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Robert Jilka

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Endo
Address828 Cancer Institute
4104 Outpatient Circle
Mail Slot # 587
Little Rock AR 72205
Phone501-247-0744
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Piemontese M, Almeida M, Robling AG, Kim HN, Xiong J, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA, Jilka RL. Old age causes de novo intracortical bone remodeling and porosity in mice. JCI Insight. 2017 Sep 07; 2(17). PMID: 28878136.
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    2. Kim HN, Chang J, Shao L, Han L, Iyer S, Manolagas SC, O'Brien CA, Jilka RL, Zhou D, Almeida M. DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age. Aging Cell. 2017 Aug; 16(4):693-703. PMID: 28401730.
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    3. Ucer S, Iyer S, Kim HN, Han L, Rutlen C, Allison K, Thostenson JD, de Cabo R, Jilka RL, O'Brien C, Almeida M, Manolagas SC. The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct. J Bone Miner Res. 2017 Mar; 32(3):560-574. PMID: 27714847.
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    4. Jilka RL. The Road to Reproducibility in Animal Research. J Bone Miner Res. 2016 Jul; 31(7):1317-9. PMID: 27255286; PMCID: PMC4935620 [Available on 07/01/17].
    5. Liu Y, Almeida M, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice. Am J Physiol Endocrinol Metab. 2016 May 01; 310(9):E762-73. PMID: 26956187.
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    6. Jilka RL, O'Brien CA. The Role of Osteocytes in Age-Related Bone Loss. Curr Osteoporos Rep. 2016 Feb; 14(1):16-25. PMID: 26909563.
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    7. Ucer S, Iyer S, Bartell SM, Martin-Millan M, Han L, Kim HN, Weinstein RS, Jilka RL, O'Brien CA, Almeida M, Manolagas SC. The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERa Signaling in Osteoblasts and Osteoclasts. J Bone Miner Res. 2015 Jul; 30(7):1138-49. PMID: 25704845; PMCID: PMC4871247.
    8. Peris P, Roforth MM, Nicks KM, Fraser D, Fujita K, Jilka RL, Khosla S, McGregor U. Ability of circulating human hematopoietic lineage negative cells to support hematopoiesis. J Cell Biochem. 2015 Jan; 116(1):58-66. PMID: 25145595; PMCID: PMC4729456.
    9. Bartell SM, Kim HN, Ambrogini E, Han L, Iyer S, Serra Ucer S, Rabinovitch P, Jilka RL, Weinstein RS, Zhao H, O'Brien CA, Manolagas SC, Almeida M. FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun. 2014 Apr 30; 5:3773. PMID: 24781012; PMCID: PMC4015330.
    10. Manolagas SC, Almeida M, Jilka RL. The ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Gonadal Steroids. 2014.
    11. Jilka RL, O'Brien CA, Roberson PK, Bonewald LF, Weinstein RS, Manolagas SC. Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age. J Bone Miner Res. 2014 Jan; 29(1):103-17. PMID: 23761243; PMCID: PMC3823639.
    12. Iyer S, Ambrogini E, Bartell SM, Han L, Roberson PK, de Cabo R, Jilka RL, Weinstein RS, O'Brien CA, Manolagas SC, Almeida M. FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest. 2013 Aug; 123(8):3409-19. PMID: 23867625; PMCID: PMC3726166.
    13. Jilka RL. The relevance of mouse models for investigating age-related bone loss in humans. J Gerontol A Biol Sci Med Sci. 2013 Oct; 68(10):1209-17. PMID: 23689830; PMCID: PMC3779631.
    14. Onal M, Piemontese M, Xiong J, Wang Y, Han L, Ye S, Komatsu M, Selig M, Weinstein RS, Zhao H, Jilka RL, Almeida M, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem. 2013 Jun 14; 288(24):17432-40. PMID: 23645674; PMCID: PMC3682543.
    15. Bartell SM, Han L, Kim HN, Kim SH, Katzenellenbogen JA, Katzenellenbogen BS, Chambliss KL, Shaul PW, Roberson PK, Weinstein RS, Jilka RL, Almeida M, Manolagas SC. Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass. Mol Endocrinol. 2013 Apr; 27(4):649-56. PMID: 23443267; PMCID: PMC3607700.
    16. Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, Onal M, Xiong J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013; 123(1):394 - 404.
    17. Jilka RL, O'Brien CA, Roberson PK, Bonewald LF, Weinstein RS, Manolagas SC. Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates bone porosity with age. J Bone Mineral Res. 2013.
    18. Jilka RL, Noble B, Weinstein RS. Osteocyte apoptosis. Bone. 2013 Jun; 54(2):264-71. PMID: 23238124; PMCID: PMC3624050.
    19. Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, Onal M, Xiong J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013 Jan; 123(1):394-404. PMID: 23221342; PMCID: PMC3533305.
    20. Shoshana Bartell, Aaron Warren, Li Han, Srividhya Iyer, Sung Kim, Benita Katzenellenbogen, John Katzenellenbogen, Paula Roberson, Robert Weinstein, Charles O'Brien, Robert Jilka, Maria Jose Almeida, Stavros Manolagas. An Estrogen Dendrimer Conjugate Incapable of Stimulating the Nuclear-initiated Actions of Estrogen Receptors Prevents the Loss of Cortical Bone Mass in Estrogen Deficient Mice. Journal of Bone and Mineral Research. 2012; S21.
    21. Robert Jilka, Annick DeLoose, Leslie Climer, Lynda Bonewald, Robert Weinstein, Charles O'Brien, Stavros Manolagas. Dysfunctional Osteocytes Increase RANKL and Promote Cortical Pore Formation in Their Vicinity: a Mechanical Explanation for the Development of Cortical Porosity with Age. Journal of Bone and Mineral Research. 2012; S348.
    22. Srividhya Iyer, Aaron Warren, Martha Martin-Millan, Li Han, Shoshana Bartell, Elena Ambrogini, Jinhu Xiong, Julie Crawford, Robert Weinstein, Robert Jilka, Charles O'Brien, Maria Jose Almeida, Stavros Manolagas. The ERa of Osteoblast Progenitors is Required for Normal Accrual of Cortical Bone Mass Independently of Estrogens. Journal of Bone and Mineral Research. 2012; S68.
    23. Melda Onal, Jinhu Xiong, Shiqiao Ye, Li Han, Robert Jilka, Robert Weinstein, Maria Jose Almeida, Haibo Zhao, Stavros Manolagas, Charles O'Brien. Suppression of Autophagy in Osteoblasts and Osteocytes Increases Oxidative Stress and Recapitulates the Effects of Aging on the Murine Skeleton. Journal of Bone and Mineral Research. 2012; S349.
    24. Xiong J, Onal M, Jilka RL, Weinstein RS, Manolagas SC, O'Brien CA. Matrix-embedded cells control osteoclast formation. Nat Med. 2011 Sep 11; 17(10):1235-41. PMID: 21909103; PMCID: PMC3192296.
    25. Weinstein RS, O'Brien CA, Almeida M, Zhao H, Roberson PK, Jilka RL, Manolagas SC. Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice. Endocrinology. 2011 Sep; 152(9):3323-31. PMID: 21771887; PMCID: PMC3159783.
    26. Sun Y, Li W, Lu Z, Chen R, Ling J, Ran Q, Jilka RL, Chen XD. Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix. FASEB J. 2011 May; 25(5):1474-85. PMID: 21248241; PMCID: PMC3079301.
    27. Manolagas SC, Jilka RL. The study of skeletal aging is coming of age: a forum on aging and skeletal health. IBMS BoneKey. 2011; 8:420-427.
    28. Jilka RL, O'Brien CA, Bartell SM, Weinstein RS, Manolagas SC. Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms. J Bone Miner Res. 2010 Nov; 25(11):2427-37. PMID: 20533302; PMCID: PMC3179285.
    29. Jilka RL, Almeida M, Ambrogini E, Han L, Roberson PK, Weinstein RS, Manolagas SC. Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration. Aging Cell. 2010 Oct; 9(5):851-67. PMID: 20698835; PMCID: PMC2958819.
    30. Lai Y, Sun Y, Skinner CM, Son EL, Lu Z, Tuan RS, Jilka RL, Ling J, Chen XD. Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells. Stem Cells Dev. 2010 Jul; 19(7):1095-107. PMID: 19737070; PMCID: PMC3128312.
    31. Weinstein RS, Jilka RL, Almeida M, Roberson PK, Manolagas SC. Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice. Endocrinology. 2010 Jun; 151(6):2641-9. PMID: 20410195; PMCID: PMC2875832.
    32. Almeida M, Martin-Millan M, Ambrogini E, Bradsher R, Han L, Chen XD, Roberson PK, Weinstein RS, O'Brien CA, Jilka RL, Manolagas SC. Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha. J Bone Miner Res. 2010 Apr; 25(4):769-81. PMID: 19821774; PMCID: PMC3153331.
    33. Ambrogini E, Almeida M, Martin-Millan M, Paik JH, Depinho RA, Han L, Goellner J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 2010 Feb 03; 11(2):136-46. PMID: 20142101; PMCID: PMC2819984.
    34. Martin-Millan M, Almeida M, Ambrogini E, Han L, Zhao H, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol. 2010 Feb; 24(2):323-34. PMID: 20053716; PMCID: PMC2817608.
    35. Weinstein RS, Jilka RL, Roberson PK, Manolagas SC. Intermittent parathyroid hormone administration prevents glucocorticoid-induced osteoblast and osteocyte apoptosis, decreased bone formation, and reduced bone strength in mice. Endocrinol. 2010; 151:2641-2649.
    36. Almeida M, Ambrogini E, Han L, Manolagas SC, Jilka RL. Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem. 2009 Oct 02; 284(40):27438-48. PMID: 19657144; PMCID: PMC2785673.
    37. Jilka RL. Inhibiting the inhibitor: a new route to bone anabolism. J Bone Miner Res. 2009 Apr; 24(4):575-7. PMID: 19335216.
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    38. Galli C, Fu Q, Wang W, Olsen BR, Manolagas SC, Jilka RL, O'Brien CA. Commitment to the osteoblast lineage is not required for RANKL gene expression. J Biol Chem. 2009 May 08; 284(19):12654-62. PMID: 19279010; PMCID: PMC2675994.
    39. Almeida M, Ambrogini E, Han L, Manolagas S, Jilka RL. Increased lipid oxidation causes oxidative stress, increased PPARgamma expression and diminished pro-osteogenic Wnt signaling in the skeleton. J.Biol.Chem. 2009; 284:27438-27448.
    40. Almeida M, Martin-Millan M, Ambrogini E, Bradsher III R, Han L, Chen X-D,, Roberson PK, Weinstein RS, O’Brien CA, Jilka RL, Manolagas SC. Estrogens attenuate oxidative stress, osteoblast differentiation and apoptosis by DNA binding-independent actions of the ERalpha. J.Bone Miner.Res. 2009; 25:769-781.
    41. Jilka RL, O'Brien CA, Ali AA, Roberson PK, Weinstein RS, Manolagas SC. Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts. Bone. 2009 Feb; 44(2):275-86. PMID: 19010455; PMCID: PMC2655212.
    42. O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One. 2008 Aug 13; 3(8):e2942. PMID: 18698360; PMCID: PMC2491588.
    43. Chen XD, Dusevich V, Feng JQ, Manolagas SC, Jilka RL. Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts. J Bone Miner Res. 2007 Dec; 22(12):1943-56. PMID: 17680726.
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    44. Jilka RL, Weinstein RS, Parfitt AM, Manolagas SC. Quantifying osteoblast and osteocyte apoptosis: challenges and rewards. J Bone Miner Res. 2007 Oct; 22(10):1492-501. PMID: 17542686.
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    45. Almeida M, Han L, Martin-Millan M, Plotkin LI, Stewart SA, Roberson PK, Kousteni S, O'Brien CA, Bellido T, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007 Sep 14; 282(37):27285-97. PMID: 17623659; PMCID: PMC3119455.
    46. Jilka RL. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone. 2007 Jun; 40(6):1434-46. PMID: 17517365; PMCID: PMC1995599.
    47. Szumska D, Benes H, Kang P, Weinstein RS, Jilka RL, Manolagas SC, Shmookler Reis RJ. A novel locus on the X chromosome regulates post-maturity bone density changes in mice. Bone. 2007 Mar; 40(3):758-66. PMID: 17185055; PMCID: PMC1861851.
    48. Kousteni S, Almeida M, Han L, Bellido T, Jilka RL, Manolagas SC. Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol. 2007 Feb; 27(4):1516-30. PMID: 17158928; PMCID: PMC1800724.
    49. Manolagas SC, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L. Response to Windahl et al. J Clin Invest. 2006 Nov; 116(11):2834. PMID: 17080186; PMCID: PMC1626133.
    50. Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'Brien CA, Manolagas SC, Jilka RL. Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology. 2005 Nov; 146(11):4577-83. PMID: 16081646.
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    51. O'Brien CA, Jilka RL, Fu Q, Stewart S, Weinstein RS, Manolagas SC. IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E784-93. PMID: 15956054.
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    52. Ali AA, Weinstein RS, Stewart SA, Parfitt AM, Manolagas SC, Jilka RL. Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology. 2005 Mar; 146(3):1226-35. PMID: 15591153.
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    53. Chen JR, Plotkin LI, Aguirre JI, Han L, Jilka RL, Kousteni S, Bellido T, Manolagas SC. Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens. J Biol Chem. 2005 Feb 11; 280(6):4632-8. PMID: 15557324.
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    54. Weinstein RS, Jia D, Powers CC, Stewart SA, Jilka RL, Parfitt AM, Manolagas SC. The skeletal effects of glucocorticoid excess override those of orchidectomy in mice. Endocrinology. 2004 Apr; 145(4):1980-7. PMID: 14715712.
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    55. Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem. 2003 Dec 12; 278(50):50259-72. PMID: 14523023.
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    56. Jilka RL. Biology of the basic multicellular unit and the pathophysiology of osteoporosis. Med Pediatr Oncol. 2003 Sep; 41(3):182-5. PMID: 12868116.
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    57. Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O'Brien CA, Plotkin L, Fu Q, Mancino AT, Wen Y, Vertino AM, Powers CC, Stewart SA, Ebert R, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science. 2002 Oct 25; 298(5594):843-6. PMID: 12399595.
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    58. Fu Q, Jilka RL, Manolagas SC, O'Brien CA. Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein. J Biol Chem. 2002 Dec 13; 277(50):48868-75. PMID: 12364326.
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    59. Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology. 2002 Jun; 143(6):2376-84. PMID: 12021203.
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    60. Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JR, Manolagas SC, Jilka RL. Divergent Effects of Selective Peroxisome Proliferator-Activated Receptor-?2 Ligands on Adipocyte Versus Osteoblast Differentiation. Endocrinology. 2002 Jun 01; 143(6):2376-2384. PMID: 28204437.
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    61. Weinstein RS, Chen JR, Powers CC, Stewart SA, Landes RD, Bellido T, Jilka RL, Parfitt AM, Manolagas SC. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Invest. 2002 Apr; 109(8):1041-8. PMID: 11956241; PMCID: PMC150947.
    62. Manolagas SC, Kousteni S, Jilka RL. Sex steroids and bone. Recent Prog Horm Res. 2002; 57:385-409. PMID: 12017554.
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    63. Gaddy-Kurten D, Coker JK, Abe E, Jilka RL, Manolagas SC. Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures. Endocrinology. 2002 Jan; 143(1):74-83. PMID: 11751595.
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    64. Di Gregorio GB, Yamamoto M, Ali AA, Abe E, Roberson P, Manolagas SC, Jilka RL. Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17 beta-estradiol. J Clin Invest. 2001 Apr; 107(7):803-12. PMID: 11285299; PMCID: PMC199573.
    65. Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell. 2001 Mar 09; 104(5):719-30. PMID: 11257226.
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    66. Abe E, Yamamoto M, Taguchi Y, Lecka-Czernik B, O'Brien CA, Economides AN, Stahl N, Jilka RL, Manolagas SC. Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J Bone Miner Res. 2000 Apr; 15(4):663-73. PMID: 10780858.
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    67. Benes H, Weinstein RS, Zheng W, Thaden JJ, Jilka RL, Manolagas SC, Shmookler Reis RJ. Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains. J Bone Miner Res. 2000 Apr; 15(4):626-33. PMID: 10780854.
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    68. Grey A, Mitnick MA, Masiukiewicz U, Sun BH, Rudikoff S, Jilka RL, Manolagas SC, Insogna K. A role for interleukin-6 in parathyroid hormone-induced bone resorption in vivo. Endocrinology. 1999 Oct; 140(10):4683-90. PMID: 10499526.
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    69. Grey A, Mitnick MA, Masiukiewicz U, Sun BH, Rudikoff S, Jilka RL, Manolagas SC, Insogna K. A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo1. Endocrinology. 1999 Oct 01; 140(10):4683-4690. PMID: 28204269.
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    70. Lecka-Czernik B, Gubrij I, Moerman EJ, Kajkenova O, Lipschitz DA, Manolagas SC, Jilka RL. Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2. J Cell Biochem. 1999 Sep 01; 74(3):357-71. PMID: 10412038.
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    71. Jilka RL, Weinstein RS, Bellido T, Roberson P, Parfitt AM, Manolagas SC. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J Clin Invest. 1999 Aug; 104(4):439-46. PMID: 10449436; PMCID: PMC408524.
    72. Manolagas SC, Weinstein RS, Jilka RL, Parfitt AM. Parathyroid hormone and corticosteroid-induced osteoporosis. Lancet. 1998 Dec 12; 352(9144):1940. PMID: 9863825.
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    73. Jilka RL. Cytokines, bone remodeling, and estrogen deficiency: a 1998 update. Bone. 1998 Aug; 23(2):75-81. PMID: 9701464.
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    74. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest. 1998 Jul 15; 102(2):274-82. PMID: 9664068; PMCID: PMC508885.
    75. Jilka RL, Takahashi K, Munshi M, Williams DC, Roberson PK, Manolagas SC. Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption. J Clin Invest. 1998 May 01; 101(9):1942-50. PMID: 9576759; PMCID: PMC508781.
    76. Jilka RL, Weinstein RS, Bellido T, Parfitt AM, Manolagas SC. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J Bone Miner Res. 1998 May; 13(5):793-802. PMID: 9610743.
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    77. Kajkenova O, Lecka-Czernik B, Gubrij I, Hauser SP, Takahashi K, Parfitt AM, Jilka RL, Manolagas SC, Lipschitz DA. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res. 1997 Nov; 12(11):1772-9. PMID: 9383681.
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    78. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. Endocrinology. 1997 Sep; 138(9):4013-21. PMID: 9275093.
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    79. Mocharla H, Butch AW, Pappas AA, Flick JT, Weinstein RS, De Togni P, Jilka RL, Roberson PK, Parfitt AM, Manolagas SC. Quantification of vitamin D receptor mRNA by competitive polymerase chain reaction in PBMC: lack of correspondence with common allelic variants. J Bone Miner Res. 1997 May; 12(5):726-33. PMID: 9144338.
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    80. Jilka RL, Weinstein RS, Takahashi K, Parfitt AM, Manolagas SC. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J Clin Invest. 1996 Apr 01; 97(7):1732-40. PMID: 8601639; PMCID: PMC507238.
    81. Bellido T, Jilka RL, Boyce BF, Girasole G, Broxmeyer H, Dalrymple SA, Murray R, Manolagas SC. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest. 1995 Jun; 95(6):2886-95. PMID: 7769130; PMCID: PMC295976.
    82. Jilka RL, Passeri G, Girasole G, Cooper S, Abrams J, Broxmeyer H, Manolagas SC. Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6. Exp Hematol. 1995 Jun; 23(6):500-6. PMID: 7768305.
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    83. Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med. 1995 Feb 02; 332(5):305-11. PMID: 7816067.
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    84. Manolagas SC, Bellido T, Jilka RL. New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: roles of IL-6 and gp130. Int J Immunopharmacol. 1995 Feb; 17(2):109-16. PMID: 7657404.
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    85. Manolagas SC, Bellido T, Jilka RL. Sex steroids, cytokines and the bone marrow: new concepts on the pathogenesis of osteoporosis. Ciba Found Symp. 1995; 191:187-96; discussion 197-202. PMID: 8582197.
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    86. Girasole G, Passeri G, Jilka RL, Manolagas SC. Interleukin-11: a new cytokine critical for osteoclast development. J Clin Invest. 1994 Apr; 93(4):1516-24. PMID: 8163655; PMCID: PMC294166.
    87. Passeri G, Girasole G, Manolagas SC, Jilka RL. Endogenous production of tumor necrosis factor by primary cultures of murine calvarial cells: influence on IL-6 production and osteoclast development. Bone Miner. 1994 Feb; 24(2):109-26. PMID: 8199531.
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    88. Bellido T, Girasole G, Passeri G, Yu XP, Mocharla H, Jilka RL, Notides A, Manolagas SC. Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3. Endocrinology. 1993 Aug; 133(2):553-62. PMID: 8393768.
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    89. Passeri G, Girasole G, Jilka RL, Manolagas SC. Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal. Endocrinology. 1993 Aug; 133(2):822-8. PMID: 8393776.
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    90. Manolagas SC, Jilka RL, Girasole G, Passeri G, Bellido T. Estrogen, cytokines, and the control of osteoclast formation and bone resorption in vitro and in vivo. Osteoporos Int. 1993; 3 Suppl 1:114-6. PMID: 8461536.
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    91. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science. 1992 Jul 03; 257(5066):88-91. PMID: 1621100.
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    92. Girasole G, Jilka RL, Passeri G, Boswell S, Boder G, Williams DC, Manolagas SC. 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest. 1992 Mar; 89(3):883-91. PMID: 1541679; PMCID: PMC442934.
    93. Manolagas SC, Jilka RL. Cytokines, hematopoiesis, osteoclastogenesis, and estrogens. Calcif Tissue Int. 1992 Mar; 50(3):199-202. PMID: 1617492.
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    94. Graves L, Jilka RL. Comparison of bone and parathyroid hormone as stimulators of osteoclast development and activity in calvarial cell cultures from normal and osteopetrotic (mi/mi) mice. J Cell Physiol. 1990 Oct; 145(1):102-9. PMID: 2211836.
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    95. Jilka RL. Stimulation of collagenolytic enzyme release from cultured bone cells of normal and osteopetrotic (mi/mi) mice by parathyroid hormone and lipopolysaccharide. Bone Miner. 1989 Jul; 6(3):277-87. PMID: 2547466.
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    96. Horowitz MC, Coleman DL, Flood PM, Kupper TS, Jilka RL. Parathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor. J Clin Invest. 1989 Jan; 83(1):149-57. PMID: 2642917; PMCID: PMC303655.
    97. Horowitz MC, Einhorn TA, Philbrick W, Jilka RL. Functional and molecular changes in colony stimulating factor secretion by osteoblasts. Connect Tissue Res. 1989; 20(1-4):159-68. PMID: 2558840.
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    98. Jilka RL. Procollagenase associated with the noncalcified matrix of bone and its regulation by parathyroid hormone. Bone. 1989; 10(5):353-8. PMID: 2557874.
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    99. Stechschulte DJ, Sharma R, Dileepan KN, Simpson KM, Aggarwal N, Clancy J, Jilka RL. Effect of the mi allele on mast cells, basophils, natural killer cells, and osteoclasts in C57Bl/6J mice. J Cell Physiol. 1987 Sep; 132(3):565-70. PMID: 3654766.
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    100. Jilka RL. Are osteoblastic cells required for the control of osteoclast activity by parathyroid hormone? Bone Miner. 1986 Sep; 1(4):261-6. PMID: 2849485.
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    101. MacGregor RR, Jilka RL, Hamilton JW. Formation and secretion of fragments of parathormone. Identification of cleavage sites. J Biol Chem. 1986 Feb 05; 261(4):1929-34. PMID: 3944119.
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    102. Hamilton JW, MacGregor RR, Jilka RL. Formation of parathormone 8-34 by cathepsin-D digestion of parathormone and its efficacy as a hormone antagonist. Mol Cell Endocrinol. 1986 Feb; 44(2):179-83. PMID: 3005087.
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    103. Jilka RL. Parathyroid hormone-stimulated development of osteoclasts in cultures of cells from neonatal murine calvaria. Bone. 1986; 7(1):29-40. PMID: 3008795.
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    104. Jilka RL, Hamilton JW. Evidence for two pathways for stimulation of collagenolysis in bone. Calcif Tissue Int. 1985 May; 37(3):300-6. PMID: 3926280.
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    105. Jilka RL, Rogers JI, Khalifah RG, Vaananen HK. Carbonic anhydrase isozymes of osteoclasts and erythrocytes of osteopetrotic microphthalmic mice. Bone. 1985; 6(6):445-9. PMID: 3938292.
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    106. Jilka RL, Hamilton JW. Inhibition of parathormone-stimulated bone resorption by type I interferon. Biochem Biophys Res Commun. 1984 Apr 30; 120(2):553-8. PMID: 6732771.
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    107. Boonekamp PM, Hekkelman JW, Hamilton JW, Cohn DV, Jilka RL. Effect of culture on the hormone responsiveness of bone cells isolated by an improved sequential digestion procedue. Proc Kon Med Akad Wet. 1984; B:371-381.
    108. Martin KJ, Bellorin-Font E, Morrissey JJ, Jilka RL, MacGregor RR, Cohn DV. Relative sensitivity of kidney and bone to the amino-terminal fragment b-PTH (1-30) of native bovine parathyroid hormone: implications for assessment of bioactivity of parathyroid hormone fragments in vivo and in vitro. Calcif Tissue Int. 1983 Jul; 35(4-5):520-5. PMID: 6311376.
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    109. Hamilton JW, Jilka RL, MacGregor RR. Cleavage of parathyroid hormone to the 1-34 and 35-84 fragments by cathepsin D-like activity in bovine parathyroid gland extracts. Endocrinology. 1983 Jul; 113(1):285-92. PMID: 6861702.
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    110. Jilka RL, Cohn DV. A collagenolytic response to parathormone, 1,25-dihydroxycholecalciferol D3, and prostaglandin E2 in bone of osteopetrotic (mi/mi) mice. Endocrinology. 1983 Mar; 112(3):945-50. PMID: 6571820.
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    111. Simmons DJ, Kent GN, Jilka RL, Scott DM, Fallon M, Cohn DV. Formation of bone by isolated, cultured osteoblasts in millipore diffusion chambers. Calcif Tissue Int. 1982 May; 34(3):291-4. PMID: 6809292.
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    112. Jilka RL, Cohn DV. Role of phosphodiesterase in the parathormone-stimulated adenosine 3',5'-monophosphate response in bone cell populations enriched in osteoclasts and osteoblasts. Endocrinology. 1981 Sep; 109(3):743-7. PMID: 6167435.
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    113. Kent GN, Jilka RL, Cohn DV. Homologous and heterologous control of bone cell adenosine 3',5'-monophosphate response to hormones by parathoromone, prostaglandin E2, calcitonin, and 1,25-dihydroxycholecalciferol. Endocrinology. 1980 Nov; 107(5):1474-81. PMID: 6253267.
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    114. Jilka RL, Pestka S. Amino acid sequence of MOPC-315 mouse immunoglobulin heavy and light chain precursor regions. J Biol Chem. 1979; 254(18):9270 - 9276.
    115. Jilka RL, Pestka S. Amino acid sequence of the MOPC-315 heavy chain precursor region. Proc Natl Acad Sci U S A. 1977; 74(12):5692 - 5696.
    116. Jilka RL, Martonosi AN, Tillack TW. Effect of the purified (Mg2+ + Ca2+)-activated ATPase of sarcoplasmic reticulum upon the passive Ca2+ permeability and ultrastructure of phospholipid vesicles. J Biol Chem. 1975 Sep 25; 250(18):7511-24. PMID: 126238.
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    117. Nordin P, Jilka RL, Chase P, Whitlock L. Extraction of polysaccharides from wheat seedlings with sodium dodecyl sulphate. Phytochem. 1975; 14:1355-1358.
    118. Martonosi A, Jilka RL, Fortier F. The permeability of sacroplasmic reticulum membranes. 1974; 113-124.
    119. Manolagas SC, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L. Letter to: Let us not toss out the baby with the bath water. J Clin Invest. 2006.
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