 Drug Overdose
"Drug Overdose" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Descriptor ID |
D062787
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| MeSH Number(s) |
C25.341 C25.723.276.531 E02.319.754.500
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| Concept/Terms |
Drug Overdose- Drug Overdose
- Drug Overdoses
- Overdose, Drug
- Overdoses, Drug
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Below are MeSH descriptors whose meaning is more general than "Drug Overdose".
Below are MeSH descriptors whose meaning is more specific than "Drug Overdose".
This graph shows the total number of publications written about "Drug Overdose" by people in UAMS Profiles by year, and whether "Drug Overdose" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 2 | 0 | 2 | | 2021 | 2 | 0 | 2 | | 2020 | 2 | 4 | 6 | | 2019 | 3 | 1 | 4 | | 2018 | 6 | 0 | 6 | | 2017 | 3 | 0 | 3 | | 2016 | 3 | 2 | 5 | | 2015 | 6 | 4 | 10 | | 2014 | 5 | 2 | 7 | | 2013 | 3 | 3 | 6 | | 2012 | 0 | 2 | 2 | | 2011 | 3 | 4 | 7 | | 2010 | 0 | 2 | 2 | | 2009 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2005 | 0 | 4 | 4 | | 2004 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2002 | 0 | 3 | 3 | | 2001 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1990 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Drug Overdose" by people in Profiles over the past ten years.
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Stephens RJ, Filip AB, Baumgartner KT, Schwarz ES, Liss DB. Benzonatate Overdose Presenting as Cardiac Arrest with Rapidly Narrowing QRS Interval. J Med Toxicol. 2022 10; 18(4):344-349.
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Hayes CJ, Koonce RM, Gressler LE, Hu B, Williams JS, Martin BC. Association between opioid therapy trajectories and potential opioid-related adverse health events. Pharmacoepidemiol Drug Saf. 2022 10; 31(10):1075-1090.
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Hayes CJ, Krebs EE, Li C, Brown J, Hudson T, Martin BC. Association between discontinuing chronic opioid therapy and newly diagnosed substance use disorders, accidents, self-inflicted injuries and drug overdoses within the prescribers' health care system: a retrospective cohort study. Addiction. 2022 04; 117(4):946-968.
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Nemanich A, Liebelt E, Sabbatini AK. Increased rates of diphenhydramine overdose, abuse, and misuse in the United States, 2005-2016. Clin Toxicol (Phila). 2021 Nov; 59(11):1002-1008.
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Ostrach B, Buer LM, Armbruster S, Brown H, Yochym G, Zaller N. COVID-19 and Rural Harm Reduction Challenges in the US Southern Mountains. J Rural Health. 2021 01; 37(1):252-255.
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Chichester K, Drawve G, Sisson M, McCleskey B, Dye DW, Cropsey K. Examining the neighborhood-level socioeconomic characteristics associated with fatal overdose by type of drug involved and overdose setting. Addict Behav. 2020 12; 111:106555.
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Worley LLM, Wise-Ehlers A. Telepsychiatry in Obstetrics. Obstet Gynecol Clin North Am. 2020 Jun; 47(2):333-340.
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Acharya M, Chopra D, Hayes CJ, Teeter B, Martin BC. Cost-Effectiveness of Intranasal Naloxone Distribution to High-Risk Prescription Opioid Users. Value Health. 2020 04; 23(4):451-460.
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Vazquez JH, Clemens MM, Allard FD, Yee EU, Kennon-McGill S, Mackintosh SG, Jaeschke H, Hambuchen MD, McGill MR. Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations. Toxicol Sci. 2020 02 01; 173(2):244-254.
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Hayes CJ, Krebs EE, Hudson T, Brown J, Li C, Martin BC. Impact of opioid dose escalation on the development of substance use disorders, accidents, self-inflicted injuries, opioid overdoses and alcohol and non-opioid drug-related overdoses: a retrospective cohort study. Addiction. 2020 06; 115(6):1098-1112.
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Chiew AL, James LP, Isbister GK, Pickering JW, McArdle K, Chan BSH, Buckley NA. Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). J Hepatol. 2020 03; 72(3):450-462.
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Ruchi R, Bozorgmehri S, Ozrazgat-Baslanti T, Segal MS, Shukla AM, Mohandas R, Kumar S. Opioid Safety and Concomitant Benzodiazepine Use in End-Stage Renal Disease Patients. Pain Res Manag. 2019; 2019:3865924.
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Dye DW, McGwin G, Atherton DS, McCleskey B, Davis GG. Correctly Identifying Deaths Due to Drug Toxicity Without a Forensic Autopsy. Am J Forensic Med Pathol. 2019 Jun; 40(2):99-101.
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Jiang S, Vozmediano V, Abdel-Rahman SM, Schmidt S, James LP. Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen. J Clin Pharmacol. 2019 10; 59(10):1291-1299.
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Dayer LE, Painter JT, McCain K, King J, Cullen J, Foster HR. A recent history of opioid use in the US: Three decades of change. Subst Use Misuse. 2019; 54(2):331-339.
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Monroig-Bosque PDC, Balk J, Segura F, Salazar E, Leveque CM, Ipe TS. The utility of therapeutic plasma exchange for amphotericin B overdose. Transfus Apher Sci. 2018 Dec; 57(6):756-758.
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Olfson M, Wall M, Wang S, Crystal S, Blanco C. Risks of fatal opioid overdose during the first year following nonfatal overdose. Drug Alcohol Depend. 2018 09 01; 190:112-119.
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Lutkewitte AJ, Schweitzer GG, Kennon-McGill S, Clemens MM, James LP, Jaeschke H, Finck BN, McGill MR. Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration. Food Chem Toxicol. 2018 May; 115:273-283.
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Gressler LE, Martin BC, Hudson TJ, Painter JT. Relationship between concomitant benzodiazepine-opioid use and adverse outcomes among US veterans. Pain. 2018 03; 159(3):451-459.
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Brinkley-Rubinstein L, Zaller N, Martino S, Cloud DH, McCauley E, Heise A, Seal D. Criminal justice continuum for opioid users at risk of overdose. Addict Behav. 2018 11; 86:104-110.
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Yu D, Wu L, Gill P, Tolleson WH, Chen S, Sun J, Knox B, Jin Y, Xiao W, Hong H, Wang Y, Ren Z, Guo L, Mei N, Guo Y, Yang X, Shi L, Chen Y, Zeng L, Dreval K, Tryndyak V, Pogribny I, Fang H, Shi T, McCullough S, Bhattacharyya S, Schnackenberg L, Mattes W, Beger RD, James L, Tong W, Ning B. Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb; 92(2):845-858.
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Gill P, Bhattacharyya S, McCullough S, Letzig L, Mishra PJ, Luo C, Dweep H, James L. MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity. Sci Rep. 2017 09 26; 7(1):12331.
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Brinkley-Rubinstein L, Cloud DH, Davis C, Zaller N, Delany-Brumsey A, Pope L, Martino S, Bouvier B, Rich J. Addressing excess risk of overdose among recently incarcerated people in the USA: harm reduction interventions in correctional settings. Int J Prison Health. 2017 03 13; 13(1):25-31.
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Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Weemhoff JL, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Beschin A, Van Ginderachter JA, Penuela S, Jaeschke H, Cogliati B, Vinken M. Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity. Arch Toxicol. 2017 May; 91(5):2245-2261.
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Bhushan B, Chavan H, Borude P, Xie Y, Du K, McGill MR, Lebofsky M, Jaeschke H, Krishnamurthy P, Apte U. Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice. Toxicol Sci. 2017 02; 155(2):363-378.
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Saucier CD, Zaller N, Macmadu A, Green TC. An Initial evaluation of law enforcement overdose training in Rhode Island. Drug Alcohol Depend. 2016 May 01; 162:211-8.
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McGill MR, Kennon-McGill S, Durham D, Jaeschke H. Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study. Toxicol Mech Methods. 2016 Feb; 26(2):104-11.
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Kee JR, Smith RG, Barnes CL. Recognizing and Reducing the Risk of Opioid Misuse in Orthopaedic Practice. J Surg Orthop Adv. 2016 Winter; 25(4):238-243.
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Davis CS, Green TC, Zaller ND. Addressing the overdose epidemic requires timely access to data to guide interventions. Drug Alcohol Rev. 2016 07; 35(4):383-6.
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Spiller HA, Mowry JB, Aleguas A, Griffith JR, Goetz R, Ryan ML, Bangh S, Klein-Schwartz W, Schaeffer S, Casavant MJ. An Observational Study of the Factor Xa Inhibitors Rivaroxaban and Apixaban as Reported to Eight Poison Centers. Ann Emerg Med. 2016 Feb; 67(2):189-95.
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James L, Yan K, Pence L, Simpson P, Bhattacharyya S, Gill P, Letzig L, Kearns G, Beger R. Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. PLoS One. 2015; 10(7):e0131010.
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Du K, Xie Y, McGill MR, Jaeschke H. Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity. Expert Opin Drug Metab Toxicol. 2015; 11(11):1769-79.
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Alonso EM, James LP, Zhang S, Squires RH. Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2015 Jul; 61(1):102-7.
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Katragadda L, Murphy MC, Harris NS, Wilkerson G, Bazydlo LA, Zumberg MS. Steps to diagnosis of a case of surreptitious intake of one of the newer direct oral anticoagulants: a case report and literature review. Blood Coagul Fibrinolysis. 2015 Jul; 26(5):574-6.
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Xie Y, McGill MR, Cook SF, Sharpe MR, Winefield RD, Wilkins DG, Rollins DE, Jaeschke H. Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells. Xenobiotica. 2015; 45(10):921-9.
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Du K, McGill MR, Xie Y, Bajt ML, Jaeschke H. Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity. Food Chem Toxicol. 2015 Jul; 81:62-70.
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Hopper AB, Vilke GM, Castillo EM, Campillo A, Davie T, Wilson MP. Ketamine use for acute agitation in the emergency department. J Emerg Med. 2015 Jun; 48(6):712-9.
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Yang X, Salminen WF, Shi Q, Greenhaw J, Gill PS, Bhattacharyya S, Beger RD, Mendrick DL, Mattes WB, James LP. Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children. Toxicol Appl Pharmacol. 2015 Apr 15; 284(2):180-7.
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Yokell MA, Delgado MK, Zaller ND, Wang NE, McGowan SK, Green TC. Presentation of prescription and nonprescription opioid overdoses to US emergency departments. JAMA Intern Med. 2014 Dec; 174(12):2034-7.
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Laurenzana EM, Stevens MW, Frank JC, Hambuchen MD, Hendrickson HP, White SJ, Williams DK, Owens SM, Gentry WB. Pharmacological effects of two anti-methamphetamine monoclonal antibodies. Supporting data for lead candidate selection for clinical development. Hum Vaccin Immunother. 2014; 10(9):2638-47.
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Woolbright BL, McGill MR, Staggs VS, Winefield RD, Gholami P, Olyaee M, Sharpe MR, Curry SC, Lee WM, Jaeschke H. Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients. Toxicol Sci. 2014 Dec; 142(2):436-44.
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Cobaugh DJ, Gainor C, Gaston CL, Kwong TC, Magnani B, McPherson ML, Painter JT, Krenzelok EP. The opioid abuse and misuse epidemic: implications for pharmacists in hospitals and health systems. Am J Health Syst Pharm. 2014 Sep 15; 71(18):1539-54.
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McGill MR, Jaeschke H. Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients. Expert Opin Drug Metab Toxicol. 2014 Jul; 10(7):1005-17.
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McGill MR, Cao M, Svetlov A, Sharpe MR, Williams CD, Curry SC, Farhood A, Jaeschke H, Svetlov SI. Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans. Biomarkers. 2014 May; 19(3):222-30.
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Williams CD, Bajt ML, Sharpe MR, McGill MR, Farhood A, Jaeschke H. Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans. Toxicol Appl Pharmacol. 2014 Mar 01; 275(2):122-33.
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Williams CD, McGill MR, Lebofsky M, Bajt ML, Jaeschke H. Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning. Toxicol Appl Pharmacol. 2014 Feb 01; 274(3):417-24.
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Ramachandran A, McGill MR, Xie Y, Ni HM, Ding WX, Jaeschke H. Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology. 2013 Dec; 58(6):2099-108.
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Green TC, Zaller N, Palacios WR, Bowman SE, Ray M, Heimer R, Case P. Law enforcement attitudes toward overdose prevention and response. Drug Alcohol Depend. 2013 Dec 01; 133(2):677-84.
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McGill MR, Li F, Sharpe MR, Williams CD, Curry SC, Ma X, Jaeschke H. Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. Arch Toxicol. 2014 Feb; 88(2):391-401.
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Zaller ND, Yokell MA, Green TC, Gaggin J, Case P. The feasibility of pharmacy-based naloxone distribution interventions: a qualitative study with injection drug users and pharmacy staff in Rhode Island. Subst Use Misuse. 2013 Jun; 48(8):590-9.
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Green TC, Bowman SE, Zaller ND, Ray M, Case P, Heimer R. Barriers to medical provider support for prescription naloxone as overdose antidote for lay responders. Subst Use Misuse. 2013 May; 48(7):558-67.
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