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Clint Kilts

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPSY Psychiatry, College of Medicine
Address Campus General
4224 Shuffield Dr.
Mail Slot # 554
Little Rock AR 72205
Phone501-526-8163
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    Collapse Overview 
    Collapse overview
    Dr. Kilts received his postgraduate training in psychopharmacology and neurochemistry in the Department of Pharmacology and Toxicology at Michigan State University. He continued his training in neuropharmacology, analytical neurochemistry, and human psychopharmacology in the Biological Sciences Research Center at the University of North Carolina. He subsequently joined the faculties of the Departments of Psychiatry and Pharmacology at Duke University where he served as Director of the Clinical Psychopharmacology Laboratory. In 1992, Dr. Kilts joined the faculty of the Department of Psychiatry and Behavioral Sciences in the Emory University School of Medicine. At Emory, he served as the Interim Director of the Center for Positron Emission Tomography (PET) and, in 2000, became the first Vice Chair for Research for the Department of Psychiatry and Behavioral Sciences. In 2009, he joined the faculty of the Department of Psychiatry and Behavioral Sciences in the College of Medicine at the University of Arkansas for Medical Sciences (UAMS). He is the founding Director of the Brain Imaging Research Center (BIRC) in the UAMS Psychiatric Research Institute (PRI) and an Associate Director of the PRI. He has a long record of NIH-funded research, most recently in the use of in vivo brain functional, molecular and connectivity imaging to explore the neural network processing basis of human behavior. With a focus on drug abuse and addiction, he has a clinical research focus on the use of neuroimaging technology to define the brain basis of psychiatric disorders and their treatment. Additional academic accomplishments relate to organizational research planning, organization, and mentoring. His current goals as Director of the BIRC are to extend magnetic resonance imaging (MRI)-based technology and human neuroscience to areas of clinical problem solving in psychiatry and related disciplines within the PRI and at UAMS.


    Collapse Research 
    Collapse research activities and funding
    27312     (ESCALONA-VARGAS, DIANA)Jan 15, 2019 - Jan 14, 2021
    Brain & Behavior Research Foundation
    Studying the effect of Buprenorphine on Fetal Brain Development Using Magnetoencephalography
    Role: Co-Investigator
    R01DA044608     (KILTS, CLINT)Jul 1, 2018 - Apr 30, 2023
    NIH/Nat. Inst. on Drug Abuse
    The sex-specific roles and neural processing correlates of future outcome estimation in the drug addiction process
    Role: Principal Investigator
    BI Trial No. 1289-0032     (KILTS, CLINT)Jun 25, 2018
    Boehringer Ingleheim Pharmaceuticals, Inc.
    A phase II randomised, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of orally administered BI 409306 during a 52-week treatment period as an early intervention in patients with attenuated psychosis syndrome.
    Role: Principal Investigator
    BITrialNo.1289     (KILTS, CLINT)Jun 25, 2018
    Boehringer Ingleheim Pharmaceuticals, Inc.
    A phase II randomised, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of orally administered BI 409306 during a 52-week treatment period as an early intervention in patients with attenuated psychosis syndrome.
    Role: Principal Investigator
    F30DA043928     (MARTINS, BRADFORD)Mar 30, 2018 - Mar 29, 2021
    NIH/Nat. Inst. on Drug Abuse
    Multi-Level Modeling of Addiction Comorbidity
    Role: Co-Investigator
    R21DA042396     (JAMES, GEORGE ANDREW)Sep 1, 2017 - Aug 31, 2021
    NIH
    Modeling sex-differences in trauma-related neural organization conferring resilience against addiction
    Role: Co-Investigator
    1735820     (BUSH, KEITH)Sep 1, 2017 - Feb 28, 2021
    National Science Foundation
    Cognitive Control Theoretic Mechanisms of Real-time fMRI-Guided Neuromodulation
    Role: Co-Investigator
    R21MH108753     (KILTS, CLINT D)Mar 7, 2017 - Dec 31, 2018
    NIH/Nat. Inst. of Mental Health - Pass Through: University of Wisconsin-Madison
    Dopamine Enhancement of Fear Extinction Learning in PTSD
    Role: Co-Investigator
    R21MH106860     (CISLER, JOSHUA)Apr 15, 2015 - Jan 31, 2017
    NIH/Nat. Inst. of Mental Health
    A critical test of neural models of risk among adolescent assault victims
    Role: Co-Investigator
    R01DA036360     (KILTS, CLINT)May 15, 2014 - Mar 31, 2020
    NIH/Nat. Inst. on Drug Abuse
    A risk factor analysis of human brain states related to development of addiction
    Role: Principal Investigator
    R21MH097784     (CISLER, JOSHUA)Jun 15, 2012 - May 31, 2015
    NIH/Nat. Inst. of Mental Health
    Neural Network Predictors of Treatment Outcome Among Adolescent Assault Victims
    Role: Co-Investigator
    R21DA029442     (STANGER, CATHERINE)Apr 1, 2010 - Mar 31, 2015
    NIH
    The Neuroeconomics of Behavioral Therapies for Adolescent Substance Abuse
    Role: Principal Investigator
    U19MH069056     (KILTS, CLINT)Aug 1, 2009 - Jul 31, 2014
    NIH/Nat. Inst. of Mental Health - Pass Through: Emory University
    Emory-MSSM_GSK-NIMH collaborative Mood and Anxiety Disorders Initiative
    Role: Principal Investigator
    R21DA025243     (KILTS, CLINT D)Jun 15, 2008 - May 31, 2011
    NIH/Nat. Inst. on Drug Abuse
    The Clinical and Neural Response of Cocaine Addicts to Combination Treatment with
    Role: Principal Investigator
    R01DA019999     (KILTS, CLINT D)May 1, 2007 - Feb 28, 2012
    NIH/Nat. Inst. on Drug Abuse
    AN FMRI STUDY OF THE IMPACT OF STRESS ON DRUG ADDICTION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Nye JA, Purselle D, Plisson C, Voll RJ, Stehouwer JS, Votaw JR, Kilts CD, Goodman MM, Nemeroff CB. DECREASED BRAINSTEM AND PUTAMEN SERT BINDING POTENTIAL IN DEPRESSED SUICIDE ATTEMPTERS USING [ C]-ZIENT PET IMAGING. Depress Anxiety. 2013.
    2. Cisler JM, James GA, Tripathi S, Mletzko T, Heim C, Mayberg HS, Nemeroff CB, Kilts CD. ifferential functional connectivity within an emotion regulation network among individuals resilient and susceptible to the depressogenic effects of early life stress. Psychol Med. 2012; 43(3):507-518.
    3. Gilkey R, Caceda R, Bate A,, Robertson D, Kilts CD. Using the whole brain to improve strategic reasoning. NeuroLeadership Journal. 2012; (4):6-69.
    4. Nye JA, Votaw JR, Jarkas N, Camp V, Bremner JD, Kilts CD, Nemeroff CB, Goodman MM. Compartmental modeling of C-HOMADAM binding to the serotonin transporter in the healthy human brain. J Nuc Med. 2008; 49:2018-2025.
    5. Robertson D, Snarey J, Ousley O, Harenski K, Bowman FB, Gilkey R, Kilts CD. An fMRI study of ethical decision making: The neural basis of moral sensitivity to issues of care and justice. Neuropsychologia. 2007; 45:755-766.
    6. Duncan E, Bosheven W, Harenski K, Fallios A, Tracy H, Jovanovic T, Hu X, Drexler K, Kilts C. An fMRI study of the interaction of stress and cocaine cues on craving. Am J Addiction. 2007; 16(3):174-182.
    7. Zeng F, Jarkas N, Owens MJ, Kilts CD, Nemeroff CB, Godman MM. Synthesis and monoamine transporter affinity of front bridged tricyclic 3ß-(4’-halo or 4’-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2ß -position. Bioorganic Medicinal Chem Letters. 2006; (16):4661-4663.
    8. Westen D, Blagov P, Harenski K, Kilts C, Hamann S. Neural basis of motivated reasoning: An fMRI study of emotional constraints on partisan political judgment in the 2004 U.S. J Cognit Neurosci. 2006; (18):1947-1958.
    9. Jarkas N, McConathy J, Votaw JR, Voll RJ, Mallveaux E, Camp VM, Williams L, Goodman RR, Kilts CD, Goodman MM. Synthesis and characterization of EADAM: A selective radioligand for mapping the brain serotonin transporter by positron emission tomography. Nuc Med Biol. 2005; (32):75-86.
    10. Kilts C, VanNess SH, Owens MJ. The variable number of tandem repeats (VNTR) element in DAT1 regulates dopamine transporter density. BMC Genetics. 2005; (6):55-66.
    11. Rilling JK, Winslow JT, Kilts CD. The neural correlates of mate competition in dominant male rhesus monkeys. Biol Psychiatry. 2004; (56):364-375.
    12. Kilts CD, Gross RE, Ely TD, Drexler KPG. The neural correlates of drug cue-induced craving in cocaine-dependent women. Am J Psychiatry. 2004; (161):233-241.
    13. Leonard SK, Petitto JM, Anderson CM, Mooney DH, Lachowicz JE, Schulz DW, Kilts CD, Mailman RB. D1 dopamine receptors in the amygdala exhibit unique properties. Ann NY Acad Sci. 2003; (985):536-539.
    14. Wade AG, Schlaepfer TE, Andersen HF. Clinical milestones predict symptom remission over 6-months and choice of treatment of patients with major depressive disorder (MDD). J Psychiatric Res.
    15. Derado, G, Bowman FD, Ely TD. Evaluating functional autocorrelation within spatially distributed neural processing networks. Statistics and Its Interface. 1:45-57.
    16. Caceda, R, James GA, Ely TD, Snarey J. Mode of effective connectivity within putative neural networks differentiates moral cognitions related to care and justice ethics. PLOS ONE. 2(e14730).
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