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Boris Zybaylov

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiochemistry & Molecular Biology, College of Medicine
Address433-2 Biomedical Research II
1120 Marshall Street
Mail Slot # 516
Little Rock AR 72202
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    Collapse Overview 
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    The current focus of my laboratory is investigation of protein-protein and protein-nucleic acid interactions in the context of stress granule assembly. Specifically, we are interested in the role of G4 DNA structures and their protein interactors in mediating intracellular stress during aging. Over the past 12 years I worked in the area of quantitative mass spectrometry developing label-free and stable isotope-based proteomics methods and applying them to various bio-analytical problems. First, during my post-doctoral training with Mike Washburn at Stowers Institute (Kansas City, MO) I developed the statistical framework for the spectral counting methods and applied it to the study of differential accumulation of yeast membrane proteins. During my second post-doc with Klaas van Wijk at Cornell University (Ithaca, NY) I used spectral counting to study organelle proteome dynamics and protein homeostasis in Arabidopsis. In addition to the large-scale proteomics studies I also was involved in targeted analysis of protein complexes: mammalian mediator complex (at Stowers) and Clp protease complex (at Cornell). During my work as a Research Associate with David Goldfarb, as a part of newly formed company - Calorics Pharmaceuticals - I designed proteomics screens to identify targets of caloric restriction mimetics – small molecules extending replicative lifespan in yeast. We routinely use methods of systems biology, mass-spectrometry based proteomics, large-scale OMICS data integration and big data mining.

    Collapse Affiliation 
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    American Society for Mass Spectrometry
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    Kevin D Raney
    Galina Glazko

    Collapse Biography 
    Collapse awards and honors
    2003Frederick C.Wedler Outstanding Doctoral Dissertation Award , Penn State University

    Collapse Research 
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    S10 OD026736     (MACKINTOSH, SAMUEL)Aug 1, 2019 - Jul 31, 2020
    NIH/Office of the Director
    Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer
    Role: Co-Investigator

    P20GM121293     (ZYBAYLOV, BORIS)Jul 1, 2017 - Jun 30, 2022
    NIH/National Institutes of Health - Pass Through: Arkansas Children's Hospital
    Microbiome-Derived Therapeutic Targets for Chronic Kidney Disease - Continuation
    Role: Principal Investigator

    R35GM122601     (RANEY, KEVIN DOUGLAS)May 1, 2017 - Apr 30, 2022
    Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids
    Role: Co-Investigator

    R01GM117439     (RANEY, KEVIN DOUGLAS)Sep 21, 2015 - Jun 30, 2019
    G-quadruplex DNA as a chemical signaling agent
    Role: Co-Investigator

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    1. Kosovsky GY, Glazko VI, Glazko GV, Zybaylov BL, Glazko TT. Leukocytosis and Expression of Bovine Leukemia Virus microRNAs in Cattle. Front Vet Sci. 2020; 7:272. PMID: 32582774.
      View in: PubMed
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