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Steven Post

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPathology, College of Medicine
DivisionPathology Academic
Address609-2 Biomedical Research II
200 South Cedar
Mail Slot # 845
Little Rock AR 72202
Phone501-526-6046
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPharmacology and Toxicology, College of Medicine


    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Associate Vice Chair of Research, Dept. of Pathology

    Director, Division of Experimental Pathology

    Associate Director of Shared Resources, Winthrop P. Rockefeller Cancer Institute

    Director, Experimental Pathology Research Core

    Director, UAMS Tissue Biorepository and Procurement Service

    Director, Pathobiology Graduate Program


    Collapse Research Funds 
    Collapse research overview
    The goal of our research is to better understand the key role that macrophages play in the development and progression of chronic inflammatory diseases including cardiovascular disease and cancer. Our studies indicate that a specific macrophage receptor, the class A macrophage scavenger receptor (SR-A), may differentially function to enhance or diminish inflammation. Our ongoing studies seek to provide mechanistic details regarding the functional interactions between SR-A and inflammatory signaling pathways. Results of these studies will advance understanding of the pathologic role of macrophages in cardiovascular disease and cancer, and may indicate novel therapeutic approaches targeting the inflammatory responses in these disease.


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    Collapse additional bibliographic sources
    The links below are provided by the researcher to provide access to external online bibliographies that they keep independently from the Profiles System.
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J. A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. J Immunol. 2017 May 15; 198(10):3775-3789. PMID: 28483986.
      View in: PubMed
    2. Post GR, Bell RC, Rjoop A, Lobo RH, Yuan Y, Post SR. Diagnostic Utility of Interleukin-6 Expression by Immunohistochemistry in Differentiating Castleman Disease Subtypes and Reactive Lymphadenopathies. Ann Clin Lab Sci. 2016 Sep; 46(5):474-9. PMID: 27650613.
      View in: PubMed
    3. Holthoff ER, Spencer H, Kelly T, Post SR, Quick CM. Pathologic features of aggressive vulvar carcinoma are associated with epithelial-mesenchymal transition. Hum Pathol. 2016 Oct; 56:22-30. PMID: 27327194; PMCID: PMC5021565 [Available on 10/01/17].
    4. Mazur A, Holthoff E, Vadali S, Kelly T, Post SR. Cleavage of Type I Collagen by Fibroblast Activation Protein-a Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion. PLoS One. 2016; 11(3):e0150287. PMID: 26934296; PMCID: PMC4774960.
    5. Jeffus SK, Gehlot A, Holthoff E, Stone R, Spencer H, Kelly T, Post SR, Quick CM. A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva. Am J Surg Pathol. 2015 Sep; 39(9):1226-33. PMID: 26274029; PMCID: PMC4538995.
    6. Holthoff ER, Jeffus SK, Gehlot A, Stone R, Erickson SW, Kelly T, Quick CM, Post SR. Perineural Invasion Is an Independent Pathologic Indicator of Recurrence in Vulvar Squamous Cell Carcinoma. Am J Surg Pathol. 2015 Aug; 39(8):1070-4. PMID: 25786085; PMCID: PMC4503485.
    7. Jeffus SK, Joiner AK, Siegel ER, Massoll NA, Meena N, Chen C, Post SR, Bartter T. Rapid on-site evaluation of EBUS-TBNA specimens of lymph nodes: Comparative analysis and recommendations for standardization. Cancer Cytopathol. 2015 Jun; 123(6):362-72. PMID: 25931443.
      View in: PubMed
    8. Nikolic DM, Vadali S, He B, Ware J, Kelly T, Post SR. Prostaglandins produced during class A scavenger receptor-mediated macrophage adhesion differentially regulate cytokine production. J Leukoc Biol. 2015 May; 97(5):901-908. PMID: 25717147.
      View in: PubMed
    9. Ware J, Post SR. Platelets: balancing the septic triad. Blood. 2014 Dec 11; 124(25):3670-2. PMID: 25498452.
      View in: PubMed
    10. Vadali S, Post SR. Lipid rafts couple class A scavenger receptors to phospholipase A2 activation during macrophage adhesion. J Leukoc Biol. 2014 Nov; 96(5):873-81. PMID: 25070949; PMCID: PMC4197562.
    11. Prabhudas M, Bowdish D, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, Means TK, Moestrup SK, Post S, Sawamura T, Silverstein S, Wang XY, El Khoury J. Standardizing scavenger receptor nomenclature. J Immunol. 2014 Mar 01; 192(5):1997-2006. PMID: 24563502; PMCID: PMC4238968.
    12. Corken A, Russell S, Dent J, Post SR, Ware J. Platelet glycoprotein Ib-IX as a regulator of systemic inflammation. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):996-1001. PMID: 24504734; PMCID: PMC3991762.
    13. Scotland RL, Allen L, Hennings LJ, Post GR, Post SR. The ral exchange factor rgl2 promotes cardiomyocyte survival and inhibits cardiac fibrosis. PLoS One. 2013; 8(9):e73599. PMID: 24069211; PMCID: PMC3775766.
    14. Pandey S, Post SR, Alapat DV, Smock KJ, Post GR. Prolonged prothrombin time correlates with serum monoclonal protein concentration in patients with plasma cell dyscrasia. Int J Lab Hematol. 2013 Aug; 35(4):421-7. PMID: 23217011.
      View in: PubMed
    15. Nikolic D, Calderon L, Du L, Post SR. SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38 MAPK activation. BMC Immunol. 2011 Jul 07; 12:37. PMID: 21736734; PMCID: PMC3141791.
    16. Cholewa J, Nikolic D, Post SR. Regulation of class A scavenger receptor-mediated cell adhesion and surface localization by PI3K: identification of a regulatory cytoplasmic motif. J Leukoc Biol. 2010 Mar; 87(3):443-9. PMID: 19952357; PMCID: PMC2830124.
    17. Nikolic DM, Gong MC, Turk J, Post SR. Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation. J Biol Chem. 2007 Nov 16; 282(46):33405-11. PMID: 17873277; PMCID: PMC2080787.
    18. Nikolic DM, Cholewa J, Gass C, Gong MC, Post SR. Class A scavenger receptor-mediated cell adhesion requires the sequential activation of Lyn and PI3-kinase. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1450-8. PMID: 17192284.
      View in: PubMed
    19. Lin YL, de Villiers WJ, Garvy B, Post SR, Nagy TR, Safadi FF, Faugere MC, Wang G, Malluche HH, Williams JP. The effect of class a scavenger receptor deficiency in bone. J Biol Chem. 2007 Feb 16; 282(7):4653-60. PMID: 17166840.
      View in: PubMed
    20. Shetty S, Eckhardt ER, Post SR, van der Westhuyzen DR. Phosphatidylinositol-3-kinase regulates scavenger receptor class B type I subcellular localization and selective lipid uptake in hepatocytes. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):2125-31. PMID: 16794223.
      View in: PubMed
    21. Xie Z, Su W, Guo Z, Pang H, Post SR, Gong MC. Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells. Cardiovasc Res. 2006 Feb 01; 69(2):491-501. PMID: 16336954.
      View in: PubMed
    22. Berwin B, Delneste Y, Lovingood RV, Post SR, Pizzo SV. SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. J Biol Chem. 2004 Dec 03; 279(49):51250-7. PMID: 15371419.
      View in: PubMed
    23. Du L, Post SR. Macrophage colony-stimulating factor differentially regulates low density lipoprotein and transferrin receptors. J Lipid Res. 2004 Sep; 45(9):1733-40. PMID: 15210846.
      View in: PubMed
    24. Berwin B, Hart JP, Rice S, Gass C, Pizzo SV, Post SR, Nicchitta CV. Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. EMBO J. 2003 Nov 17; 22(22):6127-36. PMID: 14609958; PMCID: PMC275431.
    25. Kosswig N, Rice S, Daugherty A, Post SR. Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains. J Biol Chem. 2003 Sep 05; 278(36):34219-25. PMID: 12819208.
      View in: PubMed
    26. Post SR, Gass C, Rice S, Nikolic D, Crump H, Post GR. Class A scavenger receptors mediate cell adhesion via activation of G(i/o) and formation of focal adhesion complexes. J Lipid Res. 2002 Nov; 43(11):1829-36. PMID: 12401881.
      View in: PubMed
    27. Insel PA, Ostrom RS, Zambon AC, Hughes RJ, Balboa MA, Shehnaz D, Gregorian C, Torres B, Firestein BL, Xing M, Post SR. P2Y receptors of MDCK cells: epithelial cell regulation by extracellular nucleotides. Clin Exp Pharmacol Physiol. 2001 Apr; 28(4):351-4. PMID: 11339212.
      View in: PubMed
    28. Whitman SC, Daugherty A, Post SR. Macrophage colony-stimulating factor rapidly enhances beta-migrating very low density lipoprotein metabolism in macrophages through activation of a Gi/o protein signaling pathway. J Biol Chem. 2000 Nov 17; 275(46):35807-13. PMID: 10964909.
      View in: PubMed
    29. Ostrom RS, Post SR, Insel PA. Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s). J Pharmacol Exp Ther. 2000 Aug; 294(2):407-12. PMID: 10900212.
      View in: PubMed
    30. Whitman SC, Daugherty A, Post SR. Regulation of acetylated low density lipoprotein uptake in macrophages by pertussis toxin-sensitive G proteins. J Lipid Res. 2000 May; 41(5):807-13. PMID: 10787441.
      View in: PubMed
    31. Post SR, Ostrom RS, Insel PA. Biochemical methods for detection and measurement of cyclic AMP and adenylyl cyclase activity. Methods Mol Biol. 2000; 126:363-74. PMID: 10685423.
      View in: PubMed
    32. Xing M, Post S, Ostrom RS, Samardzija M, Insel PA. Inhibition of phospholipase A2-mediated arachidonic acid release by cyclic AMP defines a negative feedback loop for P2Y receptor activation in Madin-Darby canine kidney D1 cells. J Biol Chem. 1999 Apr 09; 274(15):10035-8. PMID: 10187781.
      View in: PubMed
    33. Meyer M, Bluhm WF, He H, Post SR, Giordano FJ, Lew WY, Dillmann WH. Phospholamban-to-SERCA2 ratio controls the force-frequency relationship. Am J Physiol. 1999 Mar; 276(3 Pt 2):H779-85. PMID: 10070059.
      View in: PubMed
    34. Post SR, Hammond HK, Insel PA. Beta-adrenergic receptors and receptor signaling in heart failure. Annu Rev Pharmacol Toxicol. 1999; 39:343-60. PMID: 10331088.
      View in: PubMed
    35. Post SR, Rump LC, Zambon A, Hughes RJ, Buda MD, Jacobson JP, Kao CC, Insel PA. ATP activates cAMP production via multiple purinergic receptors in MDCK-D1 epithelial cells. Blockade of an autocrine/paracrine pathway to define receptor preference of an agonist. J Biol Chem. 1998 Sep 04; 273(36):23093-7. PMID: 9722536.
      View in: PubMed
    36. Gao M, Ping P, Post S, Insel PA, Tang R, Hammond HK. Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A. 1998 Feb 03; 95(3):1038-43. PMID: 9448281; PMCID: PMC18663.
    37. Insel PA, Balboa MA, Mochizuki N, Post SR, Urasawa K, Xing M. Mechanisms for activation of multiple effectors by alpha 1-adrenergic receptors. Adv Pharmacol. 1998; 42:451-3. PMID: 9327936.
      View in: PubMed
    38. Insel PA, Firestein BL, Xing M, Post SR, Jacobson JP, Balboa MA, Hughes RJ. P2-purinoceptors utilize multiple signalling pathways in MDCK-D1 cells. J Auton Pharmacol. 1996 Dec; 16(6):311-3. PMID: 9131405.
      View in: PubMed
    39. Hecht JH, Weiner JA, Post SR, Chun J. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol. 1996 Nov; 135(4):1071-83. PMID: 8922387; PMCID: PMC2133395.
    40. Post SR, Jacobson JP, Insel PA. P2 purinergic receptor agonists enhance cAMP production in Madin-Darby canine kidney epithelial cells via an autocrine/paracrine mechanism. J Biol Chem. 1996 Jan 26; 271(4):2029-32. PMID: 8567655.
      View in: PubMed
    41. Post SR, Aguila-Buhain O, Insel PA. A key role for protein kinase A in homologous desensitization of the beta 2-adrenergic receptor pathway in S49 lymphoma cells. J Biol Chem. 1996 Jan 12; 271(2):895-900. PMID: 8557702.
      View in: PubMed
    42. Post SR, Hilal-Dandan R, Urasawa K, Brunton LL, Insel PA. Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes. Biochem J. 1995 Oct 01; 311 ( Pt 1):75-80. PMID: 7575483; PMCID: PMC1136121.
    43. Jasper JR, Post SR, Desai KH, Insel PA, Bernstein D. Colchicine and cytochalasin B enhance cyclic AMP accumulation via postreceptor actions. J Pharmacol Exp Ther. 1995 Aug; 274(2):937-42. PMID: 7636757.
      View in: PubMed
    44. Post SR, Rubinstein PG, Tager HS. Mechanism of action of des-His1-[Glu9]glucagon amide, a peptide antagonist of the glucagon receptor system. Proc Natl Acad Sci U S A. 1993 Mar 01; 90(5):1662-6. PMID: 8383321; PMCID: PMC45939.
    45. Post SR, Miyazaki H, Tager HS. Identification of a Mg(2+)- and guanyl nucleotide-dependent glucagon receptor cycle by use of permeabilized canine hepatocytes. J Biol Chem. 1992 Dec 25; 267(36):25776-85. PMID: 1334486.
      View in: PubMed
    46. Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):251-5. PMID: 1346068; PMCID: PMC48214.
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