 Platelet Aggregation Inhibitors
"Platelet Aggregation Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
| Descriptor ID |
D010975
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| MeSH Number(s) |
D27.505.954.502.780
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| Concept/Terms |
Platelet Aggregation Inhibitors- Platelet Aggregation Inhibitors
- Aggregation Inhibitors, Platelet
- Inhibitors, Platelet Aggregation
- Blood Platelet Antiaggregants
- Antiaggregants, Blood Platelet
- Platelet Antiaggregants
- Antiaggregants, Platelet
- Blood Platelet Aggregation Inhibitors
Antiplatelet Agents- Antiplatelet Agents
- Agents, Antiplatelet
- Antiplatelet Drugs
- Drugs, Antiplatelet
Platelet Antagonists- Platelet Antagonists
- Antagonists, Platelet
- Blood Platelet Antagonists
- Antagonists, Blood Platelet
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Below are MeSH descriptors whose meaning is more general than "Platelet Aggregation Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Platelet Aggregation Inhibitors".
This graph shows the total number of publications written about "Platelet Aggregation Inhibitors" by people in UAMS Profiles by year, and whether "Platelet Aggregation Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2022 | 0 | 4 | 4 | | 2021 | 2 | 1 | 3 | | 2020 | 3 | 4 | 7 | | 2019 | 3 | 3 | 6 | | 2018 | 5 | 1 | 6 | | 2017 | 5 | 1 | 6 | | 2016 | 3 | 2 | 5 | | 2015 | 6 | 5 | 11 | | 2014 | 4 | 1 | 5 | | 2013 | 10 | 4 | 14 | | 2012 | 10 | 4 | 14 | | 2011 | 2 | 2 | 4 | | 2010 | 3 | 3 | 6 | | 2009 | 6 | 4 | 10 | | 2008 | 2 | 1 | 3 | | 2007 | 4 | 2 | 6 | | 2006 | 2 | 0 | 2 | | 2005 | 1 | 3 | 4 | | 2004 | 5 | 0 | 5 | | 2003 | 1 | 2 | 3 | | 2002 | 4 | 2 | 6 | | 2001 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1992 | 0 | 1 | 1 | | 1991 | 2 | 2 | 4 |
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Below are the most recent publications written about "Platelet Aggregation Inhibitors" by people in Profiles over the past ten years.
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Corken A, Ware J, Dai J, Arthur JM, Smyth S, Davis CL, Liu J, Harville TO, Phadnis MA, Mehta JL, Rahmatallah Y, Jain N. Platelet-Dependent Inflammatory Dysregulation in Patients with Stages 4 or 5 Chronic Kidney Disease: A Mechanistic Clinical Study. Kidney360. 2022 12 29; 3(12):2036-2047.
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Park DY, An S, Kumar A, Malhotra S, Jolly N, Kaur A, Kattoor A, Doukky R, Kalra A, Vij A. Abbreviated versus Standard Duration of DAPT after PCI: A Systematic Review and Network Meta-analysis. Am J Cardiovasc Drugs. 2022 Nov; 22(6):633-645.
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Lopez-Candales A, Norgard N. Will the new pharmaceutical lipid-aspirin complex formulation restore the once lost trust of aspirin on cardiovascular protection? Postgrad Med. 2022 08; 134(6):573-575.
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Mhanna M, Beran A, Al-Abdouh A, Jabri A, Al-Aaraj A, Sajdeya O, Abuhelwa Z, Khokher W, Bhuta S, Burmeister CJ, Eltahawy EA. Single Versus Dual Antiplatelet Therapy following Left Atrial Appendage Occlusion in Patients With High Bleeding Risk. Curr Probl Cardiol. 2022 Sep; 47(9):101269.
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Jain N, Phadnis MA, Martin BC, Mehta JL. Potent Antiplatelet Therapy May Reduce Death from Sepsis in Patients on Chronic Dialysis. Am J Cardiol. 2022 01 01; 162:209-211.
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Balanescu DV, Aziz MK, Donisan T, Palaskas N, Lopez-Mattei J, Hassan S, Kim P, Song J, Ntim W, Cilingiroglu M, Marmagkiolis K, Iliescu C. Cancer treatment resumption in patients with new-generation drug-eluting stents. Coron Artery Dis. 2021 Jun 01; 32(4):295-301.
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Ramanan B, Jeon-Slaughter H, Chen X, Kashyap VS, Kirkwood ML, Timaran CH, Modrall JG, Tsai S. Impact of dual antiplatelet therapy after lower extremity revascularization for chronic limb-threatening ischemia. J Vasc Surg. 2021 10; 74(4):1327-1334.
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Abo-Aly M, George B, Shokri E, Chelvarajan L, El-Helw M, Smyth SS, Abdel-Latif A, Ziada K. Cangrelor in addition to standard therapy reduces cardiac damage and inflammatory markers in patients with ST-segment elevation myocardial infarction. J Thromb Thrombolysis. 2021 Oct; 52(3):934-940.
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Bhattarai M, Ibrahim AM, Salih M, Tandan N, Al-Akchar M, Ayan M, Kulkarni A, Hafiz AM. Comprehensive Outcomes Evaluation After Percutaneous Coronary Intervention in Stable Ischemic Heart Disease and Acute Coronary Syndrome for Short- Versus Standard-Term Dual Antiplatelet Therapy: A Systematic Review and Meta-analysis of Randomized Control Trials. J Cardiovasc Pharmacol. 2020 11; 76(5):574-583.
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Rettenmaier LA, Garg A, Limaye K, Leira EC, Adams HP, Shaban A. Management of Ischemic Stroke Following Left Ventricular Assist Device. J Stroke Cerebrovasc Dis. 2020 Dec; 29(12):105384.
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Zanaty M, Osorno-Cruz C, Byer S, Roa JA, Limaye K, Ishii D, Nakagawa D, Torner J, Yongjun L, Ortega-Gutiérrez S, Samaniego EA, Allan L, Hasan D. Tirofiban Protocol Protects Against Delayed Cerebral Ischemia: A Case-Series Study. Neurosurgery. 2020 10 15; 87(5):E552-E556.
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Moliterno DJ, Smyth SS, Abdel-Latif A. CYP2C19 Genotyping to Guide Antiplatelet Therapy After Percutaneous Coronary Interventions: One Size Rarely Fits All. JAMA. 2020 08 25; 324(8):747-749.
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Elzanaty AM, Nazir S, Awad MT, Elsheikh E, Ahuja KR, Donato A, Eltahawy EA. Meta-Analysis of the Efficacy and Safety of P2Y12 Inhibitor Monotherapy After Short Course of Dual-Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention. Cardiovasc Revasc Med. 2020 12; 21(12):1500-1506.
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Nazir S, Ahuja KR, Virk HUH, Elzanaty A, Waheed TA, Changal KH, Wohlfarth K, Lakhter V, Grande RD, Eltahawy EA. A meta-analysis of efficacy and safety of genotype-guided versus standard of care treatment strategies in selecting antiplatelet therapy in patients with acute coronary syndrome. Catheter Cardiovasc Interv. 2021 04 01; 97(5):788-794.
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Limaye K, Zanaty M, Hudson J, Nakagawa D, Al Kasab S, Alvarez C, Dandapat S, Kung DK, Ortega-Gutierrez S, Jabbour P, Samaniego EA, Hasan D. The Safety and Efficacy of Continuous Tirofiban as a Monoantiplatelet Therapy in the Management of Ruptured Aneurysms Treated Using Stent-Assisted Coiling or Flow Diversion and Requiring Ventricular Drainage. Neurosurgery. 2019 12 01; 85(6):E1037-E1042.
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Kamran S, Akhtar N, George P, Singh R, Imam Y, Salam A, Babu B, Burke P, Own A, Vattoth S, Perkins J, Parray A, Qadri S, Hamid T. Embolic Pattern of Stroke Associated with Cardiac Wall Motion Abnormalities; Narrowing the Embolic Stroke of Undetermined Source Category. J Stroke Cerebrovasc Dis. 2020 Feb; 29(2):104509.
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Jain N, Hunt SL, Cui H, Phadnis MA, Mahnken JD, Shireman TI, Dai J, Mehta JL, Rasu RS. Trends for and Clinical Factors Associated with Choice of Oral P2Y12 Inhibitors for Patients on Chronic Dialysis. Cardiovasc Drugs Ther. 2019 10; 33(5):511-521.
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Saad M, Abdelaziz HK, Mehta JL. Aspirin for primary prevention in the elderly. Aging (Albany NY). 2019 09 06; 11(17):6618-6619.
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Samanta D, Cobb S, Arya K. Sneddon Syndrome: A Comprehensive Overview. J Stroke Cerebrovasc Dis. 2019 Aug; 28(8):2098-2108.
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Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Chauhan A, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M. Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat Med. 2019 04; 25(4):641-655.
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Iliescu C, Balanescu DV, Donisan T, Giza DE, Muñoz Gonzalez ED, Cilingiroglu M, Song J, Mukerji SS, Lopez-Mattei JC, Kim PY, Palaskas N, Mouhayar EN, Durand JB, Marmagkiolis K. Safety of Diagnostic and Therapeutic Cardiac Catheterization in Cancer Patients With Acute Coronary Syndrome and Chronic Thrombocytopenia. Am J Cardiol. 2018 11 01; 122(9):1465-1470.
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Würtz M, Schmidt M, Grove EL, Horváth-Puhó E, Henderson VW, Christiansen CF, Sørensen HT. Pre-admission use of platelet inhibitors and short-term stroke mortality: a population-based cohort study. Eur Heart J Cardiovasc Pharmacother. 2018 07 01; 4(3):158-165.
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Hernandez-Suarez DF, Núñez-Medina H, Scott SA, Lopez-Candales A, Wiley JM, Garcia MJ, Melin K, Nieves-Borrero K, Rodriguez-Ruiz C, Marshall L, Duconge J. Effect of cilostazol on platelet reactivity among patients with peripheral artery disease on clopidogrel therapy. Drug Metab Pers Ther. 2018 03 28; 33(1):49-55.
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Smer A, Salih M, Mahfood Haddad T, Guddeti R, Saadi A, Saurav A, Belbase R, Ayan M, Traina M, Alla V, Del Core M. Meta-analysis of Randomized Controlled Trials on Patent Foramen Ovale Closure Versus Medical Therapy for Secondary Prevention of Cryptogenic Stroke. Am J Cardiol. 2018 06 01; 121(11):1393-1399.
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Yang X, Leesar MA, Ahmed H, Lendel V, Rodriguez G, Mutlu D, Cawich I, Prasad A, Oglesby M, Marmagkiolis K, Phillips NE, Jouke D, Michalek J, Liu Q, Milner T, McElroy A, Hoyt T, Feldman MD, Cilingiroglu M. Impact of ticagrelor and aspirin versus clopidogrel and aspirin in symptomatic patients with peripheral arterial disease: Thrombus burden assessed by optical coherence tomography. Cardiovasc Revasc Med. 2018 10; 19(7 Pt A):778-784.
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Becker RC, Sexton T, Smyth SS. Translational Implications of Platelets as Vascular First Responders. Circ Res. 2018 02 02; 122(3):506-522.
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Battle B, Sexton KW, Fitzgerald RT. Understanding the Value of Repeat Head CT in Elderly Trauma Patients on Anticoagulant or Antiplatelet Therapy. J Am Coll Radiol. 2018 02; 15(2):319-321.
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Pandey S, Cottler-Fox M. Acetylsalicylic Acid During Leukapheresis Reduces the Incidence of Clotting in Hematopoietic Progenitor Cell Products. Ann Clin Lab Sci. 2017 Sep; 47(5):551-555.
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Iliescu CA, Cilingiroglu M, Giza DE, Rosales O, Lebeau J, Guerrero-Mantilla I, Lopez-Mattei J, Song J, Silva G, Loyalka P, Paixao ARM, Yusuf SW, Perin E, Anderson VH, Marmagkiolis K. "Bringing on the light" in a complex clinical scenario: Optical coherence tomography-guided discontinuation of antiplatelet therapy in cancer patients with coronary artery disease (PROTECT-OCT registry). Am Heart J. 2017 Dec; 194:83-91.
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Hernandez-Suarez DF, Scott SA, Tomey MI, Melin K, Lopez-Candales A, Buckley CE, Duconge J. Clinical determinants of clopidogrel responsiveness in a heterogeneous cohort of Puerto Rican Hispanics. Ther Adv Cardiovasc Dis. 2017 Sep; 11(9):235-241.
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Lowery CL, Elliott C, Cooper A, Hadden C, Sonon RN, Azadi P, Williams DK, Marsh JD, Woulfe DS, Kilic F. Cigarette Smoking-Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets. J Am Heart Assoc. 2017 May 18; 6(5).
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Elbadawi A, Saad M, Nairooz R. Aspirin Use Prior to Coronary Artery Bypass Grafting Surgery: a Systematic Review. Curr Cardiol Rep. 2017 02; 19(2):18.
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Hinduja A, Limaye K, Ravilla R, Sasapu A, Papanikolaou X, Wei L, Torbey M, Waheed S. Spectrum of Cerebrovascular Disease in Patients with Multiple Myeloma Undergoing Chemotherapy-Results of a Case Control Study. PLoS One. 2016; 11(11):e0166627.
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Nairooz R, Valgimigli M, Rochlani Y, Pothineni NV, Raina S, Sardar P, Mukherjee D, Naidu SS, Shavelle DM. Meta-analysis of clopidogrel pretreatment in acute coronary syndrome patients undergoing invasive strategy. Int J Cardiol. 2017 Feb 15; 229:82-89.
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Brice AE, Hernandez GA, Sanchez M, Haynick M, Mendoza CE. In-stent thrombosis when switching ticagrelor to clopidogrel after percutaneous coronary intervention. Platelets. 2017 May; 28(3):305-309.
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Meena N, Abouzgheib W, Patolia S, Rosenheck J, Boujaoude Z, Bartter T. EBUS-TBNA and EUS-FNA: Risk Assessment for Patients Receiving Clopidogrel. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):303-307.
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Pothineni NV, Watts TE, Ding Z, Dai Y, Deshmukh AJ. Eptifibatide-Induced Thrombocytopenia--When Inhibitor Turns Killer. Am J Ther. 2016 Jan-Feb; 23(1):e298-9.
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Jain N, Li X, Adams-Huet B, Sarode R, Toto RD, Banerjee S, Hedayati SS. Differences in Whole Blood Platelet Aggregation at Baseline and in Response to Aspirin and Aspirin Plus Clopidogrel in Patients With Versus Without Chronic Kidney Disease. Am J Cardiol. 2016 Feb 15; 117(4):656-663.
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Trindade AJ, Hirten R, Slattery E, Inamdar S, Sejpal DV. Endoscopic ultrasound-guided fine-needle aspiration of solid lesions on clopidogrel may not be a high-risk procedure for bleeding: A case series. Dig Endosc. 2016 Mar; 28(2):216-9.
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Hoh BL, Gong Y, McDonough CW, Waters MF, Royster AJ, Sheehan TO, Burkley B, Langaee TY, Mocco J, Zuckerman SL, Mummareddy N, Stephens ML, Ingram C, Shaffer CM, Denny JC, Brilliant MH, Kitchner TE, Linneman JG, Roden DM, Johnson JA. CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease. J Neurosurg. 2016 Jun; 124(6):1746-51.
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Nairooz R, Ayoub K, Shavelle D. Duration of Triple Therapy: A Clinical Question Yet to Be Answered. J Am Coll Cardiol. 2015 Nov 17; 66(20):2266.
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Limaye K, Abla AA. We Will Use Antiplatelets As Our First Choice for Prevention of Stroke Recurrence in Cervical Arterial Dissection After Reading CADISS--Will You? World Neurosurg. 2015 Nov; 84(5):1182-4.
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Gaynor BG, Haussen DC, Ambekar S, Peterson EC, Yavagal DR, Elhammady MS. Covered Stents for the Prevention and Treatment of Carotid Blowout Syndrome. Neurosurgery. 2015 Aug; 77(2):164-7.
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Beavers CJ, Heron P, Smyth SS, Bain JA, Macaulay TE. Obesity and Antiplatelets-Does One Size Fit All? Thromb Res. 2015 Oct; 136(4):712-6.
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Ayoub K, Marji M, Nairooz R. Antithrombotic and Antiplatelet Therapy in Patients Requiring Oral Anticoagulation After Percutaneous Coronary Intervention. Am J Cardiol. 2015 Sep 01; 116(5):828-9.
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Wilkes S, Stansby G, Sims A, Haining S, Allen J. Peripheral arterial disease: diagnostic challenges and how photoplethysmography may help. Br J Gen Pract. 2015 Jun; 65(635):323-4.
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Azzalini L, Al-Hawwas M, L'Allier PL. Very late bioresorbable vascular scaffold thrombosis: a new clinical entity. EuroIntervention. 2015 May 19; 11(1):e1-2.
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Paixao AR, Enriquez JR, Wang TY, Li S, Berry JD, Khera A, Das SR, de Lemos JA, Kontos MC. Risk factor burden and control at the time of admission in patients with acute myocardial infarction: Results from the NCDR. Am Heart J. 2015 Jul; 170(1):173-9, 179.e1.
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Mallikarjuna Rao Edupuganti M, Marmagkiolis K, Cilingiroglu M, Uretsky BF, Hakeem A. Optimizing selection of antithrombotic therapy in patients requiring PCI and long term anticoagulation. Cardiovasc Revasc Med. 2014 Nov-Dec; 15(8):414-20.
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Nairooz R, Sardar P, Amin H, Swaminathan RV, Kim LK, Chatterjee S, Feldman DN. Meta-analysis of randomized clinical trials comparing bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitors in patients undergoing percutaneous coronary intervention and in patients with ST-segment elevation myocardial infarction. Am J Cardiol. 2014 Jul 15; 114(2):250-9.
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Steinhubl SR, Eikelboom JW, Hylek EM, Dauerman HL, Smyth SS, Becker RC. Antiplatelet therapy in prevention of cardio- and venous thromboembolic events. J Thromb Thrombolysis. 2014 Apr; 37(3):362-71.
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Kern MJ, Applegate RJ, Bell M, Brilakis ES, Butman SM, Bach RG, Kaul P, Klein LW, Krucoff MW, Moore JA, Price MJ, Rao SV, Stone GW, Uretsky BF. Conversations in cardiology: bridging antiplatelet therapy before surgery. Catheter Cardiovasc Interv. 2014 Apr 01; 83(5):748-52.
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Russo F, De Nittis G, Zerboni SC, Valli P, Galli M, Abdou SM, Sachdeva R. How should I treat critical stenosis of a saphenous venous graft to the posterior descending artery on the bifurcation site? EuroIntervention. 2014; 9(12):1478-82.
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Khan AR, Bin Abdulhak A, Eltahawy EA. Device closure of patent foramen ovale in cryptogenic stroke: still stuck in hamlet mode. Catheter Cardiovasc Interv. 2014 Jul 01; 84(1):167.
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Chang J, Ahn JE, Landsman N, Rhee K, Chun L, Patel KK. Efficacy of contemporary medical management for asymptomatic carotid artery stenosis. Am Surg. 2013 Oct; 79(10):987-91.
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Abouzgheib W, Meena N, Jagtap P, Schorr C, Boujaoude Z, Bartter T. Percutaneous dilational tracheostomy in patients receiving antiplatelet therapy: is it safe? J Bronchology Interv Pulmonol. 2013 Oct; 20(4):322-5.
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Yin H, Stojanovic-Terpo A, Xu W, Corken A, Zakharov A, Qian F, Pavlovic S, Krbanjevic A, Lyubimov AV, Wang ZJ, Ware J, Du X. Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2529-37.
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Kim SD, Kim HN, Lee JH, Jin WJ, Hwang SJ, Kim HH, Ha H, Lee ZH. Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice. Biochem Pharmacol. 2013 Sep 15; 86(6):782-90.
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