Last Name

Richard Frye

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Neurology
Address Campus General
1120 Marshall Street
Mail Slot # 512-41B
Little Rock AR 72202
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    Collapse Research Funds 
    Collapse principal investigator
    Funding Agency: - Title: The effect of phytocannabinoids on mitochondrial function in Chronic Fatigue Syndrome - Start Date: 2017-07-01

    Funding Agency: Autism Research Institute - Title: Atypical tryptophan metabolism is related to autism characteristics: Development of plasma and urine biomarkers - Start Date: 2017-05-17

    Pass Through Agency: Arizona State University - Funding Agency: Department of Defense - Title: Microbiota Transfer Therapy (MTT) for Treating Gastrointestinal Problems in Adults with ASD - Start Date: 2016-09-01

    Funding Agency: Research Triangle Institute - Title: Assessment of Gastrointestinal Symptoms - Start Date: 2016-07-21

    Pass Through Agency: Saint Peter's Healthcare System - Funding Agency: New Jersey Governor's Council for Medical Research and Treatment of Autism - Title: Autism Mitochondrial Analyses - Subcontract with Saint Peter's Healthcare System - Start Date: 2016-07-01

    Funding Agency: - Title: Phytocannabinoids protective effect on oxidative stress induced mitochondrial dysfunction in control and autistic cell lines. - Start Date: 2016-07-01

    Funding Agency: Reata Pharmaceuticals, Inc. - Title: Effect of AIMs and HSP90 inhibitors on in Vitro Mitochondrial respiration in control and autism lymphoblastoid cell lines - Start Date: 2016-05-13

    Funding Agency: Curemark LLC - Title: An Open-Label Extension Study of CM-AT for the Treatment of Children with Autism - Start Date: 2016-03-01

    Funding Agency: Curemark LLC - Title: A Double Blind Placebo Controlled Study of CM-AT for the Treatment of Autism in Children with All Levels of Fecal Chymotryspin - Start Date: 2015-09-14

    Funding Agency: - Title: Children's Autism Metabolome Project (CAMP): Development and Clinical Evaluation of the Stemina Metabolic Biomarker-Based Test to Diagnose Autism Spectrum Disorder in Early Childhood - Start Date: 2015-05-28

    Funding Agency: Autism Research Institute - Title: Mitochondrial dysfunction and autism spectrum disorders-inflammatory subtype (ASD-IS) - Start Date: 2015-02-11

    Funding Agency: MitoSynergy - Title: Effect of Cunermuspir on In-Vitro Mitochondrial Respiration in Normal and Autistic Cell Lines - Start Date: 2014-10-01

    Funding Agency: Edison Pharmaceuticals, Inc - Title: An Exploratory Open-Label Phase II Study of WPI-743 (Vincerinone) in Children with Autism Spectrum Disorder - Start Date: 2014-08-29

    Funding Agency: Coronado Biosciences, Inc - Title: A Randomized, Double-Blind, Phase 2A Crossover Study to Assess the Safety and Efficacy of Trichuris Suis Ova for the Treatment of Autism Spectrum Disorder - Start Date: 2014-06-01

    Funding Agency: Autism Research Institute - Title: Health GFCF Modified Atkins Diet for Treating Seizures in Autism - Start Date: 2014-01-01

    Funding Agency: University of California San Francisco - Title: AT3 - Start Date: 2013-09-01

    Pass Through Agency: Arkansas Children's Hospital Foundation - Funding Agency: Jane Botsford Johnson Foundation - Title: Mitochondrial Dysfunction in Autism - Start Date: 2013-01-01

    Funding Agency: Forest Laboratories - Title: An Open-Label Study of the Safety and Tolerability of Memantine in Pediatric Patients with Autism, Asperger's Disorder or PDD-NOS - MEM-MD-91 - Start Date: 2012-05-01

    Funding Agency: Forest Laboratories - Title: A Double Blind, Placebo-Controlled, Randomized Withdrawal Study of the Safety and Efficacy of Memantine in Ped Patients with Autism, Asperger's Disorder, or PDD-NOS - Start Date: 2012-05-01

    Funding Agency: Forest Laboratories - Title: An Open-Label Extension Study of the Safety and Tolerability of Memantine in Pediatric Patients with Autism, Asperger's Disorder, or PDD-NOS - MEM-MD-69 - Start Date: 2012-05-01

    Funding Agency: BioMarin Pharmaceutical Inc. - Title: Biomarkers of Central Nervous System Tetrahydrobiopterin Concentration and Response - Start Date: 2012-04-05

    Funding Agency: UAMS ACHRI Flow Through - Title: Biomarkers of CNS Tetrahydrobiopterin (033182) - Award Number: 33182 - Start Date: 2012-04-05

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hamdan FF, Myers CT, Cossette P, Lemay P, Spiegelman D, Laporte AD, Nassif C, Diallo O, Monlong J, Cadieux-Dion M, Dobrzeniecka S, Meloche C, Retterer K, Cho MT, Rosenfeld JA, Bi W, Massicotte C, Miguet M, Brunga L, Regan BM, Mo K, Tam C, Schneider A, Hollingsworth G. High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies. Am J Hum Genet. 2017 Nov 02; 101(5):664-685. PMID: 29100083.
      View in: PubMed
    2. Rose S, Bennuri SC, Murray KF, Buie T, Winter H, Frye RE. Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study. PLoS One. 2017; 12(10):e0186377. PMID: 29028817.
      View in: PubMed
    3. Burger BJ, Rose S, Bennuri SC, Gill PS, Tippett ML, Delhey L, Melnyk S, Frye RE. Autistic Siblings with Novel Mutations in Two Different Genes: Insight for Genetic Workups of Autistic Siblings and Connection to Mitochondrial Dysfunction. Front Pediatr. 2017; 5:219. PMID: 29075622.
      View in: PubMed
    4. Delhey L, Kilinc EN, Yin L, Slattery J, Tippett M, Wynne R, Rose S, Kahler S, Damle S, Legido A, Goldenthal MJ, Frye RE. Bioenergetic variation is related to autism symptomatology. Metab Brain Dis. 2017 Dec; 32(6):2021-2031. PMID: 28852932.
      View in: PubMed
    5. Khemakhem AM, Frye RE, El-Ansary A, Al-Ayadhi L, Bacha AB. Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers. Metab Brain Dis. 2017 Aug 22. PMID: 28831647.
      View in: PubMed
    6. Frye RE, Slattery JC, Quadros EV. Folate metabolism abnormalities in autism: potential biomarkers. Biomark Med. 2017 Aug 03. PMID: 28770615.
      View in: PubMed
    7. Parikh S, Goldstein A, Karaa A, Koenig MK, Anselm I, Brunel-Guitton C, Christodoulou J, Cohen BH, Dimmock D, Enns GM, Falk MJ, Feigenbaum A, Frye RE, Ganesh J, Griesemer D, Haas R, Horvath R, Korson M, Kruer MC, Mancuso M, McCormack S, Raboisson MJ, Reimschisel T, Salvarinova R, Saneto RP, Scaglia F, Shoffner J, Stacpoole PW, Sue CM, Tarnopolsky M, Van Karnebeek C, Wolfe LA, Cunningham ZZ, Rahman S, Chinnery PF. Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society. Genet Med. 2017 Jul 27. PMID: 28749475.
      View in: PubMed
    8. Morris G, Puri BK, Frye RE. The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved? Metab Brain Dis. 2017 Oct; 32(5):1335-1355. PMID: 28752219.
      View in: PubMed
    9. Frye RE, Rose S, Wynne R, Bennuri SC, Blossom S, Gilbert KM, Heilbrun L, Palmer RF. Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity in Autistic and Control Lymphoblastoid Cell Lines. Sci Rep. 2017 Jun 30; 7(1):4478. PMID: 28667285.
      View in: PubMed
    10. Delhey LM, Nur Kilinc E, Yin L, Slattery JC, Tippett ML, Rose S, Bennuri SC, Kahler SG, Damle S, Legido A, Goldenthal MJ, Frye RE. The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder. J Clin Med. 2017 Feb 13; 6(2). PMID: 28208802.
      View in: PubMed
    11. Frye RE, Rosin DF, Morrison AR, Leon-Sarmiento FE, Doty RL. Modulation of the ultradian human nasal cycle by sleep stage and body position. Arq Neuropsiquiatr. 2017 Jan; 75(1):9-14. PMID: 28099555.
      View in: PubMed
    12. Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE. Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study. FASEB J. 2017 Mar; 31(3):904-909. PMID: 27864377.
      View in: PubMed
    13. Slattery J, MacFabe DF, Frye RE. The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood. Clin Med Insights Pediatr. 2016; 10:91-107. PMID: 27774001.
      View in: PubMed
    14. Chen JR, Lazarenko OP, Blackburn ML, Rose S, Frye RE, Badger TM, Andres A, Shankar K. Maternal Obesity Programs Senescence Signaling and Glucose Metabolism in Osteo-Progenitors From Rat and Human. Endocrinology. 2016 Nov; 157(11):4172-4183. PMID: 27653035.
      View in: PubMed
    15. Shah M, Frye R, Marzinsky A, Phillips MR, Adamson W, McLean SE. Complications Associated with Bar Fixation after Nuss Repair for Pectus Excavatum. Am Surg. 2016 Sep; 82(9):781-2. PMID: 27670561.
      View in: PubMed
    16. Frye RE, Rossignol DA. Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes. Clin Med Insights Pediatr. 2016; 10:43-56. PMID: 27330338; PMCID: PMC4910649.
    17. Niyazov DM, Kahler SG, Frye RE. Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment. Mol Syndromol. 2016 Jul; 7(3):122-37. PMID: 27587988; PMCID: PMC4988248 [Available on 01/01/17].
    18. Frye RE, Casanova MF, Fatemi SH, Folsom TD, Reutiman TJ, Brown GL, Edelson SM, Slattery JC, Adams JB. Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder. Front Neurosci. 2016; 10:192. PMID: 27242398; PMCID: PMC4861974.
    19. Frye RE, Delhey L, Slattery J, Tippett M, Wynne R, Rose S, Kahler SG, Bennuri SC, Melnyk S, Sequeira JM, Quadros E. Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups. Front Neurosci. 2016; 10:80. PMID: 27013943; PMCID: PMC4783401.
    20. Frye RE, Cox D, Slattery J, Tippett M, Kahler S, Granpeesheh D, Damle S, Legido A, Goldenthal MJ. Mitochondrial Dysfunction may explain symptom variation in Phelan-McDermid Syndrome. Sci Rep. 2016 Jan 29; 6:19544. PMID: 26822410; PMCID: PMC4731780.
    21. Slattery J, MacFabe DF, Kahler SG, Frye RE. Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored? Curr Pharm Des. 2016; 22(40):6107-6121. PMID: 27592717.
      View in: PubMed
    22. Tilford JM, Payakachat N, Kuhlthau KA, Pyne JM, Kovacs E, Bellando J, Williams DK, Brouwer WB, Frye RE. Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects. J Autism Dev Disord. 2015 Nov; 45(11):3613-23. PMID: 26126749; PMCID: PMC4609586 [Available on 11/01/16].
    23. Hasan KM, Mwangi B, Cao B, Keser Z, Tustison NJ, Kochunov P, Frye RE, Savatic M, Soares J. Entorhinal Cortex Thickness across the Human Lifespan. J Neuroimaging. 2016 May; 26(3):278-82. PMID: 26565394; PMCID: PMC4826319 [Available on 05/01/17].
    24. Frye RE, Slattery J. Introduction. Microb Ecol Health Dis. 2015; 26:28168. PMID: 25956239; PMCID: PMC4425811.
    25. Frye RE, Rose S, Slattery J, MacFabe DF. Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microb Ecol Health Dis. 2015; 26:27458. PMID: 25956238; PMCID: PMC4425813.
    26. Frye RE, Slattery J, MacFabe DF, Allen-Vercoe E, Parker W, Rodakis J, Adams JB, Krajmalnik-Brown R, Bolte E, Kahler S, Jennings J, James J, Cerniglia CE, Midtvedt T. Approaches to studying and manipulating the enteric microbiome to improve autism symptoms. Microb Ecol Health Dis. 2015; 26:26878. PMID: 25956237; PMCID: PMC4425814.
    27. Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. Neurosci Biobehav Rev. 2015 Aug; 55:294-321. PMID: 25957927.
      View in: PubMed
    28. Rose S, Wynne R, Frye RE, Melnyk S, James SJ. Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines. J Toxicol. 2015; 2015:573701. PMID: 25688267; PMCID: PMC4320799.
    29. Frye RE. RASopathies: a window into the molecular mechanisms underlying neurodevelopmental disorders. Dev Med Child Neurol. 2015 Apr; 57(4):315-6. PMID: 25403734.
      View in: PubMed
    30. Frye RE. Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder. Epilepsy Behav. 2015 Jun; 47:147-57. PMID: 25440829.
      View in: PubMed
    31. Frye RE, Liederman J. Cortical organization of language pathways in children with non-localized cryptogenic epilepsy. Front Hum Neurosci. 2014; 8:808. PMID: 25346681; PMCID: PMC4191195.
    32. Rossignol DA, Frye RE. The use of medications approved for Alzheimer's disease in autism spectrum disorder: a systematic review. Front Pediatr. 2014; 2:87. PMID: 25202686; PMCID: PMC4141213.
    33. Samanta D, Ramakrishnaiah R, Willis E, Frye RE. Myoclonic epilepsy evolved into West syndrome: a patient with a novel de novo KCNQ2 mutation. Acta Neurol Belg. 2015 Sep; 115(3):475-8. PMID: 25092550.
      View in: PubMed
    34. Frye RE, Rossignol DA. Treatments for biomedical abnormalities associated with autism spectrum disorder. Front Pediatr. 2014; 2:66. PMID: 25019065; PMCID: PMC4073259.
    35. Frye RE. Clinical potential, safety, and tolerability of arbaclofen in the treatment of autism spectrum disorder. Drug Healthc Patient Saf. 2014; 6:69-76. PMID: 24872724; PMCID: PMC4025936.
    36. Rossignol DA, Frye RE. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front Physiol. 2014; 5:150. PMID: 24795645; PMCID: PMC4001006.
    37. Rose S, Frye RE, Slattery J, Wynne R, Tippett M, Pavliv O, Melnyk S, James SJ. Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort. PLoS One. 2014; 9(1):e85436. PMID: 24416410; PMCID: PMC3885720.
    38. Frye RE, James SJ. Metabolic pathology of autism in relation to redox metabolism. Biomark Med. 2014; 8(3):321-30. PMID: 24712422.
      View in: PubMed
    39. Rossignol DA, Frye RE. Melatonin in autism spectrum disorders. Curr Clin Pharmacol. 2014; 9(4):326-34. PMID: 24050742.
      View in: PubMed
    40. Frye RE, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW, Walters L, James SJ. Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status. Autism Res Treat. 2013; 2013:609705. PMID: 24224089; PMCID: PMC3810468.
    41. Frye RE, Rossignol D, Casanova MF, Brown GL, Martin V, Edelson S, Coben R, Lewine J, Slattery JC, Lau C, Hardy P, Fatemi SH, Folsom TD, Macfabe D, Adams JB. A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel. Front Public Health. 2013 Sep 13; 1:31. PMID: 24350200; PMCID: PMC3859980.
    42. Frye RE, Delatorre R, Taylor H, Slattery J, Melnyk S, Chowdhury N, James SJ. Redox metabolism abnormalities in autistic children associated with mitochondrial disease. Transl Psychiatry. 2013 Jun 18; 3:e273. PMID: 23778583; PMCID: PMC3693408.
    43. Ellmore TM, Li H, Xue Z, Wong ST, Frye RE. Tract-based spatial statistics reveal altered relationship between non-verbal reasoning abilities and white matter integrity in autism spectrum disorder. J Int Neuropsychol Soc. 2013 Jul; 19(6):723-8. PMID: 23561717.
      View in: PubMed
    44. Frye RE, DeLatorre R, Taylor HB, Slattery J, Melnyk S, Chowdhury N, James SJ. Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study. Transl Psychiatry. 2013 Mar 05; 3:e237. PMID: 23462988; PMCID: PMC3625913.
    45. Frye RE. A lack of statistical pitfalls in the comparison of multivariate causality measures for effective causality. Comput Biol Med. 2013 Aug 01; 43(7):962-5. PMID: 23485200.
      View in: PubMed
    46. Frye RE, Melnyk S, Macfabe DF. Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Transl Psychiatry. 2013 Jan 22; 3:e220. PMID: 23340503; PMCID: PMC3566723.
    47. Rossignol, D., Frye, R.E. Melatonin in Autism Spectrum Disorders. Current Clinical Pharmacology. 2013.
    48. Rossignol, D.A., Frye, R.E. Studies on Psychiatric Disorders. Mitochondrial Dysfunction in Psychiatric Disorders. 2013.
    49. Frye, R.E. Tetrahydrobiopterin may be transported into the central nervous system by the folate receptor a. The North American Journal of Medicine and Science. 2013.
    50. Zhao, K., Frye, R.E. Handbook of Clinical Olfaction and Gustation. Nasal Patency and the Aerodynamics of Nasal Airflow in Relation to Olfactory Function. 2013.
    51. Rossignol, D.A., Frye, R.E. Cerebral Folate Deficiency. Journal of Pediatric Biochemistry. 2013; 263-271.
    52. Frye, R.E.,, Rossignol, D.A. Mitochondrial Physiology in Autism Spectrum Disorder. OA Autism. 2013; 1:5.
    53. Hasan, K.M., Walimuni, I.S., Frye, R.E. Global and Regional Multimodal Neuroimaging Markers of the Neurobiology of Autism: Development and Cognition. Journal of Child Neurology. 2013; 28(874-85).
    54. Frye, R.E., Rossignol, D.A. Frontiers in Autism Research, Diagnosis, and Treatment. Achieving optimal outcomes in autism: Treating potentially reversal conditions associated with autism spectrum disorder. 2013.
    55. Frye, R.E., DeLaTorre, R., Taylor, H., Slattery, J., Melnyk, S., James, S.J. Metabolic Effects of Sapropterin Treatment in Autism Spectrum Disorder. Translational Psychiatry. 2013.
    56. Li, H, Xue, Z., Ellmore, T.M., Frye, R.E., Wong, S.T.C. Network-Based Analysis Reveals Stronger Local Diffusion-Based Connectivity and Different Correlations with Oral Language Skills in Brains of High Functioning Autism Spectrum Disorders. Human Brain Mapping. 2013.
    57. Li H, Xue Z, Ellmore TM, Frye RE, Wong ST. Network-based analysis reveals stronger local diffusion-based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders. Hum Brain Mapp. 2014 Feb; 35(2):396-413. PMID: 23008187.
      View in: PubMed
    58. Hasan KM, Walimuni IS, Frye RE. Global cerebral and regional multimodal neuroimaging markers of the neurobiology of autism: development and cognition. J Child Neurol. 2013 Jul; 28(7):874-85. PMID: 22899798.
      View in: PubMed
    59. Rossignol DA, Bradstreet JJ, Van Dyke K, Schneider C, Freedenfeld SH, O'Hara N, Cave S, Buckley JA, Mumper EA, Frye RE. Hyperbaric oxygen treatment in autism spectrum disorders. Med Gas Res. 2012 Jun 15; 2(1):16. PMID: 22703610; PMCID: PMC3472266.
    60. Rossignol DA, Frye RE. Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy. J Autism Dev Disord. 2012 Apr; 42(4):640-2; author reply 643-6. PMID: 21556966.
      View in: PubMed
    61. Rossignol, D., Frye, R.E. A review of research trends in physiological abnormalitieis in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Molescular Psychiatry. 2012; 17(4):389-401.
    62. Leon-Carrion J, Leon-Dominguez U, Pollonini L, Wu MH, Frye RE, Dominguez-Morales MR, Zouridakis G. Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI). Brain Res. 2012 Oct 02; 1476:22-30. PMID: 22534483.
      View in: PubMed
    63. Liederman J, Fisher JM, Coty A, Matthews G, Frye RE, Lincoln A, Alexander R. Sex differences in the use of delayed semantic context when listening to disrupted speech. Arch Sex Behav. 2013 Feb; 42(2):197-201. PMID: 22434397.
      View in: PubMed
    64. Rossignol, D., Frye, R.E. Mitrochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis. Molescular Psychiatry. 2012; 17(3):290-314.
    65. Frye RE. Mitochondrial disease in 22q13 duplication syndrome. J Child Neurol. 2012 Jul; 27(7):942-9. PMID: 22378673.
      View in: PubMed
    66. Frye RE, Sequeira JM, Quadros EV, James SJ, Rossignol DA. Cerebral folate receptor autoantibodies in autism spectrum disorder. Mol Psychiatry. 2013 Mar; 18(3):369-81. PMID: 22230883; PMCID: PMC3578948.
    67. Frye, R.E. Novel mitochondrial Cytochrombe b gene polymporphisms associated with autism. Journal of Pediatric Neurology. 2012; 10:35-40.
    68. Frye, R.E., Rossignol, D. Metabolic Disorders Associated with Autism Spectrum Disorder. Journal of Pediatric Biochemistry. 2012; 4:181-191.
    69. Frye. Cutting Edge Therapies for Autism. Treatments for Mitochondrial Dysfunction. 2012.
    70. Frye, R.E., Rossignol, D. Cutting Edge Therapies for Autism. Cerebral Folate Deficiency in Autism Spectrum Disorders. 2012.
    71. Frye, R.E. Biomarkers of Abnormal Energy Metabolism in Children with Autism Spectrum Disorder. The North American Journal of Medicine and Science. 2012; 3:141-7.
    72. Rose, S., Melnyk, S., Pavliv, O., Bia, S., Nick, T., Frye, R.E., James, J.S. Evidence of oxidative damage and inflammation associated with low glutathione redox status and mitochondrial dysfunction in the autism brain. Translational Psychiatry. 2012; 2:e134.
    73. Frye, R.E., Rossignol, D.A. Treatments for Mitochondrial Dysfunction. Journal of Pediatric Biochemistry. 2012; 4:241-249.
    74. Frye RE, Wu MH. Multichannel least-squares linear regression provides a fast, accurate, unbiased and robust estimation of Granger causality for neurophysiological data. Comput Biol Med. 2011 Dec; 41(12):1118-31. PMID: 21640990.
      View in: PubMed
    75. Frye, R.E., Wu, M.H. Multichannel least-squares linear regerssion provides a fast, accurate, unbiased and robust estimation of Granger causality for neurophysiological data. Computers in Biology and Medicine. 2011; 41(12):1118-31.
    76. Frye RE. Advances and limitations in our knowledge of cortical reorganization in cerebral palsy. Dev Med Child Neurol. 2012 Apr; 54(4):298-9. PMID: 22107337.
      View in: PubMed
    77. Hasan KM, Walimuni IS, Abid H, Frye RE, Ewing-Cobbs L, Wolinsky JS, Narayana PA. Multimodal quantitative magnetic resonance imaging of thalamic development and aging across the human lifespan: implications to neurodegeneration in multiple sclerosis. J Neurosci. 2011 Nov 16; 31(46):16826-32. PMID: 22090508; PMCID: PMC3230860.
    78. Hasan, K., Walimuni, I., Abid, H., Frye, R., Ewing-Cobb, L., Wolinsky, J., Narayana, P. Multimodal Quantitative Magnetic Resonance Imaging of Thalamic Development and Again Across the Human Lifespan: Implications to Neurodegeneration in Multiple Sclerosis. Journal of Neuroscience. 2011; 31(46):16826-32.
    79. Frye RE. Special issue on techniques for measuring brain connectivity: advanced anatomic, function, effective and network neuroconnectivity techniques. Comput Biol Med. 2011 Dec; 41(12):1058-61. PMID: 22047795.
      View in: PubMed
    80. Fisher JM, Liederman J, Johnsen J, Lincoln A, Frye R. A demonstration that task difficulty can confound the interpretation of lateral differences in brain activation between typical and dyslexic readers. Laterality. 2012; 17(3):340-60. PMID: 22594815.
      View in: PubMed
    81. Frye RE, Liederman J, McGraw Fisher J, Wu MH. Laterality of temporoparietal causal connectivity during the prestimulus period correlates with phonological decoding task performance in dyslexic and typical readers. Cereb Cortex. 2012 Aug; 22(8):1923-34. PMID: 21980019; PMCID: PMC3394369.
    82. Frye RE. Mitochondrial dysfunction and myoclonic epilepsy: cause or effect or both? J Child Neurol. 2011 Oct; 26(10):1332-4. PMID: 21986953.
      View in: PubMed
    83. Wu MH, Frye RE, Zouridakis G. A comparison of multivariate causality based measures of effective connectivity. Comput Biol Med. 2011 Dec; 41(12):1132-41. PMID: 21742321.
      View in: PubMed
    84. Frye RE, Sreenivasula S, Adams JB. Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey. BMC Pediatr. 2011 May 18; 11:37. PMID: 21592359; PMCID: PMC3123184.
    85. Pearlman M, Frye R, Butler I, Papanicolaou AC, Castillo E, Slopis J. Patterns of electromagnetic activity recorded from neoplastic tissue. J Neurooncol. 2011 Nov; 105(2):445-9. PMID: 21573889.
      View in: PubMed
    86. Frye RE, Rossignol DA. Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders. Pediatr Res. 2011 May; 69(5 Pt 2):41R-7R. PMID: 21289536; PMCID: PMC3179978.
    87. Frye RE. Leber's hereditary optic neuropathy mutations associated with infantile-onset myoclonic epilepsy. J Child Neurol. 2011 Jun; 26(6):782-5. PMID: 21527392.
      View in: PubMed
    88. Rossignol DA, Frye RE. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev Med Child Neurol. 2011 Sep; 53(9):783-92. PMID: 21518346.
      View in: PubMed
    89. Liederman J, Gilbert K, Fisher JM, Mathews G, Frye RE, Joshi P. Are women more influenced than men by top-down semantic information when listening to disrupted speech? Lang Speech. 2011 Mar; 54(Pt 1):33-48. PMID: 21524011.
      View in: PubMed
    90. Hasan KM, Frye RE. Diffusion tensor-based regional gray matter tissue segmentation using the international consortium for brain mapping atlases. Hum Brain Mapp. 2011 Jan; 32(1):107-17. PMID: 20799340.
      View in: PubMed
    91. Frye RE, Wu MH, Liederman J, Fisher JM. Greater Pre-Stimulus Effective Connectivity from the Left Inferior Frontal Area to other Areas is Associated with Better Phonological Decoding in Dyslexic Readers. Front Syst Neurosci. 2010; 4:156. PMID: 21160549; PMCID: PMC3001755.
    92. Kamali A, Kramer LA, Frye RE, Butler IJ, Hasan KM. Diffusion tensor tractography of the human brain cortico-ponto-cerebellar pathways: a quantitative preliminary study. J Magn Reson Imaging. 2010 Oct; 32(4):809-17. PMID: 20882611; PMCID: PMC4492525.
    93. Hasan KM, Walimuni IS, Kramer LA, Frye RE. Human brain atlas-based volumetry and relaxometry: application to healthy development and natural aging. Magn Reson Med. 2010 Nov; 64(5):1382-9. PMID: 20740662.
      View in: PubMed
    94. Frye RE, Liederman J, Hasan KM, Lincoln A, Malmberg B, McLean J, Papanicolaou A. Diffusion tensor quantification of the relations between microstructural and macrostructural indices of white matter and reading. Hum Brain Mapp. 2011 Aug; 32(8):1220-35. PMID: 20665719.
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    95. Frye RE. Central tetrahydrobiopterin concentration in neurodevelopmental disorders. Front Neurosci. 2010; 4:52. PMID: 20661295; PMCID: PMC2906199.
    96. Frye RE, Malmberg B, Swank P, Smith K, Landry S. Preterm birth and maternal responsiveness during childhood are associated with brain morphology in adolescence. J Int Neuropsychol Soc. 2010 Sep; 16(5):784-94. PMID: 20609271.
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    97. Frye RE, Huffman LC, Elliott GR. Tetrahydrobiopterin as a novel therapeutic intervention for autism. Neurotherapeutics. 2010 Jul; 7(3):241-9. PMID: 20643376; PMCID: PMC2908599.
    98. Frye RE, Malmberg B, McLean J, Swank P, Smith K, Papanicolaou A, Landry S. Increased left prefrontal activation during an auditory language task in adolescents born preterm at high risk. Brain Res. 2010 Jun 08; 1336:89-97. PMID: 20381475; PMCID: PMC2881563.
    99. Frye RE, Butler I, Strickland D, Castillo E, Papanicolaou A. Electroencephalogram discharges in atypical cognitive development. J Child Neurol. 2010 May; 25(5):556-66. PMID: 20299700; PMCID: PMC2896832.
    100. Pollonini L, Pophale S, Situ N, Wu MH, Frye RE, Leon-Carrion J, Zouridakis G. Information communication networks in severe traumatic brain injury. Brain Topogr. 2010 Jun; 23(2):221-6. PMID: 20224956.
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    101. Frye RE, Hasan K, Malmberg B, Desouza L, Swank P, Smith K, Landry S. Superior longitudinal fasciculus and cognitive dysfunction in adolescents born preterm and at term. Dev Med Child Neurol. 2010 Aug; 52(8):760-6. PMID: 20187879; PMCID: PMC2910222.
    102. Frye RE, Liederman J, Malmberg B, McLean J, Strickland D, Beauchamp MS. Surface area accounts for the relation of gray matter volume to reading-related skills and history of dyslexia. Cereb Cortex. 2010 Nov; 20(11):2625-35. PMID: 20154011; PMCID: PMC2981021.
    103. Frye RE, Malmberg B, Desouza L, Swank P, Smith K, Landry S. Increased prefrontal activation in adolescents born prematurely at high risk during a reading task. Brain Res. 2009 Dec 15; 1303:111-9. PMID: 19796631; PMCID: PMC2783693.
    104. Frye RE. 15q11.2-13 duplication, mitochondrial dysfunction, and developmental disorders. J Child Neurol. 2009 Oct; 24(10):1316-20. PMID: 19535813; PMCID: PMC2919279.
    105. Frye RE. Reversible posterior leukoencephalopathy syndrome in sickle-cell anemia. Pediatr Neurol. 2009 Apr; 40(4):298-301. PMID: 19302944; PMCID: PMC2903963.
    106. Frye RE, Rezaie R, Papanicolaou AC. Functional Neuroimaging of Language Using Magnetoencephalography. Phys Life Rev. 2009 Mar 01; 6(1):1-10. PMID: 20160985.
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    107. Frye RE, Beauchamp MS. Receptive language organization in high-functioning autism. J Child Neurol. 2009 Feb; 24(2):231-6. PMID: 19182164; PMCID: PMC2896833.
    108. Frye RE, Landry SH, Swank PR, Smith KE. Executive dysfunction in poor readers born prematurely at high risk. Dev Neuropsychol. 2009; 34(3):254-71. PMID: 19437202; PMCID: PMC2692028.
    109. Frye RE, Hasan K, Xue L, Strickland D, Malmberg B, Liederman J, Papanicolaou A. Splenium microstructure is related to two dimensions of reading skill. Neuroreport. 2008 Oct 29; 19(16):1627-31. PMID: 18806688; PMCID: PMC2667961.
    110. Beauchamp MS, Yasar NE, Frye RE, Ro T. Touch, sound and vision in human superior temporal sulcus. Neuroimage. 2008 Jul 01; 41(3):1011-20. PMID: 18440831; PMCID: PMC2409200.
    111. Frye RE, Fisher JM, Witzel T, Ahlfors SP, Swank P, Liederman J, Halgren E. Objective phonological and subjective perceptual characteristics of syllables modulate spatiotemporal patterns of superior temporal gyrus activity. Neuroimage. 2008 May 01; 40(4):1888-901. PMID: 18356082; PMCID: PMC2443388.
    112. Frye RE, Rotenberg A, Ousley M, Pascual-Leone A. Transcranial magnetic stimulation in child neurology: current and future directions. J Child Neurol. 2008 Jan; 23(1):79-96. PMID: 18056688; PMCID: PMC2539109.
    113. Frye RE, Fisher JM, Coty A, Zarella M, Liederman J, Halgren E. Linear coding of voice onset time. J Cogn Neurosci. 2007 Sep; 19(9):1476-87. PMID: 17714009; PMCID: PMC2393546.
    114. Frye RE, Polling JS, Ma LC. Choroid plexus papilloma expansion over 7 years in Aicardi syndrome. J Child Neurol. 2007 Apr; 22(4):484-7. PMID: 17621535; PMCID: PMC2536525.
    115. Frye RE. Cerebral arterial gas embolism following cardiopulmonary bypass surgery. J Pediatr Neurol. 2007; 5(2):179-180. PMID: 18725965.
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    116. Frye RE. Recurrent aseptic encephalitis in periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome. Pediatr Infect Dis J. 2006 May; 25(5):463-5. PMID: 16645518; PMCID: PMC2394724.
    117. Frye RE, Hait EJ. Air swallowing caused recurrent ileus in Tourette's syndrome. Pediatrics. 2006 Jun; 117(6):e1249-52. PMID: 16651280; PMCID: PMC2587247.
    118. Poling JS, Frye RE, Shoffner J, Zimmerman AW. Developmental regression and mitochondrial dysfunction in a child with autism. J Child Neurol. 2006 Feb; 21(2):170-2. PMID: 16566887; PMCID: PMC2536523.
    119. Dobson CP, Neuwirth M, Frye RE, Gorman M. Index of suspicion. Pediatr Rev. 2006 Jan; 27(1):29-33. PMID: 16387926.
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    120. Liederman J, Frye R, Fisher JM, Greenwood K, Alexander R. A temporally dynamic context effect that disrupts voice onset time discrimination of rapidly successive stimuli. Psychon Bull Rev. 2005 Apr; 12(2):380-6. PMID: 16082822.
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    121. Frye RE, Newburger JW, Nugent A, Sahin M. Focal seizure and cerebral contrast retention after cardiac catheterization. Pediatr Neurol. 2005 Mar; 32(3):213-6. PMID: 15730907.
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    122. Frye RE, Donner E, Golja A, Rooney CM. Folinic acid-responsive seizures presenting as breakthrough seizures in a 3-month-old boy. J Child Neurol. 2003 Aug; 18(8):562-9. PMID: 13677584.
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