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William Gentry

TitleDepartment Chairperson
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentAnesthesiology, College of Medicine
AddressB112 Biomedical Research I
324 UAMS Campus Dr.
Mail Slot # 515
Little Rock AR 72205
Phone501-686-6119
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPharmacology and Toxicology, College of Medicine


    Collapse Research Funds 
    Collapse principal investigator
    Pass Through Agency: InterveXion Therapeutics, LLC - Funding Agency: NIH/Nat. Inst. on Drug Abuse - Title: STAMPOUT: A Phase 2a Study of Antibody for Methamphetamine Outpatient Therapy - Award Number: 1 U01 DA045366-01 - Start Date: 2017-10-01

    Pass Through Agency: InterveXion Therapeutics, LLC - Funding Agency: NIH/Nat. Inst. on Drug Abuse - Title: STAMPOUT: A Phase 2a Study of Antibody for Methamphetamine Outpatient Therapy - Award Number: 5 U01 DA045366-02 - Start Date: 2017-10-01

    Pass Through Agency: InterveXion Therapeutics, LLC - Funding Agency: NIH/Nat. Inst. on Drug Abuse - Title: STAMPOUT: A Phase 2a Study of Antibody for Methamphetamine Outpatient Therapy - Award Number: 5 U01 DA045366-03 - Start Date: 2017-10-01

    Pass Through Agency: InterveXion Therapeutics, LLC - Funding Agency: NIH/Nat. Inst. on Drug Abuse - Title: Transition to Human Phase 1b Trials: Nonclinical Studies of an Anti-METH mAb - Award Number: 1 U01 DA037593-01A1 - Start Date: 2014-09-15

    Pass Through Agency: InterveXion Therapeutics, LLC - Funding Agency: NIH/Nat. Inst. on Drug Abuse - Title: Transition to Human Phase 1b Trials: Nonclinical Studies of an Anti-METH mAb - Award Number: 5 U01 DA037593-02 - Start Date: 2014-09-15

    Pass Through Agency: InterveXion Therapeutics, LLC - Funding Agency: NIH/Nat. Inst. on Drug Abuse - Title: Transition to Human Phase 1b Trials: Nonclinical Studies of an Anti-METH mAb - Award Number: 5 U01 DA037593-03 - Start Date: 2014-09-15

    Pass Through Agency: InterveXion Therapeutics, LLC - Funding Agency: NIH/Nat. Inst. on Drug Abuse - Title: Transition to Human Phase 1b Trials: Nonclinical Studies of an Anti-METH mAb - Award Number: 5 U01 DA037593-04 - Start Date: 2014-09-15

    Pass Through Agency: InterveXion Therapeutics, LLC - Funding Agency: NIH/Nat. Inst. on Drug Abuse - Title: Transition to Human Phase 1b Trials: Nonclinical Studies of an Anti-METH mAb - Award Number: 1 U01 DA037593-01A1 - Total direct costs: $1,668,758 - Start Date: 2014-09-15


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Laurenzana EM, Stevens MW, Frank JC, Hambuchen MD, Hendrickson HP, White SJ, Williams DK, Owens SM, Gentry WB. Pharmacological effects of two anti-methamphetamine monoclonal antibodies. Supporting data for lead candidate selection for clinical development. Hum Vaccin Immunother. 2014; 10(9):2638-47. PMID: 25483484; PMCID: PMC4852362.
      View in: PubMed, PubMed Central
    2. White SJ, Hendrickson HP, Atchley WT, Laurenzana EM, Gentry WB, Williams DK, Owens SM. Treatment with a monoclonal antibody against methamphetamine and amphetamine reduces maternal and fetal rat brain concentrations in late pregnancy. Drug Metab Dispos. 2014 Aug; 42(8):1285-91. PMID: 24839971; PMCID: PMC4109208.
      View in: PubMed, PubMed Central
    3. Stevens MW, Henry RL, Owens SM, Schutz R, Gentry WB. First human study of a chimeric anti-methamphetamine monoclonal antibody in healthy volunteers. MAbs. 2014; 6(6):1649-56. PMID: 25484042; PMCID: PMC4623385.
      View in: PubMed, PubMed Central
    4. Peterson EC, Gentry WB, Owens SM. Customizing monoclonal antibodies for the treatment of methamphetamine abuse: current and future applications. Adv Pharmacol. 2014; 69:107-27. PMID: 24484976; PMCID: PMC4491432.
      View in: PubMed, PubMed Central
    5. Stevens MW, Tawney RL, West CM, Kight AD, Henry RL, Owens SM, Gentry WB. Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use. MAbs. 2014 Mar-Apr; 6(2):547-55. PMID: 24492290; PMCID: PMC3984342.
      View in: PubMed, PubMed Central
    6. Sanders NC, Mancino MJ, Gentry WB, Guise JB, Bickel WK, Thostenson J, Oliveto AH. Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure. Exp Clin Psychopharmacol. 2013 Aug; 21(4):294-302. PMID: 23855333; PMCID: PMC3972066.
      View in: PubMed, PubMed Central
    7. Oliveto A, Mancino M, Sanders N, Cargile C, Guise JB, Bickel W, Gentry W Brooks. Effects of Prototypic Calcium Channel Blockers in Methadone-Maintained Humans Under a Naloxone Discrimination Procedure. Eur J Pharmacol. 2013.
    8. Walker BL, Vander Schilden JL, Gentry W Brooks. Intraarticular Analgesia Using a Meperidine-Local Anesthetic Combination in Arthroscopic Knee Procedures. Chirurgia Kolana, Atroskopia, Traumatologia Sportowa. 2013; 8(1):21-27.
    9. Dilley JD, Gentry WB, Golden KJ. Ketamine infusion as a treatment for major depressive disorder: a new role for anesthesiologists? Middle East J Anaesthesiol. 2012 Oct; 21(6):871-3. PMID: 23634571.
      View in: PubMed
    10. Owens SM, Atchley WT, Hambuchen MD, Peterson EC, Gentry WB. Monoclonal antibodies as pharmacokinetic antagonists for the treatment of (+)-methamphetamine addiction. CNS Neurol Disord Drug Targets. 2011 Dec; 10(8):892-8. PMID: 22229314; PMCID: PMC3653579.
      View in: PubMed, PubMed Central
    11. Hubbard JJ, Laurenzana EM, Williams DK, Gentry WB, Owens SM. Chronic anti-phencyclidine monoclonal antibody therapy decreases phencyclidine-induced in utero fetal mortality in pregnant rats. Int Immunopharmacol. 2011 Dec; 11(12):2181-7. PMID: 22001428; PMCID: PMC3285273.
      View in: PubMed, PubMed Central
    12. White S, Laurenzana E, Hendrickson H, Gentry WB, Owens SM. Gestation time-dependent pharmacokinetics of intravenous (+)-methamphetamine in rats. Drug Metab Dispos. 2011 Sep; 39(9):1718-26. PMID: 21632964; PMCID: PMC3164273.
      View in: PubMed, PubMed Central
    13. White SJ, Laurenzana EM, Hendrickson HP, Gentry WB, Owens SM. Gestation time-dependent pharmacokinetics of intravenous (+)-methamphetamine and (+)-amphetamine in rats. Drug Metab Disp. 2011; 39:1718-26.
    14. Hubbard JJ, Laurenzana EM, Williams DK, Gentry WB, Owens SM. The Fate and Function of Therapeutic Anti-addiction Monoclonal Antibodies. J Pharmacol Exp Ther. 2011; 336:414-22.
    15. Hubbard JJ, Laurenzana EM, Williams DK, Gentry WB, Owens SM. The fate and function of therapeutic antiaddiction monoclonal antibodies across the reproductive cycle of rats. J Pharmacol Exp Ther. 2011 Feb; 336(2):414-22. PMID: 20962030; PMCID: PMC3033712.
      View in: PubMed, PubMed Central
    16. Gentry WB, Rüedi-Bettschen D, Owens SM. Anti-(+)-methamphetamine monoclonal antibody antagonists designed to prevent the progression of human diseases of addiction. Clin Pharmacol Ther. 2010 Sep; 88(3):390-3. PMID: 20668443; PMCID: PMC3652404.
      View in: PubMed, PubMed Central
    17. Oliveto A, Gentry WB, Pruzinsky R, Gonsai K, Kosten TR, Martell B, Poling J. Behavioral effects of gamma-hydroxybutyrate in humans. Behav Pharmacol. 2010 Jul; 21(4):332-42. PMID: 20526195; PMCID: PMC2911496.
      View in: PubMed, PubMed Central
    18. Oliveto A, Gentry WB, Pruzinsky R, Gonsai K, Kosten TR, Martell B, Poling J. Behavioral Effects of Gamma-Hydroxybutyrate (GHB) in Humans. Behavioral Pharmacology. 2010; 21:332-342.
    19. Laurenzana EM, Hendrickson HP, Carpenter D, Peterson EC, Gentry WB, West M, Che Y, Carroll FI, Owens SM. Functional and biological determinants affecting the duration of action and efficacy of anti-(+)-methamphetamine monoclonal antibodies in rats. Vaccine. 2009 Nov 23; 27(50):7011-20. PMID: 19800446; PMCID: PMC2792920.
      View in: PubMed, PubMed Central
    20. McGaugh J, Mancino MJ, Feldman Z, Chopra MP, Gentry WB, Cargile C, Oliveto A. Open-label pilot study of modafinil for methamphetamine dependence. J Clin Psychopharmacol. 2009 Oct; 29(5):488-91. PMID: 19745650; PMCID: PMC3610177.
      View in: PubMed, PubMed Central
    21. White SJ, Laurenzana EM, Gentry WB, Hendrickson HP, Williams DK, Ward KW, Owens SM. Vulnerability to (+)-methamphetamine effects and the relationship to drug disposition in pregnant rats during chronic infusion. Toxicol Sci. 2009 Sep; 111(1):27-36. PMID: 19520673; PMCID: PMC2726297.
      View in: PubMed, PubMed Central
    22. Gentry WB, Rüedi-Bettschen D, Owens SM. Development of active and passive human vaccines to treat methamphetamine addiction. Hum Vaccin. 2009 Apr; 5(4):206-13. PMID: 19276653; PMCID: PMC2741685.
      View in: PubMed, PubMed Central
    23. Dunning D, Martin MP, Tickel JL, Gentry WB, Cowen P, Slenning BD. Preparedness and disaster response training for veterinary students: literature review and description of the North Carolina State University Credentialed Veterinary Responder Program. J Vet Med Educ. 2009; 36(3):317-30. PMID: 19861720.
      View in: PubMed
    24. Gurley BJ, Swain A, Hubbard MA, Hartsfield F, Thaden J, Williams DK, Gentry WB, Tong Y. Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo. Clin Pharmacol Ther. 2008 Jan; 83(1):61-9. PMID: 17495878.
      View in: PubMed
    25. Kumar P, Gentry WB. Ultrasound Guidance in Regional Anesthesia. J Anaesth Clin Pharmacol. 2007; 23(2):121-128.
    26. Meta G, Ghaleb A, Gentry WB, Firnhaber J. Intrathecal therapy-associated masses. Anesth Analg. 2006 Jul; 103(1):260-1. PMID: 16790677.
      View in: PubMed
    27. Pitas G, Laurenzana EM, Williams DK, Owens SM, Gentry WB. Anti-phencyclidine monoclonal antibody binding capacity is not the only determinant of effectiveness, disproving the concept that antibody capacity is easily surmounted. Drug Metab Dispos. 2006 Jun; 34(6):906-12. PMID: 16507651.
      View in: PubMed
    28. Gentry WB, Laurenzana EM, Williams DK, West JR, Berg RJ, Terlea T, Owens SM. Safety and efficiency of an anti-(+)-methamphetamine monoclonal antibody in the protection against cardiovascular and central nervous system effects of (+)-methamphetamine in rats. Int Immunopharmacol. 2006 Jun; 6(6):968-77. PMID: 16644483.
      View in: PubMed
    29. Gurley B, Hubbard MA, Williams DK, Thaden J, Tong Y, Gentry WB, Breen P, Carrier DJ, Cheboyina S. Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. J Clin Pharmacol. 2006 Feb; 46(2):201-13. PMID: 16432272; PMCID: PMC1865122.
      View in: PubMed, PubMed Central
    30. Gentry WB, Laurenzana EM, Williams DK, West JR, Berg RJ, Terlea T, Owens SM. Safety and Efficiency of an Anti-(+)-Methamphetamine Monoclonal IgG in the Protection against Cardiovascular and Central Nervous System Effects of (+)-Methamphetamine in Rats. International Immunopharmacology. 2006; 6:968-977.
    31. Pitas G, Laurenzana EM, Williams DK, Owens SM, Gentry WB. Anti-PCP Monoclonal Antibody Binding Capacity is not the Only Determinant of Effectiveness, Disproving the Concept that Antibody Capacity is easily Surmounted. Drug Metab Dispos. 2006; 34:906-912.
    32. Gurley B, Hubbard MA, Williams DK, Thaden J, Tong Y, Gentry WB, Breen P, Carrier DJ, Cheboyina S. Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A4 Activity: Comparison of Milk Thistle and Black Cohosh to rifampin and Clarithromycin. J Clin Pharmacol. 2006; 46:201-213.
    33. Milesi-Hallé A, Hendrickson HP, Laurenzana EM, Gentry WB, Owens SM. Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats. Toxicol Appl Pharmacol. 2005 Dec 15; 209(3):203-13. PMID: 15916788.
      View in: PubMed
    34. Byrnes-Blake KA, Laurenzana EM, Landes RD, Gentry WB, Owens SM. Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats. Eur J Pharmacol. 2005 Oct 03; 521(1-3):86-94. PMID: 16182279.
      View in: PubMed
    35. Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Khan IA, Shah A. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther. 2005 May; 77(5):415-26. PMID: 15900287; PMCID: PMC1894911.
      View in: PubMed, PubMed Central
    36. Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Cui Y, Ang CY. Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba. Drugs Aging. 2005; 22(6):525-39. PMID: 15974642; PMCID: PMC1858666.
      View in: PubMed, PubMed Central
    37. Gentry WB, Ghafoor AU, Wessinger WD, Laurenzana EM, Hendrickson HP, Owens SM. (+)-Methamphetamine-induced spontaneous behavior in rats depends on route of (+)METH administration. Pharmacol Biochem Behav. 2004 Dec; 79(4):751-60. PMID: 15582684.
      View in: PubMed
    38. Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Carrier J, Khan IA, Edwards DJ, Shah A. In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther. 2004 Nov; 76(5):428-40. PMID: 15536458.
      View in: PubMed
    39. Laurenzana EM, Byrnes-Blake KA, Milesi-Hallé A, Gentry WB, Williams DK, Owens SM. Use of anti-(+)-methamphetamine monoclonal antibody to significantly alter (+)-methamphetamine and (+)-amphetamine disposition in rats. Drug Metab Dispos. 2003 Nov; 31(11):1320-6. PMID: 14570763.
      View in: PubMed
    40. Laurenzana EM, Gunnell MG, Gentry WB, Owens SM. Treatment of adverse effects of excessive phencyclidine exposure in rats with a minimal dose of monoclonal antibody. J Pharmacol Exp Ther. 2003 Sep; 306(3):1092-8. PMID: 12829731.
      View in: PubMed
    41. Ghafoor AU, Mayhew JF, Gentry WB, Schmitz ML. Transpleural subclavian central venous catheter placement in a child with scoliosis discovered during a thoracotomy. J Clin Anesth. 2003 Mar; 15(2):142-4. PMID: 12719056.
      View in: PubMed
    42. Byrnes-Blake KA, Laurenzana EM, Carroll FI, Abraham P, Gentry WB, Landes RD, Owens SM. Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats. Eur J Pharmacol. 2003 Feb 14; 461(2-3):119-28. PMID: 12586207.
      View in: PubMed
    43. Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Cui Y, Ang CY. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther. 2002 Sep; 72(3):276-87. PMID: 12235448.
      View in: PubMed
    44. Arora H, Owens SM, Gentry WB. Intravenous (+)-methamphetamine causes complex dose-dependent physiologic changes in awake rats. Eur J Pharmacol. 2001 Aug 24; 426(1-2):81-7. PMID: 11525775.
      View in: PubMed
    45. Proksch JW, Gentry WB, Owens SM. The effect of rate of drug administration on the extent and time course of phencyclidine distribution in rat brain, testis, and serum. Drug Metab Dispos. 2000 Jul; 28(7):742-7. PMID: 10859146.
      View in: PubMed
    46. Proksch JW, Gentry WB, Owens SM. Anti-phencyclidine monoclonal antibodies provide long-term reductions in brain phencyclidine concentrations during chronic phencyclidine administration in rats. J Pharmacol Exp Ther. 2000 Mar; 292(3):831-7. PMID: 10688594.
      View in: PubMed
    47. Rivière GJ, Gentry WB, Owens SM. Disposition of methamphetamine and its metabolite amphetamine in brain and other tissues in rats after intravenous administration. J Pharmacol Exp Ther. 2000 Mar; 292(3):1042-7. PMID: 10688621.
      View in: PubMed
    48. Rivière GJ, Byrnes KA, Gentry WB, Owens SM. Spontaneous locomotor activity and pharmacokinetics of intravenous methamphetamine and its metabolite amphetamine in the rat. J Pharmacol Exp Ther. 1999 Dec; 291(3):1220-6. PMID: 10565845.
      View in: PubMed
    49. Krejcie TC, Henthorn TK, Gentry WB, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ. Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid, and total body water. J Pharmacol Exp Ther. 1999 Dec; 291(3):1308-16. PMID: 10565856.
      View in: PubMed
    50. Proksch JW, Gentry WB, Owens SM. Pharmacokinetic mechanisms for obtaining high renal coelimination of phencyclidine and a monoclonal antiphencyclidine antigen-binding fragment of immunoglobulin G in the rat. J Pharmacol Exp Ther. 1998 Nov; 287(2):616-24. PMID: 9808688.
      View in: PubMed
    51. Wright CD, Jilka J, Gentry WB. Efficacy of promethazine suppositories dispensed to outpatient surgical patients. Yale J Biol Med. 1998 Sep-Oct; 71(5):391-5. PMID: 10527366; PMCID: PMC2578928.
      View in: PubMed, PubMed Central
    52. Avram MJ, Krejcie TC, Niemann CU, Klein C, Gentry WB, Shanks CA, Henthorn TK. The effect of halothane on the recirculatory pharmacokinetics of physiologic markers. Anesthesiology. 1997 Dec; 87(6):1381-93. PMID: 9416724.
      View in: PubMed
    53. Krejcie TC, Avram MJ, Gentry WB, Niemann CU, Janowski MP, Henthorn TK. A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs. J Pharmacokinet Biopharm. 1997 Apr; 25(2):169-90. PMID: 9408858.
      View in: PubMed
    54. Krejcie TC, Henthorn TK, Niemann CU, Klein C, Gupta DK, Gentry WB, Shanks CA, Avram MJ. Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly. J Pharmacol Exp Ther. 1996 Sep; 278(3):1050-7. PMID: 8819485.
      View in: PubMed
    55. Gentry WB, Krejcie TC, Henthorn TK, Avram MJ. Induction and maintenance of anesthesia in dogs by intravenous administration of methohexital. Am J Vet Res. 1996 Jul; 57(7):1044-9. PMID: 8807019.
      View in: PubMed
    56. Gentry WB, Krejcie TC, Henthorn TK, Shanks CA, Howard KA, Gupta DK, Avram MJ. Effect of infusion rate on thiopental dose-response relationships. Assessment of a pharmacokinetic-pharmacodynamic model. Anesthesiology. 1994 Aug; 81(2):316-24; discussion 25A. PMID: 8053580.
      View in: PubMed
    57. Gentry WB, Shanks CA. Reevaluation of a maneuver to visualize the anterior larynx after intubation. Anesth Analg. 1993 Jul; 77(1):161-3. PMID: 8317725.
      View in: PubMed
    58. Shanks CA, Avram MJ, Krejcie TC, Henthorn TK, Gentry WB. A pharmacokinetic-pharmacodynamic model for quantal responses with thiopental. J Pharmacokinet Biopharm. 1993 Jun; 21(3):309-21. PMID: 8258770.
      View in: PubMed
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