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Connection

Co-Authors

This is a "connection" page, showing publications co-authored by Rosalia Simmen and Frank Simmen.

 
Connection Strength
  
 
 
7.522
  
  1. Simmen FA, Alhallak I, Simmen RCM. Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism. J Mol Endocrinol. 2020 11; 65(4):R77-R90.
    View in: PubMed
    Score: 0.860
  2. Simmen FA, Simmen RC. The maternal womb: a novel target for cancer prevention in the era of the obesity pandemic? Eur J Cancer Prev. 2011 Nov; 20(6):539-48.
    View in: PubMed
    Score: 0.461
  3. Simmen FA, Su Y, Xiao R, Zeng Z, Simmen RC. The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression. Reprod Biol Endocrinol. 2008 Sep 10; 6:41.
    View in: PubMed
    Score: 0.371
  4. Simmen FA, Xiao R, Velarde MC, Nicholson RD, Bowman MT, Fujii-Kuriyama Y, Oh SP, Simmen RC. Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1757-69.
    View in: PubMed
    Score: 0.335
  5. Simmen FA, Simmen RC. Orchestrating the menstrual cycle: discerning the music from the noise. Endocrinology. 2006 Mar; 147(3):1094-6.
    View in: PubMed
    Score: 0.311
  6. Simmen RC, Simmen FA. Progesterone receptors and Sp/Krüppel-like family members in the uterine endometrium . Front Biosci. 2002 Jun 01; 7:d1556-65.
    View in: PubMed
    Score: 0.240
  7. Brown AR, Alhallak I, Simmen RCM, Melnyk SB, Heard-Lipsmeyer ME, Montales MTE, Habenicht D, Van TT, Simmen FA. Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet. Cancers (Basel). 2022 Mar 29; 14(7).
    View in: PubMed
    Score: 0.237
  8. Simmen RC, Zhang XL, Michel FJ, Min SH, Zhao G, Simmen FA. Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Krüppel-like factor BTEB1. DNA Cell Biol. 2002 Feb; 21(2):115-28.
    View in: PubMed
    Score: 0.234
  9. Heard-Lipsmeyer ME, Alhallak I, Simmen FA, Melnyk SB, Simmen RCM. Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice. Front Physiol. 2021; 12:702674.
    View in: PubMed
    Score: 0.228
  10. Alhallak I, Wolter KG, Castro Munoz A, Simmen FA, Ward RJ, Petty SA, Li LX, Simmen RCM. Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10. J Mol Endocrinol. 2021 09 09; 67(4):173-188.
    View in: PubMed
    Score: 0.228
  11. Pabona JMP, Burnett AF, Brown DM, Quick CM, Simmen FA, Montales MTE, Liu SJ, Rose T, Alhallak I, Siegel ER, Simmen RC. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reprod Sci. 2020 01; 27(1):267-277.
    View in: PubMed
    Score: 0.203
  12. Fernandes LM, Al-Dwairi A, Simmen RCM, Marji M, Brown DM, Jewell SW, Simmen FA. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 09 24; 8(1):14268.
    View in: PubMed
    Score: 0.186
  13. Brown DM, Lee HC, Liu S, Quick CM, Fernandes LM, Simmen FA, Tsai SJ, Simmen RCM. Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis. J Endocr Soc. 2018 Jul 01; 2(7):765-778.
    View in: PubMed
    Score: 0.182
  14. Montales MT, Melnyk SB, Liu SJ, Simmen FA, Liu YL, Simmen RC. Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice. Endocr Relat Cancer. 2016 09; 23(9):677-90.
    View in: PubMed
    Score: 0.159
  15. Heard ME, Melnyk SB, Simmen FA, Yang Y, Pabona JM, Simmen RC. High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status. Endocrinology. 2016 07; 157(7):2870-82.
    View in: PubMed
    Score: 0.158
  16. Montales MT, Simmen RC, Ferreira ES, Neves VA, Simmen FA. Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. Genes Nutr. 2015 Nov; 10(6):49.
    View in: PubMed
    Score: 0.152
  17. Brown AR, Simmen RC, Raj VR, Van TT, MacLeod SL, Simmen FA. Krüppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling. Carcinogenesis. 2015 Sep; 36(9):946-55.
    View in: PubMed
    Score: 0.149
  18. Heard ME, Velarde MC, Giudice LC, Simmen FA, Simmen RC. Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis. Biol Reprod. 2015 Jun; 92(6):140.
    View in: PubMed
    Score: 0.147
  19. Pabona JM, Zhang D, Ginsburg DS, Simmen FA, Simmen RC. Prolonged pregnancy in women is associated with attenuated myometrial expression of progesterone receptor co-regulator Krüppel-like Factor 9. J Clin Endocrinol Metab. 2015 Jan; 100(1):166-74.
    View in: PubMed
    Score: 0.143
  20. Al-Dwairi A, Brown AR, Pabona JM, Van TH, Hamdan H, Mercado CP, Quick CM, Wight PA, Simmen RC, Simmen FA. Enhanced gastrointestinal expression of cytosolic malic enzyme (ME1) induces intestinal and liver lipogenic gene expression and intestinal cell proliferation in mice. PLoS One. 2014; 9(11):e113058.
    View in: PubMed
    Score: 0.142
  21. Montales MT, Melnyk SB, Simmen FA, Simmen RC. Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes. Carcinogenesis. 2014 Sep; 35(9):2102-12.
    View in: PubMed
    Score: 0.137
  22. Heard ME, Simmons CD, Simmen FA, Simmen RC. Krüppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis. Endocrinology. 2014 Apr; 155(4):1532-46.
    View in: PubMed
    Score: 0.135
  23. Brown AR, Simmen RC, Simmen FA. The role of thyroid hormone signaling in the prevention of digestive system cancers. Int J Mol Sci. 2013 Aug 06; 14(8):16240-57.
    View in: PubMed
    Score: 0.130
  24. Heard ME, Pabona JM, Clayberger C, Krensky AM, Simmen FA, Simmen RC. The reproductive phenotype of mice null for transcription factor Krüppel-like factor 13 suggests compensatory function of family member Krüppel-like factor 9 in the peri-implantation uterus. Biol Reprod. 2012 Nov; 87(5):115.
    View in: PubMed
    Score: 0.124
  25. Rahal OM, Pabona JM, Kelly T, Huang Y, Hennings LJ, Prior RL, Al-Dwairi A, Simmen FA, Simmen RC. Suppression of Wnt1-induced mammary tumor growth and lower serum insulin in offspring exposed to maternal blueberry diet suggest early dietary influence on developmental programming. Carcinogenesis. 2013 Feb; 34(2):464-74.
    View in: PubMed
    Score: 0.124
  26. Al-Dwairi A, Pabona JM, Simmen RC, Simmen FA. Cytosolic malic enzyme 1 (ME1) mediates high fat diet-induced adiposity, endocrine profile, and gastrointestinal tract proliferation-associated biomarkers in male mice. PLoS One. 2012; 7(10):e46716.
    View in: PubMed
    Score: 0.123
  27. Pabona JM, Simmen FA, Nikiforov MA, Zhuang D, Shankar K, Velarde MC, Zelenko Z, Giudice LC, Simmen RC. Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2012 Mar; 97(3):E376-92.
    View in: PubMed
    Score: 0.117
  28. Simmons CD, Pabona JM, Heard ME, Friedman TM, Spataro MT, Godley AL, Simmen FA, Burnett AF, Simmen RC. Krüppel-like factor 9 loss-of-expression in human endometrial carcinoma links altered expression of growth-regulatory genes with aberrant proliferative response to estrogen. Biol Reprod. 2011 Aug; 85(2):378-85.
    View in: PubMed
    Score: 0.111
  29. Pabona JM, Zeng Z, Simmen FA, Simmen RC. Functional differentiation of uterine stromal cells involves cross-regulation between bone morphogenetic protein 2 and Kruppel-like factor (KLF) family members KLF9 and KLF13. Endocrinology. 2010 Jul; 151(7):3396-406.
    View in: PubMed
    Score: 0.104
  30. Zeng Z, Velarde MC, Simmen FA, Simmen RC. Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Krüppel-like factor 9. Biol Reprod. 2008 Jun; 78(6):1029-37.
    View in: PubMed
    Score: 0.089
  31. Xiao R, Su Y, Simmen RC, Simmen FA. Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G868-76.
    View in: PubMed
    Score: 0.089
  32. Velarde MC, Zeng Z, McQuown JR, Simmen FA, Simmen RC. Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells. Mol Endocrinol. 2007 Dec; 21(12):2988-3001.
    View in: PubMed
    Score: 0.086
  33. Su Y, Simmen FA, Xiao R, Simmen RC. Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors. Physiol Genomics. 2007 Jun 19; 30(1):8-16.
    View in: PubMed
    Score: 0.083
  34. Kwak I, Song S, Blum JL, Simmen RC, Simmen FA. Enhancer- and silencer-like sequences that mediate insulin-like growth factor-binding protein-2 gene expression in uterine cells of pregnancy. DNA Cell Biol. 2006 Jan; 25(1):6-18.
    View in: PubMed
    Score: 0.077
  35. Eason RR, Till SR, Frank JA, Badger TM, Korourian S, Simmen FA, Simmen RC. Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesis. Nutr Cancer. 2006; 55(2):171-7.
    View in: PubMed
    Score: 0.077
  36. Velarde MC, Iruthayanathan M, Eason RR, Zhang D, Simmen FA, Simmen RC. Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1. Endocrinology. 2006 Apr; 147(4):1969-78.
    View in: PubMed
    Score: 0.077
  37. Eason RR, Till SR, Velarde MC, Geng Y, Chatman L, Gu L, Badger TM, Simmen FA, Simmen RC. Uterine phenotype of young adult rats exposed to dietary soy or genistein during development. J Nutr Biochem. 2005 Oct; 16(10):625-32.
    View in: PubMed
    Score: 0.076
  38. Velarde MC, Geng Y, Eason RR, Simmen FA, Simmen RC. Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice. Biol Reprod. 2005 Sep; 73(3):472-81.
    View in: PubMed
    Score: 0.074
  39. Badger TM, Ronis MJ, Simmen RC, Simmen FA. Soy protein isolate and protection against cancer. J Am Coll Nutr. 2005 Apr; 24(2):146S-149S.
    View in: PubMed
    Score: 0.073
  40. Simmen RC, Eason RR, McQuown JR, Linz AL, Kang TJ, Chatman L, Till SR, Fujii-Kuriyama Y, Simmen FA, Oh SP. Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene. J Biol Chem. 2004 Jul 09; 279(28):29286-94.
    View in: PubMed
    Score: 0.068
  41. Kowalski AA, Vale-Cruz DS, Simmen FA, Simmen RC. Uterine androgen receptors: roles in estrogen-mediated gene expressionand DNA synthesis. Biol Reprod. 2004 May; 70(5):1349-57.
    View in: PubMed
    Score: 0.067
  42. Zhang XL, Zhang D, Michel FJ, Blum JL, Simmen FA, Simmen RC. Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells. J Biol Chem. 2003 Jun 13; 278(24):21474-82.
    View in: PubMed
    Score: 0.064
  43. Zhang D, Simmen RC, Michel FJ, Zhao G, Vale-Cruz D, Simmen FA. Secretory leukocyte protease inhibitor mediates proliferation of human endometrial epithelial cells by positive and negative regulation of growth-associated genes. J Biol Chem. 2002 Aug 16; 277(33):29999-30009.
    View in: PubMed
    Score: 0.060
  44. Kowalski AA, Graddy LG, Vale-Cruz DS, Choi I, Katzenellenbogen BS, Simmen FA, Simmen RC. Molecular cloning of porcine estrogen receptor-beta complementary DNAs and developmental expression in periimplantation embryos. Biol Reprod. 2002 Mar; 66(3):760-9.
    View in: PubMed
    Score: 0.059
  45. Zhang D, Zhang XL, Michel FJ, Blum JL, Simmen FA, Simmen RC. Direct interaction of the Krüppel-like family (KLF) member, BTEB1, and PR mediates progesterone-responsive gene expression in endometrial epithelial cells. Endocrinology. 2002 Jan; 143(1):62-73.
    View in: PubMed
    Score: 0.058
  46. Min SH, Simmen RC, Alhonen L, Halmekyto M, Porter CW, Janne J, Simmen FA. Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT). J Biol Chem. 2002 Feb 01; 277(5):3647-57.
    View in: PubMed
    Score: 0.058
  47. Yu S, Wu X, Ferguson M, Simmen RC, Cleves MA, Simmen FA, Fang N. Diets Containing Shiitake Mushroom Reduce Serum Lipids and Serum Lipophilic Antioxidant Capacity in Rats. J Nutr. 2016 Dec; 146(12):2491-2496.
    View in: PubMed
    Score: 0.041
  48. Gaucher EA, Graddy LG, Li T, Simmen RC, Simmen FA, Schreiber DR, Liberles DA, Janis CM, Benner SA. The planetary biology of cytochrome P450 aromatases. BMC Biol. 2004 Aug 17; 2:19.
    View in: PubMed
    Score: 0.017
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.