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Piotr Zimniak

TitleProfessor Emeritus
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
Address BIOMED B304
4301 W Markham St.
Mail Slot # 611
Little Rock AR 72205
Phone501-257-4843
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    Collapse Research Funds 
    Collapse research activities
    R01AG032643     (SINGH, SHARDA P)Sep 1, 2009 - Jul 31, 2014
    NIH/NIA
    Causative role of lipid peroxidation products in obesity and aging
    Role: Co-Principal Investigator

    R01AG028088     (ZIMNIAK, PIOTR)Feb 1, 2007 - Oct 31, 2012
    NIH/NIA
    Role of glutathione transferases in life span extension of C. elegans
    Role: Principal Investigator

    P01AG020641     (REIS, ROBERT)Feb 15, 2003 - Jan 31, 2008
    NIH/Nat. Inst. on Aging
    Metabolic Mechanisms Limiting and Protecting Longevity
    Role: Co-Investigator

    R01ES09140     (ZIMNIAK, PIOTR)Aug 1, 2002 - Jul 31, 2006
    NIH/Nat. Inst. of Environmental Health Sciences - Pass Through: University of Pittsburgh
    Toxicological Releavane of the Human GSTP1-1 Polymorphism (University of Pittsburgh Subcontract)
    Role: Principal Investigator

    R01AG018845     (ZIMNIAK, PIOTR)Mar 1, 2002 - Feb 28, 2009
    NIH/NIA
    Role of Lipid peroxidation and 4-hydroxynonenal in aging
    Role: Principal Investigator

    R01AG18845     (ZIMNIAK, PIOTR)Dec 1, 2001 - Nov 30, 2006
    NIH/Nat. Inst. on Aging
    Role of Lipid peroxidation and 4 hydroxynonal in aging
    Role: Principal Investigator

    P01AG013918     (MANOLAGAS, STAVROS C.)Aug 27, 1996 - May 31, 2011
    NIH/NIA
    Molecular and Cellular Mechanisms of Osteoporosis
    Role: Co-Investigator

    R01ES007804     (ZIMNIAK, PIOTR)Aug 1, 1996 - Jun 30, 1999
    NIH/NIEHS
    Glutathione transferases and oxidative stress toxicology
    Role: Principal Investigator

    R23AM036453     (ZIMNIAK, PIOTR)Apr 1, 1985 - Jul 31, 1987
    NIH/NIADDK
    CHARACTERIZATION OF HEPATIC BILE ACID TRANSPOTERS
    Role: Principal Investigator

    R23DK036453     (ZIMNIAK, PIOTR)Apr 1, 1985 - Jul 31, 1987
    NIH/NIDDK
    CHARACTERIZATION OF HEPATIC BILE ACID TRANSPOTERS
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Ronis M, Mercer K, Engi B, Pulliam C, Zimniak P, Hennings L, Shearn C, Badger T, Petersen D. Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis. Am J Pathol. 2017 Feb; 187(2):418-430. PMID: 27998724.
      View in: PubMed
    2. Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR. Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice. Redox Biol. 2016 Apr; 7:68-77. PMID: 26654979.
      View in: PubMed
    3. Ronis MJ, Mercer KE, Gannon B, Engi B, Zimniak P, Shearn CT, Orlicky DJ, Albano E, Badger TM, Petersen DR. Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-a double knockout mice enhance injury during early stages of alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 01; 308(5):G403-15. PMID: 25501545.
      View in: PubMed
    4. Zimniak P. What is the Proximal Cause of Aging? Front Genet. 2012; 3:189. PMID: 23056007.
      View in: PubMed
    5. Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P. The second international conference "genetics of aging and longevity". Aging (Albany NY). 2012 May; 4(5):305-17. PMID: 22661237.
      View in: PubMed
    6. Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P, Hamblin MR, Tompkins RG, Xiao W, Rahme LG. Down-regulation of glutatione S-transferase a 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. FASEB J. 2012 Feb; 26(2):730-7. PMID: 22038048.
      View in: PubMed
    7. Zimniak P. Relationship of electrophilic stress to aging. Free Radic Biol Med. 2011 Sep 15; 51(6):1087-105. PMID: 21708248.
      View in: PubMed
    8. Shmookler Reis RJ, Xu L, Lee H, Chae M, Thaden JJ, Bharill P, Tazearslan C, Siegel E, Alla R, Zimniak P, Ayyadevara S. Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging (Albany NY). 2011 Feb; 3(2):125-47. PMID: 21386131.
      View in: PubMed
    9. Zimniak P. 4-Hydroxynonenal and fat storage: A paradoxical pro-obesity mechanism? Cell Cycle. 2010 Sep 01; 9(17):3393-4. PMID: 20855977.
      View in: PubMed
    10. Singh SP, Niemczyk M, Saini D, Sadovov V, Zimniak L, Zimniak P. Disruption of the mGsta4 gene increases life span of C57BL mice. J Gerontol A Biol Sci Med Sci. 2010 Jan; 65(1):14-23. PMID: 19880816.
      View in: PubMed
    11. Singh SP, Zimniak L, Zimniak P. The human hGSTA5 gene encodes an enzymatically active protein. Biochim Biophys Acta. 2010 Jan; 1800(1):16-22. PMID: 19664689.
      View in: PubMed
    12. Ahmed BA, Bukhari IA, Jeffus BC, Harney JT, Thyparambil S, Ziu E, Fraer M, Rusch NJ, Zimniak P, Lupashin V, Tang D, Kilic F. The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network. PLoS One. 2009; 4(3):e4730. PMID: 19270731.
      View in: PubMed
    13. Singh SP, Niemczyk M, Zimniak L, Zimniak P. Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-hydroxynonenal (4-HNE). Aging (Albany NY). 2008 Dec 18; 1(1):68-80. PMID: 20157589.
      View in: PubMed
    14. Sharma A, Sharma R, Chaudhary P, Vatsyayan R, Pearce V, Jeyabal PV, Zimniak P, Awasthi S, Awasthi YC. 4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells. Arch Biochem Biophys. 2008 Dec 15; 480(2):85-94. PMID: 18930016.
      View in: PubMed
    15. Zimniak P. Detoxification reactions: relevance to aging. Ageing Res Rev. 2008 Dec; 7(4):281-300. PMID: 18547875.
      View in: PubMed
    16. Singh SP, Niemczyk M, Saini D, Awasthi YC, Zimniak L, Zimniak P. Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in mice. Biochemistry. 2008 Mar 25; 47(12):3900-11. PMID: 18311940.
      View in: PubMed
    17. Sharma R, Sharma A, Dwivedi S, Zimniak P, Awasthi S, Awasthi YC. 4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. Biochemistry. 2008 Jan 08; 47(1):143-56. PMID: 18069800.
      View in: PubMed
    18. Ayyadevara S, Dandapat A, Singh SP, Siegel ER, Shmookler Reis RJ, Zimniak L, Zimniak P. Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. Mech Ageing Dev. 2007 Feb; 128(2):196-205. PMID: 17157356.
      View in: PubMed
    19. Li J, Sharma R, Patrick B, Sharma A, Jeyabal PV, Reddy PM, Saini MK, Dwivedi S, Dhanani S, Ansari NH, Zimniak P, Awasthi S, Awasthi YC. Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal. Biochemistry. 2006 Oct 10; 45(40):12253-64. PMID: 17014078.
      View in: PubMed
    20. Dwivedi S, Sharma R, Sharma A, Zimniak P, Ceci JD, Awasthi YC, Boor PJ. The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (-/-) mice. Toxicology. 2006 Jan 20; 218(1):58-66. PMID: 16325313.
      View in: PubMed
    21. Ayyadevara S, Dandapat A, Singh SP, Benes H, Zimniak L, Shmookler Reis RJ, Zimniak P. Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2. Aging Cell. 2005 Dec; 4(6):299-307. PMID: 16300482.
      View in: PubMed
    22. Ayyadevara S, Engle MR, Singh SP, Dandapat A, Lichti CF, Benes H, Shmookler Reis RJ, Liebau E, Zimniak P. Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. Aging Cell. 2005 Oct; 4(5):257-71. PMID: 16164425.
      View in: PubMed
    23. Gong H, Singh SV, Singh SP, Mu Y, Lee JH, Saini SP, Toma D, Ren S, Kagan VE, Day BW, Zimniak P, Xie W. Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol. 2006 Feb; 20(2):279-90. PMID: 16195250.
      View in: PubMed
    24. McEwen JE, Zimniak P, Mehta JL, Shmookler Reis RJ. Molecular pathology of aging and its implications for senescent coronary atherosclerosis. Curr Opin Cardiol. 2005 Sep; 20(5):399-406. PMID: 16093759.
      View in: PubMed
    25. Patrick B, Li J, Jeyabal PV, Reddy PM, Yang Y, Sharma R, Sinha M, Luxon B, Zimniak P, Awasthi S, Awasthi YC. Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression. Biochem Biophys Res Commun. 2005 Aug 26; 334(2):425-32. PMID: 16005854.
      View in: PubMed
    26. Singh SP, Chen T, Chen L, Mei N, McLain E, Samokyszyn V, Thaden JJ, Moore MM, Zimniak P. Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells. J Pharmacol Exp Ther. 2005 May; 313(2):855-61. PMID: 15701709.
      View in: PubMed
    27. Gu Y, Guo J, Pal A, Pan SS, Zimniak P, Singh SV, Ji X. Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity. Biochemistry. 2004 Dec 21; 43(50):15673-9. PMID: 15595823.
      View in: PubMed
    28. Singh SV, Varma V, Zimniak P, Srivastava SK, Marynowski SW, Desai D, Amin S, Ji X. Structural basis for catalytic differences between alpha class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide. Biochemistry. 2004 Aug 03; 43(30):9708-15. PMID: 15274625.
      View in: PubMed
    29. Wu Z, Minhas GS, Wen D, Jiang H, Chen K, Zimniak P, Zheng J. Design, synthesis, and structure-activity relationships of haloenol lactones: site-directed and isozyme-selective glutathione S-transferase inhibitors. J Med Chem. 2004 Jun 03; 47(12):3282-94. PMID: 15163208.
      View in: PubMed
    30. Sharma R, Brown D, Awasthi S, Yang Y, Sharma A, Patrick B, Saini MK, Singh SP, Zimniak P, Singh SV, Awasthi YC. Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells. Eur J Biochem. 2004 May; 271(9):1690-701. PMID: 15096208.
      View in: PubMed
    31. Yang Y, Yang Y, Trent MB, He N, Lick SD, Zimniak P, Awasthi YC, Boor PJ. Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis. Atherosclerosis. 2004 Apr; 173(2):211-21. PMID: 15064094.
      View in: PubMed
    32. Engle MR, Singh SP, Czernik PJ, Gaddy D, Montague DC, Ceci JD, Yang Y, Awasthi S, Awasthi YC, Zimniak P. Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse. Toxicol Appl Pharmacol. 2004 Feb 01; 194(3):296-308. PMID: 14761685.
      View in: PubMed
    33. Cheng K, Zimniak P, Raufman JP. Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells. Cancer Res. 2003 Oct 15; 63(20):6744-50. PMID: 14583469.
      View in: PubMed
    34. Awasthi S, Singhal SS, Sharma R, Zimniak P, Awasthi YC. Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance. Int J Cancer. 2003 Sep 20; 106(5):635-46. PMID: 12866021.
      View in: PubMed
    35. Raufman JP, Cheng K, Zimniak P. Activation of muscarinic receptor signaling by bile acids: physiological and medical implications. Dig Dis Sci. 2003 Aug; 48(8):1431-44. PMID: 12924634.
      View in: PubMed
    36. Yang Y, Sharma A, Sharma R, Patrick B, Singhal SS, Zimniak P, Awasthi S, Awasthi YC. Cells preconditioned with mild, transient UVA irradiation acquire resistance to oxidative stress and UVA-induced apoptosis: role of 4-hydroxynonenal in UVA-mediated signaling for apoptosis. J Biol Chem. 2003 Oct 17; 278(42):41380-8. PMID: 12888579.
      View in: PubMed
    37. Awasthi S, Singhal SS, Singhal J, Yang Y, Zimniak P, Awasthi YC. Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity. Int J Oncol. 2003 Apr; 22(4):721-32. PMID: 12632061.
      View in: PubMed
    38. Awasthi S, Singhal SS, Singhal J, Cheng J, Zimniak P, Awasthi YC. Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76. Int J Oncol. 2003 Apr; 22(4):713-20. PMID: 12632060.
      View in: PubMed
    39. Sawicki R, Singh SP, Mondal AK, Benes H, Zimniak P. Cloning, expression and biochemical characterization of one Epsilon-class (GST-3) and ten Delta-class (GST-1) glutathione S-transferases from Drosophila melanogaster, and identification of additional nine members of the Epsilon class. Biochem J. 2003 Mar 01; 370(Pt 2):661-9. PMID: 12443531.
      View in: PubMed
    40. Singhal SS, Singhal J, Sharma R, Singh SV, Zimniak P, Awasthi YC, Awasthi S. Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. Int J Oncol. 2003 Feb; 22(2):365-75. PMID: 12527936.
      View in: PubMed
    41. Raufman JP, Chen Y, Cheng K, Compadre C, Compadre L, Zimniak P. Selective interaction of bile acids with muscarinic receptors: a case of molecular mimicry. Eur J Pharmacol. 2002 Dec 20; 457(2-3):77-84. PMID: 12464352.
      View in: PubMed
    42. Awasthi S, Sharma R, Singhal SS, Zimniak P, Awasthi YC. RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics. Drug Metab Dispos. 2002 Dec; 30(12):1300-10. PMID: 12433796.
      View in: PubMed
    43. Cheng K, Chen Y, Zimniak P, Raufman JP, Xiao Y, Frucht H. Functional interaction of lithocholic acid conjugates with M3 muscarinic receptors on a human colon cancer cell line. Biochim Biophys Acta. 2002 Oct 09; 1588(1):48-55. PMID: 12379313.
      View in: PubMed
    44. Bose C, Guo J, Zimniak L, Srivastava SK, Singh SP, Zimniak P, Singh SV. Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemopreventive agent in garlic. Carcinogenesis. 2002 Oct; 23(10):1661-5. PMID: 12376475.
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    45. Cheng K, Khurana S, Chen Y, Kennedy RH, Zimniak P, Raufman JP. Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist. J Pharmacol Exp Ther. 2002 Oct; 303(1):29-35. PMID: 12235229.
      View in: PubMed
    46. Guo J, Zimniak L, Zimniak P, Orchard JL, Singh SV. Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme. Biochem J. 2002 Sep 15; 366(Pt 3):817-24. PMID: 12069689.
      View in: PubMed
    47. Raufman JP, Chen Y, Zimniak P, Cheng K. Deoxycholic acid conjugates are muscarinic cholinergic receptor antagonists. Pharmacology. 2002 Aug; 65(4):215-21. PMID: 12119452.
      View in: PubMed
    48. Yang Y, Sharma R, Zimniak P, Awasthi YC. Role of alpha class glutathione S-transferases as antioxidant enzymes in rodent tissues. Toxicol Appl Pharmacol. 2002 Jul 15; 182(2):105-15. PMID: 12140174.
      View in: PubMed
    49. Awasthi S, Sharma R, Yang Y, Singhal SS, Pikula S, Bandorowicz-Pikula J, Singh SV, Zimniak P, Awasthi YC. Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76). Acta Biochim Pol. 2002; 49(4):855-67. PMID: 12545192.
      View in: PubMed
    50. Sharma R, Sharma A, Yang Y, Awasthi S, Singhal SS, Zimniak P, Awasthi YC. Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal. Acta Biochim Pol. 2002; 49(3):693-701. PMID: 12422239.
      View in: PubMed
    51. Singh SP, Janecki AJ, Srivastava SK, Awasthi S, Awasthi YC, Xia SJ, Zimniak P. Membrane association of glutathione S-transferase mGSTA4-4, an enzyme that metabolizes lipid peroxidation products. J Biol Chem. 2002 Feb 08; 277(6):4232-9. PMID: 11714719.
      View in: PubMed
    52. Awasthi YC, Awasthi S, Zimniak P. Multiple transport proteins involved in the detoxification of endo- and xenobiotics. Front Biosci. 1997 09 01; 2:d427-437. PMID: 28481204.
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