Last Name

Jill James

InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Developmental Peds
Address4023 ACH Research Institute
1120 Marshall Street
Mail Slot # 512-40B
Little Rock AR 72202
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Frye RE, Slattery J, MacFabe DF, Allen-Vercoe E, Parker W, Rodakis J, Adams JB, Krajmalnik-Brown R, Bolte E, Kahler S, Jennings J, James J, Cerniglia CE, Midtvedt T. Approaches to studying and manipulating the enteric microbiome to improve autism symptoms. Microb Ecol Health Dis. 2015; 26:26878. PMID: 25956237; PMCID: PMC4425814.
    2. James SJ, Shpyleva S, Melnyk S, Pavliv O, Pogribny IP. Complex epigenetic regulation of engrailed-2 (EN-2) homeobox gene in the autism cerebellum. Transl Psychiatry. 2013 Feb 19; 3:e232. PMID: 23423141; PMCID: PMC3590998.
    3. Koturbash I, Melnyk S, James SJ, Beland FA, Pogribny IP. Role of epigenetic and miRNA alteration in the downreulation of Mat 1a and MTHFR genes in early preneoplastic rats induced by 2-AAF. Mol Carcinogenesis. 2013; 52:18-27.
    4. Zhao M, Ralat MA, Da Silva V, Garrett TJ, Melnyk S, James SJ, Gregory JF 3rd. Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells. Am J Physiol Endocrinol Metab. 2013; 304:E342-51.
    5. Hyman SL, Stewart PA, Schmidt B, Cain U, Lemcke N, Foley JT, Peck R, Clemons T, Reynolds A, Johnson C, Handen B, James SJ, Courtney PM, Molloy C, Ng PK. Nutrient intake from food in children with autism. Pediatrics. 2012; 130:Suppl 2:S145-53.
    6. Melnyk S, Fuchs GJ, Schulz E, Lopez M, Kahler SG, Fussell JJ, Bellando J, Pavliv O, Rose S, Seidel L, Gaylor DW, James SJ. Metabolic Imbalance associated with methylation dysregulatio and oxidative damage in children with autism. Journal of Autism and Developmental Disabilities. 2012; 42(3):367-77.
    7. Moore, E, Crook, T, Gonzoles, D, James SJ, Hakkak, R. Nutrient intake among children with autism. Nutritional Disorders and Therapy. 2012.
    8. Reynolds A, Krebs NF, Stewart PA, Austin H, Johnson SL, Withrow N, Molloy C, James SJ, Johnson C, Clemons T, Schmidt B, Hyman SL. Iron status in children with autism spectrum disorder. Pediatrics. 2012; 130:Suppl 2:S154-9.
    9. Neuhouser ML, Nijhout HF, Gregory JF 3rd, Reed MC, James SJ, Liu A, Shane B, Ulrich CM. Mathematical modeling predicts the effect of folate deficiency and excess on cancer related biomarkers. Cancer Epidemiol Biomarkers Prev. 2011; 20(9):1912-7.
    10. James SJ, Melnyk S, Jernigan S, Pavliv O, Trusty T, Lehman S, Seidel L, Gaylor DW, Cleves MA. A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism. Am J Med Genet B Neuropsychiatr Genet. 2010 Sep; 153B(6):1209-20. PMID: 20468076; PMCID: PMC2943349.
    11. Bertoglio T, Hendren R, James SJ. (In Press). Altern. Compl. Med. 2010. Altern. Compl. Med. 2010.
    12. Bertoglio K, James SJ, Deprey L, Brule N, Hendren, R. A pilot study of methyl B12 treatment. J Altern Compl Med. 2010; 16:1-6.
    13. James SJ, Rose S, Melnyk S, Jernigan S, Blossom S, Pavliv O, Gaylor DW. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J. 2009 Aug; 23(8):2374-83. PMID: 19307255; PMCID: PMC2717775.
    14. James SJ, Melnyk, S., Fuchs, G, Reid, T, Jernigan, S, Pavliv, O, Hubanks, A, Gaylor DW. Efficacy of Methylcobalamin and Folinic Acid treatment on Glu. Redox status in Children with Autism. Am J Clin Nutr. 2009; 89:425-430.
    15. James SJ, Rose S, Melnyk S, Jernigan S, Blossom S, Pavliv O, Gaylor D. Cellular and mitochondrial glutathione redox imbalance in lymphblastoid cells derived from children with autism. FASEB J. 2009; (23):2374-2383.
    16. James SJ, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr. 2009 Jan; 89(1):425-30. PMID: 19056591; PMCID: PMC2647708.
    17. James SJ, Melnyk S, Jernigan S, Hubanks A, Rose S, Gaylor DW. Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism. J Autism Dev Disord. 2008 Nov; 38(10):1976. PMID: 19011973.
      View in: PubMed
    18. James SJ, Jill James S, Melnyk S, Jernigan S, Hubanks A, Rose S, Gaylor DW. Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism. J Autism Dev Disord. 2008 Nov; 38(10):1966-75. PMID: 18512136; PMCID: PMC2584168.
    19. James S, Melnyk, S. Jernigan, S. Hubanks, A. Rose, S. Gaylor, DW. Abnormal Transmethylation/Transsulfuration Metabolism and DNA. Jour. of Autism & Dev. Disabiities. 2008; 38:1976-1980.
    20. James J. Autism: Theories and Evidence. Metabolic pathology of autism. 2008; 11.
    21. James S, Ulrich, C.M. Mathematical Modeling of Folate Metabolism. Cancer Epi Biomakers and Prev. 2008; 17:1822-31.
    22. James S. Autism: Current Theories and Evidence. Oxidative Stress and the Metabolic Pathology of Autism. 2008; 11.
    23. James S. Altered Expression of Methyltetrahydofolate Reductase Modifies Response to Methotrexate in Mice. Genomics. 2008; 18(7):577-589.
    24. James S. Mefolinate but not Folic Acid Decreases Mortality in an Animal Model of Severe Methylene. Reductase Deficiency. J. Inherrited Metabolic Disease. 2008; 31(3):403-411.
    25. Reed, MC, Thomas, RL, Pavisic, J, James, SJ, Ulrich, CM, Nijhout. A mathematical model of glutathione metabolism. Theoretical Biology and Medical Modeling. 2008; 5:8-14.
    26. James J. Oxidative Stress and the Metabolic Pathology of Autism. Current Theories and Evidence. 2008.
    27. James S, Blossom, SJ.Doss, J. Hennings, L. Jernigan S. Melnyk, S. Developmental Exposure to Trichloroethylene PRomotes CD4+ T CEll. Toxicology and Applied Pharmacology. 2008; 231:344-353.
    28. James, SJ, Melnyk, S, Jernigan, S, Hubanks, A, Rose, S, Gaylor, DW. Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of autistic children. Journal of Autism and Developmental Disabilities. 2008.
    29. Innis SM, Davidson AG, Melynk S, James SJ. Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis. Am J Clin Nutr. 2007; 85(3):702 - 708.
    30. Rose, S., Melnyk, S., Savenka, A., Hubanks, A., Cleves, M., James, SJ. The frequency of polymorphisms affecting lead and mercury toxicity among children with autism. Am. J. Biochem. Biotechnol. 2007; 4:85-94.
    31. James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH, Cutler P, Bock K, Boris M, Bradstreet JJ, Baker SM, Gaylor DW. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 05; 141B(8):947-56. PMID: 16917939; PMCID: PMC2610366.
    32. Reed MC, Nijhout HF, Neuhouser ML, Gregory JF, Shane B, James SJ, Boynton A, Ulrich CM. A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr. 2006; 136(10):2653 - 2661.
    33. Nijhout HF, Reed MC, Anderson DF, Mattingly JC, James SJ, Ulrich CM. Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate. Epigenetics. 2006; 1(2):81 - 87.
    34. James J. The Molecular Dynamics of Folate Metabolism and DNA. Methylenetetrahydrofolate Reductase. 2006.
    35. Chango A, Fillon-Emery N, Mircher C, Blehaut H, Lambert D, Herbeth B, James SJ, Rethore MO, Nicolas JP. No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers. Br J Nutr. 2005; 94(2):166 - 169.
    36. Chen AH, Innis SM, Davidson AG, James SJ. Phosphatidylcholine and lysophosphatidylcholine excretion is increased in children with cystic fibrosis and is associated with plasma homocysteine, S-adenosylhomocysteine, and S-adenosylmethionine. Am J Clin Nutr. 2005; 81(3):686 - 691.
    37. James SJ, Slikker W, Melnyk S, New E, Pogribna M, Jernigan S. Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors. Neurotoxicology. 2005 Jan; 26(1):1-8. PMID: 15527868.
      View in: PubMed
    38. James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec; 80(6):1611-7. PMID: 15585776.
      View in: PubMed
    39. Taub JW, Mundschau G, Ge Y, Poulik JM, Qureshi F, Jensen T, James SJ, Matherly LH, Wechsler J, Crispino JD. Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Blood. 2004; 104(5):1588 - 1589.
    40. MacLennan NK, James SJ, Melnyk S, Piroozi A, Jernigan S, Hsu JL, Janke SM, Pham TD, Lane RH. Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics. 2004; 18(1):43 - 50.
    41. James SJ. Maternal metabolic phenotype and risk of Down syndrome: beyond genetics. Am J Med Genet A. 2004; 127(1):1 - 4.
    42. James SJ, Pogribny IP, Pogribna M, Miller BJ, Jernigan S, Melnyk S. Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis. J Nutr. 2003 Nov; 133(11 Suppl 1):3740S-3747S. PMID: 14608108.
      View in: PubMed
    43. Motiwala T, Ghoshal K, Das A, Majumder S, Weichenhan D, Wu YZ, Holman K, James SJ, Jacob ST, Plass C. Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. Oncogene. 2003; 22(41):6319 - 6331.
    44. Chango A, Mircher C, James SJ, Rethore MO, Nicolas JP. [One carbon metabolism and trisomy 21: analysis of the genetic polymorphism]. Ann Biol Clin (Paris). 2002; 60(6):647 - 653.
    45. Finnell RH, Spiegelstein O, Wlodarczyk B, Triplett A, Pogribny IP, Melnyk S, James JS. DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation. J Nutr. 2002 Aug; 132(8 Suppl):2457S-2461S. PMID: 12163711.
      View in: PubMed
    46. Carmel R, James SJ. Alcohol abuse: an important cause of severe hyperhomocysteinemia. Nutr Rev. 2002; 60(7 Pt 1):215 - 221.
    47. Halsted CH, Villanueva JA, Devlin AM, James SJ. Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig. Trans Am Clin Climatol Assoc. 2002; 113:151 - 162.
    48. Hassold TJ, Burrage LC, Chan ER, Judis LM, Schwartz S, James SJ, Jacobs PA, Thomas NS. Maternal folate polymorphisms and the etiology of human nondisjunction. Am J Hum Genet. 2001; 69(2):434 - 439.
    49. James J. Folate Deficiency and the Molecular Determinants. Folate and Human Development. 2001; 3 pp 43-70.
    50. Hine RJ, James SJ. Down syndrome and folic acid update. J Am Diet Assoc. 2000; 100(9):1004 - .
    51. Pipkin JL, Hinson WG, James SJ, Shaddock JG, Lyn-Cook LE, Feuers RJ, Morris SM, Tolleson WH, Casciano DA. The relationship of p53 and stress proteins in response to bleomycin and retinoic acid in the p53 heterozygous mouse. Biochim Biophys Acta. 1999; 1450(2):164 - 176.
    52. Goksoy EO, James C, James SJ. Non-uniformity of surface temperatures after microwave heating of poultry meat. J Microw Power Electromagn Energy. 1999; 34(3):149 - 160.
    53. James SJ. Fetal brain death syndrome--a case report and literature review. Aust N Z J Obstet Gynaecol. 1998; 38(2):217 - 220.
    54. Pipkin JL, Hinson WG, James SJ, Lyn-Cook LE, Duffy PH, Feuers RJ, Shaddock JG, Aly KB, Hart RW, Casciano DA. P53 synthesis and phosphorylation in the aging diet-restricted rat following retinoic acid administration. Mech Ageing Dev. 1997; 97(1):15 - 34.
    55. Perkins SN, Hursting SD, Haines DC, James SJ, Miller BJ, Phang JM. Chemoprevention of spontaneous tumorigenesis in nullizygous p53-deficient mice by dehydroepiandrosterone and its analog 16alpha-fluoro-5-androsten-17-one. Carcinogenesis. 1997; 18(5):989 - 994.
    56. James SJ, Pogribna M, Miller BJ, Bolon B, Muskhelishvili L. Characterization of cellular response to silicone implants in rats: implications for foreign-body carcinogenesis. Biomaterials. 1997; 18(9):667 - 675.
    57. Jackson CD, Weis C, Miller BJ, James SJ. Dietary nucleotides: effects on cell proliferation following partial hepatectomy in rats fed NIH-31, AIN-76A, or folate/methyl-deficient diets. J Nutr. 1997; 127(5 Suppl):834S - 837S.
    58. Muskhelishvili L, Turturro A, Hart RW, James SJ. Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction. Am J Pathol. 1996; 149(5):1585 - 1591.
    59. Halsted CH, Villanueva J, Chandler CJ, Stabler SP, Allen RH, Muskhelishvili L, James SJ, Poirier L. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology. 1996; 23(3):497 - 505.
    60. Tolleson WH, Melchior WB, Morris SM, McGarrity LJ, Domon OE, Muskhelishvili L, James SJ, Howard PC. Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells. Carcinogenesis. 1996; 17(2):239 - 249.
    61. Corry JE, James C, James SJ, Hinton M. Salmonella, Campylobacter and Escherichia coli O157:H7 decontamination techniques for the future. Int J Food Microbiol. 1995; 28(2):187 - 196.
    62. Muskhelishvili L, Hart RW, Turturro A, James SJ. Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice. Am J Pathol. 1995; 147(1):20 - 24.
    63. James J. Decline in Immune Functionn with Age. 1995.
    64. James SJ, Muskhelishvili L. Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 x C3H F1 mice. Cancer Res. 1994; 54(21):5508 - 5510.
    65. Littlefield NA, Hass BS, James SJ, Poirier LA. Protective effect of magnesium on DNA strand breaks induced by nickel or cadmium. Cell Biol Toxicol. 1994; 10(2):127 - 135.
    66. Kharazi AI, James SJ, Taylor JM, Lubinski JM, Nakamura LT, Makinodan T. Combined chronic low dose radiation-caloric restriction: a model for regression of spontaneous mammary tumor. Int J Radiat Oncol Biol Phys. 1994; 28(3):641 - 647.
    67. James J. In Principles and Practice of Geriatric Medicine. 1994.
    68. James J. Possible Role of Apoptosis in Immune Enhancement and Disease. 1994.
    69. James SJ, Miller BJ, Cross DR, McGarrity LJ, Morris SM. The essentiality of folate for the maintenance of deoxynucleotide precursor pools, DNA synthesis, and cell cycle progression in PHA-stimulated lymphocytes. Environ Health Perspect. 1993; 101 Suppl 5:173 - 178.
    70. Lubinski JM, James SJ, Nakamura LT, Serrano-Williams A, Munekata MT, Ho SC, Chung JC, Makinodan T. Double-negative (L3T4-, Lyt2-) thymocytes of autoimmune lpr/lpr mice are resistant to down-regulation of DNA synthesis by a thymic stromal cell product. Cell Immunol. 1993; 150(2):425 - 438.
    71. Cross DR, Miller BJ, James SJ. A simplified HPLC method for simultaneously quantifying ribonucleotides and deoxyribonucleotides in cell extracts or frozen tissues. Cell Prolif. 1993; 26(4):327 - 336.
    72. Nogami M, Huang JT, James SJ, Lubinski JM, Nakamura LT, Makinodan T. Mice chronically exposed to low dose ionizing radiation possess splenocytes with elevated levels of HSP70 mRNA, HSC70 and HSP72 and with an increased capacity to proliferate. Int J Radiat Biol. 1993; 63(6):775 - 783.
    73. James SJ, Cross DR, Miller BJ. Alterations in nucleotide pools in rats fed diets deficient in choline, methionine and/or folic acid. Carcinogenesis. 1992; 13(12):2471 - 2474.
    74. James SJ, Enger SM, Makinodan T. DNA strand breaks and DNA repair response in lymphocytes after chronic in vivo exposure to very low doses of ionizing radiation in mice. Mutat Res. 1991; 249(1):255 - 263.
    75. Makinodan T, James SJ. T cell potentiation by low dose ionizing radiation: possible mechanisms. Health Phys. 1990; 59(1):29 - 34.
    76. James SJ, Enger SM, Peterson WJ, Makinodan T. Immune potentiation after fractionated exposure to very low doses of ionizing radiation and/or caloric restriction in autoimmune-prone and normal C57Bl/6 mice. Clin Immunol Immunopathol. 1990; 55(3):427 - 437.
    77. James SJ, Yin L. Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats. Carcinogenesis. 1989; 10(7):1209 - 1214.
    78. James SJ, Yin L, Swendseid ME. DNA strand break accumulation, thymidylate synthesis and NAD levels in lymphocytes from methyl donor-deficient rats. J Nutr. 1989; 119(4):661 - 664.
    79. James SJ, Makinodan T. T cell potentiation in normal and autoimmune-prone mice after extended exposure to low doses of ionizing radiation and/or caloric restriction. Int J Radiat Biol Relat Stud Phys Chem Med. 1988; 53(1):137 - 152.
    80. James SJ, Swendseid M, Makinodan T. Macrophage-mediated depression of T-cell proliferation in zinc-deficient mice. J Nutr. 1987; 117(11):1982 - 1988.
    81. James J. Age-Associated Immunodeficiency and Cancer. 1985.
    82. James J. Nutritional Intervention During Immunlogic Aging. Nutritional Intervention in the Aging Process. 1984; 13.
    83. Makinodan T, James SJ, Inamizu T, Chang MP. Immunologic basis for susceptibility to infection in the aged. Gerontology. 1984; 30(5):279 - 289.
    84. Garfinkel AS, Kempner ES, Ben-Zeev O, Nikazy J, James SJ, Schotz MC. Lipoprotein lipase: size of the functional unit determined by radiation inactivation. J Lipid Res. 1983; 24(6):775 - 780.
    85. Bailey C, James SJ, Kitchell AG, Hudson WR. Air-, water- and vacuum-thawing of frozen pork legs. J Sci Food Agric. 1974; 25(1):81 - 97.
    86. James J. Modulation of Age-Associated Immune Dysfunction by Nutritional Intervention. 15.
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