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Wayne Wahls

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiochemistry & Molecular Biology, College of Medicine
AddressB421C Biomedical Research I
325 S. Elm St.
Mail Slot # 516
Little Rock AR 72205
Phone501-686-5787
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    Collapse Research 
    Collapse research activities and funding
    P20GM152281     (EOFF, ROBERT L)Mar 5, 2024 - Dec 31, 2028
    NIH
    Center for Molecular Interactions in Cancer (CMIC)
    Role: Co-Investigator
    R01GM145834     (WAHLS, WAYNE P)May 10, 2022 - Mar 31, 2026
    NIH
    Systematic elucidation of DNA sequence codes that regulate meiotic recombination
    Role: Principal Investigator
    R01GM145834     (WAHLS, WAYNE P)May 10, 2022 - Mar 31, 2026
    NIH/Nat. Inst. of General Medical Sciences
    Systematic elucidation of DNA sequence codes that regulate meiotic recombination
    Role: Principal Investigator
    117-1003535     (WAHLS, WAYNE P)Jul 1, 2015 - Jun 30, 2016
    UAMS College of Medicine
    Wahls start up account
    Role: Principal Investigator
    R01GM081766     (WAHLS, WAYNE P)Aug 10, 2007 - May 31, 2020
    NIH
    Biochemistry of recombination in meiosis
    Role: Principal Investigator
    R01ES013787     (DAVIDSON, MARI K)Apr 1, 2005 - Dec 31, 2009
    NIH
    Molecular mechanisms of aneuploidy
    Role: Co-Investigator
    R01GM062801     (WAHLS, WAYNE P)Aug 1, 2001 - Jul 31, 2006
    NIH
    Combinatoial CREB/ATF dimers and cellular growth control
    Role: Principal Investigator
    R01GM062244     (WAHLS, WAYNE P)Feb 1, 2001 - Jan 31, 2006
    NIH
    REGULATION OF MEIOTIC DEVELOPMENT BY MTS1-MTS2 PROTEIN
    Role: Principal Investigator
    Check #312114     (WAHLS, WAYNE P)Jul 1, 1999 - Jun 30, 2003
    Human Frontier Science Program
    Transcription-coupled Homologous Recombination
    Role: Principal Investigator
    Check#312114     (WAHLS, WAYNE P)Jul 1, 1999 - Jun 30, 2003
    Human Frontier Science Program
    Transcription-coupled Homologous Recombination
    Role: Principal Investigator
    R55GM054671     (WAHLS, WAYNE P)Sep 30, 1997 - Sep 29, 1999
    NIH
    HOMOLOGUS RECOMBINATION HOTSPOTS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Gao J, Proffitt DR, Marecki JC, Protacio RU, Wahls WP, Byrd AK, Raney KD. Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth. Nucleic Acids Res. 2024 Jun 24; 52(11):6543-6557. PMID: 38752483.
      View in: PubMed
    2. Davidson MK, Protacio RU, Helmlinger D, Wahls WP. Laboratory horror stories: Poison in the agars. bioRxiv. 2024 Jun 06. PMID: 38895319.
      View in: PubMed
    3. Protacio RU, Malone EG, Wahls WP. DNA sequences and distinct mechanisms for ura4-595 and ura4-294 alleles of S. pombe. MicroPubl Biol. 2024; 2024. PMID: 38440330.
      View in: PubMed
    4. Protacio RU, Davidson MK, Wahls WP. Adaptive Control of the Meiotic Recombination Landscape by DNA Site-dependent Hotspots With Implications for Evolution. Front Genet. 2022; 13:947572. PMID: 35812747.
      View in: PubMed
    5. Protacio RU, Mukiza TO, Davidson MK, Wahls WP. Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination. Genetics. 2022 02 04; 220(2). PMID: 34888655.
      View in: PubMed
    6. Storey AJ, Hardman RE, Byrum SD, Mackintosh SG, Edmondson RD, Wahls WP, Tackett AJ, Lewis JA. Accurate and Sensitive Quantitation of the Dynamic Heat Shock Proteome Using Tandem Mass Tags. J Proteome Res. 2020 03 06; 19(3):1183-1195. PMID: 32027144.
      View in: PubMed
    7. Storey AJ, Wang HP, Protacio RU, Davidson MK, Wahls WP. Targeted Forward Genetics: Population-Scale Analyses of Allele Replacements Spanning Thousands of Base Pairs in Fission Yeast. G3 (Bethesda). 2019 12 03; 9(12):4097-4106. PMID: 31597677.
      View in: PubMed
    8. Mukiza TO, Protacio RU, Davidson MK, Steiner WW, Wahls WP. Diverse DNA Sequence Motifs Activate Meiotic Recombination Hotspots Through a Common Chromatin Remodeling Pathway. Genetics. 2019 11; 213(3):789-803. PMID: 31511300.
      View in: PubMed
    9. Wahls WP. Opinion: The National Institutes of Health needs to better balance funding distributions among US institutions. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13150-13154. PMID: 31266906.
      View in: PubMed
    10. Wahls WP. NIH dollars go to too few US states. Nature. 2018 12; 564(7735):190. PMID: 30542174.
      View in: PubMed
    11. Storey AJ, Wang HP, Protacio RU, Davidson MK, Tackett AJ, Wahls WP. Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot. Epigenetics Chromatin. 2018 10 29; 11(1):64. PMID: 30373637.
      View in: PubMed
    12. Kriss CL, Gregory-Lott E, Storey AJ, Tackett AJ, Wahls WP, Stevens SM. In Vivo Metabolic Tracing Demonstrates the Site-Specific Contribution of Hepatic Ethanol Metabolism to Histone Acetylation. Alcohol Clin Exp Res. 2018 10; 42(10):1909-1923. PMID: 30030934.
      View in: PubMed
    13. Wahls WP. The NIH must reduce disparities in funding to maximize its return on investments from taxpayers. Elife. 2018 03 23; 7. PMID: 29570053.
      View in: PubMed
    14. Wahls WP. NIH's ineffective funding policies. Science. 2017 Jun 16; 356(6343):1132-1133. PMID: 28619908.
      View in: PubMed
    15. Wahls WP. Biases in grant proposal success rates, funding rates and award sizes affect the geographical distribution of funding for biomedical research. PeerJ. 2016; 4:e1917. PMID: 27077009.
      View in: PubMed
    16. Protacio RU, Storey AJ, Davidson MK, Wahls WP. Nonsense codon suppression in fission yeast due to mutations of tRNA(Ser.11) and translation release factor Sup35 (eRF3). Curr Genet. 2015 May; 61(2):165-73. PMID: 25519804.
      View in: PubMed
    17. Garc?a P, Paulo E, Gao J, Wahls WP, Ayt? J, Lowy E, Hidalgo E. Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription. Nucleic Acids Res. 2014; 42(16):10351-9. PMID: 25122751.
      View in: PubMed
    18. Waldrip ZJ, Byrum SD, Storey AJ, Gao J, Byrd AK, Mackintosh SG, Wahls WP, Taverna SD, Raney KD, Tackett AJ. A CRISPR-based approach for proteomic analysis of a single genomic locus. Epigenetics. 2014 Sep; 9(9):1207-11. PMID: 25147920.
      View in: PubMed
    19. Gao J, Kan F, Wagnon JL, Storey AJ, Protacio RU, Davidson MK, Wahls WP. Rapid, efficient and precise allele replacement in the fission yeast Schizosaccharomyces?pombe. Curr Genet. 2014 May; 60(2):109-19. PMID: 24026504.
      View in: PubMed
    20. Gao J, Wagnon JL, Protacio RM, Glazko GV, Beggs M, Raj V, Davidson MK, Wahls WP. A stress-activated, p38 mitogen-activated protein kinase-ATF/CREB pathway regulates posttranscriptional, sequence-dependent decay of target RNAs. Mol Cell Biol. 2013 Aug; 33(15):3026-35. PMID: 23732911.
      View in: PubMed
    21. Wahls WP, Davidson MK. New paradigms for conserved, multifactorial, cis-acting regulation of meiotic recombination. Nucleic Acids Res. 2012 Nov 01; 40(20):9983-9. PMID: 22904082.
      View in: PubMed
    22. Wahls WP, Davidson MK. DNA sequence-mediated, evolutionarily rapid redistribution of meiotic recombination hotspots. Genetics. 2011 Nov; 189(3):685-94. PMID: 22084420.
      View in: PubMed
    23. Kan F, Davidson MK, Wahls WP. Meiotic recombination protein Rec12: functional conservation, crossover homeostasis and early crossover/non-crossover decision. Nucleic Acids Res. 2011 Mar; 39(4):1460-72. PMID: 21030440.
      View in: PubMed
    24. Wahls WP, Davidson MK. Discrete DNA sites regulate global distribution of meiotic recombination. Trends Genet. 2010 May; 26(5):202-8. PMID: 20381894.
      View in: PubMed
    25. Misty, J., Wood, V., Finn, R. D., Wahls WP. Atf1 osmotic stress activation (OSA) domain (founding member, domain organization, alignments, curation and models, trees, species). The Pfam protein families database. 2010.
    26. Misty, J., Wood, V., Finn, R. D., Wahls WP. Atf1 Homologous recombination repression *HRR) domain (founding member, domain, domain organization, alignments, curation and models, trees, species). The Pfam protein families database. 2010.
    27. Gao J, Davidson MK, Wahls WP. Phosphorylation-independent regulation of Atf1-promoted meiotic recombination by stress-activated, p38 kinase Spc1 of fission yeast. PLoS One. 2009; 4(5):e5533. PMID: 19436749.
      View in: PubMed
    28. Gao J, Davidson MK, Wahls WP. Phosphorylation-independent regualtion of Atf1-promoted meiotic recombination by stress-activated p38 kinase Spc1 of fission yeast. PLoS One. 2009; 5(e5533).
    29. Wahls WP, Davidson MK. Low-copy episomal vector pFY20 and high-saturation coverage genomic libraries for the fission yeast Schizosaccharomyces pombe. Yeast. 2008 Sep; 25(9):643-50. PMID: 18613214.
      View in: PubMed
    30. Wahls WP, Siegel ER, Davidson MK. Meiotic recombination hotspots of fission yeast are directed to loci that express non-coding RNA. PLoS One. 2008 Aug 06; 3(8):e2887. PMID: 18682829.
      View in: PubMed
    31. Gao J, Davidson MK, Wahls WP. Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response. Nucleic Acids Res. 2008 May; 36(9):2838-51. PMID: 18375981.
      View in: PubMed
    32. DeWall KM, Davidson MK, Sharif WD, Wiley CA, Wahls WP. A DNA binding motif of meiotic recombinase Rec12 (Spo11) defined by essential glycine-202, and persistence of Rec12 protein after completion of recombination. Gene. 2005 Aug 15; 356:77-84. PMID: 16009511.
      View in: PubMed
    33. Wu H, Gao J, Sharif WD, Davidson MK, Wahls WP. Purification, folding, and characterization of Rec12 (Spo11) meiotic recombinase of fission yeast. Protein Expr Purif. 2004 Nov; 38(1):136-44. PMID: 15477092.
      View in: PubMed
    34. Davidson MK, Shandilya HK, Hirota K, Ohta K, Wahls WP. Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+. J Biol Chem. 2004 Dec 03; 279(49):50857-63. PMID: 15448137.
      View in: PubMed
    35. Davidson MK, Young NP, Glick GG, Wahls WP. Meiotic chromosome segregation mutants identified by insertional mutagenesis of fission yeast Schizosaccharomyces pombe; tandem-repeat, single-site integrations. Nucleic Acids Res. 2004; 32(14):4400-10. PMID: 15316103.
      View in: PubMed
    36. Yamada T, Mizuno K, Hirota K, Kon N, Wahls WP, Hartsuiker E, Murofushi H, Shibata T, Ohta K. Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO J. 2004 Apr 21; 23(8):1792-803. PMID: 14988732.
      View in: PubMed
    37. Sharif WD, Glick GG, Davidson MK, Wahls WP. Distinct functions of S. pombe Rec12 (Spo11) protein and Rec12-dependent crossover recombination (chiasmata) in meiosis I; and a requirement for Rec12 in meiosis II. Cell Chromosome. 2002 Sep 19; 1(1):1. PMID: 12437782.
      View in: PubMed
    38. Sharif WD, Glick GG, Davidson MK, Wahls WP. Distinct functions of S. pombe Rec12 (Spo11) protein and Rec12-dependent crossover recombination (chiasmata) in meiosis I; and a requirement for Rec12 in meiosis II. Cell Chromosome. 2002; 1(1):1 - .
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