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Lee Macmillan-Crow

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
Address323D Biomedical Research I
325 S. Elm St.
Mail Slot # 638
Little Rock AR 72205
Phone501-686-5289
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    Collapse Overview 
    Collapse overview
    My laboratory has been funded by the NIH since 2001 and has a long-term interest in oxidant generation and mitochondrial damage during renal ischemia/reperfusion, as it relates to transplantation injury. In addition, we are examining the therapeutic potential of several agents to block renal mitochondrial injury during warm and cold ischemia, using rat, porcine, and a human model of transplantation. This research has led to a Use Patent. Another recent area of study in collaboration with Dr. Philip Mayeux’s laboratory, is currently supported by an NIH RO1 grant is related to the role that mitochondrial superoxide has on mitochondrial and renal damage during sepsis.


    Collapse Research 
    Collapse research activities and funding
    P20GM125503     (OBRIEN, CHARLES)Feb 16, 2018 - Jan 31, 2023
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Co-Investigator
    16PRE30830010     (MACMILLAN-CROW, LEE A)Jul 1, 2016 - Jun 30, 2018
    American Heart Association (SouthWest Affiliate)
    Role of mitoBK channels in rat renal cold preservation
    Role: Principal Investigator
    P20GM109005     (BOERMA, MARJAN)Jun 24, 2015 - May 31, 2025
    NIH
    Center for Studies of Host Response to Cancer Therapy
    Role: Co-Investigator
    R01GM106419     (MACMILLAN-CROW, LEE A)Feb 1, 2014 - Jan 31, 2020
    NIH
    Mitochondrial injury and repair in sepsis-induced acute kidney injury
    Role: Principal Investigator
    R43DK089659     (MACMILLAN-CROW, LEE A)Sep 1, 2010 - Feb 29, 2012
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Cell & Tissue Systems, Inc
    Assessment of MitoQ Therapy for Cold Preservation Renal Damage
    Role: Principal Investigator
    R01DK078936     (MACMILLAN-CROW, LEE A)Jan 16, 2009 - Nov 30, 2015
    NIH
    Manganese Superoxide Dismutase and Renal Ischemia/Reperfusion
    Role: Principal Investigator
    R01DK059872     (MACMILLAN-CROW, LEE A)Sep 1, 2001 - Aug 31, 2007
    NIH
    Oxidants, Mitochondria,and Renal Ischemia/Reperfusion
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Shoeib AM, Benson LN, Mu S, MacMillan-Crow LA, Prather PL. Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death. Int J Mol Sci. 2022 Mar 11; 23(6). PMID: 35328467.
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    2. Tobacyk J, Kc G, MacMillan-Crow LA. Overexpression of MnSOD Protects against Cold Storage-Induced Mitochondrial Injury but Not against OMA1-Dependent OPA1 Proteolytic Processing in Rat Renal Proximal Tubular Cells. Antioxidants (Basel). 2021 Aug 11; 10(8). PMID: 34439520.
      View in: PubMed
    3. Tobacyk J, MacMillan-Crow LA. Fluorescence-Based Assay For Measuring OMA1 Activity. Methods Mol Biol. 2021; 2276:325-332. PMID: 34060052.
      View in: PubMed
    4. Rodríguez-Graciani KM, Chapa-Dubocq XR, MacMillan-Crow LA, Javadov S. Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats. Cell Physiol Biochem. 2020 Oct 30; 54(6):1101-1114. PMID: 33119220.
      View in: PubMed
    5. Shrum S, Tobacyk J, Lo S, Parajuli N, MacMillan-Crow LA. The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury. Arch Biochem Biophys. 2020 07 30; 688:108410. PMID: 32446891.
      View in: PubMed
    6. Shrum S, Rusch NJ, MacMillan-Crow LA. Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage-Induced Mitochondrial Injury In Vitro. Biomolecules. 2019 12 04; 9(12). PMID: 31817165.
      View in: PubMed
    7. Tobacyk J, Parajuli N, Shrum S, Crow JP, MacMillan-Crow LA. The first direct activity assay for the mitochondrial protease OMA1. Mitochondrion. 2019 05; 46:1-5. PMID: 30926535.
      View in: PubMed
    8. Lo S, MacMillan-Crow LA, Parajuli N. Renal cold storage followed by transplantation impairs proteasome function and mitochondrial protein homeostasis. Am J Physiol Renal Physiol. 2019 01 01; 316(1):F42-F53. PMID: 30303714.
      View in: PubMed
    9. MacMillan-Crow LA, Mayeux PR. Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis. Intern Med Rev (Wash D C). 2018 Oct; 4(10). PMID: 30506014.
      View in: PubMed
    10. Parajuli N, Shrum S, Tobacyk J, Harb A, Arthur JM, MacMillan-Crow LA. Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. PLoS One. 2017; 12(10):e0185542. PMID: 28977005.
      View in: PubMed
    11. Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, MacMillan-Crow LA, Hallberg LM, Ameredes BT, Boysen G. 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice. Toxicology. 2017 03 01; 378:114-124. PMID: 28082109.
      View in: PubMed
    12. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    13. Patil NK, Parajuli N, MacMillan-Crow LA, Mayeux PR. Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury. Am J Physiol Renal Physiol. 2014 Apr 01; 306(7):F734-43. PMID: 24500690.
      View in: PubMed
    14. Marine A, Krager KJ, Aykin-Burns N, Macmillan-Crow LA. Peroxynitrite induced mitochondrial biogenesis following MnSOD knockdown in normal rat kidney (NRK) cells. Redox Biol. 2014; 2:348-57. PMID: 24563852.
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    15. Marecki JC, Parajuli N, Crow JP, MacMillan-Crow LA. The use of the Cre/loxP system to study oxidative stress in tissue-specific manganese superoxide dismutase knockout models. Antioxid Redox Signal. 2014 Apr 01; 20(10):1655-70. PMID: 23641945.
      View in: PubMed
    16. Marecki JC, Parajuli N, Crow JP, MacMillan-Crow LA. The Use of the Cre/loxP System to Study Oxidative Stress in Tissue-Specific Manganese Superoxide Dismustase Knockout Models. Antioxid Redox Signal. 2013; PMID: 23641945.
    17. Patil NK, Saba H, MacMillan-Crow LA. Effect of S-nitrosoglutathione on renal mitochondrial function: a new mechanism for reversible regulation of manganese superoxide dismutase activity? Free Radic Biol Med. 2013 Mar; 56:54-63. PMID: 23246566.
      View in: PubMed
    18. Parajuli N, MacMillan-Crow LA. Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis? Am J Physiol Renal Physiol. 2013 Feb 01; 304(3):F257-67. PMID: 23195678.
      View in: PubMed
    19. Parajuli N, Campbell LH, Marine A, Brockbank KG, Macmillan-Crow LA. MitoQ blunts mitochondrial and renal damage during cold preservation of porcine kidneys. PLoS One. 2012; 7(11):e48590. PMID: 23139796.
      View in: PubMed
    20. Mayeux PR, MacMillan-Crow LA. Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury. Pharmacol Ther. 2012 May; 134(2):139-55. PMID: 22274552.
      View in: PubMed
    21. Pathak E, MacMillan-Crow LA, Mayeux PR. Role of mitochondrial oxidants in an in vitro model of sepsis-induced renal injury. J Pharmacol Exp Ther. 2012 Jan; 340(1):192-201. PMID: 22011433.
      View in: PubMed
    22. Agarwal R, Hennings L, Rafferty TM, Letzig LG, McCullough S, James LP, MacMillan-Crow LA, Hinson JA. Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice. J Pharmacol Exp Ther. 2012 Jan; 340(1):134-42. PMID: 22001257.
      View in: PubMed
    23. Parajuli N, Marine A, Simmons S, Saba H, Mitchell T, Shimizu T, Shriasawa T, MacMillan-Crow LA. Generation and characterization of novel kidney-specific manganese superoxide dismutase knockout mouse. Free Radical Biol Med. 2011; 51(2):406-416 [PMID: 21571061].
    24. Parajuli N, Marine A, Simmons S, Saba H, Mitchell T, Shimizu T, Shirasawa T, Macmillan-Crow LA. Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse. Free Radic Biol Med. 2011 Jul 15; 51(2):406-16. PMID: 21571061.
      View in: PubMed
    25. Agarwal R, MacMillan-Crow LA, Rafferty TM, Saba H, Roberts DW, Fifer EK, James LP, Hinson JA. Acetaiminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismustase. J Pharmacol Exp Ther. 2011; 337(1):110-116 [PMID: 21205919].
    26. MacMillan-Crow LA, Crow JP. Does more MnSOD mean more hydrogen peroxide? Anticancer Agents Med Chem. 2011 Feb; 11(2):178-80. PMID: 21291402.
      View in: PubMed
    27. Agarwal R, MacMillan-Crow LA, Rafferty TM, Saba H, Roberts DW, Fifer EK, James LP, Hinson JA. Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase. J Pharmacol Exp Ther. 2011 Apr; 337(1):110-6. PMID: 21205919.
      View in: PubMed
    28. Mitchell T, Rotaru D, Saba H, Smith RA, Murphy MP, MacMillan-Crow LA. The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys. J Pharmacol Exp Ther. 2011 Mar; 336(3):682-92. PMID: 21159749.
      View in: PubMed
    29. Burke AS, MacMillan-Crow LA, Hinson JA. The Hepatocyte Suspension Assay Is Superior to the Cultured Hepatocyte Assay for Determining Mechanisms of Acetaminophen Hepatotoxicity Relevant to in Vivo Toxicity. Chem Res Toxicol. 2010; [PMID: 21082830].
    30. Mitchell T, Saba H, Laakman J, Parajuli N, MacMillan-Crow LA. Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury. Free Radic Biol Med. 2010 Nov 01; 49(8):1273-82. PMID: 20659553.
      View in: PubMed
    31. Burke AS, MacMillan-Crow LA, Hinson JA. Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes. Chem Res Toxicol. 2010 Jul 19; 23(7):1286-92. PMID: 20578685.
      View in: PubMed
    32. Burke AS, MacMillan-Crow LA, Hinson JA. ). Peroxynitrite in Acetaminophen-Induced Mitochondrial Permeability Transition and Toxicity in Mouse Hepatocytes. Chem Res Toxicol. 2010; 23(7):1286-1292 [PMID: 20578685].
    33. Gilbert KM, Przybyla B, Pumford NR, Han T, Fuscoe J, Schnackenberg LK, Holland RD, Doss JC, Macmillan-Crow LA, Blossom SJ. Delineating liver events in trichloroethylene-induced autoimmune hepatitis. Chem Res Toxicol. 2009 Apr; 22(4):626-32. PMID: 19254012.
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    34. Munusamy S, MacMillan-Crow LA. Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells. Free Radic Biol Med. 2009 Apr 15; 46(8):1149-57. PMID: 19439219.
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    35. Munusamy S, Saba H, Mitchell T, Megyesi JK, Brock RW, Macmillan-Crow LA. Alteration of renal respiratory Complex-III during experimental type-1 diabetes. BMC Endocr Disord. 2009 Jan 23; 9:2. PMID: 19166612.
      View in: PubMed
    36. Saba H, Munusamy S, Macmillan-Crow LA. Cold preservation mediated renal injury: involvement of mitochondrial oxidative stress. Ren Fail. 2008; 30(2):125-33. PMID: 18300110.
      View in: PubMed
    37. Saba H, Batinic-Haberle I, Munusamy S, Mitchell T, Lichti C, Megyesi J, MacMillan-Crow LA. Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion. Free Radic Biol Med. 2007 May 15; 42(10):1571-8. PMID: 17448904.
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    38. Dorman RB, Wunder C, Saba H, Shoemaker JL, MacMillan-Crow LA, Brock RW. NAD(P)H oxidase contributes to the progression of remote hepatic parenchymal injury and endothelial dysfunction, but not microvascular perfusion deficits. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G1025-32. PMID: 16339298.
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    39. Cruthirds DL, Saba H, MacMillan-Crow LA. Overexpression of manganese superoxide dismutase protects against ATP depletion-mediated cell death of proximal tubule cells. Arch Biochem Biophys. 2005 May 01; 437(1):96-105. PMID: 15820221.
      View in: PubMed
    40. Gray KD, MacMillan-Crow LA, Simovic MO, Stain SC, May AK. Pulmonary MnSOD is nitrated following hepatic ischemia-reperfusion. Surg Infect (Larchmt). 2004; 5(2):166-73. PMID: 15353113.
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    41. Bagnasco P, MacMillan-Crow LA, Greendorfer JS, Young CJ, Andrews L, Thompson JA. Peroxynitrite modulates acidic fibroblast growth factor (FGF-1) activity. Arch Biochem Biophys. 2003 Nov 15; 419(2):178-89. PMID: 14592461.
      View in: PubMed
    42. Cruthirds DL, Novak L, Akhi KM, Sanders PW, Thompson JA, MacMillan-Crow LA. Mitochondrial targets of oxidative stress during renal ischemia/reperfusion. Arch Biochem Biophys. 2003 Apr 01; 412(1):27-33. PMID: 12646264.
      View in: PubMed
    43. Vickers SM, Huang ZQ, MacMillan-Crow L, Greendorfer JS, Thompson JA. Ligand activation of alternatively spliced fibroblast growth factor receptor-1 modulates pancreatic adenocarcinoma cell malignancy. J Gastrointest Surg. 2002 Jul-Aug; 6(4):546-53. PMID: 12127120.
      View in: PubMed
    44. Pittman KM, Macmillan-Crow LA, Peters BP, Allen JB. Nitration of manganese superoxide dismutase during ocular inflammation. Exp Eye Res. 2002; 74(4):463 - 471 [PMID: 12076090].
    45. Macmillan-Crow LA, Cruthirds DL, Ahki KM, Sanders PW, Thompson JA. Mitochondrial tyrosine nitration precedes chronic allograft nephropathy. Free Radic Biol Med. 2001; 31(12):1603 - 1608 [PMID: 11744334].
    46. Cobbs CS, Samanta M, Harkins LE, Gillespie GY, Merrick BA, Macmillan-Crow LA. Evidence for peroxynitrite-mediated modifications to p53 in human gliomas: possible functional consequences. Arch Biochem Biophys. 2001; 394(2):167 - 172 [PMID: 11594730].
    47. Vickers SM, MacMillan-Crow L, Huang Z, Thompson JA. Acidic fibroblast growth factor (FGF-1) signaling inhibits peroxynitrite-induced cell death during pancreatic tumorigenesis. Free Radic Biol Med. 2001; 30(9):957 - 966.
    48. Macmillan-Crow LA, Cruthirds DL. Invited review: manganese superoxide dismutase in disease. Free Radic Res. 2001; 34(4):325 - 336 [PMID: 11328670].
    49. Sanders PW, Gibbs CL, Akhi KM, MacMillan-Crow LA, Zinn KR, Chen YF, Young CJ, Thompson JA. Increased dietary salt accelerates chronic allograft nephropathy in rats. Kidney Int. 2001; 59(3):1149 - 1157 [PMID: 11231373].
    50. MacMillan-Crow LA, Greendorfer JS, Vickers SM, Thompson JA. Tyrosine nitration of c-SRC tyrosine kinase in human pancreatic ductal adenocarcinoma. Arch Biochem Biophys. 2000; 377(2):350 - 356 [PMID: 10845713].
    51. Takakura K, Beckman JS, Macmillan-Crow LA, Crow JP. Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite. Arch Biochem Biophys. 1999; 369(2):197 - 207 [PMID: 10486138].
    52. Macmillan-Crow LA, Thompson JA. Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. Arch Biochem Biophys. 1999; 366(1):82 - 88 [PMID: 10334867].
    53. Vickers SM, MacMillan-Crow LA, Green M, Ellis C, Thompson JA. Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer. Arch Surg. 1999; 134(3):245 - 251 [PMID: 10088562].
    54. MacMillan-Crow LA, Thompson JA. Immunoprecipitation of nitrotyrosine-containing proteins. Methods Enzymol. 1999; 301:135 - 145 [PMID: 9919561].
    55. MacMillan-Crow LA, Crow JP, Thompson JA. Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues. Biochemistry. 1998; 37(6):1613 - 1622 [PMID: 9484232].
    56. Shin JT, Barbeito L, Macmillan-Crow LA, Beckman JS, Thompson JA. Acidic fibroblast growth factor enhances peroxynitrite-induced apoptosis in primary murine fibroblasts. Arch Biochem Biophys. 1996; 335(1):32 - 41 [PMID: 8914832].
    57. Macmillan-Crow LA, Crow JP, Kerby JD, Beckman JS, Thompson JA. Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts. Proc Natl Acad Sci U S A. 1996; 93(21):11853 - 11858 [PMID: 8876227].
    58. Robinson ML, MacMillan-Crow LA, Thompson JA, Overbeek PA. Expression of a truncated FGF receptor results in defective lens development in transgenic mice. Development. 1995; 121(12):3959 - 3967 [PMID: 8575296].
    59. Lincoln TM, Komalavilas P, Boerth NJ, MacMillan-Crow LA, Cornwell TL. cGMP signaling through cAMP- and cGMP-dependent protein kinases. Adv Pharmacol. 1995; 34:305 - 322 [PMID: 8562442].
    60. Macmillan-Crow LA, Lincoln TM. High-affinity binding and localization of the cyclic GMP-dependent protein kinase with the intermediate filament protein vimentin. Biochemistry. 1994; 33(26):8035 - 8043 [PMID: 8025108].
    61. Macmillan-Crow LA, Murphy-Ullrich JE, Lincoln TM. Identification and possible localization of cGMP-dependent protein kinase in bovine aortic endothelial cells. Biochem Biophys Res Commun. 1994; 201(2):531 - 537 [PMID: 8002983].
    62. Lincoln TM, Pryzwansky KB, Cornwell TL, Wyatt TA, MacMillan LA. Cyclic-GMP-dependent protein kinase in smooth muscle and neutrophils. Adv Second Messenger Phosphoprotein Res. 1993; 28:121 - 132.
    63. Thompson ME, Zimmer WE, Wear LB, MacMillan LA, Thompson WJ, Huttner WB, Hidaka H, Scammell JG. Differential regulation of chromogranin B/secretogranin I and secretogranin II by forskolin in PC12 cells. Brain Res Mol Brain Res. 1992; 12(1-3):195 - 202.
    64. Rondon IJ, MacMillan LA, Beckman BS, Goldberg MA, Schneider T, Bunn HF, Malter JS. Hypoxia up-regulates the activity of a novel erythropoietin mRNA binding protein. J Biol Chem. 1991; 266(25):16594 - 16598.
    65. Minkes RK, MacMillan LA, Bellan JA, Kerstein MD, McNamara DB, Kadowitz PJ. Analysis of regional responses to endothelin in hindquarters vascular bed of cats. Am J Physiol. 1989; 256(2 Pt 2):H598 - H602.
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