 Drug Carriers
"Drug Carriers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
| Descriptor ID |
D004337
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| MeSH Number(s) |
D26.255.260 D27.720.280.260 E02.319.300.380
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Drug Carriers".
Below are MeSH descriptors whose meaning is more specific than "Drug Carriers".
This graph shows the total number of publications written about "Drug Carriers" by people in UAMS Profiles by year, and whether "Drug Carriers" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2019 | 1 | 0 | 1 | | 2018 | 2 | 5 | 7 | | 2017 | 6 | 2 | 8 | | 2016 | 2 | 2 | 4 | | 2015 | 7 | 2 | 9 | | 2014 | 6 | 1 | 7 | | 2013 | 2 | 3 | 5 | | 2012 | 3 | 0 | 3 | | 2011 | 1 | 1 | 2 | | 2010 | 1 | 1 | 2 | | 2009 | 3 | 1 | 4 | | 2008 | 1 | 2 | 3 | | 2007 | 2 | 0 | 2 | | 2006 | 2 | 1 | 3 | | 2005 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1997 | 0 | 2 | 2 | | 1994 | 0 | 3 | 3 |
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Below are the most recent publications written about "Drug Carriers" by people in Profiles over the past ten years.
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Bhattacharya D, Tiwari R, Bhatia T, Purohit MP, Pal A, Jagdale P, Mudiam MKR, Chaudhari BP, Shukla Y, Ansari KM, Kumar A, Kumar P, Srivastava V, Gupta KC. Accelerated and scarless wound repair by a multicomponent hydrogel through simultaneous activation of multiple pathways. Drug Deliv Transl Res. 2019 12; 9(6):1143-1158.
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Banala VT, Urandur S, Sharma S, Sharma M, Shukla RP, Marwaha D, Gautam S, Dwivedi M, Mishra PR. Targeted co-delivery of the aldose reductase inhibitor epalrestat and chemotherapeutic doxorubicin via a redox-sensitive prodrug approach promotes synergistic tumor suppression. Biomater Sci. 2019 Jun 25; 7(7):2889-2906.
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Urandur S, Marwaha D, Gautam S, Banala VT, Sharma M, Mishra PR. Nonlamellar liquid crystals: a new paradigm for the delivery of small molecules and bio-macromolecules. Ther Deliv. 2018 09; 9(9):667-689.
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Banala VT, Sharma S, Barnwal P, Urandur S, Shukla RP, Ahmad N, Mittapelly N, Pandey G, Dwivedi M, Kalleti N, Mitra K, Rath SK, Trivedi R, Mishra PR. Synchronized Ratiometric Codelivery of Metformin and Topotecan through Engineered Nanocarrier Facilitates In Vivo Synergistic Precision Levels at Tumor Site. Adv Healthc Mater. 2018 10; 7(19):e1800300.
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Taghizadehghalehjoughi A, Hacimuftuoglu A, Cetin M, Ugur AB, Galateanu B, Mezhuev Y, Okkay U, Taspinar N, Taspinar M, Uyanik A, Gundogdu B, Mohammadzadeh M, Nalci KA, Stivaktakis P, Tsatsakis A, Jung TW, Jeong JH, Abd El-Aty AM. Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies. Nanomedicine (Lond). 2018 07; 13(13):1595-1606.
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Kumari M, Purohit MP, Patnaik S, Shukla Y, Kumar P, Gupta KC. Curcumin loaded selenium nanoparticles synergize the anticancer potential of doxorubicin contained in self-assembled, cell receptor targeted nanoparticles. Eur J Pharm Biopharm. 2018 Sep; 130:185-199.
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Pinto MN, Martinez-Gonzalez J, Chakraborty I, Mascharak PK. Incorporation of a Theranostic "Two-Tone" Luminescent Silver Complex into Biocompatible Agar Hydrogel Composite for the Eradication of ESKAPE Pathogens in a Skin and Soft Tissue Infection Model. Inorg Chem. 2018 Jun 04; 57(11):6692-6701.
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Pandey G, Mittapelly N, Banala VT, Mishra PR. Multifunctional Glycoconjugate Assisted Nanocrystalline Drug Delivery for Tumor Targeting and Permeabilization of Lysosomal-Mitochondrial Membrane. ACS Appl Mater Interfaces. 2018 May 23; 10(20):16964-16976.
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Urandur S, Banala VT, Shukla RP, Mittapelly N, Pandey G, Kalleti N, Mitra K, Rath SK, Trivedi R, Ramarao P, Mishra PR. Anisamide-Anchored Lyotropic Nano-Liquid Crystalline Particles with AIE Effect: A Smart Optical Beacon for Tumor Imaging and Therapy. ACS Appl Mater Interfaces. 2018 Apr 18; 10(15):12960-12974.
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Khan MA, Zafaryab M, Mehdi SH, Ahmad I, Rizvi MMA. Physicochemical Characterization of Curcumin Loaded Chitosan Nanoparticles: Implications in Cervical Cancer. Anticancer Agents Med Chem. 2018; 18(8):1131-1137.
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Bajpayee AG, De la Vega RE, Scheu M, Varady NH, Yannatos IA, Brown LA, Krishnan Y, Fitzsimons TJ, Bhattacharya P, Frank EH, Grodzinsky AJ, Porter RM. Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis. Eur Cell Mater. 2017 12 05; 34:341-364.
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Purohit MP, Verma NK, Kar AK, Singh A, Ghosh D, Patnaik S. Inhibition of Thioredoxin Reductase by Targeted Selenopolymeric Nanocarriers Synergizes the Therapeutic Efficacy of Doxorubicin in MCF7 Human Breast Cancer Cells. ACS Appl Mater Interfaces. 2017 Oct 25; 9(42):36493-36512.
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Nima ZA, Alwbari AM, Dantuluri V, Hamzah RN, Sra N, Motwani P, Arnaoutakis K, Levy RA, Bohliqa AF, Nedosekin D, Zharov VP, Makhoul I, Biris AS. Targeting nano drug delivery to cancer cells using tunable, multi-layer, silver-decorated gold nanorods. J Appl Toxicol. 2017 Dec; 37(12):1370-1378.
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Tripathi P, Jaiswal AK, Dube A, Mishra PR. Hexadecylphosphocholine (Miltefosine) stabilized chitosan modified Ampholipospheres as prototype co-delivery vehicle for enhanced killing of L. donovani. Int J Biol Macromol. 2017 Dec; 105(Pt 1):625-637.
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Berretta JM, Jennings JA, Courtney HS, Beenken KE, Smeltzer MS, Haggard WO. Blended Chitosan Paste for Infection Prevention: Preliminary and Preclinical Evaluations. Clin Orthop Relat Res. 2017 Jul; 475(7):1857-1870.
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Harris MA, Beenken KE, Smeltzer MS, Haggard WO, Jennings JA. Phosphatidylcholine Coatings Deliver Local Antimicrobials and Reduce Infection in a Murine Model: A Preliminary Study. Clin Orthop Relat Res. 2017 Jul; 475(7):1847-1853.
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Sharma M, Sharma S, Sharma V, Sharma K, Yadav SK, Dwivedi P, Agrawal S, Paliwal SK, Dwivedi AK, Maikhuri JP, Gupta G, Mishra PR, Rawat AKS. Oleanolic-bioenhancer coloaded chitosan modified nanocarriers attenuate breast cancer cells by multimode mechanism and preserve female fertility. Int J Biol Macromol. 2017 Nov; 104(Pt A):1345-1358.
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Kumari M, Ray L, Purohit MP, Patnaik S, Pant AB, Shukla Y, Kumar P, Gupta KC. Curcumin loading potentiates the chemotherapeutic efficacy of selenium nanoparticles in HCT116 cells and Ehrlich's ascites carcinoma bearing mice. Eur J Pharm Biopharm. 2017 Aug; 117:346-362.
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Chakraborty I, Jimenez J, Sameera WM, Kato M, Mascharak PK. Luminescent Re(I) Carbonyl Complexes as Trackable PhotoCORMs for CO delivery to Cellular Targets. Inorg Chem. 2017 Mar 06; 56(5):2863-2873.
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Khan MA, Zafaryab M, Mehdi SH, Quadri J, Rizvi MM. Characterization and carboplatin loaded chitosan nanoparticles for the chemotherapy against breast cancer in vitro studies. Int J Biol Macromol. 2017 Apr; 97:115-122.
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Sharma S, Verma A, Singh J, Teja BV, Mittapelly N, Pandey G, Urandur S, Shukla RP, Konwar R, Mishra PR. Vitamin B6 Tethered Endosomal pH Responsive Lipid Nanoparticles for Triggered Intracellular Release of Doxorubicin. ACS Appl Mater Interfaces. 2016 Nov 09; 8(44):30407-30421.
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Verma NK, Purohit MP, Equbal D, Dhiman N, Singh A, Kar AK, Shankar J, Tehlan S, Patnaik S. Targeted Smart pH and Thermoresponsive N,O-Carboxymethyl Chitosan Conjugated Nanogels for Enhanced Therapeutic Efficacy of Doxorubicin in MCF-7 Breast Cancer Cells. Bioconjug Chem. 2016 Nov 16; 27(11):2605-2619.
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Khan MA, Zafaryab M, Mehdi SH, Ahmad I, Rizvi MM. Characterization and anti-proliferative activity of curcumin loaded chitosan nanoparticles in cervical cancer. Int J Biol Macromol. 2016 Dec; 93(Pt A):242-253.
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Mallick N, Anwar M, Asfer M, Mehdi SH, Rizvi MMA, Panda AK, Talegaonkar S, Ahmad FJ. Chondroitin sulfate-capped super-paramagnetic iron oxide nanoparticles as potential carriers of doxorubicin hydrochloride. Carbohydr Polym. 2016 Oct 20; 151:546-556.
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Carrington SJ, Chakraborty I, Bernard JM, Mascharak PK. A Theranostic Two-Tone Luminescent PhotoCORM Derived from Re(I) and (2-Pyridyl)-benzothiazole: Trackable CO Delivery to Malignant Cells. Inorg Chem. 2016 Aug 15; 55(16):7852-8.
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Albayati ZA, Sunkara M, Schmidt-Malan SM, Karau MJ, Morris AJ, Steckelberg JM, Patel R, Breen PJ, Smeltzer MS, Taylor KG, Merten KE, Pierce WM, Crooks PA. Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. Antimicrob Agents Chemother. 2015 Dec 14; 60(3):1865-8.
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Verma A, Sharma S, Gupta PK, Singh A, Teja BV, Dwivedi P, Gupta GK, Trivedi R, Mishra PR. Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin. Acta Biomater. 2016 Feb; 31:288-300.
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Jennings JA, Carpenter DP, Troxel KS, Beenken KE, Smeltzer MS, Courtney HS, Haggard WO. Novel Antibiotic-loaded Point-of-care Implant Coating Inhibits Biofilm. Clin Orthop Relat Res. 2015 Jul; 473(7):2270-82.
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Nedosekin DA, Foster S, Nima ZA, Biris AS, Galanzha EI, Zharov VP. Photothermal confocal multicolor microscopy of nanoparticles and nanodrugs in live cells. Drug Metab Rev. 2015 08; 47(3):346-55.
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Gupta PK, Jaiswal AK, Asthana S, Teja B V, Shukla P, Shukla M, Sagar N, Dube A, Rath SK, Mishra PR. Synergistic enhancement of parasiticidal activity of amphotericin B using copaiba oil in nanoemulsified carrier for oral delivery: an approach for non-toxic chemotherapy. Br J Pharmacol. 2015 Jul; 172(14):3596-610.
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Oh B, Melchert RB, Lee CH. Biomimicking Robust Hydrogel for the Mesenchymal Stem Cell Carrier. Pharm Res. 2015 Oct; 32(10):3213-27.
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Zhou Z, Badkas A, Stevenson M, Lee JY, Leung YK. Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery. Int J Pharm. 2015 Jun 20; 487(1-2):81-90.
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Rychahou P, Haque F, Shu Y, Zaytseva Y, Weiss HL, Lee EY, Mustain W, Valentino J, Guo P, Evers BM. Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration. ACS Nano. 2015 Feb 24; 9(2):1108-16.
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Jain K, Verma AK, Mishra PR, Jain NK. Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers. Nanomedicine. 2015 Apr; 11(3):705-13.
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Gupta PK, Jaiswal AK, Asthana S, Verma A, Kumar V, Shukla P, Dwivedi P, Dube A, Mishra PR. Self assembled ionically sodium alginate cross-linked amphotericin B encapsulated glycol chitosan stearate nanoparticles: applicability in better chemotherapy and non-toxic delivery in visceral leishmaniasis. Pharm Res. 2015 May; 32(5):1727-40.
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Saeed LM, Mahmood M, Pyrek SJ, Fahmi T, Xu Y, Mustafa T, Nima ZA, Bratton SM, Casciano D, Dervishi E, Radominska-Pandya A, Biris AS. Single-walled carbon nanotube and graphene nanodelivery of gambogic acid increases its cytotoxicity in breast and pancreatic cancer cells. J Appl Toxicol. 2014 Nov; 34(11):1188-99.
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Gozuacik D, Yagci-Acar HF, Akkoc Y, Kosar A, Dogan-Ekici AI, Ekici S. Anticancer use of nanoparticles as nucleic acid carriers. J Biomed Nanotechnol. 2014 Sep; 10(9):1751-83.
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Shukla P, Dwivedi P, Gupta PK, Mishra PR. Optimization of novel tocopheryl acetate nanoemulsions for parenteral delivery of curcumin for therapeutic intervention of sepsis. Expert Opin Drug Deliv. 2014 Nov; 11(11):1697-712.
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Bajpayee AG, Scheu M, Grodzinsky AJ, Porter RM. Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints. J Orthop Res. 2014 Aug; 32(8):1044-51.
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Jain V, Shukla P, Pal R, Mishra PR. Cationic nanoemulsions bearing ciprofloxacin surf-plexes enhances its therapeutic efficacy in conditions of E. coli induced peritonitis and sepsis. Pharm Res. 2014 Oct; 31(10):2630-42.
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Khatik R, Dwivedi P, Khare P, Kansal S, Dube A, Mishra PR, Dwivedi AK. Development of targeted 1,2-diacyl-sn-glycero-3-phospho-l-serine-coated gelatin nanoparticles loaded with amphotericin B for improved in vitro and in vivo effect in leishmaniasis. Expert Opin Drug Deliv. 2014 May; 11(5):633-46.
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Martin DT, Steinbach JM, Liu J, Shimizu S, Kaimakliotis HZ, Wheeler MA, Hittelman AB, Mark Saltzman W, Weiss RM. Surface-modified nanoparticles enhance transurothelial penetration and delivery of survivin siRNA in treating bladder cancer. . 2014 Jan; 13(1):71-81.
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Jana B, Mondal G, Biswas A, Chakraborty I, Saha A, Kurkute P, Ghosh S. Dual functionalized graphene oxide serves as a carrier for delivering oligohistidine- and biotin-tagged biomolecules into cells. Macromol Biosci. 2013 Nov; 13(11):1478-84.
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Martin DT, Hoimes CJ, Kaimakliotis HZ, Cheng CJ, Zhang K, Liu J, Wheeler MA, Kelly WK, Tew GN, Saltzman WM, Weiss RM. Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer. Nanomedicine. 2013 Nov; 9(8):1124-34.
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Rodriguez-Feo CL, Sexton KW, Boyer RB, Pollins AC, Cardwell NL, Nanney LB, Shack RB, Mikesh MA, McGill CH, Driscoll CW, Bittner GD, Thayer WP. Blocking the P2X7 receptor improves outcomes after axonal fusion. J Surg Res. 2013 Sep; 184(1):705-13.
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Shao J, Griffin RJ, Galanzha EI, Kim JW, Koonce N, Webber J, Mustafa T, Biris AS, Nedosekin DA, Zharov VP. Photothermal nanodrugs: potential of TNF-gold nanospheres for cancer theranostics. Sci Rep. 2013; 3:1293.
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Kansal S, Tandon R, Dwivedi P, Misra P, Verma PR, Dube A, Mishra PR. Development of nanocapsules bearing doxorubicin for macrophage targeting through the phosphatidylserine ligand: a system for intervention in visceral leishmaniasis. J Antimicrob Chemother. 2012 Nov; 67(11):2650-60.
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Jain V, Swarnakar NK, Mishra PR, Verma A, Kaul A, Mishra AK, Jain NK. Paclitaxel loaded PEGylated gleceryl monooleate based nanoparticulate carriers in chemotherapy. Biomaterials. 2012 Oct; 33(29):7206-20.
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Hackett MJ, Joolakanti S, Hartranft ME, Guley PC, Cho MJ. A dicarboxylic fatty acid derivative of paclitaxel for albumin-assisted drug delivery. J Pharm Sci. 2012 Sep; 101(9):3292-304.
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Carroll FI, Blough BE, Pidaparthi RR, Abraham P, Gong PK, Deng L, Huang X, Gunnell M, Lay JO, Peterson EC, Owens SM. Synthesis of mercapto-(+)-methamphetamine haptens and their use for obtaining improved epitope density on (+)-methamphetamine conjugate vaccines. J Med Chem. 2011 Jul 28; 54(14):5221-8.
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Lyzogubov VV, Tytarenko RG, Liu J, Bora NS, Bora PS. Polyethylene glycol (PEG)-induced mouse model of choroidal neovascularization. J Biol Chem. 2011 May 06; 286(18):16229-37.
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