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Rosalia Simmen

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPhysiology & Cell Biology, College of Medicine
DivisionPhysiology & Cell Biology Bst Cancer
Address212D Biomedical Research I
325 S. Elm St.
Mail Slot # 750
Little Rock AR 72205
Phone501-526-7575
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    Collapse Overview 
    Collapse overview
    I am Full Professor, Department of Physiology & Biophysics and Faculty Affiliate in the Winthrop P Rockefeller Cancer Institute Breast Cancer Program. I have been conducting basic and translational research in hormone-related aspects of women’s diseases for the last 30 years. I have a broad background in molecular, cellular and developmental biology, with specific training and expertise in steroid hormone receptors, signaling pathways, and tumor biology. As PI or Co-I on numerous university, Department of Defense, USDA and NIH-funded grants over the span of my independent academic career, I have collaborated with many groups of scientists to study the mechanistic underpinnings of steroid hormone receptors and associated co-regulators in the biology and pathobiology of the female reproductive tract. Our studies were the first to identify the Sp-related transcription factors Kruppel-like (KLF) family members KLF 9 and KLF13, as novel regulators of steroid receptor signaling in vivo and in vitro and to delineate their mechanisms of gene activation in concert with progesterone receptor and estrogen receptor, in endometrial and myometrial cells. These studies have provided strong support for the involvement of these and other KLFs in human uterine pathologies (endometriosis, endometrial cancer, and prolonged labor). In recent years, my research has established the infrastructure for elucidating the pathogenesis of endometriosis. In particular, we have developed an immunocompetent mouse model of endometriosis and have fortified our collaborations with clinicians within and outside of UAMS to provide medical translational relevance to our basic research on endometriosis.

    My research program in mammary biology aims to understand how early exposure to a favorable ‘nutritional’ milieu influences neonatal/perinatal mammary development to promote molecular events favoring increased tissue differentiation and increase resistance to genetic and epigenetic changes that drive breast cancer. My group is one of the first to demonstrate that specific dietary factors regulate mammary tumor risk by targeting oncogenes and tumor suppressor genes in mammary epithelial populations with tumor initiating potential. We have found that a major target of dietary factors is the tumor suppressor PTEN via cross-talk with insulin and p53 signaling. My team also showed that very early developmental events in utero can alter mammary gland biology in female progeny to increase predisposition to tumor risk. Our research aims to mechanistically evaluate the epigenome and the metabolome as regulatory nexus by which the maternal environment controls breast cancer risk in progeny.


    Collapse Affiliation 
    Collapse member of
    The Winthrop P Rockefeller Cancer Institute's Cancer Prevention and Population Sciences (CPPS) Program
    Collapse collaborator
    Charles Matt Quick, M.D.
    Frank A Simmen, Ph.D.
    Keith G Wolter, M.D., Ph.D.
    Issam Makhoul, M.D.
    Alexander Burnett, M.D.
    Angus Macnicol, Ph.D.
    Stephan B Melnyk, M.D.Ph.D.
    Shi (Jesse) Liu

    Collapse Research 
    Collapse research activities and funding
    ACHRI 037013     (SIMMEN, ROSALIA)Jan 1, 2012 - Sep 30, 2013
    Arkansas Children's Research Institute
    Childhood/Adolescent Obesity and predisposition to Adult Endometrial Dysfunction
    Role: Principal Investigator
    R01CA136493     (SIMMEN, FRANK ALBERT)Dec 15, 2009 - May 31, 2016
    NIH
    Dietary Factors in Colon Cancer Prevention
    Role: Co-Investigator
    R01HD021961     (SIMMEN, ROSALIA C)Jul 1, 1986 - Sep 30, 2010
    NIH
    Uteroferrin gene expression during development
    Role: Principal Investigator
    R29HD021961     (SIMMEN, ROSALIA C)Jul 1, 1986 - Jun 30, 1991
    NIH
    UTEROFERRIN GENE EXPRESSION DURING DEVELOPMENT
    Role: Principal Investigator
    R23HD021961     (SIMMEN, ROSALIA C)Jul 1, 1986 - Jun 30, 1989
    NIH
    UTEROFERRIN GENE EXPRESSION DURING DEVELOPMENT
    Role: Principal Investigator
         (SIMMEN, ROSALIA)
    UAMS College of Medicine Barton Award
    Novel Pathways Linking Mammary Epithelial Hierarchy and Adiposity
    Role: Principal Investigator
         (SIMMEN, ROSALIA)
    The Sturgis Diabetes Foundation
    Co-Morbid Conditions of Type 1 Diabetes and Endometriosis: A Pilot Study
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Alhallak I, Wolter KG, Castro Munoz A, Simmen FA, Ward RJ, Petty SA, Li LX, Simmen RCM. Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10. J Mol Endocrinol. 2021 09 09; 67(4):173-188. PMID: 34382943.
      View in: PubMed
    2. Simmen FA, Alhallak I, Simmen RCM. Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism. J Mol Endocrinol. 2020 11; 65(4):R77-R90. PMID: 33064660.
      View in: PubMed
    3. Saguyod SJU, Alhallak I, Simmen RCM, Velarde MC. Metformin regulation of progesterone receptor isoform-B expression in human endometrial cancer cells is glucose-dependent. Oncol Lett. 2020 Nov; 20(5):249. PMID: 32994812.
      View in: PubMed
    4. Pabona JMP, Burnett AF, Brown DM, Quick CM, Simmen FA, Montales MTE, Liu SJ, Rose T, Alhallak I, Siegel ER, Simmen RC. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reprod Sci. 2020 01; 27(1):267-277. PMID: 32046384.
      View in: PubMed
    5. Simmen RCM, Brown DM, Quick CM, Alhallak I, Rose TK, Liu S, Kelley AS. Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus. J Endocrinol. 2019 Aug 01. PMID: 31472479.
      View in: PubMed
    6. Simmen RCM, Kelley AS. Seeing red: diet and endometriosis risk. Ann Transl Med. 2018 Dec; 6(Suppl 2):S119. PMID: 30740440.
      View in: PubMed
    7. Fernandes LM, Al-Dwairi A, Simmen RCM, Marji M, Brown DM, Jewell SW, Simmen FA. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 09 24; 8(1):14268. PMID: 30250042.
      View in: PubMed
    8. Brown DM, Lee HC, Liu S, Quick CM, Fernandes LM, Simmen FA, Tsai SJ, Simmen RCM. Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis. J Endocr Soc. 2018 Jul 01; 2(7):765-778. PMID: 30151432.
      View in: PubMed
    9. Yu S, Wu X, Ferguson M, Simmen RC, Cleves MA, Simmen FA, Fang N. Diets Containing Shiitake Mushroom Reduce Serum Lipids and Serum Lipophilic Antioxidant Capacity in Rats. J Nutr. 2016 Dec; 146(12):2491-2496. PMID: 27798348.
      View in: PubMed
    10. Montales MT, Melnyk SB, Liu SJ, Simmen FA, Liu YL, Simmen RC. Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice. Endocr Relat Cancer. 2016 09; 23(9):677-90. PMID: 27402613.
      View in: PubMed
    11. Simmen RC, Kelley AS. Reversal of fortune: estrogen receptor-ß in endometriosis. J Mol Endocrinol. 2016 08; 57(2):F23-7. PMID: 27272520.
      View in: PubMed
    12. Heard ME, Melnyk SB, Simmen FA, Yang Y, Pabona JM, Simmen RC. High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status. Endocrinology. 2016 07; 157(7):2870-82. PMID: 27175969.
      View in: PubMed
    13. Montales MT, Simmen RC, Ferreira ES, Neves VA, Simmen FA. Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. Genes Nutr. 2015 Nov; 10(6):49. PMID: 26506839.
      View in: PubMed
    14. Brown AR, Simmen RC, Raj VR, Van TT, MacLeod SL, Simmen FA. Krüppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling. Carcinogenesis. 2015 Sep; 36(9):946-55. PMID: 26210742.
      View in: PubMed
    15. Heard ME, Velarde MC, Giudice LC, Simmen FA, Simmen RC. Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis. Biol Reprod. 2015 Jun; 92(6):140. PMID: 25904015.
      View in: PubMed
    16. Simmen RC, Heard ME, Simmen AM, Montales MT, Marji M, Scanlon S, Pabona JM. The Krüppel-like factors in female reproductive system pathologies. J Mol Endocrinol. 2015 Apr; 54(2):R89-R101. PMID: 25654975.
      View in: PubMed
    17. Pabona JM, Zhang D, Ginsburg DS, Simmen FA, Simmen RC. Prolonged pregnancy in women is associated with attenuated myometrial expression of progesterone receptor co-regulator Krüppel-like Factor 9. J Clin Endocrinol Metab. 2015 Jan; 100(1):166-74. PMID: 25313913.
      View in: PubMed
    18. Al-Dwairi A, Brown AR, Pabona JM, Van TH, Hamdan H, Mercado CP, Quick CM, Wight PA, Simmen RC, Simmen FA. Enhanced gastrointestinal expression of cytosolic malic enzyme (ME1) induces intestinal and liver lipogenic gene expression and intestinal cell proliferation in mice. PLoS One. 2014; 9(11):e113058. PMID: 25402228.
      View in: PubMed
    19. Montales MT, Melnyk SB, Simmen FA, Simmen RC. Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes. Carcinogenesis. 2014 Sep; 35(9):2102-12. PMID: 24832086.
      View in: PubMed
    20. Heard ME, Simmons CD, Simmen FA, Simmen RC. Krüppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis. Endocrinology. 2014 Apr; 155(4):1532-46. PMID: 24476135.
      View in: PubMed
    21. Bajpai G, Simmen RC, Stenken JA. In vivo microdialysis sampling of adipokines CCL2, IL-6, and leptin in the mammary fat pad of adult female rats. Mol Biosyst. 2014 Apr; 10(4):806-12. PMID: 24457312.
      View in: PubMed
    22. Meyer M, Bauer RN, Letang BD, Brighton L, Thompson E, Simmen RC, Bonner J, Jaspers I. Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers. Am J Physiol Lung Cell Mol Physiol. 2014 Feb; 306(3):L269-76. PMID: 24285265.
      View in: PubMed
    23. Rahal OM, Machado HL, Montales MT, Pabona JM, Heard ME, Nagarajan S, Simmen RC. Dietary suppression of the mammary CD29(hi)CD24(+) epithelial subpopulation and its cytokine/chemokine transcriptional signatures modifies mammary tumor risk in MMTV-Wnt1 transgenic mice. Stem Cell Res. 2013 Nov; 11(3):1149-62. PMID: 24012543.
      View in: PubMed
    24. Brown AR, Simmen RC, Simmen FA. The role of thyroid hormone signaling in the prevention of digestive system cancers. Int J Mol Sci. 2013 Aug 06; 14(8):16240-57. PMID: 23924944.
      View in: PubMed
    25. Montales MT, Rahal OM, Nakatani H, Matsuda T, Simmen RC. Repression of mammary adipogenesis by genistein limits mammosphere formation of human MCF-7 cells. J Endocrinol. 2013 Jul; 218(1):135-49. PMID: 23645249.
      View in: PubMed
    26. Meyer M, Kesic MJ, Clarke J, Ho E, Simmen RC, Diaz-Sanchez D, Noah TL, Jaspers I. Sulphorane induces SLPI secretion in the nasal mucosa. Respir Med. 2013; 107:472-475.
    27. Simmen RCM, Rahal OM, Montales MTE, Pabona JMP, Heard ME, Al-Dwairi A, Brown AR, Simmen FA. Cancer Chemoprevention and Treatment by Diet Therapy. Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer. 2013; 5.
    28. Montales MTE, Melnyk S, Simmen RCM. Maternal high diet promotion of mammary tumor risk in adult progeny is associated with early expansion of mammary cancer stem-like cells and increased maternal oxidative environment. FASEB J (Proceedings). 2013.
    29. Heard ME, Simmen FA, Simmen RCM. Aberrant Activation of Stem Cell-Associated Regulatory Pathways and Pro-Inflammatory Cytokine Expression with Absence of Endometrial Kruppel-like Factor 9 (KLF9) in a Mouse Model of Endometriosis. Endocrine Rev. 2013; OR36-6.
    30. Montales MTE, Melnyk S, Priol RL, Simmen RCM. Maternal metabolic changes with dietary intake of blueberry during pregnancy and lactation predispose adult progeny to lower mammary tumor growth rate. FASEB J (Proceedings. 2013.
    31. Meyer M, Kesic MJ, Clarke J, Ho E, Simmen RC, Diaz-Sanchez D, Noah TL, Jaspers I. Sulforaphane induces SLPI secretion in the nasal mucosa. Respir Med. 2013 Mar; 107(3):472-5. PMID: 23195333.
      View in: PubMed
    32. Heard ME, Pabona JM, Clayberger C, Krensky AM, Simmen FA, Simmen RC. The reproductive phenotype of mice null for transcription factor Krüppel-like factor 13 suggests compensatory function of family member Krüppel-like factor 9 in the peri-implantation uterus. Biol Reprod. 2012 Nov; 87(5):115. PMID: 22993382.
      View in: PubMed
    33. Rahal OM, Pabona JM, Kelly T, Huang Y, Hennings LJ, Prior RL, Al-Dwairi A, Simmen FA, Simmen RC. Suppression of Wnt1-induced mammary tumor growth and lower serum insulin in offspring exposed to maternal blueberry diet suggest early dietary influence on developmental programming. Carcinogenesis. 2013 Feb; 34(2):464-74. PMID: 23144318.
      View in: PubMed
    34. Al-Dwairi A, Pabona JM, Simmen RC, Simmen FA. Cytosolic malic enzyme 1 (ME1) mediates high fat diet-induced adiposity, endocrine profile, and gastrointestinal tract proliferation-associated biomarkers in male mice. PLoS One. 2012; 7(10):e46716. PMID: 23056418.
      View in: PubMed
    35. Pabona JM, Dave B, Su Y, Montales MT, de Lumen BO, de Mejia EG, Rahal OM, Simmen RC. The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein. Genes Nutr. 2013 Jan; 8(1):79-90. PMID: 22864686.
      View in: PubMed
    36. Pabona JM, Simmen FA, Nikiforov MA, Zhuang D, Shankar K, Velarde MC, Zelenko Z, Giudice LC, Simmen RC. Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2012 Mar; 97(3):E376-92. PMID: 22259059.
      View in: PubMed
    37. Montales MT, Rahal OM, Kang J, Rogers TJ, Prior RL, Wu X, Simmen RC. Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells. Carcinogenesis. 2012 Mar; 33(3):652-60. PMID: 22219179.
      View in: PubMed
    38. Simmen RCM. Mouse models of diseases: Why they are important in biology. 2012.
    39. Montales MTE, Rahal O, Kang J, Rogers T, Prior RL, Wu X, Simmen RC. Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggest diet-mediated targeting of cancer stem-cell like/progenitor cells. Carcinogenesis. 2012; 33:6520660.
    40. Pabona JMP, Simmen FA, Nikiforov M, Zhuang D, Shankar K, Velarde MC, Zelenco Z, Giudice LC, Simmen RC. Krüppel-like factor 9 and progesterone receptor co-regulation of decidualizing stromal cells: implications for the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2012; 97:376-392.
    41. Pabona JMP, Zhang D, Ginsburg D, Simmen FA, Simmen RCM. Prolonged pregnancy in women is associated with myometrial expression of progesterone receptor co-regulator Kruppel-like factor 9. Endocrrine Rev. 2012; 33:SAT-3.
    42. Simmen FA, Simmen RC. The maternal womb: a novel target for cancer prevention in the era of the obesity pandemic? Eur J Cancer Prev. 2011 Nov; 20(6):539-48. PMID: 21701386.
      View in: PubMed
    43. Rahal OM, Simmen RC. Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen receptor ß signaling. Endocrinology. 2011 Sep; 152(9):3409-21. PMID: 21712365.
      View in: PubMed
    44. Simmons CD, Pabona JM, Heard ME, Friedman TM, Spataro MT, Godley AL, Simmen FA, Burnett AF, Simmen RC. Krüppel-like factor 9 loss-of-expression in human endometrial carcinoma links altered expression of growth-regulatory genes with aberrant proliferative response to estrogen. Biol Reprod. 2011 Aug; 85(2):378-85. PMID: 21543766.
      View in: PubMed
    45. Su Y, Shankar K, Rahal O, Simmen RC. Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer--preventive actions of dietary factors. J Nutr Biochem. 2011 Jul; 22(7):605-11. PMID: 21292471.
      View in: PubMed
    46. Rahal OM, Simmen RC. PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation. Carcinogenesis. 2010 Aug; 31(8):1491-500. PMID: 20554748.
      View in: PubMed
    47. Pabona JM, Zeng Z, Simmen FA, Simmen RC. Functional differentiation of uterine stromal cells involves cross-regulation between bone morphogenetic protein 2 and Kruppel-like factor (KLF) family members KLF9 and KLF13. Endocrinology. 2010 Jul; 151(7):3396-406. PMID: 20410205.
      View in: PubMed
    48. Dave B, Wynne R, Su Y, Korourian S, Chang JC, Simmen RC. Enhanced mammary progesterone receptor-A isoform activity in the promotion of mammary tumor progression by dietary soy in rats. Nutr Cancer. 2010; 62(6):774-82. PMID: 20661826.
      View in: PubMed
    49. Dave B, Wynne R, Su Y, Korourian S, Chang JC, Simmen RCM. Enhanced mammary progesterone receptor isoform activity in the promotion of mammary tumor progression by dietary soy in rats. Nutr Cancer. 2010; 62:774-782.
    50. Simmen RCM, Pabona JMP, Velarde MC, Simmons C, Rahal O, Simmen FA. The emerging role of Kruppel-like factors in endocrine-responsive cancers of female reproductive tissues. J Endocrinol. 2010; (204):223-231.
    51. Simmons C, Pabona JMP, Burnett A, Friedman T, Spataro M, Gaddy D, Simmen FA, Simmen RCM. Transcription factor Kruppel-like factor 9 (KLF9) as potential predictor of dysfunctional estrogen receptor-alpha signaling in the uterus. Annual Meeting of the Endocrine Society. 2010.
    52. Simmons CD, Pabona JMP, Zeng Z, Velarde MC, Gaddy D, Simmen FA, Simmen RCM. Response of adult mouse uterus to early disruption of estrogen receptor-alpha signaling is influenced by Kruppel-like factor 9. J Endrocrinol. 2010; (205):147-157.
    53. Wu X, Rahal O, Kang J, Till SR, Prior RL, Simmen RC. In utero and lactational exposure to blueberry via maternal diet promotes mammary epithelial differentiation in prepubescent female rats. Nutr Res. 2009 Nov; 29(11):802-11. PMID: 19932869.
      View in: PubMed
    54. Simmen RC, Pabona JM, Velarde MC, Simmons C, Rahal O, Simmen FA. The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues. J Endocrinol. 2010 Mar; 204(3):223-31. PMID: 19833720.
      View in: PubMed
    55. Su Y, Shankar K, Simmen RC. Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes. J Nutr. 2009 May; 139(5):945-51. PMID: 19321580.
      View in: PubMed
    56. Pabona JMP, Simmen FA, Simmen RCM. Bone morphogenetic protein 2 (BMP2) and Kruppel-like factor 9 (KLF9) cross-regulation in uterine stromal cells promotes timing of uterine endometrial receptivity. Biol Reprod. 2009.
    57. Su Y, Shankar K, Simmen FA, Simmen R.C.M. Regulation of adipocyte lipid homeostasis by genistein alters mammary epithelial cell differentiation: a paracrine mechanism for mammary tumor protection. 2009; 325s.
    58. Pabona JMP, Velarde MC, Zeng Z, Simmen FA, Simmen R.C.M. Nuclear receptor co-regulator Kruppel-like factor-9 and prohibitin 2 expression in oestrogen-induced epithelial cell proliferation in the mouse uterus. J Endocrinol. 2009; (200):63-73.
    59. Simmen RCM, Su Y, Pabona JM, Rahal O, Simmons CD, Hennings L. Early effects of dietary soy and genistein in rodent models of mammary tumor development. Experimental Biology 2009 Annual Meeting. 2009.
    60. Su Y, Simmen RC. Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells. Carcinogenesis. 2009 Feb; 30(2):331-9. PMID: 19073877.
      View in: PubMed
    61. Simmen FA, Su Y, Xiao R, Zeng Z, Simmen RC. The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression. Reprod Biol Endocrinol. 2008 Sep 10; 6:41. PMID: 18783612.
      View in: PubMed
    62. Zeng Z, Velarde MC, Simmen FA, Simmen RCM. Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice mull for Kruppel-like factor 9. Biol Reprod. 2008; (78):1029-1037.
    63. Zeng Z, Velarde MC, Simmen FA, Simmen RCM. Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Kruppel-like factor 9. Biol Reprod. 2008; 78:1029-1037.
    64. Xiao R, Simmen RCM, Simmen FA. Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuate expression of fatty acid synthase. Am J Physiol: Gastrointest Liver Physiol. 2008; (294):868-876.
    65. Zeng Z, Velarde MC, Simmen FA, Simmen RC. Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Krüppel-like factor 9. Biol Reprod. 2008 Jun; 78(6):1029-37. PMID: 18305227.
      View in: PubMed
    66. Xiao R, Su Y, Simmen RC, Simmen FA. Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G868-76. PMID: 18239060.
      View in: PubMed
    67. Simmen FA, Su Y, Xiao R, Zeng Z, Simmen R.C.M. The Kruppel-like factor-9 (KLF9) network in HEC-1A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression. Reprod Biol Endocrinol. 2008; (6):41.
    68. Velarde MC, Zeng Z, McQuown JR, Simmen FA, Simmen RC. Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells. Mol Endocrinol. 2007 Dec; 21(12):2988-3001. PMID: 17717078.
      View in: PubMed
    69. Simmen FA, Xiao R, Velarde MC, Nicholson RD, Bowman MT, Fujii-Kuriyama Y, Oh SP, Simmen RC. Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1757-69. PMID: 17379758.
      View in: PubMed
    70. Su Y, Simmen FA, Xiao R, Simmen RC. Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors. Physiol Genomics. 2007 Jun 19; 30(1):8-16. PMID: 17341692.
      View in: PubMed
    71. Su Y, Simmen F.A, Xiao R, Simmen R.C.M. Prepubertal Changes in Lipid Homeostatis Gene Expression in Mammary Glands of Rats Exposed to Dietary Soy. 89th Annual Meeting of the Endocrine Society. 2007; 221, P1-250.
    72. Su Y, Eason RR, Geng Y, Till SR, Badger TM, Simmen RC. In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis. Carcinogenesis. 2007 May; 28(5):1046-51. PMID: 17166883.
      View in: PubMed
    73. Dave B, Eason RR, Geng Y, Su Y, Badger TM, Simmen RC. Tp53-associated growth arrest and DNA damage repair gene expression is attenuated in mammary epithelial cells of rats fed whey proteins. J Nutr. 2006 May; 136(5):1156-60. PMID: 16614397.
      View in: PubMed
    74. Velarde MC, Iruthayanathan M, Eason RR, Zhang D, Simmen FA, Simmen RC. Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Kruppel-like factor 9/basic transcription element binding protein-1. Endocrinology. 2006; 147(4):1969 - 1978.
    75. Simmen FA, Simmen RC. Orchestrating the menstrual cycle: discerning the music from the noise. Endocrinology. 2006 Mar; 147(3):1094-6. PMID: 16481481.
      View in: PubMed
    76. Eason RR, Till SR, Frank JA, Badger TM, Korourian S, Simmen FA, Simmen RC. Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesis. Nutr Cancer. 2006; 55(2):171-7. PMID: 17044772.
      View in: PubMed
    77. Kwak I, Song S, Blum JL, Simmen RC, Simmen FA. Enhancer- and silencer-like sequences that mediate insulin-like growth factor-binding protein-2 gene expression in uterine cells of pregnancy. DNA Cell Biol. 2006 Jan; 25(1):6-18. PMID: 16405396.
      View in: PubMed
    78. Su Y, Xiao R, Geng Y, Skinner C.M, Simmen F.A, Simmen R.C.M. Identification of gene networks underlying mammary tumor protection by dietary exposure to soy and genistein. 2006; 20(4), A560.
    79. Dave B, Eason R.R, Till S.R, Korourian S, Simmen R.C.M. Enhanced progesterone receptor A expression by dietary soy in a hormone-dependent (NMU) model of rat mammary carcinogenesis: implications for tumor progression. Annual Meeting, American Association for Cancer Research. 2006; 47:A5582.
    80. Geng Y, Till S.R, Frank J.A, Ferguson M, Badger T.M, Simmen R.C.M, Simmen F.A. Diets containing soy protein isolate or the soy isoflavone genistein suppress p53-mediated activation of the colon DNA damage response pathway in azoxymethane (AOM)-treated rats. 2006; 20(4), A564.
    81. Ronis M.J.J, Gilchrist J.M, Nagarajan S, Simmen F.A, Simmen R.C.M, Badger T.M. Developmental exposure to soy protein isolate: Potential health effects. Annual Meeting of Experimental Biology. 2006.
    82. Velarde M.C, Geng Y, Simmen F.A, Simmen R.C.M. Induction of progesterone receptor isoform expression by Kruppel-like factor 9/basic transcription element binding protein 1 in the myometrium is associated with labor onset in mice. 88th Annual Meeting of the Endocrine Society. 2006; 290, P1-517.
    83. Velarde MC, Iruthayanathan M, Eason RR, Zhang D, Simmen FA, Simmen RC. Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1. Endocrinology. 2006 Apr; 147(4):1969-78. PMID: 16384861.
      View in: PubMed
    84. Eason RR, Till SR, Velarde MC, Geng Y, Chatman L, Gu L, Badger TM, Simmen FA, Simmen RC. Uterine phenotype of young adult rats exposed to dietary soy or genistein during development. J Nutr Biochem. 2005 Oct; 16(10):625-32. PMID: 16081271.
      View in: PubMed
    85. Velarde MC, Geng Y, Eason RR, Simmen FA, Simmen RC. Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice. Biol Reprod. 2005 Sep; 73(3):472-81. PMID: 15917344.
      View in: PubMed
    86. Dave B, Eason RR, Till SR, Geng Y, Velarde MC, Badger TM, Simmen RC. The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis. 2005 Oct; 26(10):1793-803. PMID: 15905199.
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    87. Badger TM, Ronis MJ, Simmen RC, Simmen FA. Soy protein isolate and protection against cancer. J Am Coll Nutr. 2005 Apr; 24(2):146S-149S. PMID: 15798082.
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    88. Velarde M.C, Geng Y, Eason R.R, Simmen F.A, Simmen R.C.M. The Sp/Kruppel-like family (KLF) member, basic transcription element binding protein-1 (BTEB1) is important for developmental synchrony of embryo and uterine endometrium. 2005; 81.
    89. Dave B, Eason R.R, Till S.R, Geng Y, Velarde M.C, Simmen R.C.M, Badger T.M. The tumor suppressor PTEN mediates the pro-apoptotic activity of dietary genistein on mammary epithelial cells: implications for mammary cancer protection. Annual Meeting of The American Association for Cancer Research. 2005; 46:257.
    90. Ronis M.J.J, Gilchrist J.M, Nagarajan S, Simmen F.A, Simmen R.C.M, Badger T.M. Developmental exposure to soy protein isolate: potential health effects associated with feeding soy-based infant formulas. 2005.
    91. Simmen RC, Eason RR, Till SR, Chatman L, Velarde MC, Geng Y, Korourian S, Badger TM. Inhibition of NMU-induced mammary tumorigenesis by dietary soy. Cancer Lett. 2005 Jun 16; 224(1):45-52. PMID: 15911100.
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    92. Eason RR, Velarde MC, Chatman L, Till SR, Geng Y, Ferguson M, Badger TM, Simmen RC. Dietary exposure to whey proteins alters rat mammary gland proliferation, apoptosis, and gene expression during postnatal development. J Nutr. 2004 Dec; 134(12):3370-7. PMID: 15570039.
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    93. Gaucher EA, Graddy LG, Li T, Simmen RC, Simmen FA, Schreiber DR, Liberles DA, Janis CM, Benner SA. The planetary biology of cytochrome P450 aromatases. BMC Biol. 2004 Aug 17; 2:19. PMID: 15315709.
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    94. Simmen RC, Eason RR, McQuown JR, Linz AL, Kang TJ, Chatman L, Till SR, Fujii-Kuriyama Y, Simmen FA, Oh SP. Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene. J Biol Chem. 2004 Jul 09; 279(28):29286-94. PMID: 15117941.
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    95. Kowalski AA, Vale-Cruz DS, Simmen FA, Simmen RC. Uterine androgen receptors: roles in estrogen-mediated gene expressionand DNA synthesis. Biol Reprod. 2004 May; 70(5):1349-57. PMID: 14711790.
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    96. Simmen F.A, Blum J.L, Kwak I, Simmen R.C.M. Nutrition and the IGF System. Nutrition and the IGF System in Reproduction. 2004.
    97. Eason R.R, Velarde M, Chatman Jr., L, Till R, Ferguson M, Badger T.M, Simmen R.C.M. Dietary exposure to soy and whey proteins alters rat mammary gland gene expression during development. 2004; 18(4), Part 1, A356.10.
    98. Eason R.R, Linz A.L, Chatman Jr., L, Kang, T-J, Till S.R, Fujii-Kuriyama Y, Simmen F.A, Oh S.P, Simmen R.C.M. Sub-fertility in female mice lacking the Kruppel-like factor 9/basic transcription element binding protein-1 gene is correlated with decreased expression of implantation-associated genes and partial loss of progesterone responsiveness. 86th Annual Meeting of the Endocrine Society. 2004.
    99. Zhang XL, Zhang D, Michel FJ, Blum JL, Simmen FA, Simmen RC. Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells. J Biol Chem. 2003 Jun 13; 278(24):21474-82. PMID: 12672823.
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    100. Simmen R.C.M, Eason R.R, Till R, Ronis M.J, Badger T.M. Uterine growth parameters and steroid receptor gene expression in rats on soy and whey-based diets. 2003; 17(5), Part 2, A1163.
    101. Simmen R.C.M, McQuown J.R, Kang T.J, Fujii-Kuriyama Y, Simmen F.A. Functional role of the Kruppel-like transcription factor BTEB1 during pregnancy: studies with the BTEB1 knock-out mouse. 2003.
    102. Simmen R.C.M, Eason R.R, Zhang D, Zhang X-L, Simmen F.A. Overexpression of the Sp/KFL transcription factor BTEB1 alters cells cycle parameters in MCF-7 breast tumor cells. 94th Annual Meeting of the American Association for Cancer Research. 2003; Vol 44:539.
    103. Simmen RC, Simmen FA. Progesterone receptors and Sp/Krüppel-like family members in the uterine endometrium . Front Biosci. 2002 Jun 01; 7:d1556-65. PMID: 12045021.
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    104. Simmen RC, Simmen FA. Progesterone receptors and Sp/Kruppel-like family members in the uterine endometrium. Front Biosci. 2002; 7:d1556 - d1565.
    105. Zhang D, Simmen RC, Michel FJ, Zhao G, Vale-Cruz D, Simmen FA. Secretory leukocyte protease inhibitor mediates proliferation of human endometrial epithelial cells by positive and negative regulation of growth-associated genes. J Biol Chem. 2002 Aug 16; 277(33):29999-30009. PMID: 12023969.
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    106. Kowalski AA, Graddy LG, Vale-Cruz DS, Choi I, Katzenellenbogen BS, Simmen FA, Simmen RC. Molecular cloning of porcine estrogen receptor-beta complementary DNAs and developmental expression in periimplantation embryos. Biol Reprod. 2002 Mar; 66(3):760-9. PMID: 11870084.
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    107. Simmen RC, Zhang XL, Michel FJ, Min SH, Zhao G, Simmen FA. Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Krüppel-like factor BTEB1. DNA Cell Biol. 2002 Feb; 21(2):115-28. PMID: 11953011.
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    108. Simmen RC, Zhang XL, Michel FJ, Min SH, Zhao G, Simmen FA. Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Kruppel-like factor BTEB1. DNA Cell Biol. 2002; 21(2):115 - 128.
    109. McQuown J.R, Oh S.P, Michel F.J, Simmen R.C.M. Functional interaction between ligand-activated estrogen receptor (ER)-alpha and the transcription factor BTEB1 in uterine cells. 2002.
    110. Zhang D, Zhang XL, Michel FJ, Blum JL, Simmen FA, Simmen RC. Direct interaction of the Krüppel-like family (KLF) member, BTEB1, and PR mediates progesterone-responsive gene expression in endometrial epithelial cells. Endocrinology. 2002 Jan; 143(1):62-73. PMID: 11751593.
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    111. Min S.H, Simmen R.C.M, Alhonen L, Halmekyto M, Porter C.W, Janne J, Simmen F.A. Over-production of spermidine/spermine N1-acetyltransferase (SSAT) in female SSAT-transgenic mice alters expression of growth-related, endogenous retroviral, transcription factor, and novel gene transcripts in reproductive and other tissues. J. Biol. Chem. 2002; 277(5):3647-3657.
    112. Zhang D, Zhang XL, Michel FJ, Blum JL, Simmen FA, Simmen RC. Direct interaction of the Kruppel-like family (KLF) member, BTEB1, and PR mediates progesterone-responsive gene expression in endometrial epithelial cells. Endocrinology. 2002; 143(1):62 - 73.
    113. Zhang D, Zhang X-L, Michel F.J, Blum J.L, Simmen F.A, Simmen R.C.M. Direct interaction of the Kruppel-like Family (KLF) member, BTEB1 and Progesterone receptor mediates progesterone-responsive gene expression in endometrial epithelial cells. Endocrinology. 2002; 141:62-73.
    114. Min SH, Simmen RC, Alhonen L, Halmekyto M, Porter CW, Janne J, Simmen FA. Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT). J Biol Chem. 2002 Feb 01; 277(5):3647-57. PMID: 11709547.
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    115. Vale-Cruz D, Kowalski A.A, Simmen F.A, Simmen R.C.M. Expression of androgen receptors in the peri-attachment porcine uterus. 2001.
    116. Kowalski A.A, Vale-Cruz D, Zhang D, Jaeger L.A, Michel F.J, Simmen F.A, Simmen R.C.M. Estrogen receptor (ER)-beta and estrogen (E)-regulated transcripts in porcine trophoblastic cells. 2001; 64 (Suppl 1): 280.
    117. Kowalski A.A, Graddy L.G, Choi I, Katzenellenbogen B.S, Simmen F.A, Simmen R.C.M. Expression of estrogen receptor (ER)-alpha and beta and progesterone receptor (PR) by porcine embryos suggests potential autocrine functions in development. 2000; 62 (Suppl 1):106.
    118. Zhang D, Zhang X-L, Simmen F.A, Simmen R.C.M. Progesterone (P) alters functional interactions between its receptor and Sp-related transcription factors: mechanism for P control of endometrial gene expression?. 2000; 62 (Suppl. 1): 117.
    119. Min S.H, Simmen R.C.M, Porter C.W, Janne J, Simmen F.A. Over-expression of spermidine/spermine N1-acetyltransferase (SSAT) alters genome expression profiles in the reproductive organs of female mice. 2000; 62 (Suppl 1): 117.
    120. Rodriguez-Sallaberry C, Michel F.J, Zhao G, Simmen F.A, Simmen R.C.M. Polyamine regulation of porcine endometrial cell proliferation during peri-implantation. 2000; 62 (Suppl 1): 261.
    121. Rodriguez-Sallaberry C, Kwak I, Michel F.J, Simmen F.A, Simmen R.C.M. Insulin-like growth factor-I regulation of porcine endometrial spermidine/spermine N1-acetyltransferase (SSAT) gene expression at peri-implantation. 1999; 60 (Suppl. 1): 210.
    122. Parisek S.I, Michel F.J, Simmen R.C.M. Growth factor regulation of endometrial secretory leukocyte protease inhibitor expression. 1999; 60 (Suppl. 1): 241.
    123. Kwak I, Simmen R.C.M, Simmen F.A. Functional roles of uterine estrogen receptors (ER): activation of IGF-I and inhibition of IGFBP-2 gene transcription by ER-alpha, but not ER-beta, in human endometrial adenocarcinoma cells (Hec-1A). 1999.
    124. Hillier M, Michel F.J, Grant M, Caballero S, Simmen R.C.M. Metalloprotease production by the peri-implantation pig endometrium. 1998; 60 (Suppl. 1): 271.
    125. Badinga L, Simmen R.C.M, Simmen F.A. Insulin-like growth factor-II (IGF-II) and insulin-like growth factor binding protein-2 (IGFBP-2) stimulate uterine epithelial cell proliferation through distinct signaling pathways. 1998.
    126. Kowalski A, Simmen R.C.M, Green M.L, Chang S-M, Fields M.J. Differential gene expression in bovine corpora lutea during pregnancy. 1998; 58 (Suppl. 1): 177.
    127. Kwak I, Song S, Badinga I, Simmen R.C.M, Simmen F.A. Transcriptional motifs of the insulin-like growth factor-binding protein-2 (IGFBP-2) gene in the endometrium. 1998.
    128. Simmen F.A, Badinga L, Green M.L, Kwak I, Song S, Simmen R.C.M. J. Nutrition. The porcine IGF system: at the interface of nutrition, growth and reproduction. 1998.
    129. Badinga L, Hillier M.A, Michel F.J, Simmen R.C.M. Uterine-associated low molecular weight protease inhibitors stimulate DNA synthesis in endometrial glandular epithelial cells. 1998; 58 (Suppl. 1): 95.
    130. Reed K.L, Michel F.J, Hiemstra P.S, Simmen R.C.M. Interaction of secretory leukocyte protease inhibitor with placental and endometrial extracellular matrix. 1997; 56 (Suppl. 1):205.
    131. Kwak I, Perera O.P, Chung T.E, Collante W.C, Simmen R.C.M, Simmen F.A. Transcription of the insulin-like growth factor-I (IGF-I) gene in porcine endometrium: promoter usage and putative enhancers in pregnancy. 1997; 56 (Suppl. 1): 84.
    132. Badinga L, Song S, Yang J, Collante W.R, Simmen R.C.M, Simmen F.A. Recombinant porcine insulin-like growth factor-binding protein-2 (IGFBP-2) interacts with human insulin-like growth factor-2 (IGF-II) to modulate human and porcine uterine epithelial cell proliferation. 1997; 56 (Suppl. 1):104.
    133. Modric T, Green M.L, Simmen R.C.M, Simmen F.A. Expression and function of leukemia inhibitory factor and interleukin-6 genes during porcine pregnancy. 1997; 56 (Suppl. 1):202.
    134. Green M.L, Reed K.L, Chung T.E, Simmen F.A, Simmen R.C.M. Effect of insulin-like growth factor-I (IGF-I), retinol and interleukin-6 (IL-6) on in vitro expression of spermidine/spermine N1-acetyltransferase (SSAT) in porcine endometrium. 1997; (Suppl. 1):85.
    135. Fields M.J, Ndikum-Moffor F.M, Simmen R.C.M, Buhi W.C, Rollyson K, Kowalski A.A, Chang S.M.T, Fields P.A. Bovine luteal secretory proteins of the oestrus cycle and pregnancy. Reprod. Dom. Anim. 1996; 31:40725.25.
    136. Green M.L, Simmen F.A, Simmen R.C.M. Molecular cloning of spermidine/spermine N-acetyltransferase (SSAT) from the porcine uterus by mRNA differential display: temporal and conceptus-modulated gene expression during early pregnancy. 1996; 54 (Suppl. 1):103.
    137. Reed K.L, Blaeser L, Dantzer V, Green M.L, Simmen R.C.M. Conceptus modulation of antileukoproteinase (ALP) and uteroferrin (UF) gene expression in peri-implantation porcine endometrium. 1996; 54 (Suppl. 1):173.
    138. Green M.L, Simmen F.A, Simmen R.C.M. Differential expression of endometrial genes in the preimplantation porcine uterus. 1995; 52 (Suppl. 1):87.
    139. Choi I, Simmen R.C.M, Simmen F.A. Molecular cloning from the peri-implantation porcine blastocyst of full-length cytochrome P450 aromatase cDNAs exhibiting differential polyadenylation and a unique 5' untranslated sequence. 1995; 619.
    140. Reed K.L, Badinga L, Davis D.L, Chung T.E, Simmen R.C.M. Porcine endometrial cell cultures as a model to study steroid hormone regulation of antileukoproteinase (ALP) gene expression. 1995; 52 (Suppl. 1):87.
    141. Ndikum-Moffor F.M, Simmen R.C.M, Chang S-M.T, Fields M.J. Secretory proteins of the bovine corpus luteum: the estrous cycle and pregnancy. 1995; 52 (Suppl. 1):87.
    142. Song S, Simmen R.C.M, Simmen F.A. Identification of 5'flanking sequences that mediate endometrial expression of the insulin-like growth factor-binding protein-2 (IGFBP-2) gene. 1995; 165.
    143. Simmen R.C.M, Green M.L, Simmen F.A. Serono Symposium on Molecular and Cellular Aspects of Periimplantation Processes. The IGF System in Periimplantation Uterus and Embryonic Development. 1995.
    144. Conliffe P.R, Farmerie W.G, Charles G.D, Buhi W.C, Simmen R.C.M, Shiverick K.T. Expression of recombinant rat placental prolactin-like protein. 1994; 626.
    145. Ko Y, Simmen R.C.M, Young Lee C, Simmen F.A. Reversion to the nontransformed ph4enotype of tsSV40-transformed uterine endometrial epithelial cells is accompanied by decreased mitogenic responsiveness to IGFs and by enhanced secretion of at least five different IGF binding proteins. Endocrine. 1994; 2:495-504.
    146. Gonzalez B.Y, Michel F.J, Simmen R.C.M. A heptamer sequence within the uteroferrin gene 5'-flanking region binds an 80 kda protein ubiquitously expressed in endometrial cells. 1994; 567.
    147. Simmen R.C.M, Ko Y, Simmen F.A. Insulin-like growth factors and blastocyst development. Theriogenology. 1993; 39:163-175.
    148. Badinga L, Michel F.J, Simmen R.C.M. Analysis of upstream DNA sequences required for the antileukoproteinase gene expression in endomentrial cells. 1993; (Suppl. 1)48:135.
    149. Gonzalez B, Michel F.J, Simmen R.C.M. Identification and characterization of endometrial nuclear proteins binding to the uteroferrin promoter. 1993; 439.
    150. Salute M.E, Tucker K.E, Sharp D.C, Simmen R.C.M. Does insulin-like growth factor I have an effect on the production of estradiol by the equine conceptus during early development?. 1993; 71 (Suppl. 1) 222.
    151. Choi I, Ko Y, Simmen R.C.M, Simmen F.A. Expression of cytochrome P-450 aromatase in peri-implantation porcine conceptuses is correlated with insulin-like growth factor levels in uterine luminal fluids. 1993; (Suppl. 1) 48:176.
    152. Gonzalez-Yanes B, Michel F.J, Simmen R.C.M. Analysis of cis-acting elements required for endometrial expression of the uteroferrin gene. 1992; (Suppl. 1) 46:181.
    153. Lamian V, Fliss A.E, Simmen R.C.M. Functional interactions of progesterone receptor and nonconcensus progesterone response elements in the control of uteroferrin gene transcription in the endometrium. 1992; (Suppl. 1) 46:181.
    154. Ogilvie S, Simmen R.C.M, Fliss A.E, Michel F.J, Shiverick K.T. Complementary DNA cloning of a novel rat placental cathepsin L-related messenger RNA. 1992; 409.
    155. Reinhart G.A, Simmen F.A, Mahan D.C, Simmen R.C.M, White M.E, Trulzsch D.V. Perinatal ontogeny of fatty acid binding protein activity in porcine small intestine. Nutrition Res. 1992; 12:1345-1356.
    156. Ko Y, Simmen R.C.M, Simmen F.A. Identification of uterine endometrial epithelial cell growth factors: stimulation by IGF-I/-II and inhibition by TGF-beta 1 of endometrial cells in vitro. 1991; 115 (3):220a.
    157. Chen C-H, Simmen R.C.M, Chou J.Y. Chinese J Physiol. Characterization of endocrine cell lines immortalized by a temperature-sensitive mutant SV40. 1991.
    158. Harney J.P, Simmen R.C.M, Bazer F.W. Expression of mRNA encoding retinol-binding protein in placenta, endometrium, myometrium, liver and other tissues throughout pregnancy in the pig. 1991; (Suppl. 1): 173.
    159. Davis M.E, Bishop M.D, Park N.H, Michel F.J, Simmen R.C.M. Preliminary results of selection for serum insulin-like growth factor-I (IGF-I) in Angus beef cattle. 1991.
    160. Fliss A.E, Lamian V, Simmen R.C.M. Analysis of cis-acting elements involved in the progesterone-regulated and endometrial-specific expression of the pregnancy-associated uteroferrin gene. 1991; 309.
    161. Spencer T.E, Bartol F.F, Simmen R.C.M, Wiley A.A, Coleman D.A, Davenport G.M. Effect of estrogen exposure on uterine gene expression, tissue concentration and distribution of IGF-I in neonatal pigs. 1991; 44 (Suppl. 1): 115.
    162. Simmen R.C.M, Fliss A.E, Michel F.J, Smith L.C, Bazer F.W, Sharp III D.C. Expression of antileukoproteinase, a pregnancy-associated elastase/cathepsin G inhibitor in endometrium: analysis with polyclonal antibodies and cDNA probes. 1991; 277.
    163. Bazer F.W, Simmen R.C.M, Simmen F.A. The Primate Endometrium. Comparative aspects of conceptus signals for maternal recognition of pregnancy. 1990.
    164. Ko Y, Lee C.Y, Ott T.L, Davis M.A, Simmen R.C.M, Bazer F.W, Simmen F.A. Identification of insulin-like growth factors and other mitogens in uterine fluids of early pregnant sheep. Annual Meeting of the American Society of Animal Science. 1990.
    165. Fliss A.E, Chen C.L, Simmen R.C.M. Functional analysis of the promoter region of the porcine uteroferrin gene. 1990; 69.
    166. Bishop M.D, Simmen R.C.M, Simmen F.A, Davis M.E. Repeatability and rank correlations for serum insulin-like growth factor I (IGF-I) from birth through puberty in angus beef cattle. 1990; 241.
    167. Bishop M.D, Park N.H, Simmen R.C.M, Simmen F.A, Davis M.E. Prediction of carcass traits using insuline-like growth factor-I (IGF-I) in Angus beef cattle. 1990; 241.
    168. Hofig A, Simmen F.A, Simmen R.C.M. Effects of dihydroepandrosterone (DHEA) insuline-like growth factor-I (IGF-I), insuline (I) on estradiol production by porcine conceptuses in vitro. 1990; 281.
    169. Simmen F.A, Simmen R.C.M, Bazer F.W. Transactions of the Biochemical Society. Maternal growth factors as mediators of embryonic and neonatal growth. 1989.
    170. Srinivas V, Simmen R.C.M. Porcine uteroferrin gene: analysis of structure and identification of 5' regulatory sequences. 1989; 107, 308a.
    171. Simmen F.A, Simmen R.C.M, Letcher L.R, Schober D.A, Ko Y. Insulin, IGFs and their Receptors. IGFs in pregnancy: Developmental expression in uterus and mammary gland and paracrine actions during embryonic and neonatal growth. 1989.
    172. Farmer S.J, Simmen R.C.M, Simmen F.A. Pregnancy associated uterine expression of the mRNA encoding porcine antileukoproteinase. 1989; 107, 615a.
    173. Reinhart G.A, Mahan D.C, Simmen F.A, Simmen R.C.M, White M.E. The effect of mammary secretions on intestinal development in the newborn pig. Joint Annual Meeting of the American Dairy Science Assoc. and the American Society of Animal Science. 1989.
    174. Reinhart G.A, Mahan D.C, White M.E, Simmen F.A, Simmen R.C.M. Ontogeny of fatty acid binding proteins in the proximal intestine of the young pig. Joint Annual Meeting of the American Dairy Science Assoc. and American Society of Animal Science. 1989.
    175. Letcher L.R, Simmen R.C.M, Bazer F.W, Simmen F.A. Insulin-like growth factor-I in pregnant pig: Developmental expression during uterine and embryonic growth. 1989; 198.
    176. Ko Y, Simmen R.C.M, Simmen F.A. Identification and partial purification of a mitogen in porcine allantoic fluids. 80th Annual Meeting of the American Society of Animal Science. 1988.
    177. Simmen F.A, Simmen R.C.M, Letcher L.R, Tavakkol A, Bazer F.W. Tissue-specific and developmental expression of insulin-like growth factor-I in the pregnant and lactating pig. 1988.
    178. Brummet S.R, Simmen R.C.M. Porcine uteroferrin: cDNA sequence and molecular cloning of the chromosomal gene. First Annual Ohio State Biotechnology Conference. 1988.
    179. Tavakkol A, Simmen R.C.M, Simmen F.A. Complementary DNA cloning and uterine expression of messenger RNAs encoding porcine insulin-like growth factor-I. 1988.
    180. Bishop M.D, Simmen R.C.M, Simmen F.A, Davis M.E. The relationship of insulin-like growth factor I to postweaning performance in Angus beef cattle. 80th Annual Meeting of the American Society of Animal Science. 1988.
    181. Rasmussen C.D, Simmen R.C.M, MacDougall E.A, Means A.R. Methods of Enzymology. Methods for analyzing bovine papilloma virus-based calmodulin expression vectors. 1987.
    182. Epsstein P, Simmen R.C.M, Tanaka T, Means A.R. Methods of Enzymology. Isolation and structural analysis of the chromosomal gene for chicken calmodulin. 1987.
    183. Tan T.J, Simmen R.C.M, Simmen F.A. Differential expression of insulin-like growth factor I and other fibroblast mitogens in porcine colostrum and milk. American Society for Biological Chemistry. 1987.
    184. Reinhart G.A, Simmen F.A, Mahan D.C, Simmen R.C.M. Identification and isolation of a fatty acid binding protein from porcine intestinal mucosa. 1987; 65 (1) Abstract 272.
    185. Simmen R.C.M, Wilde M.H, Pope W.F, Simmen F.A. Porcine uterine luminal fluid contains epithelial cell growth stimulating factors. 26th Annual Meeting of the American Society for Cell Biology. 1986.
    186. Simmen R.C.M, Roberts R. Michael. Cloning and characterization of the porcine uteroferrin gene. 1986.
    187. Means A.R, Putkey J.A, Simmen R.C.M, Gerchtold M.W. Neurobiology: Molecular Biological Approaches to Understanding Neuronal Function and Development. Structure, function, and expression of calmodulin genes. 1985.
    188. Means A.R, Lagace L, Simmen R.C.M, Putkey J.A. Calcium and Cell Physiology. Calmodulin gene structure and expression. 1985.
    189. Means A.R, Simmen R, Slaughter G.R, Stein J.P, Putkey J.A. Structure, expression and evolution of calmodulin genes. Third Int'l Congress on Cell Biology. 1984.
    190. Means A.R, Simmen R, Stein J.P, Putkey J.A. Structure expression and evolution of calmodulin genes. 1984; 98, Suppl. 8B, Abs. #1095.
    191. Greenwood F.C, Duyao M, Setliff J, Koay E, Mercado-Simmen R, Yamamoto S, Ueno M, Bryant-Greenwood G.D. Biology of Relaxin and its Role in Human. Problems in the study of receptors for relaxin. 1983.
    192. Bryant-Greenwood G.D, Mercado-Simmen R.C, Yamamoto S, Arakaki R, Uchima F, Greenwood F.C. Relaxin. Relaxin receptors and physiological significance. 1982.
    193. Simmen R, Chafouleas J.G, Guerriero V, Clark J.H, Means A.R. Calmodulin and calmodulin binding proteins in liver nuclear matrix. 22nd Annual Meeting of the American Society for Cell Biology. 1982.
    194. Simmen R, Dunbar B.S, Greene G, Jensen E.V, Means A.R, Clark J.H. Estrogen-induced changes in nuclear matrix proteins from avian liver. 64th Annual Meeting of the Endocrine Society. 1982.
    195. Mercado-Simmen RCM, Goodwin B, Ueno MS, Yagamoto SY, Bryant-Grenwood GD. Relaxin receptors in the myometrium and cervix of the pig. Biol Reprod. 1982; (26):120-128.
    196. Bryant-Greenwood G.D, Greenwood F.C, Mercado-Simmen R.C, Weiss T, Yamamoto S, Ueno M, Arakaki R. Relaxin structure, function, and evolution. Relaxin secretion and relaxin receptors. 1982.
    197. Bryant-Greenwood GD, Mercado-Simmen R, Yamamoto SY, Arakaki RF, Uchima FD, Greenwood FC. Adv. Exp. Med. Biol. Relaxin receptors and study of the physiological roles of relaxin. 1982.
    198. Mercado-Simmen RCM, Bryant-Greenwood GD, Greenwood FC. Relaxin receptors in the rat myometrium: regulation by estrogen and relaxin. Endocrinology. 1982; (110):220-226.
    199. Greenwood F.C, Mercado-Simmen R, Yamamoto S, Ueno M, Bryant-Greenwood G.D. Relaxin. Studies of the Relaxin Receptor. 1981.
    200. Farmer SW, Licht P, BonaGallo A, Mercado-Simmen R, DeLisle FE, Papkoff H. Studies on several marsupial anterior pituitary hormones. Gen Comp Endocrinol. 1981; (43):336-345.
    201. Bryant-Greenwood G.D, Mercado-Simmen R, Ueno M, Yamamoto S. Relaxin receptors in the porcine myometrium and cervix. 14th Annual Meeting of the Society for the Study of Reproduction. 1981.
    202. Gast M.J, Mercado-Simmen R, Niall H, Boime I. Precursor Processing in the Biosynthesis of Proteins. Cell free-synthesis of high molecular weight relaxin-related protein. 1980.
    203. Niall H.D, John M, James R, Kwok S, Mercado R, Bryant-Greenwood G.D, Bradshaw R.A, Gast M, Boime I. Insulin, Chemistry, Structure and function of insulin and related hormones. 1980.
    204. Mercado-Simmen RCM, Bryant-Greenwood GD, Greenwood FC. Characterization of the binding of 125 I-relaxin to rat uterus. J Biol Chem. 1980; (255):3617-3623.
    205. Farmer S.W, Mercado R.C, DeLisle F.E, Papkoff H, Tyndall-Biscoe C.H. Marsupial prolactin and growth hormone. Biochemical, biological and radioimmunological characterization. 6th Int'l Congress of Endocrinology. 1980.
    206. Gast M, Mercado R, Bryant-Greenwood D, Niall H, Boime I. mRNA dependent synthesis of a stable precursor of relaxin in ascites tumor cell-free lysates. 61st Annual Meeting of the Endocrine Society. 1979.
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