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Richard Nicholas Jr

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentOrthopaedics Surgery, College of Medicine
DivisionOrthopaedics Surgery Faculty
Address10-122 Cancer Institute
4104 Outpatient Circle
Mail Slot # 531
Little Rock AR 72205
Phone501-686-7812
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPathology, College of Medicine


    Collapse Overview 
    Collapse overview
    Richard Nicholas, M.D., is a professor in the Department of Orthopaedics and currently serves as the Director of the Center for Bone and Soft Tissue Tumors at the Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences (UAMS).

    A 1977 graduate of the College of William & Mary in Williamsburg, Virginia, Dr. Nicholas received his medical degree from the Medical College of Virginia in 1981. An internship in general surgery at the University of California at San Francisco was followed by a residency in orthopaedics.

    After a fellowship in orthopaedic oncology at the University of Chicago, Dr. Nicholas joined the Orthopaedics staff at UAMS in 1989 to lead the Section of Musculoskeletal Oncology. From 1997 until January 2003, he served as the Director of Education at the Cancer Institute. He subsequently served as chairman of the Department of Orthopaedic surgery from 2005 until November 2013.

    Dr. Nicholas is certified by the American Board of Orthopaedic Surgeons. He is a member of the American Academy of Orthopaedic Surgeons, the American Orthopaedic Association, the Musculoskeletal Tumor Society, the Orthopaedic Research Society, the Children's Oncology Group, the International Society of Limb Salvage and the Mid-America Orthopaedic Association.


    Collapse Research Funds 
    Collapse research activities
    R25CA250979     (KELLY JR, THOMAS)Sep 1, 2020 - Aug 31, 2025
    NIH/Nat. Cancer Institute
    Partnership in Cancer Research (PCAR)
    Role: Co-Principal Investigator

    PARITY     (NICHOLAS JR, RICHARD)Apr 16, 2018
    Orthopaedic Research & Education Foundation - Pass Through: McMaster University
    Prophylactic Antibiotic Regimens In Tumor Surgery (PARITY): A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotic Regimens in Patients Undergoing Tumor Resections with Endoprosthetic Replacements
    Role: Principal Investigator

    Clinical Study Agreement     (NICHOLAS JR, RICHARD)Sep 16, 2008 - Sep 15, 2013
    Musculoskeletal Transplant Foundation
    Status of Large Allografts Following Limb Salvage Resection for Tumors or Trauma: Retrospective and Prospective Study Design
    Role: Principal Investigator

    R25CA49425     (NICHOLAS JR, RICHARD)Sep 30, 1989 - Jun 30, 2005
    NIH/Nat. Cancer Institute
    Student Partners in Cancer Research and Education
    Role: Principal Investigator

    4-63347-00-100     (NICHOLAS JR, RICHARD)
    NIH/Nat. Cancer Institute
    CANCER INFORMATION SERVICES- Sub Contract with the University of Kentucky
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Mohan M, Samant RS, Yoon D, Buros AF, Branca A, Montgomery CO, Nicholas R, Suva LJ, Morello R, Thanendrarajan S, Schinke C, Yaccoby S, van Rhee F, Davies FE, Morgan GJ, Zangari M. Extensive Remineralization of Large Pelvic Lytic Lesions Following Total Therapy Treatment in Patients With Multiple Myeloma. J Bone Miner Res. 2017 Jun; 32(6):1261-1266. PMID: 28240368.
      View in: PubMed
    2. Nicholas RW. CORR Insights®: Is There Benefit to Free Over Pedicled Vascularized Grafts in Augmenting Tibial Intercalary Allograft Constructs? Clin Orthop Relat Res. 2017 05; 475(5):1338-1340. PMID: 28078635.
      View in: PubMed
    3. Romano RC, Gardner JM, Shalin SC, Ram R, Govindarajan R, Montgomery CO, Gilley JH, Nicholas RW. High Relative Expression of Pannexin 3 (PANX3) in an Axillary Sweat Gland Carcinoma With Osteosarcomatous Transformation. Am J Dermatopathol. 2016 Nov; 38(11):846-851. PMID: 27391460.
      View in: PubMed
    4. Robertson M, Gilley J, Nicholas R. Stress Fractures of the Distal Femur Involving Small Nonossifying Fibromas in Young Athletes. Orthopedics. 2016 Nov 01; 39(6):e1197-e1200. PMID: 27458898.
      View in: PubMed
    5. Montgomery C, Nicholas R. The Danger of an Unplanned Excision. J Ark Med Soc. 2016 Jun; 112(14):274-5. PMID: 27434980.
      View in: PubMed
    6. Stine KC, Wahl EC, Liu L, Skinner RA, VanderSchilden J, Bunn RC, Montgomery CO, Aronson J, Becton DL, Nicholas RW, Swearingen CJ, Suva LJ, Lumpkin CK. Nutlin-3 treatment spares cisplatin-induced inhibition of bone healing while maintaining osteosarcoma toxicity. J Orthop Res. 2016 10; 34(10):1716-1724. PMID: 26867804.
      View in: PubMed
    7. SG DuBois, MD Krailo, MC Gebhardt, SS Donaldson, KJ Marcus, J Dormans, RC Shamberger, S Sailer, Nicholas, RW, J Healey, NJ Tarbell, M Devidas, JS Meyer, L Granowetter, R Womer, M Bernstein, N Marina, HE Grier. Evaluation of Local Control Strategies in Ewing Sarcoma of Bone: A Report from the Children's Oncology Group. 2012 ASCO Annual Meeting. 2012.
    8. Nicholas, Richard W. Imaging of Soft Tissue Sarcomas. Contemporary Diagnostic Radiology. 2010.
    9. Suva LJ, Gaddy D, Nicholas RW. Bone and Cancer. Inflammatory Cytokines and Their Role in Bone Metastasis and Osteolysis. 2009; 9.
    10. Nicholas R, Et al;. Intensive Therapy with Growth Factor Support for Patients with Ewing Tumor Metastatic at Diagnosis, POG/CCG Phase II Study 9457: A Report from the Children’s Oncology Group. J Clin Oncol. 2006; 24(1):152-9.
    11. Nicholas R. Ethical considerations in allograft tissue transplantation: a surgeon's perspective. Clin Orthop Relat Res. 2005 Jun; (435):11-6. PMID: 15930915.
      View in: PubMed
    12. Sawyer Jr, Goosen LS, Lichti-Binz R, Swanson CM, Nicholas RW. Evidence for Telomeric as a Mechanism for Recurring Structural Aberrations of Chromosome 11 in Giant Cell Tumor of Bone. Cancer Genet Cytogenet. 2005; 159(1):32-36.
    13. Justesen S, Kelly D, Nicholas R. Soft Tissue Tumors: Resection and Reconstruction. Oper Tech Orthop. 2005; 14:267-75.
    14. Sawyer JR, Nicholas R, Parham DM. A Novel Reciprocal Chromosome Translocation t(X;2)(q31;q35) in Clear Cell Sugar Tumor of Bone. Cancer Genet Cytogenet. 2004; 154(1):77-80.
    15. Sawyer JR, Thomas EL, Lukacs JL, Swanson CM, Ding Y, Parham DM, Thomas JR, Nicholas R. Recurring breakpoints of 1p13-22 in osteochondroma. Cancer Genet Cytogenet. 2002; 138(2):102-6.
    16. LaCroix M, Thomas J, Nicholas R. Subperiosteal Osteoid Osteoma of the Distal Phalanx Fourth Toe: A Case Report. Orthopaedics. 2001; 24(7):695-6.
    17. Yuen J, Nicholas R. Reconstruction of a Total Achilles Tendon and Soft-Tissue Defect with an Achilles Allograft Combined with a Rectus Muscle Free Flap. Plast Reconstr Surg. 2001; 107(7):1807-11.
    18. Sawyer J, Binz R, Gilliland J, Nicholas R, Thomas J. A Novel t(10;17)(p11.2;23) Reciprocal translocation in myxoid fibrosarcoma. Cancer Genet Cytogenet. 2001; 124(2):144-6.
    19. Les K, Nicholas R, Rougraff B, Wurtz D, Vogelzang N, Simon M, Peabody T. Local progression and survival after operative resection of skeletal metastases from kidney cancer. Clin Orthop. 2001; 390:206-11.
    20. Palmer, HE, North, P, Nicholas, RW, Allison, JW, Parham, DM. Pathologic case of the month. Extraskeletal myxoid chondrosarcoma. Arch Pediatr Adolesc Med. 1999; 153(10):1107-8.
    21. Jarka, DE, Nicholas, RW, Aronson, J. Effect of methotrexate on distraction of osteogenesis. Clin Orthop Relat Res. 1998; 354:209-15.
    22. Sawyer, JR, Swanson, CM, Lukacs, JL, Nicholas, RW, North, PE, Thomas, JR. Evidence of an association between 6q13-21 chromosome aberrations and locally aggressive behavior of patients with cartilage tumors. Cancer. 1998; 82(3):474-83.
    23. Flahiff, CM, Gober, GA, Nicholas, RW. Pullout strength of fixation screws from polymethyl methacrylate cement. Biomaterials. 1995; 16(7):533-6.
    24. Flahiff, CM, Brooks, AT, Hollis, JM, Vander Schilden, JL, Nicholas, RW. Biomechanical analysis of patellar tendon allografts from donors of various age groups. Am J Sports Med. 1995; 23(3):354-8.
    25. Skinner R, Nicholas R, Stewart C, Vireday C. Resected allograft bone containing an implanted expanded polytetrafluoroethylene prosthetic ligament: Comparison of paraffin, glycolmethacrylate, and Exakt grinding techniques. J Histotechn. 1993; 16(2):129-37.
    26. Nicholas R, Nelson C, Skinner R. Allograft bone healing histologic evaluation of retrieved specimens. Contemp Orthop. 1993; 26(1):19-25.
    27. Krajca-Radcliffe J, Nicholas R, Shah H. Case report: Loose body of the elbow mimicking tumor. J Arkansas Medical Society. 1993; 90(2):70-2.
    28. Nicholas R, Lang T. Granular tricalcium phosphate grafting of nonstructural, cavitary bone lesions in humans. 1992; 9.
    29. Draganich L, Nicholas R, Shuster J, Sathy M, Chang A, Simon M. The effects of resection of the proximal part of the fibula on stability of the knee and on gait. J Bone Joint Surg (Am). 1991; 73(4):575-83.
    30. Draganich L, Nicholas R, Simon M, Shuster J, Sathy M. Objective analysis of gait and knee stability following resection of the proximal fibula. Orthopaedic Transactions. 1991; 15(3):701.
    31. Skinner R, Nicholas R. Preparation of superior quality slides of orthopaedic tissues from fresh surgical specimens. Tech Sample, A.S.C.P. 1991; HT-2.
    32. Nicholas R, James P. Telescoping intramedullary stabilization of the lower extremity for severe osteogenesis imperfecta. J Pediatr Orthop. 1990; 10(2):219-23.
    33. Skinner R, Nicholas R. Preparing superior quality slides of orthopaedic tissue using previously decalcified material. Tech Sample, A.S.C.P. 1990; HT-4.
    34. Finn H, Nicholas R, Webb J. Skeletal reconstruction with allograft segments following bone tumor removal. Clin Orthop Relat Res. 1990; 21(5):455-71.
    35. Nicholas R. Evaluation of local control strategies in patients with localized Ewing Sarcoma of bone:   a report from the Children & rsquo's Oncology Group. ASCO 2012 Annual Meeting.
    36. Larry J. Suva, Kimo Stine, Elizabeth C. Wahl, Lichu Liu, James Aronson, Robert A. Skinner, Corey O. Montgomery, David L. Becton, Nicholas, Richard W., Charles K. Lumpkin, Jr. Nutlin-3 treatment spares cisplatin-induced inhibition of bone healing while maintaining osteosarcoma toxicity. CIBD Annual Meeting.
    37. Montgomery Corey O, Nicholas, Richard W., Suva, Larry. Anti-Interleukin 8 Therapy Inhibits Tumor-induced Osteolysis and Tumor Progression.
    38. Nicholas, Richard W., Stine, Kimo C. Sarcomas of bone in children, adolescents, & young adults. ped.com. 17(2):16-18.
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