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Maxim Dobretsov

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentAnesthesiology, College of Medicine
Address258 Biomedical Research I
325 S. Elm St.
Mail Slot # 515
Little Rock AR 72205
Phone501-526-7150
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    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentNeurobiology & Developmental Science, College of Medicine

    TitleAssociate Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPhysiology and Biophysics, College of Medicine


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yadlapalli JSK, Dogra N, Walbaum AW, Wessinger WD, Prather PL, Crooks PA, Dobretsov M. Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats. Anesth Analg. 2017 Sep; 125(3):1021-1031. PMID: 28489639.
      View in: PubMed
    2. Dobretsov M, Petkau G, Hayar A, Petkau E. Clock Scan Protocol for Image Analysis: ImageJ Plugins. J Vis Exp. 2017 Jun 19; (124). PMID: 28654075.
      View in: PubMed
    3. Yadlapalli JS, Ford BM, Ketkar A, Wan A, Penthala NR, Eoff RL, Prather PL, Dobretsov M, Crooks PA. Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors. Pharmacol Res. 2016 Nov; 113(Pt A):335-347. PMID: 27637375.
      View in: PubMed
    4. Chowdhury P, Akel N, Jamshidi-Parsian A, Gaddy D, Griffin RJ, Yadlapalli JS, Dobretsov M. Degenerative Tissue Responses to Space-like Radiation Doses in a Rodent Model of Simulated Microgravity. Ann Clin Lab Sci. 2016; 46(2):190-7. PMID: 27098627.
      View in: PubMed
    5. Climer LK, Dobretsov M, Lupashin V. Defects in the COG complex and COG-related trafficking regulators affect neuronal Golgi function. Front Neurosci. 2015; 9:405. PMID: 26578865; PMCID: PMC4621299.
      View in: PubMed, PubMed Central
    6. Shipilov VN, Shpakov AO, Chistyakova OV, Bondareva VM, Derkach KV, Dobretsov MG. Relationship between the changes in peripheral thresholds of nociception and activity of the adenylyl cyclase system in the skeletal muscles of rats with streptozotocin-induced diabetes. Dokl Biol Sci. 2014 Jan; 454:9-11. PMID: 24659277.
      View in: PubMed
    7. Kubasov IV, Arutyunyan RS, Dobretsov MG, Shpakov AO, Matrosova EV. [Effect of insulin on characteristics of contractile responses of fast and slow skeletal muscles of rats with streptozotocin-induced overt diabetes]. Zh Evol Biokhim Fiziol. 2014 Mar-Apr; 50(2):121-9. PMID: 25486817.
      View in: PubMed
    8. Kubasov IV, Arutyunyan RS, Dobretsov MG, Matrosova EV. [Action of insulin on contraction and electrical responses of rat skeletal muscle]. Ross Fiziol Zh Im I M Sechenova. 2013 Oct; 99(10):1200-13. PMID: 25507830.
      View in: PubMed
    9. Kubasov IV, Arutyunyan RS, Dobretsov MG, Matrosova EV. [Action of insulin on contraction and electrical responses of rat skeletal muscle]. Ross Fiziol Zh Im I M Sechenova. 2013 Oct; 99(10):1200-13. PMID: 25434232.
      View in: PubMed
    10. Chowdhury P, Long A, Harris G, Soulsby ME, Dobretsov M. Animal model of simulated microgravity: a comparative study of hindlimb unloading via tail versus pelvic suspension. Physiol Rep. 2013 Jun; 1(1):e00012. PMID: 24303103; PMCID: PMC3831940.
      View in: PubMed, PubMed Central
    11. Chowdhury, P, Long, A, Harris, G, Soulsby, M.E, Dobretsov, M. Animal Model of Simulated Microgravity: A comparative study of hindlimb unloading via tail vs. pelvic suspension. Physiol Rep. 2013; 1:1-15.
    12. Kubasov IV, Dobretsov MG. [Effect of barium and ouabain on electrogenesis in various sites of intact and detubulated skeletal muscle fibers of the frog R. temporaria]. Zh Evol Biokhim Fiziol. 2012 Jul-Aug; 48(4):360-6. PMID: 23013024.
      View in: PubMed
    13. Kubasov IV, Dobretsov M. Two types of extracellular action potentials recorded with narrow-tipped pipettes in skeletal muscle of frog, Rana temporaria. J Physiol. 2012 Jun 15; 590(12):2937-44. PMID: 22526885; PMCID: PMC3448157.
      View in: PubMed, PubMed Central
    14. Chowdhury P, Soulsby ME, Jayroe J, Akel NS, Gaddy D, Dobretsov M. Pressure hyperalgesia in hind limb suspended rats. Aviat Space Environ Med. 2011 Oct; 82(10):988-91. PMID: 21961404.
      View in: PubMed
    15. Kubasov I, Dobretsov MG. [Characteristics of spreading action recorded in various sites of skeletal muscle fibers of the frog Rana temporaria]. Zh Evol Biokhim Fiziol. 2011 Sep-Oct; 47(5):414-6. PMID: 22145325.
      View in: PubMed
    16. Kubasov, I.V, Dobretsov M. Characteristics of spreading action potentials recorded in various areas of skeletal muscle fibers of the frog Rana temporaria. J Evolut Biochem Physiol. 2011; 47:486-489.
    17. Khaidakov M, Szwedo J, Mitra S, Ayyadevara S, Dobretsov M, Lu J, Mehta JL. Antiangiogenic and antimitotic effects of aspirin in hypoxia–reoxygenation modulation of the LOX-1-NADPH oxidase axis as a potential mechanism. J Cardiovasc Pharmacol. 2010 Dec; 56(6):635-41. PMID: 20881612.
      View in: PubMed
    18. Dobretsov M, Stimers JR. Muscle spindle afferents and the mystery of the a3 isoform of Na+,K+-ATPase. J Physiol. 2010 Nov 01; 588(Pt 21):4061. PMID: 21037311; PMCID: PMC3002435.
      View in: PubMed, PubMed Central
    19. Romanovsky D, Dobretsov M. Pressure-induced pain: early sign of diabetes-associated impairment of insulin production in rats. Neurosci Lett. 2010 Oct 11; 483(2):110-3. PMID: 20678544; PMCID: PMC2933320.
      View in: PubMed, PubMed Central
    20. Khaidakov, M, Szwedo, J, Mitra, S, Ayyadevara, S, Dobretsov M, Lu, J, Mehta, J.L. Anti-angiogenic and anti-mitotic effects of aspirin in hypoxia-reoxygination modulation of LOX-1-NADPH oxidase axis as potential mechanism. J. Cardiovasc. Pharmacol. 2010; 56:635-641.
    21. Dobretsov M, Backonja M, Romanovsky D, Stimers J.R. Animal Models of Pain. Animal Models of Diabetic Neuropathic Pain. 2010; 9.
    22. LaCroix-Fralish ML, Mo G, Smith SB, Sotocinal SG, Ritchie J, Austin JS, Melmed K, Schorscher-Petcu A, Laferriere AC, Lee TH, Romanovsky D, Liao G, Behlke MA, Clark DJ, Peltz G, Séguéla P, Dobretsov M, Mogil JS. The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test. Pain. 2009 Aug; 144(3):294-302. PMID: 19464798; PMCID: PMC2744953.
      View in: PubMed, PubMed Central
    23. LaCroix-Fralish, M.L, Mo, G, Smith, S.B, Sotocinal, S.G, Ritchie, J, Austin, J.-S, Melmed, K, Schorsher-Petcu, A, Laferriere, A.C, Lee, T.H, Romanovsky, D, Liao, G, Behlke, M.A, Clark, D.J, Peltz, G, Seguela, P, Dobretsov, M, Mogil, J.S. The ß3 subunit of the Na+,K+-ATPase mediate variable nociceptive sensitivity in the formalin test. Pain. 2009; 144:294-302.
    24. Dobretsov M, Romanovsky D, Smith AG, Stimers JR. Mechanisms of Pain in Peripheral Neuropathy. Diabetic neuropathy and pain. 2009; 11.
    25. Chowdhury P, Dobretsov M. A report of the Sixth Annual Meeting of the International Society for the Prevention of Tobacco Induced Diseases (ISPTID). Tob Induc Dis. 2008 Dec 17; 4:11. PMID: 19091067; PMCID: PMC2614959.
      View in: PubMed, PubMed Central
    26. Romanovsky D, Walker JC, Dobretsov M. Pressure pain precedes development of type 2 disease in Zucker rat model of diabetes. Neurosci Lett. 2008 Nov 21; 445(3):220-3. PMID: 18790004; PMCID: PMC2585493.
      View in: PubMed, PubMed Central
    27. Liu BG, Dobretsov M, Stimers JR, Zhang JM. Tumor necrosis factor-a suppresses sustained potassium currents in rat small diameter sensory neurons. The Open Pain Journal. 2008; 1:01-07.
    28. Liu BG, Dobretsov M, Stimers JR, Zhang JM. Tumor Necrosis Factor-alpha Suppresses Activation of Sustained Potassium Currents in Rat Small Diameter Sensory Neurons. Open Pain J. 2008; 1:1 - .
    29. Liu BG, Dobretsov M, Stimers JR, Zhang JM. Tumor Necrosis Factor-a Suppresses Activation of Sustained Potassium Currents in Rat Small Diameter Sensory Neurons. Open Pain J. 2008 Jan 01; 1:1. PMID: 20165558.
      View in: PubMed
    30. Romanovsky D, Moseley AE, Mrak RE, Taylor MD, Dobretsov M. Phylogenetic preservation of alpha3 Na+,K+-ATPase distribution in vertebrate peripheral nervous systems. J Comp Neurol. 2007 Feb 20; 500(6):1106-16. PMID: 17183534.
      View in: PubMed
    31. Kim JH, Sizov I, Dobretsov M, von Gersdorff H. Presynaptic Ca2+ buffers control the strength of a fast post-tetanic hyperpolarization mediated by the alpha3 Na(+)/K(+)-ATPase. Nat Neurosci. 2007 Feb; 10(2):196-205. PMID: 17220883.
      View in: PubMed
    32. Dobretsov M, Romanovsky D, Stimers JR. Early diabetic neuropathy: triggers and mechanisms. World J Gastroenterol. 2007 Jan 14; 13(2):175-91. PMID: 17226897; PMCID: PMC1829411.
      View in: PubMed, PubMed Central
    33. Dobretsov M, Ghaleb AH, Romanovsky D, Pablo CS, Stimers JR. Impaired insulin signaling as a potential trigger of pain in diabetes and prediabetes. Int Anesthesiol Clin. 2007; 45(2):95-105. PMID: 17426511.
      View in: PubMed
    34. Kim JH, Sizov I, Dobretsov M, Von Gersdorff H. Presynaptic Ca2+ buffers control the strength of a fast post-tetanic hyperpolization mediated by the a3 Na+/K+ -ATPase. Nature Neuroscience. 2007; 10:196-205.
    35. Romanovsky D, Cruz NF, Dienel GA, Dobretsov M. Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats. Neurobiol Dis. 2006 Nov; 24(2):384-94. PMID: 16935517.
      View in: PubMed
    36. Dobretsov M, Romanovsky D. "Clock-scan" protocol for image analysis. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C869-79. PMID: 16738004.
      View in: PubMed
    37. Dobretsov M, Stimers JR. Neuronal function and alpha3 isoform of the Na/K-ATPase. Front Biosci. 2005 Sep 01; 10:2373-96. PMID: 15970502.
      View in: PubMed
    38. Krivoi II, Drabkina TM, Vasil'ev AN, Kravtsova VV, Dobretsov MG. [Ouabain-induced blockade of alpha2 isoform of the Na,K-ATPase on electrophysiological and contractile characteristics of the rat diaphragm]. Ross Fiziol Zh Im I M Sechenova. 2005 May; 91(5):530-42. PMID: 16117172.
      View in: PubMed
    39. Romanovsky D, Light KE, Walker J, Dobretsov M. Target-determined expression of alpha3 isoform of the Na+,K+-ATPase in the somatic nervous system of rat. J Comp Neurol. 2005 Feb 28; 483(1):114-23. PMID: 15672395.
      View in: PubMed
    40. Romanovsky D, Hastings SL, Stimers JR, Dobretsov M. Relevance of hyperglycemia to early mechanical hyperalgesia in streptozotocin-induced diabetes. J Peripher Nerv Syst. 2004 Jun; 9(2):62-9. PMID: 15104693.
      View in: PubMed
    41. Krivoi II, Drabkina TM, Dobretsov MG, Vasil'ev AN, Kravtsova VV, Eaton MJ, Skachkov SN, Mandel F. [Functional interaction between nicotinic cholinergic receptors and Na, K-ATPase in the skeletal muscles]. Ross Fiziol Zh Im I M Sechenova. 2004 Jan; 90(1):59-72. PMID: 15143493.
      View in: PubMed
    42. Krivoi II, Vasil'ev AN, Gromova VV, Prytkov AE, Marakhova II, Kravtsova VV, Dobretsov MG, Mandel F. [Porcine kidney extract contains a specific inhibitor of the ouabain-sensitive alpha2-isoform of Na, K-ATPase present in rat diaphragm fibres]. Ross Fiziol Zh Im I M Sechenova. 2003 Nov; 89(11):1340-51. PMID: 14758659.
      View in: PubMed
    43. Krivoi I, Vasiliev A, Kravtsova V, Dobretsov M, Mandel F. Porcine kidney extract contains factor(s) that inhibit the ouabain-sensitive isoform of Na,K-ATPase (alpha2) in rat skeletal muscle: a convenient electrophysiological assay. Ann N Y Acad Sci. 2003; 986:639 - 641.
    44. Dobretsov M, Hastings SL, Romanovsky D, Stimers JR, Zhang JM. Mechanical hyperalgesia in rat models of systemic and local hyperglycemia. Brain Res. 2003 Jan 17; 960(1-2):174-83. PMID: 12505670.
      View in: PubMed
    45. Dobretsov M, Hastings SL, Sims TJ, Stimers JR, Romanovsky D. Stretch receptor-associated expression of alpha 3 isoform of the Na+, K+-ATPase in rat peripheral nervous system. Neuroscience. 2003; 116(4):1069-80. PMID: 12617948.
      View in: PubMed
    46. Ha J, Dobretsov M, Kurten RC, Grant DF, Stimers JR. Effect of linoleic acid metabolites on Na(+)/K(+) pump current in N20.1 oligodendrocytes: role of membrane fluidity. Toxicol Appl Pharmacol. 2002 Jul 01; 182(1):76-83. PMID: 12127265.
      View in: PubMed
    47. Li H, Liu BG, Dobretsov M, Brull SJ, Zhang JM. Thermosensitivity of large primary sensory neurons. Brain Res. 2002 Feb 01; 926(1-2):18-26. PMID: 11814402.
      View in: PubMed
    48. Dobretsov M, Hastings SL, Stimers JR, Zhang JM. Mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution. J Neurosci Methods. 2001 Sep 30; 110(1-2):9-15. PMID: 11564519.
      View in: PubMed
    49. Dobretsov M, Dobretsov A, Kuffler DP. Influence of factors released from sciatic nerve on adult dorsal root ganglion neurons. J Neurobiol. 1994; 25(10):1249 - 1266.
    50. Dobretsov MG. [Variations in the sensitivity of the neuromuscular junctions of the frog to the blocking action of hyperkalemic solutions]. Fiziol Zh SSSR Im I M Sechenova. 1987 Mar; 73(3):366-72. PMID: 3034684.
      View in: PubMed
    51. Dobretsov MG, Drabkina TM, Zefirov AL, Matiushkin DP, Khalilov IA. [Presence of a specific (not associated with the modification of currents in nerve endings) positive effect of K+ on the release of a mediator]. Dokl Akad Nauk SSSR. 1987; 297(4):1010-3. PMID: 2895700.
      View in: PubMed
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