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Timothy Chambers

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiochemistry & Molecular Biology, College of Medicine
DivisionBiochem & Molecular Anticancer Drugs
AddressB405F Biomedical Research I
325 S. Elm St.
Mail Slot # 516
Little Rock AR 72205
Phone501-686-5755
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Urbaniak A, Delgado M, Kacprzak K, Chambers TC. Activity of resveratrol triesters against primary acute lymphoblastic leukemia cells. Bioorg Med Chem Lett. 2017 Jun 15; 27(12):2766-2770. PMID: 28499732.
      View in: PubMed
    2. Chu R, Alford SE, Hart K, Kothari A, Mackintosh SG, Kovak MR, Chambers TC. Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified. Oncotarget. 2016 Nov 29; 7(48):78958-78970. PMID: 27738316.
      View in: PubMed
    3. Kothari A, Hittelman WN, Chambers TC. Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells. Cancer Res. 2016 Jun 15; 76(12):3553-61. PMID: 27197148; PMCID: PMC4911277 [Available on 06/15/17].
    4. Kothari A, Chambers TC. CDK1/2 toolbox in need of an upgrade. Cell Cycle. 2016 Jul 02; 15(13):1663-4. PMID: 27104300; PMCID: PMC4957594 [Available on 04/22/17].
    5. Alford SE, Kothari A, Loeff FC, Eichhorn JM, Sakurikar N, Goselink HM, Saylors RL, Jedema I, Falkenburg JH, Chambers TC. BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells. Cancer Res. 2015 Apr 01; 75(7):1366-75. PMID: 25649768; PMCID: PMC4383710.
    6. Eichhorn JM, Kothari A, Chambers TC. Cyclin B1 overexpression induces cell death independent of mitotic arrest. PLoS One. 2014; 9(11):e113283. PMID: 25415322; PMCID: PMC4240608.
    7. Eichhorn JM, Alford SE, Sakurikar N, Chambers TC. Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival. Exp Cell Res. 2014 Apr 01; 322(2):415-24. PMID: 24556425; PMCID: PMC3977614.
    8. Sakurikar N, Eichhorn JM, Alford SE, Chambers TC. Identification of a mitotic death signature in cancer cell lines. Cancer Lett. 2014 Feb 28; 343(2):232-8. PMID: 24099917; PMCID: PMC3947203.
    9. Pawlowska M, Chu R, Fedejko-Kap B, Augustin E, Mazerska Z, Radominska-Pandya A, Chambers TC. Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use. Drug Metab Dispos. 2013 Feb; 41(2):414-21. PMID: 23160818; PMCID: PMC3558869.
    10. Sakurikar N, Eichhorn JM, Chambers TC. Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins. J Biol Chem. 2012 Nov 09; 287(46):39193-204. PMID: 22965228; PMCID: PMC3493959.
    11. Chu R, Terrano DT, Chambers TC. Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration. Biochem Pharmacol. 2012 Jan 15; 83(2):199-206. PMID: 22024133; PMCID: PMC3242896.
    12. Terrano DT, Upreti M, Chambers TC. Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. Mol Cell Biol. 2010 Feb; 30(3):640-56. PMID: 19917720; PMCID: PMC2812246.
    13. Bateman TD, Joshi AL, Moon K, Galitovskaya EN, Upreti M, Chambers TC, McIntosh MC. Synthesis and anticancer activity of sclerophytin-inspired hydroisobenzofurans. Bioorg Med Chem Lett. 2009 Dec 15; 19(24):6898-901. PMID: 19896844; PMCID: PMC3276365.
    14. Chu R, Upreti M, Ding WX, Yin XM, Chambers TC. Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis. Biochem Pharmacol. 2009 Aug 01; 78(3):241-8. PMID: 19427996; PMCID: PMC2692743.
    15. Bene A, Chambers TC. p21 functions in a post-mitotic block checkpoint in the apoptotic response to vinblastine. Biochem Biophys Res Commun. 2009 Mar 06; 380(2):211-7. PMID: 19161984; PMCID: PMC2672431.
    16. Chu R, Upreti M, Ding W-X, Yin X-M, Chambers TC. Regulation of Bax by JNK and Bcl-xL in vinblastine-induced apoptosis. Biochem Pharmacol. 2009; 78:241-248.
    17. Upreti M, Galitovskaya EN, Chu R, Tackett AJ, Terrano DT, Granell S, Chambers TC. Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance. J Biol Chem. 2008 Dec 19; 283(51):35517-25. PMID: 18974096; PMCID: PMC2602892.
    18. Upreti M, Chu R, Galitovskaya E, Smart SK, Chambers TC. Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. Mol Cancer Ther. 2008 Jul; 7(7):2224-32. PMID: 18645031; PMCID: PMC3276366.
    19. Kolomeichuk SN, Terrano DT, Lyle CS, Sabapathy K, Chambers TC. Distinct signaling pathways of microtubule inhibitors--vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively. FEBS J. 2008 Apr; 275(8):1889-99. PMID: 18341588.
      View in: PubMed
    20. Kolomeichuk SN, Bene A, Upreti M, Dennis RA, Lyle CS, Rajasekaran M, Chambers TC. Induction of apoptosis by vinblastine via c-Jun autoamplification and p53-independent down-regulation of p21WAF1/CIP1. Mol Pharmacol. 2008 Jan; 73(1):128-36. PMID: 18094076.
      View in: PubMed
    21. Upreti, M, Chu, R, Galitovskaya, E.N., Smart, S., Chambers TC. Critical role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. Mol Cancer Therap. 2008; 7:2233-2240.
    22. Kolomeichuk, S, Bene, A, Upreti, M, Dennis, RA, Lyle, CS, Rajasekaran, M, Chambers TC. Induction of apoptosis by vinblastine via c-Jun auto-amplification and p53-independent regulation of p21WAF1/CIP1. Mol Pharmacol. 2008; 73:128-136.
    23. Joshi, A, Bateman, TD, Galitovskayam EN, Chambers TC, McIntosh, MC. Simplified Analogs of sclerophytin A as potential anticancer agents. 2007; Abstract #3971.
    24. Zharov VP, Galitovskiy V, Lyle CS, Chambers TC. Superhigh-sensitivity photothermal monitoring of individual cell response to antitumor drug. J Biomed Opt. 2006 Nov-Dec; 11(6):064034. PMID: 17212557.
      View in: PubMed
    25. Duan L, Sterba K, Kolomeichuk S, Kim H, Brown PH, Chambers TC. Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest. Biochem Pharmacol. 2007 Feb 15; 73(4):481-90. PMID: 17126817; PMCID: PMC1829171.
    26. Upreti M, Lyle CS, Skaug B, Du L, Chambers TC. Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members. J Biol Chem. 2006 Jun 09; 281(23):15941-50. PMID: 16574665; PMCID: PMC1656399.
    27. Upreti, M, Lyle, CS, Sabapathy, K, Chambers TC. Role of Bax oligomerization and Bax activation in vinbladtine-induced apoptosis. 2006.
    28. Kolomeichuk, SN, Bene, A, Lyle, CS, Rajasekaran, M, Upreti, M, Chambers TC. Effect of siRNA blockage on C-Jun function in vinblastine-induced apoptosis. 2006.
    29. Obey TB, Lyle CS, Chambers TC. Role of c-Jun in cellular sensitivity to the microtubule inhibitor vinblastine. Biochem Biophys Res Commun. 2005 Oct 07; 335(4):1179-84. PMID: 16111654.
      View in: PubMed
    30. Du L, Lyle CS, Chambers TC. Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction. Oncogene. 2005 Jan 06; 24(1):107-17. PMID: 15531923.
      View in: PubMed
    31. Bene, A, Chambers TC. comparison of methods to block c-Jun function. 2005.
    32. Lyle, CS, Skaug, B, Upreti, M, Chambers TC. The microtubule inhibitor vinblastine promotes subcellular redistribution, posttranslational modifications and protein-protein interactions of Bcl-2familky proteins. 2005.
    33. Skaug, B, Chambers TC. Bcl-2 family proteins: Suellular localization and translocation in response to a microtubule inhibitor. 2005.
    34. Bene A, Kurten RC, Chambers TC. Subcellular localization as a limiting factor for utilization of decoy oligonucleotides. Nucleic Acids Res. 2004 Oct 21; 32(19):e142. PMID: 15498923; PMCID: PMC528816.
    35. Kurten RC, Chowdhury P, Sanders RC, Pittman LM, Sessions LW, Chambers TC, Lyle CS, Schnackenberg BJ, Jones SM. Coordinating epidermal growth factor-induced motility promotes efficient wound closure. Am J Physiol Cell Physiol. 2005 Jan; 288(1):C109-21. PMID: 15371256.
      View in: PubMed
    36. Lean J, Kirstein B, Urry Z, Chambers T, Fuller K. Thioredoxin-1 mediates osteoclast stimulation by reactive oxygen species. Biochem Biophys Res Commun. 2004 Sep 03; 321(4):845-50. PMID: 15358104.
      View in: PubMed
    37. Du L, Lyle CS, Obey TB, Gaarde WA, Muir JA, Bennett BL, Chambers TC. Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent. J Biol Chem. 2004 Mar 19; 279(12):11957-66. PMID: 14704147.
      View in: PubMed
    38. Du, L, Lyle, CS, Chambers TC. Characterization of Vinblastine-Induced Bcl-xl and Bcl-2 Phosphorylation. 2004; 1192.
    39. Zharov V., Galitovsky V, Chowdhury, P, Chambers TC. Photothermal evaluation of the influence of nicotine and antitumor drugs on cellular absorbing structures. 2004; 107.
    40. Hall-Obey, TB, Chambers TC. The Role of c-Jun in Vinblastine Sensitivity. 2004; 521.
    41. Brantley-Finley C, Lyle CS, Du L, Goodwin ME, Hall T, Szwedo D, Kaushal GP, Chambers TC. The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide. Biochem Pharmacol. 2003 Aug 01; 66(3):459-69. PMID: 12907245.
      View in: PubMed
    42. Jia J, Alaoui-El-Azher M, Chow M, Chambers TC, Baker H, Jin S. c-Jun NH2-terminal kinase-mediated signaling is essential for Pseudomonas aeruginosa ExoS-induced apoptosis. Infect Immun. 2003 Jun; 71(6):3361-70. PMID: 12761120; PMCID: PMC155783.
    43. Du, L, Lyle, CS, Hall, T, Chambers TC. Specific Inhibition of JNK by SP600125 Inhibits Growth of KB-3 Carcinoma Cells and Inhibits Mitotic Phosphorylation of C-Jun but not Bcl-2. 2003; 293.
    44. Chambers TC. Role of BCL-xl Phosphorylation in Vinblastine-Induced Apoptosis. 2003; 615.
    45. Du, L, Chambers TC. role of Bcl-xl Phosphorylation in Vinblastine-Induced Apoptosis. 2002.
    46. Du, L, Fan, M, Goodwin, ME, Chambers TC. Roles of Phosphorylated Bcl-2 Proteins in Apoptosis by Microtubule Inhibitors and in Normal Mitotic Progression. 2001; 306.
    47. Green, LD, Chambers TC, Drake, RR. Toxicity and Cell Cycle Effects of Two-Drug Combinations with Ganciclovir Plus Doxorubicin, Tamoxifen or Taxol in HSV-TK-Expressing McccCF-7 Cells. 2000; 381.
    48. Fan, M, Berry, A, Stone, AA, Chambers TC. Probing the Role of AP-1 in the Cytotoxic Actions of Microtubule Inhibitors. 2000; 399.
    49. Elsasser, C, Berry, A., Stone AA, Chambers TC. Anticancer Drugs Induce specific Alterations in Expression and Phosphorylation of AP-1 components. 1999.
    50. Chambers TC. Selective Activation of the c_june HG2-Terminal Protein Kinase signal Transduction Cascade by Microtubule-Inhibiting Anticancer Agents. 1998.
    51. Chambers TC. Methods Enzymol. ABC Transporters: Biochemical, Cellular and Molecular Aspects. Identification of the Phosphorylation Sites in Human MDR1 P-glycoprotein. 1998; 292.
    52. Germann, UA, Chambers TC. Cytotechnology, 27. Molecular Analysis of the Multidrug Transporter, P-Glycoprotein. pp 31-60. 1998.
    53. Carter, C., Parham, G.P., Chambers TC. Cytoskeletal Reorganization Induced by Retinoic Acid Treatment of Human Endometrial Adenocarcinoma (RL95-2) Cells is Correlated with Alterrations in Protein Kinase C-ol. 1998; 66:284-292.
    54. Fine, RL, Chambers TC, Sachs, CW. Oncologist. P-Glycoprotein, Multidrug Resistance and Protein Kinase C. 1996; 1 (4): 261-268.
    55. Osborn, MT, Chambers TC. Activation of ERK MAP Kinase Accompanies Phorbol Ester-Induced but not Adriamycin-Induced MDR1 Mrna Expression. 1996; 327.
    56. Chambers TC. Multidrug Resistance in Cancer Cells: Cellular, biochemical, Molecular and Biological Aspects. (Gupta, S and Tsuruo, T, eds.). Phosphorylation of Proteins Involved in Multidrug Resistance. pp 251-261. 1996.
    57. Chambers TC. Subcellular Distribution and Expression of Protein Kinase C Isoforms in Multidrug Resistant KB Cells. 1995; 338.
    58. Chambers TC, Cloud, BA, Jones, R. Expression and Subcellular Distribution of Protein Kinase C Isoforms in Multidrug Resistant KB Cells. 1995.
    59. Germann, UA, Chambers TC, Amdudkar, SV, Kuo. JF, Pastan, I, Gottesman, MM. Identification of Phosphorylation Sites in the Linker Region of Human P-glycoprotein. 1994.
    60. Chambers TC, Kuo, JF. Analysis of P-glycoprotein Phosphorylation Using a Synthetic Peptide Substrate. GM Cancer Research Foundation International Symposium. Resistance against Anticancer drugs: Molecular Mechanisms and Clinical Opportunities, Toronto, Canada. 1993.
    61. Chambers TC. Phosphorylation and Regulation of P-glycoprotein by Protein Kinase C. Proceedings of the International Symposium on the Mechanisms of Multidrug Resistance. 1992.
    62. Chambers TC, Langan, TA. Methods Enzymol. Purification and properties of Growth-Associated H1 Histone Kinase. 1991; 200.
    63. Chambers TC, Song, J, Campbell, DS, Leichtling, BH, Rickenberg, HV. Identification of a Nuclear Substrate of the Cyclic AMP-dependent Protein Kinase in Dictyostelium discoideum. 1986; 272-273.
    64. Leichtling BH, Schaller KL, Chambers TC, Rickenberg HV. cAMP-dependent protein kinase during development of D. discoideum. Prog Clin Biol Res. 1986; 217A:93 - 96.
    65. Mitchelson, K., Chambers TC, Bradbury, E.M., Matthews, H. R. Activation of Histone Kinase in G2 Phase of the Cell Cycle in Physarum polycephalum. 1978; 92:339-342.
    66. Chambers TC, McAvoy, EM, Eilon, G. Phosphorylation by Protein Kinase C of P-Glycoprotein in Multidrug Resistant KB Carcinoma Cells. 519.
    67. Chambers TC. Correlation of Protein Kinase C Activity and Severity of Disease in the Cardiomyopathic Hamster.
    68. Osborn, MT, Stone, A, Olive, M, Vinson, C, Chambers TC. Activation of the MEKK1/SEK1/JNK/C-un/AP-1AP-1 Pathway by Vinca Alkaloids, Taxol and Colchicine, and Effects of a Novel AP-1 Inhibitor on Drug cytotoxicity. 177.
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