 11-beta-Hydroxysteroid Dehydrogenase Type 1
"11-beta-Hydroxysteroid Dehydrogenase Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.
| Descriptor ID |
D043205
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| MeSH Number(s) |
D08.811.682.047.436.174.300
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| Concept/Terms |
11-beta-Hydroxysteroid Dehydrogenase Type 1- 11-beta-Hydroxysteroid Dehydrogenase Type 1
- 11beta-HSD1 Reductase
- 11beta HSD1 Reductase
- 11beta-HSD1
- 11beta-Hydroxysteroid Dehydrogenase Type 1
- 11beta Hydroxysteroid Dehydrogenase Type 1
- 11 beta-Hydroxysteroid Dehydrogenase Type 1
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Below are MeSH descriptors whose meaning is more general than "11-beta-Hydroxysteroid Dehydrogenase Type 1".
Below are MeSH descriptors whose meaning is more specific than "11-beta-Hydroxysteroid Dehydrogenase Type 1".
This graph shows the total number of publications written about "11-beta-Hydroxysteroid Dehydrogenase Type 1" by people in UAMS Profiles by year, and whether "11-beta-Hydroxysteroid Dehydrogenase Type 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2018 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2015 | 2 | 0 | 2 | | 2014 | 4 | 0 | 4 | | 2013 | 4 | 0 | 4 | | 2012 | 3 | 0 | 3 | | 2011 | 2 | 1 | 3 | | 2010 | 2 | 1 | 3 | | 2009 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2007 | 4 | 1 | 5 | | 2006 | 4 | 0 | 4 | | 2005 | 1 | 1 | 2 | | 2004 | 2 | 1 | 3 |
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Below are the most recent publications written about "11-beta-Hydroxysteroid Dehydrogenase Type 1" by people in Profiles over the past ten years.
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Morgan RA, Keen JA, Homer N, Nixon M, McKinnon-Garvin AM, Moses-Williams JA, Davis SR, Hadoke PWF, Walker BR. Dysregulation of Cortisol Metabolism in Equine Pituitary Pars Intermedia Dysfunction. Endocrinology. 2018 11 01; 159(11):3791-3800.
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Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR. Selection and early clinical evaluation of the brain-penetrant 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol. 2017 03; 174(5):396-408.
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Anderson AJ, Andrew R, Homer NZ, Jones GC, Smith K, Livingstone DE, Walker BR, Stimson RH. Metformin Increases Cortisol Regeneration by 11ßHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2016 10; 101(10):3787-3793.
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Coutinho AE, Kipari TM, Zhang Z, Esteves CL, Lucas CD, Gilmour JS, Webster SP, Walker BR, Hughes J, Savill JS, Seckl JR, Rossi AG, Chapman KE. 11ß-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice. Endocrinology. 2016 07; 157(7):2928-36.
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White CI, Jansen MA, McGregor K, Mylonas KJ, Richardson RV, Thomson A, Moran CM, Seckl JR, Walker BR, Chapman KE, Gray GA. Cardiomyocyte and Vascular Smooth Muscle-Independent 11ß-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice. Endocrinology. 2016 Jan; 157(1):346-57.
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Sooy K, Noble J, McBride A, Binnie M, Yau JL, Seckl JR, Walker BR, Webster SP. Cognitive and Disease-Modifying Effects of 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease. Endocrinology. 2015 Dec; 156(12):4592-603.
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Kilgour AH, Semple S, Marshall I, Andrews P, Andrew R, Walker BR. 11ß-Hydroxysteroid dehydrogenase activity in the brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men. J Clin Endocrinol Metab. 2015 Feb; 100(2):483-9.
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Yau JL, Wheelan N, Noble J, Walker BR, Webster SP, Kenyon CJ, Ludwig M, Seckl JR. Intrahippocampal glucocorticoids generated by 11ß-HSD1 affect memory in aged mice. Neurobiol Aging. 2015 Jan; 36(1):334-43.
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Gambineri A, Fanelli F, Tomassoni F, Munarini A, Pagotto U, Andrew R, Walker BR, Pasquali R. Tissue-specific dysregulation of 11ß-hydroxysteroid dehydrogenase type 1 in overweight/obese women with polycystic ovary syndrome compared with weight-matched controls. Eur J Endocrinol. 2014 Jul; 171(1):47-57.
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Chapagain A, Caton PW, Kieswich J, Andrikopoulos P, Nayuni N, Long JH, Harwood SM, Webster SP, Raftery MJ, Thiemermann C, Walker BR, Seckl JR, Corder R, Yaqoob MM. Elevated hepatic 11ß-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3817-22.
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Kilgour AH, Gallagher IJ, MacLullich AM, Andrew R, Gray CD, Hyde P, Wackerhage H, Husi H, Ross JA, Starr JM, Chapman KE, Fearon KC, Walker BR, Greig CA. Increased skeletal muscle 11ßHSD1 mRNA is associated with lower muscle strength in ageing. PLoS One. 2013; 8(12):e84057.
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Anderson A, Walker BR. 11ß-HSD1 inhibitors for the treatment of type 2 diabetes and cardiovascular disease. Drugs. 2013 Sep; 73(13):1385-93.
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Mitic T, Shave S, Semjonous N, McNae I, Cobice DF, Lavery GG, Webster SP, Hadoke PW, Walker BR, Andrew R. 11ß-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. Biochem Pharmacol. 2013 Jul 01; 86(1):146-53.
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Kipari T, Hadoke PW, Iqbal J, Man TY, Miller E, Coutinho AE, Zhang Z, Sullivan KM, Mitic T, Livingstone DE, Schrecker C, Samuel K, White CI, Bouhlel MA, Chinetti-Gbaguidi G, Staels B, Andrew R, Walker BR, Savill JS, Chapman KE, Seckl JR. 11ß-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis. FASEB J. 2013 Apr; 27(4):1519-31.
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Iqbal J, Macdonald LJ, Low L, Seckl JR, Yau CW, Walker BR, Hadoke PW. Contribution of endogenous glucocorticoids and their intravascular metabolism by 11ß-HSDs to postangioplasty neointimal proliferation in mice. Endocrinology. 2012 Dec; 153(12):5896-905.
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Mitic T, Andrew R, Walker BR, Hadoke PW. 11ß-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7ß-hydroxycholesterol. Biochimie. 2013 Mar; 95(3):548-55.
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Turban S, Liu X, Ramage L, Webster SP, Walker BR, Dunbar DR, Mullins JJ, Seckl JR, Morton NM. Optimal elevation of ß-cell 11ß-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced ß-cell failure. Diabetes. 2012 Mar; 61(3):642-52.
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Michailidou Z, Turban S, Miller E, Zou X, Schrader J, Ratcliffe PJ, Hadoke PW, Walker BR, Iredale JP, Morton NM, Seckl JR. Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11ß-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice. J Biol Chem. 2012 Feb 03; 287(6):4188-97.
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Gambineri A, Tomassoni F, Munarini A, Stimson RH, Mioni R, Pagotto U, Chapman KE, Andrew R, Mantovani V, Pasquali R, Walker BR. A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome. Eur J Endocrinol. 2011 Aug; 165(2):283-92.
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