factor-binding proteins (IGFBPs) secreted into the pig uterine lumen are proteolyzed in temporal association with conceptus elongation. 1998; OR2-3.
    166. Richardson RL, Hausman GJ, Simmen FA. Neutralization of insulin-like growth factor-binding protein-2 (IGFBP-2) in serum-free cultures of porcine stromal-vascular cells increases adipocyte differentiation. 1998; A852.
    167. Kwak I, Song S, Badinga L, Simmen RCM, Simmen FA. Transcriptional motifs of the insulin-like growth factor-binding protein-2 (IGFBP-2) gene in endometrium. 1998; 318.
    168. Wang Y, Michel FJ, Wing A, Simmen FA, Simmen RC. Cell-type expression, immunolocalization, and deoxyribonucleic acid-binding activity of basic transcription element binding transcription factor, an Sp-related family member, in porcine endometrium of pregnancy. Biol Reprod. 1997 Oct; 57(4):707-14. PMID: 9314570.
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    169. Choi I, Troyer DL, Cornwell DL, Kirby-Dobbels KR, Collante WR, Simmen FA. Closely related genes encode developmental and tissue isoforms of porcine cytochrome P450 aromatase. DNA Cell Biol. 1997 Jun; 16(6):769-77. PMID: 9212170.
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    170. Choi I, Collante WR, Simmen RC, Simmen FA. A developmental switch in expression from blastocyst to endometrial/placental-type cytochrome P450 aromatase genes in the pig and horse. Biol Reprod. 1997 Mar; 56(3):688-96. PMID: 9047015.
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    171. Kwak I, Perera OP, Chung TE, Collante W, Simmen RCM, Simmen FA. Transcription of the insulin-like growth factor-I (IGF-I) gene in porcine endometrium: promoter usage and putative enhances in pregnancy. 1997; 84.
    172. Hammond JM, Samaras SE, Canning SF, Barber JA, Kwak I, Simmen FA. FSH-dependent IGF-I transcription by porcine granulosa cells. 1997; 230.
    173. Modric T, Green ML, Simmen RCM, Simmen FA. Expression and function of leukemia inhibitory factor and interleukin-6 genes during porcine pregnancy. 1997; 202.
    174. Green ML, Reed KL, Chung TE, Simmen FA, Simmen RCM. Effect of insulin-like growth factor-I (IGF-I), retinol and interleukin-6 (IL-6) on in vitro expression of spermidine/spermine N1-acetyltransferase (SSAT) in porcine endometrium. 1997; 85.
    175. Badinga L, Song S, Yang J, Collante WR, Simmen RCM, Simmen FA. Recombinant porcine insulin-like growth factor-binding protein-2 (IGFBP-2) interacts with human insulin-like growth factor-2 (IGF-II) to modulate human and porcine uterine epithelial cell proliferation. 1997; 104.
    176. Green ML, Blaeser LL, Simmen FA, Simmen RC. Molecular cloning of spermidine/spermine N1-acetyltransferase from the periimplantation porcine uterus by messenger ribonucleic acid differential display: temporal and conceptus-modulated gene expression. Endocrinology. 1996 Dec; 137(12):5447-55. PMID: 8940370.
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    177. Buhi WC, Alvarez IM, Choi I, Cleaver BD, Simmen FA. Molecular cloning and characterization of an estrogen-dependent porcine oviductal secretory glycoprotein. Biol Reprod. 1996 Dec; 55(6):1305-14. PMID: 8949888.
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    178. Samaras SE, Canning SF, Barber JA, Simmen FA, Hammond JM. Regulation of insulin-like growth factor I biosynthesis in porcine granulosa cells. Endocrinology. 1996 Nov; 137(11):4657-64. PMID: 8895330.
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    179. Kirby CJ, Thatcher WW, Collier RJ, Simmen FA, Lucy MC. Effects of growth hormone and pregnancy on expression of growth hormone receptor, insulin-like growth factor-I, and insulin-like growth factor binding protein-2 and -3 genes in bovine uterus, ovary, and oviduct. Biol Reprod. 1996 Nov; 55(5):996-1002. PMID: 8902209.
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    180. de la Sota RL, Simmen FA, Diaz T, Thatcher WW. Insulin-like growth factor system in bovine first-wave dominant and subordinate follicles. Biol Reprod. 1996 Oct; 55(4):803-12. PMID: 8879493.
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    181. Song S, Lee CY, Green ML, Chung CS, Simmen RC, Simmen FA. The unique endometrial expression and genomic organization of the porcine IGFBP-2 gene. Mol Cell Endocrinol. 1996 Jul 01; 120(2):193-202. PMID: 8832579.
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    182. Choi I, Simmen RC, Simmen FA. Molecular cloning of cytochrome P450 aromatase complementary deoxyribonucleic acid from periimplantation porcine and equine blastocysts identifies multiple novel 5'-untranslated exons expressed in embryos, endometrium, and placenta. Endocrinology. 1996 Apr; 137(4):1457-67. PMID: 8625924.
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    183. Green ML, Blaeser LL, Simmen FA, Simmen RCM. Molecular cloning of spermidine/spermine N1-acetyltransferase (SSAT) from the porcine uterus by mRNA differential display: temporal and conceptus-modulated gene expression during early pregnancy. 1996; 103.
    184. Green ML, Simmen RC, Simmen FA. Developmental regulation of steroidogenic enzyme gene expression in the periimplantation porcine conceptus: a paracrine role for insulin-like growth factor-I. Endocrinology. 1995 Sep; 136(9):3961-70. PMID: 7649105.
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    185. Lucy MC, Thatcher WW, Collier RJ, Simmen FA, Ko Y, Savio JD, Badinga L. Effects of somatotropin on the conceptus, uterus, and ovary during maternal recognition of pregnancy in cattle. Domest Anim Endocrinol. 1995 Jan; 12(1):73-82. PMID: 7542581.
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    186. Choi I, Simmen RCM, Simmen FA. Molecular cloning from the peri-implantation porcine blastocyst of full-length cytochrome P450 aromatase cDNAs exhibiting differential polyadenylation and a unique 5' untranslated sequence. 1995; 618.
    187. Simmen RCM, Green ML, Simmen FA. Proceedings of Serono Symposium on Molecular and Cellular Aspects of Periimplantation Processes. IGF system in periimplantation uterus and embryonic development. 1995.
    188. Borst SE, Perera OP, Choi I, Simmen FA. Reduced IGF-I mRNA in liver of senescent BN/F344 rats. 1995.
    189. Green ML, Simmen FA, Simmen RCM. Differential expression of endometrial genes in the periimplantation porcine uterus. 1995; 117.
    190. Song S, Simmen RCM, Simmen FA. Identification of 5' flanking DNA sequences that mediate endometrial expression of the insulin-like growth factor-binding protein-2 (IGFBP-2) gene. 1995; 165.
    191. Simmen FA. Mammary growth factors and neonatal development. 1995; 4.
    192. Simmen FA. Mammary growth factors and neonatal development. 1995; 4.
    193. De la Sota RL, Simmen FA, Thatcher WW. Integration of endocrine and molecular responses in bovine follicles by stepwise regression and correlation analyses. 1995; 157.
    194. Simmen FA. Transgenesis in creatures great and small Transgenic Animal Technology. A Laboratory Handbook Edited by Carl A. Pinkert San Diego: Academic Press, Inc. (1994). 364 pp. Theriogenology. 1994 Aug 01; 42(2):213-5. PMID: 16727527.
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    195. Green ML, Simmen FA, Simmen RCM. Differentially-expressed mRNAs containing sine sequences in peri-implantation porcine endometrium. 1994; 33.
    196. Ko Y, Choi I, Green ML, Simmen FA, Simmen RC. Transient expression of the cytochrome P450 aromatase gene in elongating porcine blastocysts is correlated with uterine insulin-like growth factor levels during peri-implantation development. Mol Reprod Dev. 1994 Jan; 37(1):1-11. PMID: 8129925.
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    197. Choi I, Simmen FA. Molecular cloning of the porcine cytochrome P450 aromatase chromosomal gene, a transiently and highly expressed gene of the expanding blastocyst. 1994; 142.
    198. De la Sota RL, Good TEM, Ireland JLH, Ireland JJ, Simmen FA, Thatcher WW. Analysis of different forms of intrafollicular inhibit and inhibit A-subunited during ovarian follicular dominance in cattle. 1994; 162.
    199. Song S, Lee CY, Collante W, Chung CS, Simmen FA. Endometrial expression, chromosomal organization and potential 5'-regulatory sequences of the porcine insulin-like growth factor-binding protein-2 gene. 1994; 438.
    200. Buhi WC, Alvarez IM, Choi I, Simmen FA. A recombinant cDNA to a porcine oviductal estrogen-dependent secretory glycoprotein (POESP). 1994; 165.
    201. Reinhart GA, Mahan DC, Lepine AJ, Simmen FA, Moore BE. Dietary clofibric acid increases intestinal fatty acid binding protein activity and apparent lipid digestibility in weanling swine. J Anim Sci. 1993 Oct; 71(10):2693-9. PMID: 8226370.
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    202. Lee CY, Bazer FW, Simmen FA. Expression of components of the insulin-like growth factor system in pig mammary glands and serum during pregnancy and pseudopregnancy: effects of oestrogen. J Endocrinol. 1993 Jun; 137(3):473-83. PMID: 7690391.
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    203. Lee CY, Chung CS, Simmen FA. Ontogeny of the porcine insulin-like growth factor system. Mol Cell Endocrinol. 1993 May; 93(1):71-80. PMID: 7686518.
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    204. Simmen RCM, Simmen FA. The insulin-like growth factor (IGF) system in maternal-embryo signalling. 1993.
    205. Simmen FA. Biotechnology and animal production. 1993; 5.
    206. Choi I, Ko Y, Simmen RCM, Simmen FA. Expression of cytochrome P-450 aromatase in peri-implantation porcine conceptuses is correlated with insulin-like growth factor levels in uterine luminal fluids. 1993; 176.
    207. De la Sota RL, Schmitt E, Simmen FA, Thatcher WW. Endocrine changes associated with ovarian follicular dominance in cattle. 1993; 122.
    208. Needham GR, Jaworski DC, Lamoreaux W, Coons LB, Muller MT, Simmen FA. Homology of an Ixodid tick salivary gland protein with calreticulin. 1993; 8.
    209. Simmen FA, Simmen RC, Geisert RD, Martinat-Botte F, Bazer FW, Terqui M. Differential expression, during the estrous cycle and pre- and postimplantation conceptus development, of messenger ribonucleic acids encoding components of the pig uterine insulin-like growth factor system. Endocrinology. 1992 Mar; 130(3):1547-56. PMID: 1537304.
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    210. Lucy MC, Thatcher WW, Savio JD, Danet-Desnoyers G, Moser MT, Badinga L, Simmen FA, Collier RJ. Effect of bovine somatotropin on ovarian follicles, corpora lutea (CL) and embryos during early pregnancy in cattle. 1992; 271.
    211. Reinhart GA, Simmen FA, Mahan DC, White ME, Roehrig KL. Intestinal development and fatty acid binding protein activity of newborn pigs fed colostrum or milk. Biol Neonate. 1992; 62(2-3):155-63. PMID: 1420614.
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    212. Simmen FA. Large Dairy Herd Management. Present and Future Effects of Biotechnology. 1992.
    213. Moser MT, Simmen FA. Pregnancy-associated expression of messenger ribonucleic acid (mRNA) encoding insulin-like growth factor binding protein-2 in ovine and equine endometrium. 1992; 141.
    214. Lee CY, Chung CS, Simmen FA. An evaluation of liver as the major endocrine site of insulin-like growth factor production in the pig. 74th Ann. Mtg. of the Endocrine Society. 1992; 344.
    215. Geisert RD, Lee CY, Simmen FA, Zavy MT, Fliss AE, Bazer FW, Simmen RC. Expression of messenger RNAs encoding insulin-like growth factor-I, -II, and insulin-like growth factor binding protein-2 in bovine endometrium during the estrous cycle and early pregnancy. Biol Reprod. 1991 Dec; 45(6):975-83. PMID: 1725270.
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    216. Bishop MD, Tavakkol A, Threadgill DW, Simmen FA, Simmen RC, Davis ME, Womack JE. Somatic cell mapping and restriction fragment length polymorphism analysis of bovine insulin-like growth factor I. J Anim Sci. 1991 Nov; 69(11):4306-11. PMID: 1684360.
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    217. Hofig A, Michel FJ, Simmen FA, Simmen RC. Constitutive expression of uterine receptors for insulin-like growth factor-I during the peri-implantation period in the pig. Biol Reprod. 1991 Oct; 45(4):533-9. PMID: 1661183.
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    218. Hofig A, Simmen FA, Bazer FW, Simmen RC. Effects of insulin-like growth factor-I on aromatase cytochrome P450 activity and oestradiol biosynthesis in preimplantation porcine conceptuses in vitro. J Endocrinol. 1991 Aug; 130(2):245-50. PMID: 1833500.
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    219. Ko Y, Lee CY, Ott TL, Davis MA, Simmen RC, Bazer FW, Simmen FA. Insulin-like growth factors in sheep uterine fluids: concentrations and relationship to ovine trophoblast protein-1 production during early pregnancy. Biol Reprod. 1991 Jul; 45(1):135-42. PMID: 1878428.
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    220. Lee CY, Bazer FW, Etherton TD, Simmen FA. Ontogeny of insulin-like growth factors (IGF-I and IGF-II) and IGF-binding proteins in porcine serum during fetal and postnatal development. Endocrinology. 1991 May; 128(5):2336-44. PMID: 1708333.
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    221. Simmen FA. Expression of the insulin-like growth factor-I gene and its products: complex regulation by tissue specific and hormonal factors. Domest Anim Endocrinol. 1991 Apr; 8(2):165-78. PMID: 2070595.
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    222. Bishop MD, Simmen RCM, Simmen FA, Davis ME. Repeatability and rank correlations for serum insulin-like growth factor (IGF-I) from birth through puberty in Angus beef cattle. 1991; 8.
    223. Bazer FW, Simmen RC, Simmen FA. Comparative aspects of conceptus signals for maternal recognition of pregnancy. Ann N Y Acad Sci. 1991; 622:202-11. PMID: 2064181.
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    224. Simmen RC, Simmen FA, Bazer FW. Regulation of synthesis of uterine secretory proteins: evidence for differential induction of porcine uteroferrin and antileukoproteinase gene expression. Biol Reprod. 1991 Jan; 44(1):191-200. PMID: 2015349.
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    225. Simmen FA, Simmen RC. Peptide growth factors and proto-oncogenes in mammalian conceptus development. Biol Reprod. 1991 Jan; 44(1):1-5. PMID: 2015340.
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    226. Simmen FA, Lee CY, KoY, Head HH. Growth promoting proteins in bovine colostrum and milk: Identification and potential applications in animal biotechnology. 1991; 4.
    227. Ko Y, Simmen RCM, Simmen FA. Identification of uterine endometrial epithelial cell growth factors: Stimulation by IGF-I/-II and inhibition by TGF-beta1 of endometrial cell growth in vitro. 1991; 220.
    228. Lee CY, Hauser S, Krivi GG, Bazer FW, Simmen FA. Temporal expression during pregnancy of messenger RNAs encoding insulin-like growth factors (IGFs) -I and -II, type I IGF receptors and growth hormone (GH) receptors in pig mammary glands. 1991; 221.
    229. Geisert RD, Lee CY, Simmen FA, Zavy MT, Fliss AE. Expression of mRNAs encoding insulin-like growth factor-I, -II and insulin-like growth factor binding protein-2 in bovine endometrium during the estrous cycle and early pregnancy. 1991; 53.
    230. Simmen FA. Strategies for identifying, isolating and sequencing genes of importance in growth biology. 1991; 14.
    231. Bazer FW, Simmen RCM, Simmen FA. The Primate Endometrium. Comparative Aspects of Conceptus Signals for Maternal Recognition of Pregnancy. 1991.
    232. Reinhart GA, Simmen FA, Mahan DC, Simmen RC, White ME. Isolation, characterization, and developmental expression of pig intestinal fatty acid-binding proteins. J Nutr Biochem. 1990 Nov; 1(11):592-8. PMID: 15539179.
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    233. Simmen RC, Simmen FA, Hofig A, Farmer SJ, Bazer FW. Hormonal regulation of insulin-like growth factor gene expression in pig uterus. Endocrinology. 1990 Nov; 127(5):2166-74. PMID: 2171908.
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    234. Leaman DW, Simmen FA, Ramsay TG, White ME. Insulin-like growth factor-I and -II messenger RNA expression in muscle, heart, and liver of streptozotocin-diabetic swine. Endocrinology. 1990 Jun; 126(6):2850-7. PMID: 2190798.
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    235. Simmen FA, Whang KY, Simmen RC, Peterson GA, Bishop MD, Irvin KM. Lactational variation and relationship to postnatal growth of insulin-like growth factor-I in mammary secretions from genetically diverse sows. Domest Anim Endocrinol. 1990 Apr; 7(2):199-206. PMID: 2369820.
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    236. Schober DA, Simmen FA, Hadsell DL, Baumrucker CR. Perinatal expression of type I IGF receptors in porcine small intestine. Endocrinology. 1990 Feb; 126(2):1125-32. PMID: 2153520.
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    237. Simmen RC, Simmen FA. Regulation of uterine and conceptus secretory activity in the pig. J Reprod Fertil Suppl. 1990; 40:279-92. PMID: 2192044.
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    238. Tan TJ, Schober DA, Simmen FA. Fibroblast mitogens in swine milk include an epidermal growth factor-related peptide. Regul Pept. 1990 Jan; 27(1):61-74. PMID: 2309048.
      View in: PubMed
    239. Hofig A, Simmen FA, Simmen RCM. Endometrial receptors for insulin-like growth factor-I in preimplantation pig uterus. 1990.
    240. Jaworski DC, Rosell R, Coons LB, Muller MT, Simmen FA, Needham GR. Evidence that a 90 kDa salivary gland polypeptide is a cement component. 1990; 28.
    241. Bishop MD, Park NH, Simmen RCM, Simmen FA, Davis ME. Prediction of carcass traits using insulin-like growth factor-I (IGF-I) in Angus beef cattle. 1990; 241.
    242. Hofig A, Simmen FA, Simmen RCM. Effects of dihydroepiandrosterone (DHEA), insulin-like growth factor (IGF-I), and insulin (I) on estradiol production by porcine conceptuses in vitro. 1990; 135.
    243. Simmen FA. Developmental regulation of porcine messenger FNAs encoding insulin-like growth factors (IGFs) and an IGF binding protein. 1990; 1993.
    244. Bishop MD, Simmen RCM, Simmen FA, Davis ME. Repeatability and rank correlations for serum insulin-like growth factor I (IGF-I) from birth through puberty in Angus beef cattle. 1990; 241.
    245. Lee CY, Simmen FA, Bazer FW. Serum concentrations of insulin-like growth factors I and II during fetal and postnatal development of pigs. 1990; 309.
    246. Simmen FA. Biotechnology in animal production. 1990; 6.
    247. Bishop MD, Threadgill DW, Simmen RCM, Simmen FA, Tavakkol A, Davis ME, Womack JE. Somatic cell mapping and restriction fragment analysis of bovine insulin-like growth factor I (IGF-I). 1990; 242.
    248. Bishop MD, Davis ME, Simmen FA, Simmen RCM. Relationships of IGF-I concentration in colostrum with expected progeny differences of cows and preweaning growth of progeny. 1990; 70.
    249. Ko Y, Lee CY, Ott TL, Davis MA, Simmen RCM, Bazer FW, Simmen FA. Identification of insulin-like growth factors and other mitogens in uterine fluids of early pregnant sheep. 1990; 281.
    250. Simmen RCM, Simmen FA. Control of Pig Reproduction III. Regulation of Uterine and Conceptus Secretory Activity in the Pig. 1990.
    251. Simmen RCM, Simmen FA, Bazer FW, Ko Y, Lee CY, Hofig A. Growth factors in maternal-conceptus interactions. 1990.
    252. Simmen FA. Biotechnology in dairy production. 1990; 6.
    253. Letcher R, Simmen RC, Bazer FW, Simmen FA. Insulin-like growth factor-I expression during early conceptus development in the pig. Biol Reprod. 1989 Dec; 41(6):1143-51. PMID: 2483128.
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    254. Bishop MD, Simmen RC, Simmen FA, Davis ME. The relationship of insulin-like growth factor-I with postweaning performance in Angus beef cattle. J Anim Sci. 1989 Nov; 67(11):2872-80. PMID: 2592275.
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    255. Simmen RC, Simmen FA, Ko Y, Bazer FW. Differential growth factor content of uterine luminal fluids from large white and prolific Meishan pigs during the estrous cycle and early pregnancy. J Anim Sci. 1989 Jun; 67(6):1538-45. PMID: 2768111.
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    256. Bishop MD, Simmen RCM, Simmen FA, Davis ME. Insulin-like growth factor I (IGF-I): Phenotype relationship with weight gain, feed consumption and feed conversion during postnatal development in Angus beef cattle and the possiblity for genetic diversity. Ann. Mtg. of Midwest Section of American Soc. Anim. Sci. 1989; 82-83, 67 (Suppl. 2).
    257. Schober DA, Simmen FA, Hadsell DL, Baumrucker C. Characterization and ontogeny of expression of IGF receptors in the small intestine of neonatal pigs. Ann. Mtg. of the Endocrine Society. 1989; 48.
    258. Jaworski DC, Needham GR, Sherif N, Muller MT, Simmen FA. Characterization of the gene products from cDNA expression libraries of the salivary glands of unfed and feeding lone star ticks. 1989; 10.
    259. Reinhart GA, Mahan DC, White ME, Simmen FA, Simmen RCM. Ontogeny of fatty acid binding proteins in the proximal intestine of the young pig. 1989; 229-230.
    260. Simmen FA, Simmen RCM, Bazer FW. Maternal growth factors as mediators of embryonic and neonatal growth. 1989; 3.
    261. Reinhart GA, Mahan DC, Simmen FA, Simmen RCM, White ME. The effect of mammary secretions on intestinal development in the newborn pig. 1989; 236-237.
    262. Farmer SJ, Simmen RCM, Simmen FA. Pregnancy-associated uterine expression of the mRNA encoding porcine anti-leukoproteinase inhibitor. Ann Mtg of American Society of Cell Biology. 1989; 615a.
    263. Letcher LR, Simmen RCM, Bazer FW, Simmen FA. Insulin-like growth factor-I in the pregnant pig: Developmental expression during uterine and embryonic growth. UCLA Symp.: Early embryo develpment and paracrine relationships. 1989; 198.
    264. Simmen FA, Simmen RCM, Letcher LR, Schober DA, Ko Y. Molecular and Cellular Biology of Insulin-like Growth Factors and their Receptors. IGFs in pregnancy: Developmental expression in uterus and mammary gland and paracrine actions during embryonic and neonatal growth. 1989.
    265. Whang KY, Simmen FA, Simmen RCM. Insulin-like growth factor-I in mammary secretions from growth-selected lines of pigs: characterization and correlation with neonatal growth rate. 14th International Congress of Nutrition. 1989.
    266. Simmen FA, Simmen RC, Reinhart G. Maternal and neonatal somatomedin C/insulin-like growth factor-I (IGF-I) and IGF binding proteins during early lactation in the pig. Dev Biol. 1988 Nov; 130(1):16-27. PMID: 2460388.
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    267. Tavakkol A, Simmen FA, Simmen RC. Porcine insulin-like growth factor-I (pIGF-I): complementary deoxyribonucleic acid cloning and uterine expression of messenger ribonucleic acid encoding evolutionarily conserved IGF-I peptides. Mol Endocrinol. 1988 Aug; 2(8):674-81. PMID: 3211153.
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    268. Simmen RC, Ko Y, Liu XH, Wilde MH, Pope WF, Simmen FA. A uterine cell mitogen distinct from epidermal growth factor in porcine uterine luminal fluids: characterization and partial purification. Biol Reprod. 1988 Apr; 38(3):551-61. PMID: 3259897.
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    269. Simmen FA, Simmen RCM, Bazer FW. Maternal growth factors as mediators of embryonic and neonatal growth. 1988; 9.
    270. Simmen FA, Simmen RCM, Letcher LR, Tavakkol A, Bazer FW. Tissue-specific and developmental exprssion of insulin-like growth factor-I in the pregnant and lactating pig. 1988.
    271. Ko Y, Simmen RCM, Simmen FA. Identification and partial purification of a mitogen in porcine allantoic fluids. 1988; 421.
    272. Bishop MD, Simmen RCM, Simmen FA, Davis ME. The relationship of insulin-like growth factor I to postweaning performance in Angus beef cattle. 1988; 275.
    273. Reinhart GA, Simmen FA, Mahan DC, Simmen RCM. Species specificity of porcine fatty acid binding proteins. 1988; 32.
    274. Tan TJ, Simmen FA. Multiple low molecular weight mitogenic factors in porcine milk include an epidermal growth factor related peptide. 1988.
    275. Tan TJ, Simmen FA, Cera K. Multiple mitogenic factors in porcine milk include an epidermal growth factor related peptide. 1988; 262.
    276. Tavakkol A, Simmen RCM, Simmen FA. Complementary DNA cloning and uterine expression of messenger RNAs encoding porcine insulin-like growth factor-I. 1988; 235.
    277. Tavakkol A, Simmen RCM, Simmen FA. Characterization of complementary deoxyribonucleic acid (cDNA) for porcine insuline-like growth factor-I (IGF-I): A probe for analysis of IGF-I involvement in growth of reproductive organs in the pig model. 1988.
    278. Simmen FA. Expression of the avian c-erb B (EGF receptor) protooncogene during estrogen-promoted oviduct growth. Biochim Biophys Acta. 1987 Nov 20; 910(2):182-8. PMID: 3676321.
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    279. Simmen FA, McClure KE. Differential expression in ovine colostrum and milk of a mitogenic factor for embryonic (AKR-2B) fibroblasts. 1987; 241.
    280. Tan TJ, Simmen RCM, Simmen FA. Differential expression of insulin-like growth factor I and other fibroblast mitogens in porcine colostrum and milk. American Society for Biological Chemistry. 1987.
    281. Jaworski DC, Needham GR, Muller MT, Simmen FA. Some molecular aspects of tick-host interactions. 1987.
    282. Reinhart GA, Simmen FA, Mahan DC, Simmen RCM. Identification and isolation of a fatty acid binding protein from porcine intestinal mucosa. 1987; 306-307.
    283. Yoder J, Jaworski D, Needham G, Simmen FA. Characterization of a lone star tick salivary gland cDNA expression library. 1987.
    284. Jaworski DC, Needham GR, Muller MT, Sherif N, Simmen FA. Partial characterization of immunogenic proteins from salivary glands of fed and unfed lone star ticks. 1986.
    285. Simmen FA, Cera K, Reinhart G, Mahan DC. Polypeptide growth factors in porcine colostrum: Biochemical characterization and effects on neonatal growth parameters. 1986; 96-97.
    286. Simmen FA, Cera K, Frost L, Mahan DC. Novel fibroblast and epithelial cell mitogens isolated from porcine colostrum. Annual Meeting of the American Society for Cell Biology. 1986; 298a.
    287. Cera K, Mahan DC, Simmen FA. In vitro growth promoting activity of porcine mammary secretions. 1986; 86.
    288. Simmen RCM, Wilde MH, Pope WF, Simmen FA. Porcine uterine luminal fluid contains epithelial cell growth stimulating factors. Annual Mtg of the American Society for Cell Biology. 1986; 154a.
    289. Simmen FA, Cera K, Mahan DC. In vitro analysis of porcine-mammary-derived growth factors. 18th Miami Winter Symposium, Advances in Gene Technology. 1986; 146-147.
    290. Simmen FA. Potential impact and applications of biotechnology to the swine industry: An overview. 1985; 4.
    291. Simmen FA, Schulz TZ, O'Malley BW. Expression of the chick cellular erb B locus is regulated by steroid hormones. 69th Ann. Mtg. of FASEB. 1985; 658.
    292. Simmen FA, Headon DR, Schulz TZ, Gope M, Wright DA, Carpenter G, O'Malley BW. Methodological Surveys in Biochemistry and Analysis: Investigation and Exploitation of Antibody Combining Sites. Antibody screening of cDNA libraries. 1985.
    293. Simmen FA, Gope ML, Schulz TZ, Wright DA, Carpenter G, O'Malley BW. Isolation of an evolutionarily conserved epidermal growth factor receptor cDNA from human A431 carcinoma cells. Biochem Biophys Res Commun. 1984 Oct 15; 124(1):125-32. PMID: 6093780.
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    294. Tsai MJ, Tsai SY, Baez M, Simmen FA, O'Malley, BW. Laboratory Methods Manual for Hormone Action and Molecular Endocrinology. Expression of Eucaryotic Genes: Transcription and Analysis. 1984; 13.
    295. Simmen FA, Gope ML, Schulz TZ, Carpenter G, Wright DA, O'Malley BW. Human epidermal growth factor receptor proteins: Analysis of messenger RNA by translation in Xenopus oocytes and cDNA cloning. 1984; 46.
    296. Simmen FA, Schulz TZ, Gope ML, Wright DA, Carpenter G, O'Malley BW. Human epidermal growth factor receptor proteins: Analysis of messenger RNA by translation in Xenopus oocytes and cDNA cloning. 1984.
    297. Simmen FA, Schulz TZ, Headon DR, Gossett LA, Carpenter G, O'Malley BW. Translation and glycosylation of the human epidermal growth factor receptor in Xenopus laevis oocytes. 7th Int'l Congress of Endocrinology. 1984; 1476.
    298. Simmen FA. Characterization of the ribosomal RNA genes in the Hawaiian sea urchin, Tripneustes gratilla. PhD Thesis. 1981.
    299. Pabona JM, Zeng Z, Velarde MC, Simmen FA, Simmen RCM. Nuclear receptor coregulators Kruppel-like Factor 9 and Prohibitin 2 expression in estrogen-stimulated proliferation of mouse uterine endometrial cells. 3-37.
    300. Simmons C, Pabona JMP, Burnett A, Friedman T, Spataro M, Gaddy D, Simmen FA, Simmen RCM. Transcription factor Kruppel-like factor 9 (KLF9) as potential predictor of dysfunctional estrogen receptro-alpha signaling in the uterus.
    301. Simmen FA, Xiao R, Su Y, Simmen RCM. Nutrigenomics in cancer prevention: bountiful harvest of putative pathways and cognate dietary mediators.
    302. Pabona JMP, Simmen FA, Nikiforov MA, Zhuang D, Giudice LC, Simmen RCM. Wnt antagonist DKK1 is a target of Kruppel-like factor 9 (KLF9) in endometrial stromal cells: implications for uterine receptivity. 92nd Annual Meeting of the Endocrine Society.
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