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Kartik Shankar

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Developmental Nutrition
Address ACH Sturgis Building
1212 Marshall Street
Mail Slot # 512-20B
Little Rock AR 72202
Phone501-364-2847
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    Research in my laboratory is focused on understanding the developmental origins of childhood and adult obesity and related metabolic disorders. Currently, we are investigating the long-term consequences of maternal obesity on the offspring. The research projects involve a wide range of experimental and translational approaches including animal models, cell culture, molecular biology and genomics (microarrays and Next-gen Sequencing). Current work both in prospective clinical studies and experimental models is examining multiple facets of obesity-induced developmental programming. Our specific emphasis is to understand the transcriptomic and epigenetic/ epigenomic changes in mother and child. The overall objectives of these studies are aimed at gaining a better mechanistic understanding of the physiological basis of fetal programming and through translational studies, provide novel opportunities for effective intervention. One aspect of these efforts is aimed at early developmental periods (conception, implantation and placentation) primarily using experimental models, but also using samples from human subjects. In a related series of studies (funded by NIDDK-NIH), we are also examining the alterations in multiple organs in the young offspring consequent to exposure to maternal obesity. These studies are focused on elucidating hormonal and energy utilization pathways (insulin sensitivity and nutrient sensing) and are coupled with examining epigenetic alterations that may underlie altered sensitivity in the offspring.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Saraf MK, Piccolo BD, Bowlin AK, Mercer KE, LeRoith T, Chintapalli SV, Shankar K, Badger TM, Yeruva L. Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon?. Microbiome. 2017 Jul 14; 5(1):77. PMID: 28705171.
      View in: PubMed
    2. Thakali KM, Faske JB, Ishwar A, Alfaro MP, Cleves MA, Badger TM, Andres A, Shankar K. Maternal obesity and gestational weight gain are modestly associated with umbilical cord DNA methylation. Placenta. 2017 Sep; 57:194-203. PMID: 28864012.
      View in: PubMed
    3. Piccolo BD, Mercer KE, Bhattacharyya S, Bowlin AK, Saraf MK, Pack L, Chintapalli SV, Shankar K, Adams SH, Badger TM, Yeruva L. Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs. J Nutr. 2017 Aug; 147(8):1499-1509. PMID: 28659406.
      View in: PubMed
    4. Ruebel ML, Cotter M, Sims CR, Moutos DM, Badger TM, Cleves MA, Shankar K, Andres A. Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective. J Clin Endocrinol Metab. 2017 Jun 01; 102(6):2029-2038. PMID: 28323970.
      View in: PubMed
    5. Panasevich MR, Schuster CM, Phillips KE, Meers GM, Chintapalli SV, Wankhade UD, Shankar K, Butteiger DN, Krul ES, Thyfault JP, Rector RS. Soy compared with milk protein in a Western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats. J Nutr Biochem. 2017 Aug; 46:125-136. PMID: 28605664.
      View in: PubMed
    6. Krukowski RA, West D, DiCarlo M, Shankar K, Cleves MA, Tedford E, Andres A. A Behavioral Intervention to Reduce Excessive Gestational Weight Gain. Matern Child Health J. 2017 Mar; 21(3):485-491. PMID: 27449652.
      View in: PubMed
    7. Catalano PM, Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ. 2017 Feb 08; 356:j1. PMID: 28179267.
      View in: PubMed
    8. Krukowski RA, West DS, DiCarlo M, Shankar K, Cleves MA, Saylors ME, Andres A. Are early first trimester weights valid proxies for preconception weight? BMC Pregnancy Childbirth. 2016 Nov 21; 16(1):357. PMID: 27871260.
      View in: PubMed
    9. Chen JR, Lazarenko OP, Blackburn ML, Rose S, Frye RE, Badger TM, Andres A, Shankar K. Maternal Obesity Programs Senescence Signaling and Glucose Metabolism in Osteo-Progenitors From Rat and Human. Endocrinology. 2016 Nov; 157(11):4172-4183. PMID: 27653035.
      View in: PubMed
    10. Morris EM, Meers GM, Koch LG, Britton SL, Fletcher JA, Fu X, Shankar K, Burgess SC, Ibdah JA, Rector RS, Thyfault JP. Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis. Am J Physiol Endocrinol Metab. 2016 Oct 01; 311(4):E749-E760. PMID: 27600823.
      View in: PubMed
    11. Wankhade UD, Thakali KM, Shankar K. Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies. Mol Cell Endocrinol. 2016 Nov 05; 435:7-19. PMID: 27392497.
      View in: PubMed
    12. Ruebel M, Shankar K, Gaddy D, Lindsey F, Badger T, Andres A. Maternal obesity is associated with ovarian inflammation and upregulation of early growth response factor 1. Am J Physiol Endocrinol Metab. 2016 Jul 01; 311(1):E269-77. PMID: 27279249.
      View in: PubMed
    13. Yeruva L, Spencer NE, Saraf MK, Hennings L, Bowlin AK, Cleves MA, Mercer K, Chintapalli SV, Shankar K, Rank RG, Badger TM, Ronis MJ. Erratum to: Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model. BMC Gastroenterol. 2016 May 26; 16(1):55. PMID: 27229864.
      View in: PubMed
    14. Yeruva L, Spencer NE, Saraf MK, Hennings L, Bowlin AK, Cleves MA, Mercer K, Chintapalli SV, Shankar K, Rank RG, Badger TM, Ronis MJ. Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model. BMC Gastroenterol. 2016 Mar 22; 16:40. PMID: 27005303; PMCID: PMC4804644.
    15. Shankar K, Kang P, Zhong Y, Borengasser SJ, Wingfield C, Saben J, Gomez-Acevedo H, Thakali KM. Transcriptomic and epigenomic landscapes during cell fusion in BeWo trophoblast cells. Placenta. 2015 Dec; 36(12):1342-51. PMID: 26515927.
      View in: PubMed
    16. Shankar K. Reversing Fetal Undernutrition by Kick-Starting Early Growth. Endocrinology. 2015 Sep; 156(9):3059-62. PMID: 26295490; PMCID: PMC4541613.
    17. Andres A, Hull HR, Shankar K, Casey PH, Cleves MA, Badger TM. Longitudinal body composition of children born to mothers with normal weight, overweight, and obesity. Obesity (Silver Spring). 2015 Jun; 23(6):1252-8. PMID: 25960251.
      View in: PubMed
    18. Hinton PS, Shankar K, Eaton LM, Rector RS. Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running. Metabolism. 2015 Aug; 64(8):905-16. PMID: 25963848.
      View in: PubMed
    19. Ou X, Thakali KM, Shankar K, Andres A, Badger TM. Maternal adiposity negatively influences infant brain white matter development. Obesity (Silver Spring). 2015 May; 23(5):1047-54. PMID: 25919924; PMCID: PMC4414042.
    20. Borengasser SJ, Faske J, Kang P, Blackburn ML, Badger TM, Shankar K. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Physiol Genomics. 2014 Dec 01; 46(23):841-50. PMID: 25336449; PMCID: PMC4254938.
    21. Saben J, Thakali KM, Lindsey FE, Zhong Y, Badger TM, Andres A, Shankar K. Distinct adipogenic differentiation phenotypes of human umbilical cord mesenchymal cells dependent on adipogenic conditions. Exp Biol Med (Maywood). 2014 Oct; 239(10):1340-51. PMID: 24951473; PMCID: PMC4238288.
    22. Thakali KM, Saben J, Faske JB, Lindsey F, Gomez-Acevedo H, Lowery CL, Badger TM, Andres A, Shankar K. Maternal pregravid obesity changes gene expression profiles toward greater inflammation and reduced insulin sensitivity in umbilical cord. Pediatr Res. 2014 Aug; 76(2):202-10. PMID: 24819376; PMCID: PMC4135718.
    23. Borengasser SJ, Kang P, Faske J, Gomez-Acevedo H, Blackburn ML, Badger TM, Shankar K. High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring. PLoS One. 2014; 9(1):e84209. PMID: 24416203; PMCID: PMC3886966.
    24. Miousse IR, Sharma N, Blackburn M, Vantrease J, Gomez-Acevedo H, Hennings L, Shankar K, Cleves MA, Badger TM, Ronis MJ. Feeding soy protein isolate and treatment with estradiol have different effects on mammary gland morphology and gene expression in weanling male and female rats. Physiol Genomics. 2013 Nov 15; 45(22):1072-83. PMID: 24046281.
      View in: PubMed
    25. Borengasser SJ, Zhong Y, Kang P, Lindsey F, Ronis MJ, Badger TM, Gomez-Acevedo H, Shankar K. Maternal obesity enhances white adipose tissue differentiation and alters genome-scale DNA methylation in male rat offspring. Endocrinology. 2013 Nov; 154(11):4113-25. PMID: 23959936; PMCID: PMC3800750.
    26. Miousse IR, Gomez-Acevedo H, Sharma N, Vantrease J, Hennings L, Shankar K, Cleves MA, Badger TM, Ronis MJ. Mammary gland morphology and gene expression signature of weanling male and female rats following exposure to exogenous estradiol. Exp Biol Med (Maywood). 2013 Sep; 238(9):1033-46. PMID: 23925648.
      View in: PubMed
    27. Saben J, Zhong Y, Gomez-Acevedo H, Thakali KM, Borengasser SJ, Andres A, Shankar K. Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity. Am J Physiol Endocrinol Metab. 2013 Jul 01; 305(1):E1-14. PMID: 23632636; PMCID: PMC4116409.
    28. K SHANKAR, Borengasser SJ, Faske J, Kang P, Gomez-Acevedo H. Maternal obesity and post-natal high fat diet disrupt hepatic circadian rhythm in rat offspring. EB2013. 2013.
    29. Saben JL, Andres A, Borengasser S, Zhong Y, K SHANKAR. Early growth response protein 1 (EGR1) regulates pro-inflammatory gene expression in response to palmitate and TNFa in human placenta cells and is induced in obese placenta. EB2013. 2013.
    30. Andres A, K SHANKAR, Cleves MA, Badger TM. Maternal but not paternal fat mass is positively associated with infant fat mass at age 2 weeks. EB2013. 2013.
    31. Thakali K, Saben J, Andres A, K SHANKAR. Maternal pre-gravid body mass index and adiposity influence umbilical cord gene expression at term in AGA infants. EB2013. 2013.
    32. Ruebel, ML, K SHANKAR, Badger T, Andres A. Maternal obesity leads to an inflammatory response and insulin resistance in ovarian tissue. EB2013. 2013.
    33. Ronis M, Miousse IR, Sharma N, Vantrease J, Hennings L, K SHANKAR, Gomez-Acevedo H, Cleves M, Badger TM. Mammary gland morphology and gene expression signature of prepubertal male and female rats following exposure to exogenous estradiol. 52nd Annual Meeting & ToxExpo. 2013.
    34. Ronis MJ, Shankar K, Gomez-Acevedo H, Hennings L, Singhal R, Blackburn ML, Badger TM. Mammary gland morphology and gene expression differ in female rats treated with 17beta-estradiol or fed soy protein isolate. Endocrinology. 2012; 153(12):6021-32.
    35. Ronis MJ, Shankar K, Gomez-Acevedo H, Hennings L, Singhal R, Blackburn ML, Badger TM. Mammary gland morphology and gene expression differ in female rats treated with 17ß-estradiol or fed soy protein isolate. Endocrinology. 2012 Dec; 153(12):6021-32. PMID: 23027806.
      View in: PubMed
    36. Andres A, Shankar K, Badger TM. Body fat mass of exclusively breastfed infants born to overweight mothers. J Acad Nutr Diet. 2012 Jul; 112(7):991-5. PMID: 22889630.
      View in: PubMed
    37. Zhang J, Lazarenko OP, Wu X, Tong Y, Blackburn ML, Gomez-Acevedo H, Shankar K, Badger TM, Ronis MJ, Chen JR. Differential effects of short term feeding of a soy protein isolate diet and estrogen treatment on bone in the pre-pubertal rat. PLoS One. 2012; 7(4):e35736. PMID: 22536432; PMCID: PMC3335011.
    38. Pabona JM, Simmen FA, Nikiforov MA, Zhuang D, Shankar K, Velarde MC, Zelenko Z, Giudice LC, Simmen RC. Kruppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2012; 97(3):E376-92.
    39. Shankar K, Zhong Y, Kang P, Blackburn ML, Soares MJ, Badger TM, Gomez-Acevedo H. RNA-seq analysis of the functional compartments within the rat placentation site. Endocrinology. 2012 Apr; 153(4):1999-2011. PMID: 22355068.
      View in: PubMed
    40. Pabona JM, Simmen FA, Nikiforov MA, Zhuang D, Shankar K, Velarde MC, Zelenko Z, Giudice LC, Simmen RC. Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2012 Mar; 97(3):E376-92. PMID: 22259059; PMCID: PMC3319212.
    41. Chen JR, Zhang J, Lazarenko OP, Kang P, Blackburn ML, Ronis MJ, Badger TM, Shankar K. Inhibition of fetal bone development through epigenetic down-regulation of HoxA10 in obese rats fed high-fat diet. FASEB J. 2012 Mar; 26(3):1131-41. PMID: 22131269.
      View in: PubMed
    42. Ronis MJ, Chen Y, Shankar K, Gomez-Acevedo H, Cleves MA, Badeaux J, Blackburn ML, Badger TM. Formula feeding alters hepatic gene expression signature, iron and cholesterol homeostasis in the neonatal pig. Physiol Genomics. 2011 Dec 05; 43(23):1281-93. PMID: 21954453.
      View in: PubMed
    43. Zhang J, Lazarenko OP, Blackburn ML, Shankar K, Badger TM, Ronis MJ, Chen JR. Feeding blueberry diets in early life prevent senescence of osteoblasts and bone loss in ovariectomized adult female rats. PLoS One. 2011; 6(9):e24486. PMID: 21912699; PMCID: PMC3166322.
    44. Borengasser SJ, Lau F, Kang P, Blackburn ML, Ronis MJ, Badger TM, Shankar K. Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning. PLoS One. 2011; 6(8):e24068. PMID: 21901160; PMCID: PMC3162035.
    45. Shankar K, Zhong Y, Kang P, Lau F, Blackburn ML, Chen JR, Borengasser SJ, Ronis MJ, Badger TM. Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst. Endocrinology. 2011 Nov; 152(11):4158-70. PMID: 21862610; PMCID: PMC3199010.
    46. Su Y, Shankar K, Rahal O, Simmen RC. Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer--preventive actions of dietary factors. J Nutr Biochem. 2011 Jul; 22(7):605-11. PMID: 21292471.
      View in: PubMed
    47. Marecki JC, Ronis MJ, Shankar K, Badger TM. Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats. J Nutr Biochem. 2011 Feb; 22(2):142-52. PMID: 20435456.
      View in: PubMed
    48. Wu X, Tong Y, Shankar K, Baumgardner JN, Kang J, Badeaux J, Badger TM, Ronis MJ. Lipid fatty acid profile analyses in liver and serum in rats with nonalcoholic steatohepatitis using improved gas chromatography-mass spectrometry methodology. J Agric Food Chem. 2011 Jan 26; 59(2):747-54. PMID: 21162572.
      View in: PubMed
    49. Chen JR, Lazarenko OP, Shankar K, Blackburn ML, Lumpkin CK, Badger TM, Ronis MJ. Inhibition of NADPH oxidases prevents chronic ethanol-induced bone loss in female rats. J Pharmacol Exp Ther. 2011 Mar; 336(3):734-42. PMID: 21098090; PMCID: PMC3061541.
    50. Ronis MJ, Chen Y, Liu X, Blackburn ML, Shankar K, Landes RD, Fang N, Badger TM. Enhanced expression and glucocorticoid-inducibility of hepatic cytochrome P450 3A involve recruitment of the pregnane-X-receptor to promoter elements in rats fed soy protein isolate. J Nutr. 2011 Jan; 141(1):10-6. PMID: 21084653.
      View in: PubMed
    51. Chen JR, Lazarenko OP, Wu X, Kang J, Blackburn ML, Shankar K, Badger TM, Ronis MJ. Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/ß-catenin canonical Wnt signaling. J Bone Miner Res. 2010 Nov; 25(11):2399-411. PMID: 20499363.
      View in: PubMed
    52. Chen JR, Lazarenko OP, Wu X, Kang J, Blackburn ML, Shankar K, Badger TM, Ronis MJ. Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/beta-catenin canonical Wnt signaling. J Bone Miner Res. 2010; 25(11):2399-411.
    53. Chen JR, Lazarenko OP, Wu X, Tong Y, Blackburn ML, Shankar K, Badger TM, Ronis MJ. Obesity reduces bone density associated with activation of PPAR? and suppression of Wnt/ß-catenin in rapidly growing male rats. PLoS One. 2010 Oct 28; 5(10):e13704. PMID: 21060836; PMCID: PMC2965663.
    54. Chen JR, Lazarenko OP, Shankar K, Blackburn ML, Badger TM, Ronis MJ. A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/beta-catenin signaling. J Bone Miner Res. 2010 May; 25(5):1117-27. PMID: 20200986; PMCID: PMC3153370.
    55. Shankar K, Kang P, Harrell A, Zhong Y, Marecki JC, Ronis MJ, Badger TM. Maternal overweight programs insulin and adiponectin signaling in the offspring. Endocrinology. 2010 Jun; 151(6):2577-89. PMID: 20371699; PMCID: PMC2875830.
    56. Chen JR, Lazarenko OP, Wu X, Tong Y, Blackburn ML, Shankar K, Badger TM, Ronis MJ. Obesity reduces bone density associated with activation of PPARgamma and suppression of Wnt/beta-catenin in rapidly growing male rats. PLoS One. 2010; 5(10):e13704.
    57. Shankar K, Harrell A, Kang P, Singhal R, Ronis MJ, Badger TM. Carbohydrate-responsive gene expression in the adipose tissue of rats. Endocrinology. 2010 Jan; 151(1):153-64. PMID: 19880807.
      View in: PubMed
    58. Singhal R, Shankar K, Badger TM, Ronis MJ. Hepatic gene expression following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17{beta}-estradiol treatment. J Endocrinol. 2009 Jul; 202(1):141-52. PMID: 19372191.
      View in: PubMed
    59. Badger TM, Gilchrist JM, Pivik RT, Andres A, Shankar K, Chen JR, Ronis MJ. The health implications of soy infant formula. Am J Clin Nutr. 2009 May; 89(5):1668S-1672S. PMID: 19357221.
      View in: PubMed
    60. Su Y, Shankar K, Simmen RC. Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes. J Nutr. 2009 May; 139(5):945-51. PMID: 19321580.
      View in: PubMed
    61. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. J Nutr. 2008 Oct; 138(10):1872-9. PMID: 18806095; PMCID: PMC2935161.
    62. Ronis MJ, Butura A, Korourian S, Shankar K, Simpson P, Badeaux J, Albano E, Ingelman-Sundberg M, Badger TM. Cytokine and chemokine expression associated with steatohepatitis and hepatocyte proliferation in rats fed ethanol via total enteral nutrition. Exp Biol Med (Maywood). 2008 Mar; 233(3):344-55. PMID: 18296740.
      View in: PubMed
    63. Shankar K, Hidestrand M, Liu X, Chen JR, Haley R, Perrien DS, Skinner RA, Lumpkin CK, Badger TM, Ronis MJ. Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats. J Bone Miner Res. 2008 Mar; 23(3):338-49. PMID: 17967133.
      View in: PubMed
    64. Singhal R, Shankar K, Badger TM, Ronis MJ. Estrogenic status modulates aryl hydrocarbon receptor--mediated hepatic gene expression and carcinogenicity. Carcinogenesis. 2008 Feb; 29(2):227-36. PMID: 18174242.
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    65. Shankar K, Liu X, Singhal R, Chen JR, Nagarajan S, Badger TM, Ronis MJ. Chronic ethanol consumption leads to disruption of vitamin D3 homeostasis associated with induction of renal 1,25 dihydroxyvitamin D3-24-hydroxylase (CYP24A1). Endocrinology. 2008 Apr; 149(4):1748-56. PMID: 18162528; PMCID: PMC2276718.
    66. Shankar K, Harrell A, Liu X, Gilchrist JM, Ronis MJ, Badger TM. Maternal obesity at conception programs obesity in the offspring. Am J Physiol Regul Integr Comp Physiol. 2008 Feb; 294(2):R528-38. PMID: 18032473.
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    67. Baumgardner JN, Shankar K, Hennings L, Badger TM, Ronis MJ. A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G27-38. PMID: 17947452.
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    68. Chen JR, Shankar K, Nagarajan S, Badger TM, Ronis MJ. Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. J Pharmacol Exp Ther. 2008 Jan; 324(1):50-9. PMID: 17916759.
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    69. Baumgardner JN, Shankar K, Korourian S, Badger TM, Ronis MJ. Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G355-64. PMID: 17510198.
      View in: PubMed
    70. Shankar K, Ronis MJ, Badger TM. Effects of pregnancy and nutritional status on alcohol metabolism. Alcohol Res Health. 2007; 30(1):55-9. PMID: 17718402; PMCID: PMC3860435.
    71. Chilakapati J, Korrapati MC, Shankar K, Hill RA, Warbritton A, Latendresse JR, Mehendale HM. Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital. Toxicol Appl Pharmacol. 2007 Feb 15; 219(1):72-84. PMID: 17234228.
      View in: PubMed
    72. Chen JR, Haley RL, Hidestrand M, Shankar K, Liu X, Lumpkin CK, Simpson PM, Badger TM, Ronis MJ. Estradiol protects against ethanol-induced bone loss by inhibiting up-regulation of receptor activator of nuclear factor-kappaB ligand in osteoblasts. J Pharmacol Exp Ther. 2006 Dec; 319(3):1182-90. PMID: 16971503.
      View in: PubMed
    73. Shankar K, Hidestrand M, Liu X, Xiao R, Skinner CM, Simmen FA, Badger TM, Ronis MJ. Physiologic and genomic analyses of nutrition-ethanol interactions during gestation: Implications for fetal ethanol toxicity. Exp Biol Med (Maywood). 2006 Sep; 231(8):1379-97. PMID: 16946407.
      View in: PubMed
    74. Shankar K, Hidestrand M, Haley R, Skinner RA, Hogue W, Jo CH, Simpson P, Lumpkin CK, Aronson J, Badger TM, Ronis MJ. Different molecular mechanisms underlie ethanol-induced bone loss in cycling and pregnant rats. Endocrinology. 2006 Jan; 147(1):166-78. PMID: 16239303.
      View in: PubMed
    75. Chilakapati J, Shankar K, Korrapati MC, Hill RA, Mehendale HM. Saturation toxicokinetics of thioacetamide: role in initiation of liver injury. Drug Metab Dispos. 2005 Dec; 33(12):1877-85. PMID: 16183780.
      View in: PubMed
    76. Badger TM, Hidestrand M, Shankar K, McGuinn WD, Ronis MJ. The effects of pregnancy on ethanol clearance. Life Sci. 2005 Sep 09; 77(17):2111-26. PMID: 15925387.
      View in: PubMed
    77. Ronis MJ, Butura A, Sampey BP, Shankar K, Prior RL, Korourian S, Albano E, Ingelman-Sundberg M, Petersen DR, Badger TM. Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. Free Radic Biol Med. 2005 Sep 01; 39(5):619-30. PMID: 16085180; PMCID: PMC2956427.
    78. Hidestrand M, Shankar K, Ronis MJ, Badger TM. Effects of light and dark beer on hepatic cytochrome P-450 expression in male rats receiving alcoholic beverages as part of total enteral nutrition. Alcohol Clin Exp Res. 2005 May; 29(5):888-95. PMID: 15897735.
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    79. Sawant SP, Dnyanmote AV, Shankar K, Limaye PB, Latendresse JR, Mehendale HM. Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats. J Pharmacol Exp Ther. 2004 Feb; 308(2):694-704. PMID: 14610242.
      View in: PubMed
    80. Vaidya VS, Shankar K, Lock EA, Dixon D, Mehendale HM. Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway. Toxicol Pathol. 2003 Nov-Dec; 31(6):604-18. PMID: 14585728.
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    81. Limaye PB, Apte UM, Shankar K, Bucci TJ, Warbritton A, Mehendale HM. Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicol Appl Pharmacol. 2003 Sep 15; 191(3):211-26. PMID: 13678654.
      View in: PubMed
    82. Shankar K, Vaidya VS, Corton JC, Bucci TJ, Liu J, Waalkes MP, Mehendale HM. Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity. FASEB J. 2003 Sep; 17(12):1748-50. PMID: 12958197.
      View in: PubMed
    83. Vaidya VS, Shankar K, Lock EA, Bucci TJ, Mehendale HM. Role of tissue repair in survival from s-(1,2-dichlorovinyl)-L-cysteine-induced acute renal tubular necrosis in the mouse. Toxicol Sci. 2003 Jul; 74(1):215-27. PMID: 12730612.
      View in: PubMed
    84. Vaidya VS, Shankar K, Lock EA, Bucci TJ, Mehendale HM. Renal injury and repair following S-1, 2 dichlorovinyl-L-cysteine administration to mice. Toxicol Appl Pharmacol. 2003 Apr 15; 188(2):110-21. PMID: 12691729.
      View in: PubMed
    85. Shankar K, Vaidya VS, Wang T, Bucci TJ, Mehendale HM. Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity. Toxicol Appl Pharmacol. 2003 Apr 15; 188(2):122-34. PMID: 12691730.
      View in: PubMed
    86. Shankar K, Vaidya VS, Apte UM, Manautou JE, Ronis MJ, Bucci TJ, Mehendale HM. Type 1 diabetic mice are protected from acetaminophen hepatotoxicity. Toxicol Sci. 2003 Jun; 73(2):220-34. PMID: 12700423.
      View in: PubMed
    87. Wang T, Shankar K, Bucci TJ, Warbritton A, Mehendale HM. Diallyl sulfide inhibition of CYP2E1 does not rescue diabetic rats from thioacetamide-induced mortality. Toxicol Appl Pharmacol. 2001; 173(1):27 - 37.
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